JP2014530802A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014530802A5 JP2014530802A5 JP2014518853A JP2014518853A JP2014530802A5 JP 2014530802 A5 JP2014530802 A5 JP 2014530802A5 JP 2014518853 A JP2014518853 A JP 2014518853A JP 2014518853 A JP2014518853 A JP 2014518853A JP 2014530802 A5 JP2014530802 A5 JP 2014530802A5
- Authority
- JP
- Japan
- Prior art keywords
- sustained
- pioglitazone
- release preparation
- preparation according
- polyethylene oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims description 76
- 239000003405 delayed action preparation Substances 0.000 claims description 52
- 229960005095 pioglitazone Drugs 0.000 claims description 38
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 26
- 230000015572 biosynthetic process Effects 0.000 claims description 18
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 238000000748 compression moulding Methods 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
- 229950008138 carmellose Drugs 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 6
- GHUUBYQTCDQWRA-UHFFFAOYSA-N Pioglitazone hydrochloride Chemical compound Cl.N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 GHUUBYQTCDQWRA-UHFFFAOYSA-N 0.000 claims description 4
- 229960002827 pioglitazone hydrochloride Drugs 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229960000913 crospovidone Drugs 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 230000001629 suppression Effects 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000007922 dissolution test Methods 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000009472 formulation Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011232302 | 2011-10-21 | ||
| JP2011232302 | 2011-10-21 | ||
| PCT/JP2012/077662 WO2013058409A1 (en) | 2011-10-21 | 2012-10-19 | Sustained-release preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530802A JP2014530802A (ja) | 2014-11-20 |
| JP2014530802A5 true JP2014530802A5 (enExample) | 2015-11-26 |
| JP6093762B2 JP6093762B2 (ja) | 2017-03-08 |
Family
ID=47178262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518853A Expired - Fee Related JP6093762B2 (ja) | 2011-10-21 | 2012-10-19 | 徐放性製剤 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9907789B2 (enExample) |
| EP (1) | EP2768487B1 (enExample) |
| JP (1) | JP6093762B2 (enExample) |
| KR (1) | KR20140081826A (enExample) |
| CN (1) | CN104039313A (enExample) |
| AP (1) | AP2014007645A0 (enExample) |
| AR (1) | AR088398A1 (enExample) |
| AU (1) | AU2012326976B2 (enExample) |
| BR (1) | BR112014008744A2 (enExample) |
| CA (1) | CA2852417A1 (enExample) |
| CL (1) | CL2014000992A1 (enExample) |
| CO (1) | CO6960544A2 (enExample) |
| CR (1) | CR20140213A (enExample) |
| DO (1) | DOP2014000077A (enExample) |
| EA (1) | EA201490840A1 (enExample) |
| EC (1) | ECSP14013328A (enExample) |
| IL (1) | IL232114A0 (enExample) |
| IN (1) | IN2014DN03169A (enExample) |
| MA (1) | MA35717B1 (enExample) |
| MX (1) | MX2014004679A (enExample) |
| NZ (1) | NZ624275A (enExample) |
| PE (1) | PE20141189A1 (enExample) |
| PH (1) | PH12014500856A1 (enExample) |
| SG (2) | SG2014012025A (enExample) |
| TN (1) | TN2014000152A1 (enExample) |
| TW (1) | TW201323018A (enExample) |
| UA (1) | UA113858C2 (enExample) |
| UY (1) | UY34403A (enExample) |
| WO (1) | WO2013058409A1 (enExample) |
| ZA (1) | ZA201403103B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012326976B2 (en) | 2011-10-21 | 2017-08-17 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
| US9096586B2 (en) | 2012-04-20 | 2015-08-04 | Gilead Sciences, Inc. | Therapeutic compounds |
| US20150141517A1 (en) * | 2013-11-15 | 2015-05-21 | Shin-Etsu Chemical Co., Ltd. | Granulated composite, rapid release tablet and method for producing same |
| KR102485766B1 (ko) | 2019-12-11 | 2023-01-09 | 한국유나이티드제약 주식회사 | 생체이용률이 향상된 피오글리타존 함유 약학조성물 |
| UY39094A (es) * | 2020-02-27 | 2021-07-30 | Hk Inno N Corp | Composición farmacéutica que comprende compuesto derivado de bencimidazol |
