JP2016044170A5 - - Google Patents
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- Publication number
- JP2016044170A5 JP2016044170A5 JP2014172328A JP2014172328A JP2016044170A5 JP 2016044170 A5 JP2016044170 A5 JP 2016044170A5 JP 2014172328 A JP2014172328 A JP 2014172328A JP 2014172328 A JP2014172328 A JP 2014172328A JP 2016044170 A5 JP2016044170 A5 JP 2016044170A5
- Authority
- JP
- Japan
- Prior art keywords
- stearic acid
- excipient
- olmesartan medoxomil
- granulated product
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002051 C09CA08 - Olmesartan medoxomil Substances 0.000 claims 7
- UQGKUQLKSCSZGY-UHFFFAOYSA-N Olmesartan medoxomil Chemical compound C=1C=C(C=2C(=CC=CC=2)C2=NNN=N2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C UQGKUQLKSCSZGY-UHFFFAOYSA-N 0.000 claims 7
- 235000021355 Stearic acid Nutrition 0.000 claims 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 7
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 7
- 229960001199 olmesartan medoxomil Drugs 0.000 claims 7
- 239000008117 stearic acid Substances 0.000 claims 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920002261 Corn starch Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229920001592 potato starch Polymers 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014172328A JP6653116B2 (ja) | 2014-08-27 | 2014-08-27 | オルメサルタンのプロドラッグ製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014172328A JP6653116B2 (ja) | 2014-08-27 | 2014-08-27 | オルメサルタンのプロドラッグ製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019089234A Division JP6765473B2 (ja) | 2019-05-09 | 2019-05-09 | オルメサルタンのプロドラッグ製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016044170A JP2016044170A (ja) | 2016-04-04 |
| JP2016044170A5 true JP2016044170A5 (enExample) | 2017-08-24 |
| JP6653116B2 JP6653116B2 (ja) | 2020-02-26 |
Family
ID=55635052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014172328A Active JP6653116B2 (ja) | 2014-08-27 | 2014-08-27 | オルメサルタンのプロドラッグ製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6653116B2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3105218T (lt) | 2014-02-13 | 2019-12-10 | Incyte Corp | Ciklopropilaminai kaip lsd1 inhibitoriai |
| WO2015123424A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| EA201792205A1 (ru) | 2015-04-03 | 2018-02-28 | Инсайт Корпорейшн | Гетероциклические соединения как ингибиторы lsd1 |
| DK3334709T3 (da) | 2015-08-12 | 2025-02-03 | Incyte Holdings Corp | Salte af en lsd1-hæmmer |
| US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
| JP6765473B2 (ja) * | 2019-05-09 | 2020-10-07 | 日本ケミファ株式会社 | オルメサルタンのプロドラッグ製剤 |
| IL328515A (en) * | 2020-01-16 | 2026-07-01 | Eisai R&D Man Co Ltd | Lamborxant drug substance and medical preparation containing it |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5000491B2 (ja) * | 2005-05-20 | 2012-08-15 | 第一三共株式会社 | フィルムコーティング製剤 |
| US20070105923A1 (en) * | 2005-09-14 | 2007-05-10 | Glenmark Pharmaceuticals Limited | Substantially pure olmesartan medoxomil and processes for its preparation |
| SI1891952T1 (sl) * | 2006-05-04 | 2012-02-29 | Lek Pharmaceuticals, D.D. | Farmacevtski sestavek, ki vsebuje olmesartan medoksomil |
| CN101679390A (zh) * | 2007-03-23 | 2010-03-24 | 第一三共株式会社 | 奥美沙坦酯的粉碎结晶 |
| JP5688799B2 (ja) * | 2008-08-11 | 2015-03-25 | 第一三共株式会社 | におい抑制方法 |
| US20110256221A1 (en) * | 2008-12-30 | 2011-10-20 | Farhad Farshi | Pharmaceutical formulations of olmesartan |
| HUP0900384A2 (en) * | 2009-06-19 | 2011-01-28 | Nangenex Nanotechnologiai Zartkoerueen Muekoedoe Reszvenytarsasag | Nanoparticulate olmesartan medoxomil compositions |
| WO2011045760A2 (en) * | 2009-10-13 | 2011-04-21 | Ranbaxy Laboratories Limited | Micronized olmesartan medoxomil compositions |
| JP5680898B2 (ja) * | 2010-08-10 | 2015-03-04 | 京都薬品工業株式会社 | 苦味を抑制した速崩壊錠 |
| WO2014080365A1 (en) * | 2012-11-23 | 2014-05-30 | Ranbaxy Laboratories Limited | Method of reducing an unpleasant odor of a pharmaceutical composition |
-
2014
- 2014-08-27 JP JP2014172328A patent/JP6653116B2/ja active Active
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