JP2010530890A5 - - Google Patents

Info

Publication number

JP2010530890A5

JP2010530890A5 JP2010513435A JP2010513435A JP2010530890A5 JP 2010530890 A5 JP2010530890 A5 JP 2010530890A5 JP 2010513435 A JP2010513435 A JP 2010513435A JP 2010513435 A JP2010513435 A JP 2010513435A JP 2010530890 A5 JP2010530890 A5 JP 2010530890A5

Authority

JP

Japan

Prior art keywords

compressed tablet

sulfate

lubricant

compressed

tablet

Prior art date

2008-06-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000007891 compressed tablet Substances 0.000 claims 23
• 239000000314 lubricant Substances 0.000 claims 12
• YSIBYEBNVMDAPN-CMDGGOBGSA-N (e)-4-oxo-4-(3-triethoxysilylpropylamino)but-2-enoic acid Chemical compound CCO[Si](OCC)(OCC)CCCNC(=O)\C=C\C(O)=O YSIBYEBNVMDAPN-CMDGGOBGSA-N 0.000 claims 7
• 108010019625 Atazanavir Sulfate Proteins 0.000 claims 7
• 229960003796 atazanavir sulfate Drugs 0.000 claims 7
• 239000008187 granular material Substances 0.000 claims 6
• 229960000531 abacavir sulfate Drugs 0.000 claims 5
• WMHSRBZIJNQHKT-FFKFEZPRSA-N abacavir sulfate Chemical compound OS(O)(=O)=O.C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1.C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 WMHSRBZIJNQHKT-FFKFEZPRSA-N 0.000 claims 5
• 229960001627 lamivudine Drugs 0.000 claims 5
• JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 5
• 238000005550 wet granulation Methods 0.000 claims 3
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
• 239000003826 tablet Substances 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• 235000021314 Palmitic acid Nutrition 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 235000004443 Ricinus communis Nutrition 0.000 claims 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
• 235000021355 Stearic acid Nutrition 0.000 claims 1
• UGWQMIXVUBLMAH-IVVFTGHFSA-N [(1s,4r)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol;4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1.C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 UGWQMIXVUBLMAH-IVVFTGHFSA-N 0.000 claims 1
• 239000011230 binding agent Substances 0.000 claims 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
• 239000008116 calcium stearate Substances 0.000 claims 1
• 235000013539 calcium stearate Nutrition 0.000 claims 1
• 239000004203 carnauba wax Substances 0.000 claims 1
• 235000013869 carnauba wax Nutrition 0.000 claims 1
• 239000007884 disintegrant Substances 0.000 claims 1
• MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 1
• 229940075507 glyceryl monostearate Drugs 0.000 claims 1
• FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 claims 1
• 229940046813 glyceryl palmitostearate Drugs 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
• 235000019359 magnesium stearate Nutrition 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000002480 mineral oil Substances 0.000 claims 1
• 235000010446 mineral oil Nutrition 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
• 239000003921 oil Substances 0.000 claims 1
• 235000019198 oils Nutrition 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
• 235000010234 sodium benzoate Nutrition 0.000 claims 1
• 239000004299 sodium benzoate Substances 0.000 claims 1
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
• 229940045902 sodium stearyl fumarate Drugs 0.000 claims 1
• 239000008117 stearic acid Substances 0.000 claims 1
• XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims 1