| JP2023066053A (ja) * | 2021-10-28 | 2023-05-15 | 東和薬品株式会社 | 放出制御医薬組成物 |
| WO2025064867A1 (en) * | 2023-09-21 | 2025-03-27 | Yuva Biosciences, Inc. | Delivery system for mitochondrial health enhancers |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810502A (en) | 1987-02-27 | 1989-03-07 | Alza Corporation | Pseudoephedrine brompheniramine therapy |
| US4820522A (en) | 1987-07-27 | 1989-04-11 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
| JPH0624991A (ja) | 1991-06-20 | 1994-02-01 | Tokyo Tanabe Co Ltd | ウルソデスオキシコール酸持続性製剤 |
| JPH0624959A (ja) | 1991-10-04 | 1994-02-01 | Bayer Yakuhin Kk | 胃内浮遊型薬物徐放性固形製剤 |
| DE69332081T2 (de) | 1992-09-18 | 2003-02-06 | Yamanouchi Pharmaceutical Co., Ltd. | Hydrogelzubereitung mit verzögerter freisetzung |
| JPH06316517A (ja) | 1993-02-22 | 1994-11-15 | Grelan Pharmaceut Co Ltd | 放出制御製剤 |
| AU8532798A (en) | 1997-06-13 | 1998-12-30 | Roland Bodmeier | Compounds which delay the release of active substances |
| US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| US20040219208A1 (en) | 2001-08-03 | 2004-11-04 | Ryu Kawamura | Sustained-release medicines |
| US9060941B2 (en) | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| KR20120034211A (ko) | 2002-09-20 | 2012-04-10 | 안드렉스 랩스 엘엘씨 | 약제학적 정제 |
| MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| JP4493970B2 (ja) | 2002-10-16 | 2010-06-30 | 武田薬品工業株式会社 | 持続性製剤 |
| IN192749B (enExample) | 2002-11-15 | 2004-05-15 | Ranbaxy Lab Ltd | |
| US7442387B2 (en) | 2003-03-06 | 2008-10-28 | Astellas Pharma Inc. | Pharmaceutical composition for controlled release of active substances and manufacturing method thereof |
| CA2519208A1 (en) | 2003-03-17 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Controlled release composition |
| JP4933033B2 (ja) | 2003-03-17 | 2012-05-16 | 武田薬品工業株式会社 | 放出制御組成物 |
| CA2528164A1 (en) | 2003-06-06 | 2004-12-16 | Takeda Pharmaceutical Company Limited | Solid preparation |
| JP2005015477A (ja) | 2003-06-06 | 2005-01-20 | Takeda Chem Ind Ltd | 固形製剤 |
| US20060003002A1 (en) | 2003-11-03 | 2006-01-05 | Lipocine, Inc. | Pharmaceutical compositions with synchronized solubilizer release |
| JP4739189B2 (ja) | 2004-04-14 | 2011-08-03 | 武田薬品工業株式会社 | 固形製剤 |
| BRPI0514416A (pt) | 2004-08-31 | 2008-06-10 | Pfizer Prod Inc | formas de dosagem de liberação controlada combinando liberação imediata e liberação controlada de um fármaco de baixa solubilidade |
| EA200800880A1 (ru) | 2005-09-22 | 2009-02-27 | Смитклайн Бичам (Корк) Лимитед | Комбинация росиглитазона и донепезила, предназначенная для улучшения когнитивной функции |
| WO2007054976A2 (en) | 2005-11-08 | 2007-05-18 | Panacea Biotec Ltd. | Lipid based controlled release pharmaceutical composition |
| AU2006328328B2 (en) | 2005-12-22 | 2012-08-30 | Takeda Pharmaceutical Company Limited | Solid preparation containing an insulin sensitizer |
| EP2002828B1 (en) | 2006-03-30 | 2019-08-07 | Nippon Zoki Pharmaceutical Co. Ltd. | Solid pharmaceutical preparation |
| WO2007126135A1 (en) | 2006-04-27 | 2007-11-08 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition of angiotensin ii antagonists with pioglitazone hcl |
| JP5467870B2 (ja) | 2007-02-09 | 2014-04-09 | アルファファーム ピーティーワイ リミテッド | 異なる物理的形態の２種以上の有効医薬成分を含有する投薬形態 |
| TW200914006A (en) * | 2007-07-12 | 2009-04-01 | Takeda Pharmaceutical | Coated preparation |
| CN101269040A (zh) | 2008-05-16 | 2008-09-24 | 北京正大绿洲医药科技有限公司 | 盐酸吡格列酮缓释滴丸及其制备方法 |
| TWI478712B (zh) * | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| US8445190B2 (en) | 2008-09-30 | 2013-05-21 | The Trustees Of The University Of Pennsylvania | Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors |
| JP5827952B2 (ja) | 2009-10-09 | 2015-12-02 | ユンジン・ファーム・カンパニー・リミテッドＹｕｎｇｊｉｎ Ｐｈａｒｍ． Ｃｏ． Ｌｔｄ． | 速効性と持続性を同時に有する薬剤学的組成物 |
| JP2011232302A (ja) | 2010-04-30 | 2011-11-17 | Ricoh Elemex Corp | 画像検査方法及び画像検査装置 |
