BRPI0913021A2 - distribuição pulmonar de uma fluoroquinolona - Google Patents

distribuição pulmonar de uma fluoroquinolona

Info

Publication number
BRPI0913021A2
BRPI0913021A2 BRPI0913021A BRPI0913021A BRPI0913021A2 BR PI0913021 A2 BRPI0913021 A2 BR PI0913021A2 BR PI0913021 A BRPI0913021 A BR PI0913021A BR PI0913021 A BRPI0913021 A BR PI0913021A BR PI0913021 A2 BRPI0913021 A2 BR PI0913021A2
Authority
BR
Brazil
Prior art keywords
fluoroquinolone
pulmonary distribution
pulmonary
distribution
Prior art date
Application number
BRPI0913021A
Other languages
English (en)
Portuguese (pt)
Inventor
Jeffry Weers
Thomas Tarara
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0913021A2 publication Critical patent/BRPI0913021A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BRPI0913021A 2008-05-15 2009-05-15 distribuição pulmonar de uma fluoroquinolona BRPI0913021A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12778008P 2008-05-15 2008-05-15
PCT/US2009/044116 WO2009140587A1 (en) 2008-05-15 2009-05-15 Pulmonary delivery of a fluoroquinolone

Publications (1)

Publication Number Publication Date
BRPI0913021A2 true BRPI0913021A2 (pt) 2015-10-13

Family

ID=41099304

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0913021A BRPI0913021A2 (pt) 2008-05-15 2009-05-15 distribuição pulmonar de uma fluoroquinolona

Country Status (11)

Country Link
US (3) US8834930B2 (enExample)
EP (1) EP2285345A1 (enExample)
JP (2) JP5727927B2 (enExample)
KR (1) KR101621986B1 (enExample)
CN (1) CN102099009B (enExample)
AU (1) AU2009246217B2 (enExample)
BR (1) BRPI0913021A2 (enExample)
CA (1) CA2724009C (enExample)
MX (1) MX2010012452A (enExample)
RU (1) RU2497524C2 (enExample)
WO (1) WO2009140587A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
BRPI0514293B1 (pt) 2004-08-23 2022-07-19 Mannkind Corporation Sistema microparticulado para distribuição de droga
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
DK1928423T3 (en) 2005-09-14 2016-02-29 Mannkind Corp A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces
CA2643464C (en) 2006-02-22 2018-09-04 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2011163272A1 (en) 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
DK2230934T3 (da) 2007-12-14 2012-11-26 Aerodesigns Inc Afgivelse af aerosoliserbare næringsmiddelprodukter
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN106039494B (zh) 2008-06-13 2019-12-24 曼金德公司 干粉吸入器和用于药物输送的系统
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
CN102202649A (zh) 2008-10-07 2011-09-28 Mpex医药有限公司 用于改进的药物动力学的氟喹诺酮气雾剂制剂
DK2346509T3 (da) 2008-10-07 2020-08-03 Horizon Orphan Llc Inhalation af levofloxacin til at reducere lungeinflammation
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101639098B1 (ko) 2009-03-26 2016-07-12 풀매트릭스 오퍼레이팅 컴퍼니, 인크 폐 질환 치료용 건조 분말 제형 및 방법
CA2759874C (en) * 2009-04-24 2016-11-08 Mpex Pharmaceuticals, Inc. Methods of treating a pulmonary bacterial infection using fluoroquinolones
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
CA2938650C (en) 2009-09-04 2018-01-09 Raptor Pharmaceuticals Inc. Use of aerosolized levofloxacin for treating cystic fibrosis
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
US9061352B2 (en) 2010-08-30 2015-06-23 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
PT2621488T (pt) * 2010-09-29 2019-02-12 Pulmatrix Operating Co Inc Pós secos catiónicos
RU2640921C2 (ru) 2010-09-29 2018-01-12 Пулмэтрикс, Инк. Катионы одновалентных металлов сухих порошков для ингаляций
MY180552A (en) 2011-04-01 2020-12-02 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
JP6018640B2 (ja) 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
BR112014014399A2 (pt) * 2011-12-16 2017-06-13 Novartis Ag aparelho de aerolização para administração de medicamento independente do perfil de inalação
JP2015509788A (ja) 2012-02-29 2015-04-02 パルマトリックス，インコーポレイテッド 吸入に適した乾燥粉末
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US9757529B2 (en) * 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
KR102391750B1 (ko) 2013-03-15 2022-04-28 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
WO2014165303A1 (en) 2013-04-01 2014-10-09 Pulmatrix, Inc. Tiotropium dry powders
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10194693B2 (en) * 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
US9427376B2 (en) * 2013-10-10 2016-08-30 Chiesi Farmaceutici S.P.A. Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
AU2015222051A1 (en) * 2014-02-28 2016-10-13 Algipharma As Use of alginate oligomers in the treatment of cystic fibrosis and other conditions associated with defective CFTR ion channel function
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
WO2015157038A1 (en) * 2014-04-08 2015-10-15 Aradigm Corporation Liposomal ciprofloxacin formulations with activity against non-tuberculous mycobacteria
CN107847696B (zh) * 2014-09-10 2020-11-06 方特慕控股第一私人有限公司 用于调节递送装置中的气流的方法和装置
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3247235B1 (en) 2015-01-22 2020-09-02 Fontem Holdings 1 B.V. Electronic vaporization devices
RU2731212C2 (ru) * 2015-09-09 2020-08-31 Новартис Аг Направленная доставка высушенных распылением композиций в легкие
WO2020163416A1 (en) * 2019-02-05 2020-08-13 Mylan Inc Devices and methods for tobramycin inhalation treatment
WO2024233921A1 (en) * 2023-05-10 2024-11-14 Cornell University Compositions for the transtympanic delivery of antibiotics and methods for using the same

