JP2015509716A5 - - Google Patents
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- JP2015509716A5 JP2015509716A5 JP2014558875A JP2014558875A JP2015509716A5 JP 2015509716 A5 JP2015509716 A5 JP 2015509716A5 JP 2014558875 A JP2014558875 A JP 2014558875A JP 2014558875 A JP2014558875 A JP 2014558875A JP 2015509716 A5 JP2015509716 A5 JP 2015509716A5
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- 230000011664 signaling Effects 0.000 claims description 80
- 239000000427 antigen Substances 0.000 claims description 64
- 108091007433 antigens Proteins 0.000 claims description 64
- 102000036639 antigens Human genes 0.000 claims description 64
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 63
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 59
- 230000000139 costimulatory effect Effects 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 34
- 150000007523 nucleic acids Chemical group 0.000 claims description 26
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 24
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims description 16
- 241000124008 Mammalia Species 0.000 claims description 11
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims description 8
- 102100027207 CD27 antigen Human genes 0.000 claims description 8
- 101150013553 CD40 gene Proteins 0.000 claims description 8
- 102100035793 CD83 antigen Human genes 0.000 claims description 8
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 8
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 8
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims description 8
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 8
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 8
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 8
- -1 ICOS Proteins 0.000 claims description 8
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims description 8
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 8
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 8
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 8
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 8
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 8
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 8
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 230000003834 intracellular effect Effects 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 8
- 230000004913 activation Effects 0.000 claims description 5
- 230000005809 anti-tumor immunity Effects 0.000 claims description 5
- 230000009460 calcium influx Effects 0.000 claims description 5
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 4
- 210000003289 regulatory T cell Anatomy 0.000 claims description 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims description 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 2
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 2
- 229930186217 Glycolipid Natural products 0.000 claims description 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 2
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 2
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 2
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 2
- 102000003735 Mesothelin Human genes 0.000 claims description 2
- 108090000015 Mesothelin Proteins 0.000 claims description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 2
- 230000006786 activation induced cell death Effects 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims description 2
- 230000021633 leukocyte mediated immunity Effects 0.000 claims description 2
- 238000012737 microarray-based gene expression Methods 0.000 claims description 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 230000000638 stimulation Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 26
- 241000282412 Homo Species 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261601907P | 2012-02-22 | 2012-02-22 | |
| US61/601,907 | 2012-02-22 | ||
| PCT/US2013/027361 WO2013126729A1 (en) | 2012-02-22 | 2013-02-22 | Use of the cd2 signaling domain in second-generation chimeric antigen receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509716A JP2015509716A (ja) | 2015-04-02 |
| JP2015509716A5 true JP2015509716A5 (enExample) | 2016-04-07 |
Family
ID=49006248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558875A Withdrawn JP2015509716A (ja) | 2012-02-22 | 2013-02-22 | 第二世代キメラ抗原受容体におけるｃｄ２シグナル伝達ドメインの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9783591B2 (enExample) |
| EP (2) | EP2817331B1 (enExample) |
| JP (1) | JP2015509716A (enExample) |
| KR (1) | KR20140127829A (enExample) |
| CN (1) | CN104136458A (enExample) |
| AU (1) | AU2013222284A1 (enExample) |
| BR (1) | BR112014020502A2 (enExample) |
| CA (1) | CA2864489C (enExample) |
| EA (1) | EA201491573A1 (enExample) |
| ES (1) | ES2959443T3 (enExample) |
| IL (1) | IL233993A0 (enExample) |
| IN (1) | IN2014DN06522A (enExample) |
| MX (1) | MX2014010185A (enExample) |
| SG (1) | SG11201404284SA (enExample) |
