JP2015120736A5 - - Google Patents
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- JP2015120736A5 JP2015120736A5 JP2015028510A JP2015028510A JP2015120736A5 JP 2015120736 A5 JP2015120736 A5 JP 2015120736A5 JP 2015028510 A JP2015028510 A JP 2015028510A JP 2015028510 A JP2015028510 A JP 2015028510A JP 2015120736 A5 JP2015120736 A5 JP 2015120736A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- composition according
- methylsulfanyl
- triol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 3
- QKDRXGFQVGOQKS-CRSSMBPESA-N (2s,3r,4r,5s,6r)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](SC)O2)O)=CC=C1Cl QKDRXGFQVGOQKS-CRSSMBPESA-N 0.000 claims 2
- 208000016097 disease of metabolism Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84815606P | 2006-09-29 | 2006-09-29 | |
| US60/848,156 | 2006-09-29 | ||
| US90571407P | 2007-03-08 | 2007-03-08 | |
| US60/905,714 | 2007-03-08 | ||
| US94878007P | 2007-07-10 | 2007-07-10 | |
| US60/948,780 | 2007-07-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012254023A Division JP5701845B2 (ja) | 2006-09-29 | 2012-11-20 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015120736A JP2015120736A (ja) | 2015-07-02 |
| JP2015120736A5 true JP2015120736A5 (https=) | 2015-11-26 |
| JP5889453B2 JP5889453B2 (ja) | 2016-03-22 |
Family
ID=38947681
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530593A Active JP5283625B2 (ja) | 2006-09-29 | 2007-09-27 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
| JP2012254023A Active JP5701845B2 (ja) | 2006-09-29 | 2012-11-20 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
| JP2015028510A Active JP5889453B2 (ja) | 2006-09-29 | 2015-02-17 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530593A Active JP5283625B2 (ja) | 2006-09-29 | 2007-09-27 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
| JP2012254023A Active JP5701845B2 (ja) | 2006-09-29 | 2012-11-20 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US7781577B2 (https=) |
| EP (2) | EP2308841B1 (https=) |
| JP (3) | JP5283625B2 (https=) |
| KR (2) | KR101492277B1 (https=) |
| AR (1) | AR063047A1 (https=) |
| AT (1) | ATE496888T1 (https=) |
| AU (1) | AU2007304971B2 (https=) |
| BR (1) | BRPI0717156B8 (https=) |
| CA (1) | CA2664688C (https=) |
| DE (1) | DE602007012292D1 (https=) |
| DK (2) | DK2089361T5 (https=) |
| EA (1) | EA016511B1 (https=) |
| ES (1) | ES2477216T3 (https=) |
| FR (1) | FR19C1053I2 (https=) |
| HU (1) | HUS1900038I1 (https=) |
| IL (1) | IL197836A (https=) |
| MX (1) | MX2009003305A (https=) |
| NL (1) | NL301003I2 (https=) |
| NO (1) | NO345139B1 (https=) |
| NZ (1) | NZ575811A (https=) |
| PL (2) | PL2308841T3 (https=) |
| PT (2) | PT2089361E (https=) |
| TW (1) | TWI499414B (https=) |
| WO (1) | WO2008042688A2 (https=) |
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| WO2008109591A1 (en) * | 2007-03-08 | 2008-09-12 | Lexicon Pharmaceuticals, Inc. | Phlorizin analogs as inhibitors of sodium glucose co-transporter 2 |
| AU2008279424B2 (en) * | 2007-07-26 | 2013-06-13 | Lexicon Pharmaceuticals, Inc. | Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2009270936B2 (en) | 2008-07-15 | 2014-12-18 | Theracos, Inc. | Deuterated benzylbenzene derivatives and methods of use |
| TWI472521B (zh) * | 2008-07-17 | 2015-02-11 | Lexicon Pharmaceuticals Inc | （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法 |
| EA021983B1 (ru) | 2009-11-02 | 2015-10-30 | Пфайзер Инк. | Производные диоксабицикло[3.2.1]октан-2,3,4-триола |
| WO2011070592A2 (en) | 2009-12-09 | 2011-06-16 | Panacea Biotec Ltd. | Novel sugar derivatives |