| CN101884627B (zh) | 2010-07-07 | 2012-01-25 | 青岛黄海制药有限责任公司 | 盐酸吡格列酮胃内滞留缓释片及其制备方法 |
| EA201391017A1 (ru) * | 2011-01-10 | 2014-04-30 | Зинфандел Фармасьютикалз, Инк. | Способы и готовые лекарственные формы для лечения болезни альцгеймера |
| AU2012326976B2 (en) | 2011-10-21 | 2017-08-17 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
| KR20160056691A (ko) | 2014-11-12 | 2016-05-20 | 삼성에스디아이 주식회사 | 이차전지 |
-
2012
- 2012-10-19 AU AU2012326976A patent/AU2012326976B2/en not_active Ceased
- 2012-10-19 KR KR1020147010504A patent/KR20140081826A/ko not_active Ceased
- 2012-10-19 AP AP2014007645A patent/AP2014007645A0/xx unknown
- 2012-10-19 SG SG2014012025A patent/SG2014012025A/en unknown
- 2012-10-19 NZ NZ624275A patent/NZ624275A/en not_active IP Right Cessation
- 2012-10-19 PE PE2014000558A patent/PE20141189A1/es not_active Application Discontinuation
- 2012-10-19 JP JP2014518853A patent/JP6093762B2/ja not_active Expired - Fee Related
- 2012-10-19 BR BR112014008744A patent/BR112014008744A2/pt not_active IP Right Cessation
- 2012-10-19 US US14/352,785 patent/US9907789B2/en not_active Expired - Fee Related
- 2012-10-19 CN CN201280062591.4A patent/CN104039313A/zh active Pending
- 2012-10-19 UA UAA201405332A patent/UA113858C2/uk unknown
- 2012-10-19 AR ARP120103908A patent/AR088398A1/es unknown
- 2012-10-19 EP EP12784752.3A patent/EP2768487B1/en active Active
- 2012-10-19 TW TW101138592A patent/TW201323018A/zh unknown
- 2012-10-19 CA CA2852417A patent/CA2852417A1/en not_active Abandoned
- 2012-10-19 PH PH1/2014/500856A patent/PH12014500856A1/en unknown
- 2012-10-19 EA EA201490840A patent/EA201490840A1/ru unknown
- 2012-10-19 WO PCT/JP2012/077662 patent/WO2013058409A1/en not_active Ceased
- 2012-10-19 IN IN3169DEN2014 patent/IN2014DN03169A/en unknown
- 2012-10-19 MX MX2014004679A patent/MX2014004679A/es unknown
- 2012-10-19 UY UY0001034403A patent/UY34403A/es not_active Application Discontinuation
- 2012-10-19 SG SG10201700121YA patent/SG10201700121YA/en unknown
-
2014
- 2014-04-11 TN TNP2014000152A patent/TN2014000152A1/en unknown
- 2014-04-13 IL IL232114A patent/IL232114A0/en unknown
- 2014-04-15 DO DO2014000077A patent/DOP2014000077A/es unknown
- 2014-04-17 CL CL2014000992A patent/CL2014000992A1/es unknown
- 2014-04-29 ZA ZA2014/03103A patent/ZA201403103B/en unknown
- 2014-04-29 EC ECSP14013328 patent/ECSP14013328A/es unknown
- 2014-05-09 CR CR20140213A patent/CR20140213A/es unknown
- 2014-05-14 CO CO14103846A patent/CO6960544A2/es unknown
- 2014-05-15 MA MA37034A patent/MA35717B1/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7471675B2 (ja) | 多孔性シリカ粒子組成物 | |
| JP5937068B2 (ja) | 転用防止微粒剤および微小錠剤 | |
| JP5357032B2 (ja) | 誤用抵抗性製剤 | |
| KR101940840B1 (ko) | 디아민 유도체 함유 의약 조성물 | |
| JP2009526021A5 (enExample) | ||
| JP2016503002A (ja) | 少なくとも１つの活性化合物を即時放出するために圧潰抵抗性コーティングが施された粒子を含む経口投与剤形 | |
| TW201827049A (zh) | 含二胺衍生物之口腔崩散錠 | |
| MX2010008711A (es) | Composiciones farmaceuticas de entacapona, levopoda y carbidopa, con biodisponibilidad mejorada. | |
| JPH09500910A (ja) | パラセタモール及びドンペリドンのフィルムコーティング錠 | |
| JPWO2010038688A1 (ja) | アトルバスタチン経口投与用粒子状医薬組成物 | |
| US10010510B2 (en) | Oral pharmaceutical formulation | |
| CN102178657B (zh) | 一种奥氮平口腔崩解片 | |
| EP2740471B1 (en) | Oral pharmaceutical composition comprising dabigatran etexilate | |
| UA82268C2 (uk) | Гранули, що містять гідрохлорид венлафаксину, та спосіб їх виготовлення | |
| HK1208130A1 (en) | Extended-release levetiracetam and method of preparation | |
| JP2013237651A (ja) | ピタバスタチンの口腔内崩壊錠 | |
| JP2012140335A (ja) | 不快味マスキング粒子及びこれを含有する経口製剤 | |
| JP5566757B2 (ja) | 固形製剤 | |
| JP2013023463A (ja) | 生理活性物質含有粒子の製造方法 | |
| JP2002012540A (ja) | 水易溶性薬物含有錠剤 | |
| JP6476122B2 (ja) | 二段階の湿式造粒工程で製造される崩壊性粒子組成物及び該組成物を含む口腔内崩壊錠剤 | |
| WO2019098327A1 (ja) | 速溶性薬物の苦味が抑制された口腔内崩壊錠 | |
| JP5764811B2 (ja) | 固形製剤 | |
| JP2014101332A (ja) | 徐放性塩酸アンブロキソール口腔内崩壊錠 | |
| JP2014070061A5 (enExample) |