JP2015120736A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015120736A5 JP2015120736A5 JP2015028510A JP2015028510A JP2015120736A5 JP 2015120736 A5 JP2015120736 A5 JP 2015120736A5 JP 2015028510 A JP2015028510 A JP 2015028510A JP 2015028510 A JP2015028510 A JP 2015028510A JP 2015120736 A5 JP2015120736 A5 JP 2015120736A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- composition according
- methylsulfanyl
- triol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 3
- QKDRXGFQVGOQKS-CRSSMBPESA-N (2s,3r,4r,5s,6r)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](SC)O2)O)=CC=C1Cl QKDRXGFQVGOQKS-CRSSMBPESA-N 0.000 claims 2
- 208000016097 disease of metabolism Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84815606P | 2006-09-29 | 2006-09-29 | |
| US60/848,156 | 2006-09-29 | ||
| US90571407P | 2007-03-08 | 2007-03-08 | |
| US60/905,714 | 2007-03-08 | ||
| US94878007P | 2007-07-10 | 2007-07-10 | |
| US60/948,780 | 2007-07-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012254023A Division JP5701845B2 (ja) | 2006-09-29 | 2012-11-20 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015120736A JP2015120736A (ja) | 2015-07-02 |
| JP2015120736A5 true JP2015120736A5 (https=) | 2015-11-26 |
| JP5889453B2 JP5889453B2 (ja) | 2016-03-22 |
Family
ID=38947681
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530593A Active JP5283625B2 (ja) | 2006-09-29 | 2007-09-27 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
| JP2012254023A Active JP5701845B2 (ja) | 2006-09-29 | 2012-11-20 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
| JP2015028510A Active JP5889453B2 (ja) | 2006-09-29 | 2015-02-17 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530593A Active JP5283625B2 (ja) | 2006-09-29 | 2007-09-27 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
| JP2012254023A Active JP5701845B2 (ja) | 2006-09-29 | 2012-11-20 | ナトリウム／グルコース共輸送体２の阻害剤としてのフロリジンアナログ |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US7781577B2 (https=) |
| EP (2) | EP2308841B1 (https=) |
| JP (3) | JP5283625B2 (https=) |
| KR (2) | KR101492277B1 (https=) |
| AR (1) | AR063047A1 (https=) |
| AT (1) | ATE496888T1 (https=) |
| AU (1) | AU2007304971B2 (https=) |
| BR (1) | BRPI0717156B8 (https=) |
| CA (1) | CA2664688C (https=) |
| DE (1) | DE602007012292D1 (https=) |
| DK (2) | DK2089361T5 (https=) |
| EA (1) | EA016511B1 (https=) |
| ES (1) | ES2477216T3 (https=) |
| FR (1) | FR19C1053I2 (https=) |
| HU (1) | HUS1900038I1 (https=) |
| IL (1) | IL197836A (https=) |
| MX (1) | MX2009003305A (https=) |
| NL (1) | NL301003I2 (https=) |
| NO (1) | NO345139B1 (https=) |
| NZ (1) | NZ575811A (https=) |
| PL (2) | PL2308841T3 (https=) |
| PT (2) | PT2308841E (https=) |
| TW (1) | TWI499414B (https=) |
| WO (1) | WO2008042688A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI499414B (zh) * | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法 |
| US7846945B2 (en) * | 2007-03-08 | 2010-12-07 | Lexicon Pharmaceuticals, Inc. | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use |
| PT2183263E (pt) * | 2007-07-26 | 2012-01-11 | Lexicon Pharmaceuticals Inc | Processos e compostos úteis na preparação de inibidores do co-transportador 2 de glucose e sódio |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2009270936B2 (en) | 2008-07-15 | 2014-12-18 | Theracos, Inc. | Deuterated benzylbenzene derivatives and methods of use |
| TWI472521B (zh) * | 2008-07-17 | 2015-02-11 | Lexicon Pharmaceuticals Inc | （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法 |