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1016489B (it) * 1974-03-18 1977-05-30 Isf Spa Inalatore
SE408265B (sv) * 1975-12-12 1979-06-05 Draco Ab Anordning for koldioxiddriven endosaerosol, avsedd for inhalering
US4247066A (en) * 1978-02-21 1981-01-27 General Dynamics Corporation Airfoil variable cambering device and method
IT1116047B (it) * 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
DE3634952A1 (de) * 1986-10-14 1988-04-21 Bayer Ag Imidazo-pyrrolo-pyridin-derivate
IT1228459B (it) * 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
CA2112674C (en) * 1991-07-02 2005-10-04 John S. Patton Method and device for delivering aerosolized medicaments
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
GB9413202D0 (en) 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
JP3388896B2 (ja) * 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
US5508269A (en) * 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
WO1996032096A1 (en) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
US6503480B1 (en) * 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
AU5806898A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems Processes and compositions for spray drying hydrophobic drugs in organic solventsuspensions of hydrophilic excipients
GB9703673D0 (en) 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US5940778A (en) 1997-07-31 1999-08-17 Bp Amoco Corporation Method of seismic attribute generation and seismic exploration
NZ503464A (en) 1997-09-29 2002-05-31 Inhale Therapeutic Syst Perforated microparticles containing a bioactive agent for pulmonary delivery
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
WO1999016420A1 (en) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in nebulizers
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6257233B1 (en) * 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
DE19835346A1 (de) 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
US6630169B1 (en) * 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
JP4377076B2 (ja) 1999-05-28 2009-12-02 ネクター セラピューティクス 噴霧化された薬物の計量された量を投与する装置と方法
US20020103165A1 (en) 2000-02-29 2002-08-01 Alliance Pharmaceutical Corp., Engineered spray-dried lipid-based microparticles for cellular targeting
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
CA2382133C (en) 2000-05-10 2010-11-23 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US20020106368A1 (en) 2000-07-28 2002-08-08 Adrian Bot Novel methods and compositions to upregulate, redirect or limit immune responses to peptides, proteins and other bioactive compounds and vectors expressing the same
US6357490B1 (en) * 2000-08-22 2002-03-19 Advanced Inhalation Research, Inc. System, method and apparatus for filling containers
KR100743404B1 (ko) * 2000-12-21 2007-07-30 넥타르 테라퓨틱스 폴리엔 항균제의 폐 전달
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
EP1390012A4 (en) 2001-04-26 2009-10-28 Novartis Ag NEW METHODS AND COMPOSITIONS FOR RELEASING MACROMOLECULES TO OR BY THE AIRWAY
WO2003041777A1 (en) * 2001-11-14 2003-05-22 Nektar Therapeutics Aerosolization device with improved endpiece connection
US10124128B2 (en) * 2001-11-14 2018-11-13 Bgp Products Operations Gmbh Aerosolization apparatus with removable mouthpiece
AU2002351271A1 (en) * 2001-12-21 2003-07-24 Nektar Therapeutics Capsule package with moisture barrier
US7754242B2 (en) * 2002-03-20 2010-07-13 Alkermes, Inc. Inhalable sustained therapeutic formulations
CA2483914A1 (en) * 2002-05-07 2003-11-20 Nektar Therapeutics Capsules for dry powder inhalers and methods of making and using same
US7516741B2 (en) * 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
PL378270A1 (pl) 2002-12-31 2006-03-20 Nektar Therapeutics Preparat farmaceutyczny zawierający nierozpuszczalny środek czynny
DE10305319A1 (de) * 2003-02-10 2004-08-26 Bayer Healthcare Ag Behandlung bakteriell verursachter Lungenkrankheiten
JP4828405B2 (ja) * 2003-02-10 2011-11-30 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 呼吸器官の細菌性疾患の処置
DE10305318A1 (de) * 2003-02-10 2004-08-19 Bayer Healthcare Ag Behandlung bakteriell verursachter Lungenkrankheiten
JP4943838B2 (ja) * 2003-04-09 2012-05-30 ネクター セラピューティクス 空気入口シールドを備えたエアゾール化装置
HUE026950T2 (en) * 2003-04-09 2016-08-29 Novartis Ag Nozzle with guide wire for puncturing the capsule
US20050214224A1 (en) 2003-11-04 2005-09-29 Nektar Therapeutics Lipid formulations for spontaneous drug encapsulation
CA2570976C (en) * 2004-06-18 2013-08-13 Novartis Vaccines And Diagnostics, Inc. Methods of treatment of endobronchial infections
CN101442989B (zh) * 2004-06-21 2013-04-03 诺瓦帝斯公司 包括两性霉素b的组合物
WO2006033713A2 (en) * 2004-08-09 2006-03-30 Chiron Corporation Methods for ciprofloxacin inhalation
TWI254288B (en) * 2004-09-30 2006-05-01 Benq Corp Optical disk drive with mechanism of protecting pick-up head
EP2594272B1 (en) 2005-05-18 2018-07-11 Horizon Orphan LLC Aerosolized fluoroquinolones and uses thereof
US20060280691A1 (en) * 2005-06-13 2006-12-14 University Of Alberta Spray freeze dried liposomal ciprofloxacin powder aerosol drug delivery
US7947308B2 (en) * 2005-07-20 2011-05-24 Raimar Loebenberg Effervescent powders for inhalation
US7256576B2 (en) * 2005-07-29 2007-08-14 General Electric Company ID-OD discrimination sensor
DE102005036921A1 (de) 2005-08-05 2007-02-08 Bayerische Motoren Werke Ag Pulsationsminderer für hydraulische Systeme

