JP2015166342A5 - - Google Patents
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- Publication number
- JP2015166342A5 JP2015166342A5 JP2015027127A JP2015027127A JP2015166342A5 JP 2015166342 A5 JP2015166342 A5 JP 2015166342A5 JP 2015027127 A JP2015027127 A JP 2015027127A JP 2015027127 A JP2015027127 A JP 2015027127A JP 2015166342 A5 JP2015166342 A5 JP 2015166342A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- binder
- tablet according
- diluent
- irbesartan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011230 binding agent Substances 0.000 claims 6
- 239000003085 diluting agent Substances 0.000 claims 5
- 239000002947 C09CA04 - Irbesartan Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims 4
- 229960002198 irbesartan Drugs 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- 239000007884 disintegrant Substances 0.000 claims 3
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 229960003943 hypromellose Drugs 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 238000005550 wet granulation Methods 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 229960004977 anhydrous lactose Drugs 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000000748 compression moulding Methods 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
- 239000000391 magnesium silicate Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 235000019793 magnesium trisilicate Nutrition 0.000 claims 1
- 229940099273 magnesium trisilicate Drugs 0.000 claims 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011812 mixed powder Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015027127A JP6238921B2 (ja) | 2014-02-17 | 2015-02-16 | イルベサルタンを含有する錠剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014027875 | 2014-02-17 | ||
| JP2014027875 | 2014-02-17 | ||
| JP2015027127A JP6238921B2 (ja) | 2014-02-17 | 2015-02-16 | イルベサルタンを含有する錠剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017208701A Division JP2018012739A (ja) | 2014-02-17 | 2017-10-30 | イルベサルタンを含有する錠剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015166342A JP2015166342A (ja) | 2015-09-24 |
| JP2015166342A5 true JP2015166342A5 (enExample) | 2017-02-23 |
| JP6238921B2 JP6238921B2 (ja) | 2017-11-29 |
Family
ID=54257421
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015027127A Active JP6238921B2 (ja) | 2014-02-17 | 2015-02-16 | イルベサルタンを含有する錠剤 |
| JP2017208701A Pending JP2018012739A (ja) | 2014-02-17 | 2017-10-30 | イルベサルタンを含有する錠剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017208701A Pending JP2018012739A (ja) | 2014-02-17 | 2017-10-30 | イルベサルタンを含有する錠剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP6238921B2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6445923B2 (ja) * | 2015-04-22 | 2018-12-26 | ダイト株式会社 | イルベサルタン含有錠剤の調製方法 |
| JP6668666B2 (ja) * | 2015-10-05 | 2020-03-18 | ニプロ株式会社 | イルベサルタンを含有する医薬組成物及びその製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW442301B (en) * | 1995-06-07 | 2001-06-23 | Sanofi Synthelabo | Pharmaceutical compositions containing irbesartan |
| ATE481090T1 (de) * | 1998-07-28 | 2010-10-15 | Takeda Pharmaceutical | Leicht zerfallende feste zubereitung |
| JP2003034655A (ja) * | 2001-05-15 | 2003-02-07 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
| US20090030052A1 (en) * | 2006-02-17 | 2009-01-29 | Alembic Limited | Pharmaceutical tablet compositions containing irbesartan |
| JP5284967B2 (ja) * | 2007-02-01 | 2013-09-11 | 武田薬品工業株式会社 | 打錠障害を生じない錠剤製剤 |
| ES2377239T3 (es) * | 2007-04-17 | 2012-03-23 | Ratiopharm Gmbh | Composiciones farmacéuticas que comprenden irbesartán |
| JP5296456B2 (ja) * | 2008-08-26 | 2013-09-25 | 大日本住友製薬株式会社 | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 |
| JP2011136908A (ja) * | 2009-12-25 | 2011-07-14 | Kyowa Yakuhin Kogyo Kk | アンギオテンシンｉｉ受容体拮抗剤を含む固形製剤および固形製剤におけるアンギオテンシンｉｉ受容体拮抗剤の保存安定性向上方法 |
| JP5421945B2 (ja) * | 2010-03-10 | 2014-02-19 | 大日本住友製薬株式会社 | イルベサルタンとアムロジピンまたはその塩を含有する医薬組成物 |
| JP2012051829A (ja) * | 2010-08-31 | 2012-03-15 | Taiyo Yakuhin Kogyo Kk | 安定なアンジオテンシｉｉ受容体拮抗作用を示す薬物製剤の設計 |
| JP6041591B2 (ja) * | 2011-09-13 | 2016-12-14 | 大日本住友製薬株式会社 | イルベサルタンとアムロジピンまたはその塩を含有する安定化された医薬組成物 |
-
2015
- 2015-02-16 JP JP2015027127A patent/JP6238921B2/ja active Active
-
2017
- 2017-10-30 JP JP2017208701A patent/JP2018012739A/ja active Pending
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