JP5727927B2 - フルオロキノロンの肺送達 - Google Patents

フルオロキノロンの肺送達 Download PDF

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Publication number
JP5727927B2
JP5727927B2 JP2011509733A JP2011509733A JP5727927B2 JP 5727927 B2 JP5727927 B2 JP 5727927B2 JP 2011509733 A JP2011509733 A JP 2011509733A JP 2011509733 A JP2011509733 A JP 2011509733A JP 5727927 B2 JP5727927 B2 JP 5727927B2
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JP
Japan
Prior art keywords
powder
ciprofloxacin
particles
betaine
composition
Prior art date
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JP2011509733A
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English (en)
Japanese (ja)
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JP2011520911A5 (enExample
JP2011520911A (ja
Inventor
ウィアーズ,ジェフリー
タララ,トーマス
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of JP2011520911A5 publication Critical patent/JP2011520911A5/ja
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0041Details of the piercing or cutting means with movable piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2011509733A 2008-05-15 2009-05-15 フルオロキノロンの肺送達 Active JP5727927B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12778008P 2008-05-15 2008-05-15
US61/127,780 2008-05-15
PCT/US2009/044116 WO2009140587A1 (en) 2008-05-15 2009-05-15 Pulmonary delivery of a fluoroquinolone

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014251869A Division JP5989750B2 (ja) 2008-05-15 2014-12-12 フルオロキノロンの肺送達

Publications (3)

Publication Number Publication Date
JP2011520911A JP2011520911A (ja) 2011-07-21
JP2011520911A5 JP2011520911A5 (enExample) 2012-07-05
JP5727927B2 true JP5727927B2 (ja) 2015-06-03

Family

ID=41099304

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011509733A Active JP5727927B2 (ja) 2008-05-15 2009-05-15 フルオロキノロンの肺送達
JP2014251869A Expired - Fee Related JP5989750B2 (ja) 2008-05-15 2014-12-12 フルオロキノロンの肺送達

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014251869A Expired - Fee Related JP5989750B2 (ja) 2008-05-15 2014-12-12 フルオロキノロンの肺送達

Country Status (11)

Country Link
US (3) US8834930B2 (enExample)
EP (1) EP2285345A1 (enExample)
JP (2) JP5727927B2 (enExample)
KR (1) KR101621986B1 (enExample)
CN (1) CN102099009B (enExample)
AU (1) AU2009246217B2 (enExample)
BR (1) BRPI0913021A2 (enExample)
CA (1) CA2724009C (enExample)
MX (1) MX2010012452A (enExample)
RU (1) RU2497524C2 (enExample)
WO (1) WO2009140587A1 (enExample)

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Also Published As

Publication number Publication date
US8834930B2 (en) 2014-09-16
JP5989750B2 (ja) 2016-09-07
US20150374685A1 (en) 2015-12-31
RU2497524C2 (ru) 2013-11-10
JP2015091829A (ja) 2015-05-14
RU2010150839A (ru) 2012-06-20
CA2724009A1 (en) 2009-11-19
CN102099009B (zh) 2014-07-02
AU2009246217B2 (en) 2013-01-10
WO2009140587A1 (en) 2009-11-19
CA2724009C (en) 2016-10-11
KR101621986B1 (ko) 2016-05-17
CN102099009A (zh) 2011-06-15
US9155732B2 (en) 2015-10-13
US20140350028A1 (en) 2014-11-27
AU2009246217A1 (en) 2009-11-19
JP2011520911A (ja) 2011-07-21
US20110123626A1 (en) 2011-05-26
EP2285345A1 (en) 2011-02-23
MX2010012452A (es) 2011-03-15
KR20110020816A (ko) 2011-03-03
BRPI0913021A2 (pt) 2015-10-13
HK1155382A1 (en) 2012-05-18

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