Also Published As

Publication number Publication date
AU2009246217B2 (en) 2013-01-10
AU2009246217A1 (en) 2009-11-19
JP5727927B2 (ja) 2015-06-03
MX2010012452A (es) 2011-03-15
RU2010150839A (ru) 2012-06-20
JP5989750B2 (ja) 2016-09-07
JP2011520911A (ja) 2011-07-21
US20150374685A1 (en) 2015-12-31
CN102099009B (zh) 2014-07-02
CA2724009A1 (en) 2009-11-19
JP2015091829A (ja) 2015-05-14
WO2009140587A1 (en) 2009-11-19
RU2497524C2 (ru) 2013-11-10
CA2724009C (en) 2016-10-11
EP2285345A1 (en) 2011-02-23
US9155732B2 (en) 2015-10-13
CN102099009A (zh) 2011-06-15
KR101621986B1 (ko) 2016-05-17
US20110123626A1 (en) 2011-05-26
KR20110020816A (ko) 2011-03-03
US20140350028A1 (en) 2014-11-27
US8834930B2 (en) 2014-09-16
HK1155382A1 (en) 2012-05-18

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07E Notice of approval relating to section 229 industrial property law
B07A Technical examination (opinion): publication of technical examination (opinion)
B07A Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal
B09B Decision: refusal

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