| RS53827B1 (sr) | 2009-11-02 | 2015-06-30 | Pfizer Inc. | Derivati dioksa-biciklo[3.2.1]oktan-2,3,4-triola |
| AR079438A1 (es) | 2009-12-09 | 2012-01-25 | Panacea Biotec Ltd | Derivados de azucar, composiciones farmaceuticas y sus usos |
| TWI562775B (en) * | 2010-03-02 | 2016-12-21 | Lexicon Pharmaceuticals Inc | Methods of using inhibitors of sodium-glucose cotransporters 1 and 2 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012025857A1 (en) * | 2010-08-23 | 2012-03-01 | Hetero Research Foundation | Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors |
| CN102453026A (zh) | 2010-10-27 | 2012-05-16 | 上海艾力斯医药科技有限公司 | C-芳基葡糖苷衍生物、制备方法及其应用 |
| TWI631963B (zh) * | 2011-01-05 | 2018-08-11 | 雷西肯製藥股份有限公司 | 包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法 |
| ES2719656T3 (es) | 2011-06-01 | 2019-07-11 | Green Cross Corp | Derivados de difenilmetano novedosos como inhibidores del SGLT2 |
| BR112013031032A2 (pt) | 2011-06-03 | 2016-11-29 | Boehringer Ingelheim Int | inibidores de sglt-2 para o tratamento de distúrbios metabólicos em pacientes tratados com agentes neurolépticos |
| EP2717689A4 (en) * | 2011-06-13 | 2014-11-05 | Panacea Biotec Ltd | NEW SGLT HEMMER |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9018249B2 (en) | 2011-09-13 | 2015-04-28 | Panacea Biotec Limited | SGLT inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9200025B2 (en) * | 2012-11-20 | 2015-12-01 | Lexicon Pharmaceuticals, Inc. | Inhibitors of sodium glucose cotransporter 1 |
| MY176162A (en) | 2013-02-04 | 2020-07-24 | Taisho Pharmaceutical Co Ltd | Prophylactic or therapeutic drug for constipation |
| CN103073606B (zh) * | 2013-02-05 | 2016-05-18 | 中国医药研究开发中心有限公司 | 5’-s-(4,4’-二甲氧基三苯甲基)-2’-脱氧肌苷的合成与制备方法 |
| PT2981269T (pt) | 2013-04-04 | 2023-10-10 | Boehringer Ingelheim Vetmedica Gmbh | Tratamento de distúrbios metabólicos em animais equinos |
| ES2969764T3 (es) | 2013-12-17 | 2024-05-22 | Boehringer Ingelheim Vetmedica Gmbh | Un inhibidor de SGLT-2 para usar en el tratamiento de un trastorno metabólico en animales felinos |
| CN115671290A (zh) | 2014-01-23 | 2023-02-03 | 勃林格殷格翰动物保健有限公司 | 犬科动物中代谢紊乱的治疗 |
| WO2015150299A2 (en) | 2014-04-01 | 2015-10-08 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of metabolic disorders in equine animals |
| WO2016046150A1 (en) | 2014-09-25 | 2016-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals |
| KR102659761B1 (ko) | 2015-08-27 | 2024-04-24 | 베링거잉겔하임베트메디카게엠베하 | Sglt-2 억제제를 포함하는 액상 약제학적 조성물 |
| JP6727419B2 (ja) * | 2016-05-25 | 2020-07-22 | クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド | ナトリウム−グルコース共輸送体阻害薬の新規な結晶形及びその製造方法並びに用途 |
| US20210212968A1 (en) | 2016-10-19 | 2021-07-15 | Boehringer Ingelheim International Gmbh | Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof |
| JP6917527B2 (ja) | 2018-01-05 | 2021-08-11 | シャンドン ダンホン ファーマスーティカル カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | Ｓｇｌｔ阻害剤及びその応用 |
| WO2019166958A1 (en) * | 2018-02-28 | 2019-09-06 | Mylan Laboratories Ltd | Process for the preparation of sotagliflozin |
| CN111989103A (zh) | 2018-04-17 | 2020-11-24 | 勃林格殷格翰国际有限公司 | 药物组合物、其治疗方法和用途 |
| WO2019215633A1 (en) * | 2018-05-09 | 2019-11-14 | Janssen Pharmaceutica Nv | 5,5-difluoro- and 5-fluoro-5-methyl-c-glycoside derivatives useful as dual sglt1 / sglt2 modulators |
| WO2020039394A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | New drug combinations |