| TWI562775B (en) * | 2010-03-02 | 2016-12-21 | Lexicon Pharmaceuticals Inc | Methods of using inhibitors of sodium-glucose cotransporters 1 and 2 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012025857A1 (en) * | 2010-08-23 | 2012-03-01 | Hetero Research Foundation | Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors |
| CN102453026A (zh) | 2010-10-27 | 2012-05-16 | 上海艾力斯医药科技有限公司 | C-芳基葡糖苷衍生物、制备方法及其应用 |
| TWI631963B (zh) * | 2011-01-05 | 2018-08-11 | 雷西肯製藥股份有限公司 | 包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法 |
| WO2012165914A2 (en) | 2011-06-01 | 2012-12-06 | Green Cross Corporation | Novel diphenylmethane derivatives as sglt2 inhibitors |
| BR112013031032A2 (pt) | 2011-06-03 | 2016-11-29 | Boehringer Ingelheim Int | inibidores de sglt-2 para o tratamento de distúrbios metabólicos em pacientes tratados com agentes neurolépticos |
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| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9018249B2 (en) | 2011-09-13 | 2015-04-28 | Panacea Biotec Limited | SGLT inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| PL3489226T3 (pl) * | 2012-11-20 | 2021-08-02 | Lexicon Pharmaceuticals, Inc. | Inhibitory kotransportera glukozowo-sodowego 1 |
| EP2952206B1 (en) | 2013-02-04 | 2018-10-24 | Taisho Pharmaceutical Co., Ltd. | Prophylactic or therapeutic drug for constipation |
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| CA2932674C (en) | 2014-01-23 | 2023-01-24 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of metabolic disorders in canine animals |
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| EP4403230A3 (en) | 2014-09-25 | 2025-01-08 | Boehringer Ingelheim Vetmedica GmbH | Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals |
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| JP6727419B2 (ja) * | 2016-05-25 | 2020-07-22 | クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド | ナトリウム−グルコース共輸送体阻害薬の新規な結晶形及びその製造方法並びに用途 |
| BR112019005930A2 (pt) | 2016-10-19 | 2019-06-11 | Boehringer Ingelheim Int | combinações compreendendo um inibidor de ssao/vap-1 e um inibidor de sglt2, e usos das mesmas |
| JP6917527B2 (ja) | 2018-01-05 | 2021-08-11 | シャンドン ダンホン ファーマスーティカル カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | Ｓｇｌｔ阻害剤及びその応用 |
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| US20210238170A1 (en) * | 2018-05-09 | 2021-08-05 | Janssen Pharmaceutica Nv | 5,5-Difluoro- and 5-Fluoro-5-Methyl-C-Glycoside Derivatives Useful As Dual SGLT1 / SGLT2 Modulators |
| WO2020039394A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | New drug combinations |
| US12213970B2 (en) | 2018-10-29 | 2025-02-04 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
| DK3873600T5 (da) | 2018-10-29 | 2024-03-18 | Boehringer Ingelheim Int | Pyridinylsulfonamidderivater, farmaceutiske sammensætninger og anvendelser deraf |
| AU2020231322A1 (en) * | 2019-03-01 | 2021-09-02 | Lexicon Pharmaceuticals, Inc. | Use of sotagliflozin for the treatment of patients with type 1 diabetes mellitus |
| KR102951944B1 (ko) | 2019-07-05 | 2026-04-10 | 산동 단홍 파머수티컬 컴퍼니., 리미티드. | SGLTs 억제제의 결정형 및 그 응용 |
| CN114585358B (zh) | 2019-07-26 | 2023-11-10 | 东宝紫星(杭州)生物医药有限公司 | 一种SGLTs/DPP4抑制剂及其应用 |
| US12421269B2 (en) | 2019-07-26 | 2025-09-23 | Cgenetech (Suzhou, China) Co., Ltd. | SGLT2/DPP4 inhibitor and application thereof |
| EP3771480A1 (en) * | 2019-08-01 | 2021-02-03 | Lexicon Pharmaceuticals, Inc. | Continuous process for preparing the crystalline form ii of sotagliflozin |
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| TW202508593A (zh) | 2023-05-24 | 2025-03-01 | 德商百靈佳殷格翰維美迪加股份有限公司 | 包含一或多種sglt-2抑制劑及匹莫苯坦(pimobendan)及/或替米沙坦(telmisartan)之非人類哺乳動物心臟病之組合治療及/或預防 |
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