CN102099009B - 氟喹诺酮类的肺部递送 - Google Patents

氟喹诺酮类的肺部递送 Download PDF

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Publication number
CN102099009B
CN102099009B CN200980127383.6A CN200980127383A CN102099009B CN 102099009 B CN102099009 B CN 102099009B CN 200980127383 A CN200980127383 A CN 200980127383A CN 102099009 B CN102099009 B CN 102099009B
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CN
China
Prior art keywords
ciprofloxacin
powder
betaine
compositions
particles
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Expired - Fee Related
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CN200980127383.6A
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English (en)
Chinese (zh)
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CN102099009A (zh
Inventor
J·威尔斯
T·塔拉拉
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN200980127383.6A 2008-05-15 2009-05-15 氟喹诺酮类的肺部递送 Expired - Fee Related CN102099009B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12778008P 2008-05-15 2008-05-15
US61/127,780 2008-05-15
PCT/US2009/044116 WO2009140587A1 (en) 2008-05-15 2009-05-15 Pulmonary delivery of a fluoroquinolone

Publications (2)

Publication Number Publication Date
CN102099009A CN102099009A (zh) 2011-06-15
CN102099009B true CN102099009B (zh) 2014-07-02

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CN200980127383.6A Expired - Fee Related CN102099009B (zh) 2008-05-15 2009-05-15 氟喹诺酮类的肺部递送

Country Status (11)

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US (3) US8834930B2 (enExample)
EP (1) EP2285345A1 (enExample)
JP (2) JP5727927B2 (enExample)
KR (1) KR101621986B1 (enExample)
CN (1) CN102099009B (enExample)
AU (1) AU2009246217B2 (enExample)
BR (1) BRPI0913021A2 (enExample)
CA (1) CA2724009C (enExample)
MX (1) MX2010012452A (enExample)
RU (1) RU2497524C2 (enExample)
WO (1) WO2009140587A1 (enExample)

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Publication number Publication date
HK1155382A1 (en) 2012-05-18
CA2724009A1 (en) 2009-11-19
KR20110020816A (ko) 2011-03-03
US8834930B2 (en) 2014-09-16
AU2009246217A1 (en) 2009-11-19
JP2011520911A (ja) 2011-07-21
CN102099009A (zh) 2011-06-15
WO2009140587A1 (en) 2009-11-19
RU2497524C2 (ru) 2013-11-10
US20140350028A1 (en) 2014-11-27
US20150374685A1 (en) 2015-12-31
AU2009246217B2 (en) 2013-01-10
CA2724009C (en) 2016-10-11
JP2015091829A (ja) 2015-05-14
JP5989750B2 (ja) 2016-09-07
BRPI0913021A2 (pt) 2015-10-13
KR101621986B1 (ko) 2016-05-17
MX2010012452A (es) 2011-03-15
US20110123626A1 (en) 2011-05-26
RU2010150839A (ru) 2012-06-20
US9155732B2 (en) 2015-10-13
JP5727927B2 (ja) 2015-06-03
EP2285345A1 (en) 2011-02-23

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