| KR102812426B1 (ko) | 2018-10-29 | 2025-05-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 피리디닐 설폰아미드 유도체, 약제학적 조성물 및 이의 용도 |
| US12213970B2 (en) | 2018-10-29 | 2025-02-04 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
| CA3131594A1 (en) * | 2019-03-01 | 2020-09-10 | Lexicon Pharmaceuticals, Inc. | Use of sotagliflozin for the treatment of patients with type 1 diabetes mellitus |
| EP3957634A4 (en) * | 2019-07-05 | 2022-08-31 | Shangdong Danhong Pharmaceutical Co., Ltd. | SGLT INHIBITOR IN CRYSTAL FORM AND ITS USE |
| US12378277B2 (en) | 2019-07-26 | 2025-08-05 | Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. | SGLTS/DPP4 inhibitor and application thereof |
| US12421269B2 (en) | 2019-07-26 | 2025-09-23 | Cgenetech (Suzhou, China) Co., Ltd. | SGLT2/DPP4 inhibitor and application thereof |
| EP3771480A1 (en) | 2019-08-01 | 2021-02-03 | Lexicon Pharmaceuticals, Inc. | Continuous process for preparing the crystalline form ii of sotagliflozin |
| EP4064854A1 (en) | 2019-11-28 | 2022-10-05 | Boehringer Ingelheim Vetmedica GmbH | Use of sglt-2 inhibitors in the drying-off of non-human mammals |
| AU2021222297B2 (en) | 2020-02-17 | 2026-01-22 | Boehringer Ingelheim Vetmedica Gmbh | Use of SGLT-2 inhibitors for the prevention and/or treatment of cardiac diseases in felines |
| CN111763197A (zh) * | 2020-07-08 | 2020-10-13 | 青岛大学 | 一种新型手性吲哚类化合物的合成方法 |
| US20250129055A1 (en) * | 2020-11-19 | 2025-04-24 | Beijing Increase Innovative Drug Co., Ltd. | Glucoside derivative, and preparation method therefor and application thereof |
| JP2024525981A (ja) | 2021-07-28 | 2024-07-12 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | ヒト以外の哺乳動物における腎疾患の予防及び／又は治療のためのｓｇｌｔ－２阻害剤の使用 |
| JP2024527434A (ja) | 2021-07-28 | 2024-07-24 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | ネコ科動物を除く非ヒト哺乳動物、特にイヌ科動物における心臓疾患の予防及び／又は治療のためのｓｇｌｔ－２阻害剤の使用 |
| US20240269105A1 (en) | 2021-07-28 | 2024-08-15 | Boehringer Ingelheim Vetmedica Gmbh | Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals |
| AU2023277704A1 (en) | 2022-05-25 | 2024-12-05 | Boehringer Ingelheim Vetmedica Gmbh | Aqueous pharmaceutical compositions comprising sglt-2 inhibitors |
| EP4676494A1 (en) | 2023-03-06 | 2026-01-14 | Boehringer Ingelheim Vetmedica GmbH | Systems for delivery of liquid pharmaceutical compositions in particular comprising one or more sglt-2 inhibitor(s) |
| US20240390317A1 (en) | 2023-05-24 | 2024-11-28 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan |
| KR20260019532A (ko) | 2023-05-24 | 2026-02-10 | 베링거잉겔하임베트메디카게엠베하 | 하나 이상의 sglt-2 억제제와 텔미사르탄을 포함하는 비인간 포유류의 신장 질환 및/또는 고혈압의 병용 치료 및/또는 예방 |
| US20250108032A1 (en) | 2023-09-28 | 2025-04-03 | Lexicon Pharmaceuticals, Inc. | Methods of treating type 1 diabetes and kidney disease |
| AU2024356182A1 (en) | 2023-10-06 | 2026-04-09 | Lexicon Pharmaceuticals, Inc. | Methods of reducing the risk of cardiovascular events in patients with left ventricular hypertrophy |
| WO2025160910A1 (en) * | 2024-02-01 | 2025-08-07 | New Wish Biotechnology Wuxi Co., Ltd. | Indazole compound and pharmaceutical composition, preparation method and use thereof |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3870699A (en) * | 1973-03-06 | 1975-03-11 | Upjohn Co | Lincomycin analogs |
| CN1020944C (zh) | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
| WO1995016049A1 (en) | 1993-12-08 | 1995-06-15 | The Scripps Research Institute | Catalytic chemo-enzymatic asymmetric synthesis of carbohydrates |
| US6214331B1 (en) * | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
