CN104136458A - 在第二代嵌合抗原受体中cd2信号传导结构域的使用 - Google Patents

在第二代嵌合抗原受体中cd2信号传导结构域的使用 Download PDF

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CN104136458A
CN104136458A CN201380010713.XA CN201380010713A CN104136458A CN 104136458 A CN104136458 A CN 104136458A CN 201380010713 A CN201380010713 A CN 201380010713A CN 104136458 A CN104136458 A CN 104136458A
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cell
cells
car
signal conducting
antigen
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C·H·琼
J·朔勒
A·D·波西
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University of Pennsylvania
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University of Pennsylvania
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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CN201380010713.XA 2012-02-22 2013-02-22 在第二代嵌合抗原受体中cd2信号传导结构域的使用 Pending CN104136458A (zh)

Applications Claiming Priority (3)

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US201261601907P 2012-02-22 2012-02-22
US61/601,907 2012-02-22
PCT/US2013/027361 WO2013126729A1 (en) 2012-02-22 2013-02-22 Use of the cd2 signaling domain in second-generation chimeric antigen receptors

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CN104136458A true CN104136458A (zh) 2014-11-05

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US (5) US9783591B2 (enExample)
EP (2) EP2817331B1 (enExample)
JP (1) JP2015509716A (enExample)
KR (1) KR20140127829A (enExample)
CN (1) CN104136458A (enExample)
AU (1) AU2013222284A1 (enExample)
BR (1) BR112014020502A2 (enExample)
CA (1) CA2864489C (enExample)
EA (1) EA201491573A1 (enExample)
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CN105198790A (zh) * 2015-04-20 2015-12-30 范国煌 促进双阴性t细胞体外增殖的四环化合物
CN105384825A (zh) * 2015-08-11 2016-03-09 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
CN105647946A (zh) * 2016-03-18 2016-06-08 苏州康元生物科技有限公司 一种基于FcγRⅢa的嵌合基因及其用途
CN106459989A (zh) * 2013-12-19 2017-02-22 诺华股份有限公司 人间皮素嵌合抗原受体及其用途
CN106754725A (zh) * 2016-12-26 2017-05-31 北京普瑞金科技有限公司 一种嵌合抗原受体t细胞及其制备方法与应用
CN107428843A (zh) * 2015-01-29 2017-12-01 明尼苏达大学董事会 嵌合抗原受体、组合物以及方法
WO2018058432A1 (zh) * 2016-09-28 2018-04-05 李华顺 一种多基因重组嵌合抗原受体分子及其应用
CN107922951A (zh) * 2015-06-24 2018-04-17 学校法人庆应义塾 抗磷脂酰肌醇蛋白聚糖‑1‑免疫抗原受体
CN108135932A (zh) * 2015-08-28 2018-06-08 宾夕法尼亚大学董事会 表达嵌合细胞内信号传导分子的细胞的方法和组合物
CN108348551A (zh) * 2015-08-28 2018-07-31 宾夕法尼亚大学董事会 表达嵌合细胞内信号传导分子的细胞的方法和组合物
CN108472346A (zh) * 2015-11-05 2018-08-31 朱诺治疗学股份有限公司 含有traf诱导结构域的嵌合受体及相关组合物和方法
CN108715859A (zh) * 2018-05-31 2018-10-30 中国医学科学院血液病医院（血液学研究所） 靶向cd22的嵌合抗原受体及其应用
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