| WO (1) | WO2013126729A1 (enExample) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2014010185A (es) | 2012-02-22 | 2014-11-14 | Univ Pennsylvania | Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion. |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| EP2958943B1 (en) | 2013-02-20 | 2019-09-11 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| UY35340A (es) | 2013-02-20 | 2014-09-30 | Novartis Ag | Marcaje efectivo de leucemia humana usando células diseñadas con un receptor quimérico de antígeno anti-cd123 |
| US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| AU2014366047B2 (en) | 2013-12-19 | 2021-03-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| EP4303229A3 (en) | 2014-01-21 | 2024-04-17 | Novartis AG | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| EP4406610A3 (en) | 2014-04-07 | 2024-10-30 | Novartis AG | Treatment of cancer using anti-cd19 chimeric antigen receptor |
| US11041021B2 (en) | 2014-05-23 | 2021-06-22 | University Of Florida Research Foundation, Incorporated | Car based immunotherapy |
| MY181834A (en) | 2014-07-21 | 2021-01-08 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| US10568947B2 (en) | 2014-07-21 | 2020-02-25 | Novartis Ag | Treatment of cancer using a CLL-1 chimeric antigen receptor |
| MX390943B (es) | 2014-07-21 | 2025-03-21 | Novartis Ag | Receptores de antígeno quimérico cd33 y usos de los mismos. |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| MY189028A (en) | 2014-08-19 | 2022-01-20 | Novartis Ag | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
| DK4074735T3 (da) | 2014-08-28 | 2025-07-14 | Bioatla Inc | Betinget aktive kimæriske antigenreceptorer til modificerede t-celler |
| JP6839074B2 (ja) | 2014-09-17 | 2021-03-03 | ノバルティス アーゲー | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| CN114107424A (zh) | 2014-10-08 | 2022-03-01 | 诺华股份有限公司 | 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途 |
| HUE060047T2 (hu) | 2014-10-09 | 2023-01-28 | Univ Yamaguchi | CAR expressziós vektor és CAR-t expresszáló T-sejtek |
| KR20250075716A (ko) | 2014-12-29 | 2025-05-28 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포를 제조하는 방법 |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| CN107406516B (zh) | 2015-01-26 | 2021-11-23 | 塞勒克提斯公司 | 用于癌症免疫治疗的抗CLL1特异性单链嵌合抗原受体(scCAR) |
| JP6849600B6 (ja) * | 2015-01-29 | 2021-06-30 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | キメラ抗原受容体、組成物及び方法 |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| EP3256492A4 (en) | 2015-02-09 | 2018-07-11 | University of Florida Research Foundation, Inc. | Bi-specific chimeric antigen receptor and uses thereof |
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| SG11201708516YA (en) | 2015-04-17 | 2017-11-29 | David Maxwell Barrett | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| CN105198790B (zh) * | 2015-04-20 | 2018-02-16 | 范国煌 | 促进双阴性t细胞体外增殖的四环化合物 |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
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| US11370845B2 (en) | 2015-06-24 | 2022-06-28 | Keio University | Anti-glypican-1-immunizing antigen receptor |
| US11116795B2 (en) | 2015-07-10 | 2021-09-14 | The Trustees Of The University Of Pennsylvania | Treatment of a canine CD20 positive disease or condition using a canine CD20-specific chimeric antigen receptor |
| SG10201912978PA (en) | 2015-07-21 | 2020-02-27 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| EP3331913A1 (en) | 2015-08-07 | 2018-06-13 | Novartis AG | Treatment of cancer using chimeric cd3 receptor proteins |
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| US11649435B2 (en) * | 2015-08-28 | 2023-05-16 | The Trustees Of The University Of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
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-
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- 2013-02-22 SG SG11201404284SA patent/SG11201404284SA/en unknown
- 2013-02-22 AU AU2013222284A patent/AU2013222284A1/en not_active Abandoned
- 2013-02-22 EA EA201491573A patent/EA201491573A1/ru unknown
- 2013-02-22 EP EP13751899.9A patent/EP2817331B1/en active Active
- 2013-02-22 ES ES13751899T patent/ES2959443T3/es active Active
- 2013-02-22 EP EP23193203.9A patent/EP4275699A3/en active Pending
- 2013-02-22 IN IN6522DEN2014 patent/IN2014DN06522A/en unknown
- 2013-02-22 WO PCT/US2013/027361 patent/WO2013126729A1/en not_active Ceased
- 2013-02-22 CN CN201380010713.XA patent/CN104136458A/zh active Pending
- 2013-02-22 BR BR112014020502A patent/BR112014020502A2/pt not_active IP Right Cessation
- 2013-02-22 JP JP2014558875A patent/JP2015509716A/ja not_active Withdrawn
- 2013-02-22 CA CA2864489A patent/CA2864489C/en active Active
- 2013-02-22 US US14/375,999 patent/US9783591B2/en active Active
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2014
- 2014-08-07 IL IL233993A patent/IL233993A0/en unknown
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2017
- 2017-08-04 US US15/669,562 patent/US10501519B2/en active Active
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- 2021-08-05 US US17/444,519 patent/US12234274B2/en active Active
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- 2023-02-17 US US18/170,695 patent/US20230242612A1/en active Pending
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