| JP2885191B2 (ja) | 1996-07-09 | 1999-04-19 | 日本電気株式会社 | 液晶プロジェクタ |
| JP3928197B2 (ja) | 1997-01-23 | 2007-06-13 | 住友化学株式会社 | アリール置換芳香族類の製造方法 |
| US6664399B1 (en) | 1999-09-02 | 2003-12-16 | E. I. Du Pont De Nemours & Company | Triazole linked carbohydrates |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| NZ521369A (en) | 2000-03-17 | 2004-07-30 | Kissei Pharmaceutical | Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives |
| US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| US6555519B2 (en) | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
| US6653290B2 (en) | 2000-10-06 | 2003-11-25 | Bristol-Myers Squibb Company | Tumor proliferation inhibitors |
| EP1344780A4 (en) | 2000-11-30 | 2004-01-28 | Kissei Pharmaceutical | GLUCOPYRANOSYLOXYBENZYLBENZOLE DERIVATIVES, MEDICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION |
| ATE431830T1 (de) | 2000-12-28 | 2009-06-15 | Kissei Pharmaceutical | Glucopyranosylpyrazolderivate und deren verwendung in arzneimitteln |
| US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| AU2002254567B2 (en) | 2001-04-11 | 2007-10-11 | Bristol-Myers Squibb Company | Amino acid complexes of C-aryl glucosides for treatment of diabetes and method |
| FR2826653B1 (fr) | 2001-06-29 | 2005-10-14 | Servier Lab | Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JPWO2003011880A1 (ja) | 2001-07-31 | 2004-11-18 | キッセイ薬品工業株式会社 | グルコピラノシルオキシベンジルベンゼン誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| EP2206702B1 (en) | 2001-08-08 | 2011-12-28 | Tobira Therapeutics, Inc. | Bicyclic compound, production and use thereof |
| WO2003020737A1 (en) | 2001-09-05 | 2003-03-13 | Bristol-Myers Squibb Company | O-pyrazole glucoside sglt2 inhibitors and method of use |
| EP1432721A4 (en) | 2001-09-13 | 2008-02-20 | Bristol Myers Squibb Co | PROCESS FOR THE PREPARATION OF REBECCAMYCIN AND ANALOGUE THEREOF |
| FR2831169B1 (fr) | 2001-10-22 | 2003-12-12 | Servier Lab | Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2003051830A2 (en) | 2001-12-14 | 2003-06-26 | Purdue Research Foundation | Enantiopure 4-deoxypentenosides, dihydropyrans and tetrahydropyrans and syntheses thereof |
| US6927294B1 (en) * | 2002-03-08 | 2005-08-09 | University Of Southern California | Nitrogen-containing heterocycles |
| DE10213228A1 (de) | 2002-03-25 | 2003-10-16 | Bayer Ag | Cyclopenten-Derivate |
| US6562791B1 (en) | 2002-03-29 | 2003-05-13 | Council Of Scientific And Industrial Research | Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof |
| RU2322449C2 (ru) * | 2002-08-09 | 2008-04-20 | Тайсо Фармасьютикал Ко., Лтд. | ПРОИЗВОДНЫЕ АРИЛ 5-ТИО-β-D-ГЛЮКОПИРАНОЗИДА И ТЕРАПЕВТИЧЕСКИЕ СРЕДСТВА ПРИ ДИАБЕТЕ, СОДЕРЖАЩИЕ ИХ |
| AU2002951247A0 (en) | 2002-09-06 | 2002-09-19 | Alchemia Limited | Compounds that interact with kinases |
| FR2845996A1 (fr) | 2002-10-16 | 2004-04-23 | Servier Lab | Nouveaux derives de[3,4-a:3,4-c]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2845995A1 (fr) | 2002-10-16 | 2004-04-23 | Servier Lab | Nouveaux derives de pyrrolo[3,4-c]carbazole et de pyrido[2,3-b]pyrrolo[3,4-e]indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20060035844A1 (en) | 2002-12-04 | 2006-02-16 | Fumiaki Ito | Preventive or remedy for diseases caused by hyperglycemia |
| DE10258008B4 (de) | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258007B4 (de) | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| JP4679155B2 (ja) | 2002-12-25 | 2011-04-27 | キッセイ薬品工業株式会社 | 含窒素複素環誘導体、それを含有する医薬組成物およびその医薬用途 |
| JP2006516257A (ja) | 2003-01-03 | 2006-06-29 | ブリストル−マイヤーズ スクイブ カンパニー | Ｃ−アリールグルコシドｓｇｌｔ２阻害剤の製造法 |
| ES2363941T3 (es) | 2003-03-14 | 2011-08-19 | Astellas Pharma Inc. | Derivados de c-glucósido para el tratamiento de diabetes. |
| US7439232B2 (en) | 2003-04-01 | 2008-10-21 | Taisho Pharmaceutical Co., Ltd. | Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same |
| EP1609799A4 (en) | 2003-04-01 | 2008-10-29 | Taisho Pharmaceutical Co Ltd | HETEROARYL-5-THIO-BETA-D-GLUCOPYRANOSIDE DERIVATIVES AND AGENTS AGAINST DIABETES THEREOF |
| WO2005011592A2 (en) | 2003-08-01 | 2005-02-10 | Janssen Pharmaceutica N.V. | Substituted indazole-o-glucosides |
| WO2005012242A2 (en) | 2003-08-01 | 2005-02-10 | Janssen Pharmaceutica Nv | Substituted benzimidazole-, benztriazole-, and benzimidazolone-o-glucosides |
| EP1679965A4 (en) | 2003-08-01 | 2009-05-27 | Janssen Pharmaceutica Nv | SUBSTITUTED ANELLIERED HETEROCYCLIC C-GLYCOSIDES |
| UA86042C2 (en) | 2003-08-01 | 2009-03-25 | Янссен Фармацевтика Н.В. | Substituted indazole-o-glucosides |
| TW200526678A (en) | 2003-08-01 | 2005-08-16 | Janssen Pharmaceutica Nv | Substituted indole-O-glucosides |
| EP1660509B1 (de) | 2003-08-26 | 2009-02-04 | Boehringer Ingelheim International GmbH | Glucopyranosyloxy-pyrazole, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| US7375090B2 (en) | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
| EP1670755A4 (en) | 2003-10-08 | 2007-02-28 | Harvard College | PYROVALERON ANALOGUE AND ITS THERAPEUTIC APPLICATIONS |
| US7371732B2 (en) | 2003-12-22 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture |
| DE102004017793A1 (de) | 2004-02-21 | 2005-09-08 | Biofrontera Discovery Gmbh | Trioxacarcine und deren Verwendung |
| JP2007524744A (ja) | 2004-02-24 | 2007-08-30 | ノボザイムス アクティーゼルスカブ | 液状洗剤中の酵素の安定化 |
| PL381247A1 (pl) | 2004-03-04 | 2007-05-14 | Kissei Pharmaceutical Co., Ltd. | Skondensowana pochodna heterocykliczna, zawierająca ją kompozycja lecznicza, oraz jej zastosowanie lecznicze |
| CN103030617A (zh) | 2004-03-16 | 2013-04-10 | 贝林格尔.英格海姆国际有限公司 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
| WO2006002233A2 (en) | 2004-06-22 | 2006-01-05 | Wall, Michael, A. | Alvaradoins e-n, new antitumor and cytotoxic anthracenone g-glycosides |
| US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
| ATE446282T1 (de) | 2004-07-08 | 2009-11-15 | Basf Se | Herstellung von alphahydroxyketonen |
| JPWO2006006496A1 (ja) | 2004-07-08 | 2008-04-24 | アステラス製薬株式会社 | アズレン誘導体の製造方法及びその合成中間体 |
| DE102004034690A1 (de) | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| MX2007000811A (es) | 2004-07-21 | 2007-04-02 | Kissei Pharmaceutical | Inhibidor de avance de enfermedad atribuida a acumulacion anormal de grasa en el higado. |
| TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
| WO2006010557A1 (de) | 2004-07-27 | 2006-02-02 | Boehringer Ingelheim International Gmbh | D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| DE102004046583A1 (de) | 2004-09-23 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Xylopyranosyl-phenyl-substituierte Cyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| WO2006018150A1 (de) * | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| DE102004039096A1 (de) * | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Xylopyranosyl-phenyl-substituierte Cyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE102004048388A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| EP1809381A2 (en) | 2004-10-06 | 2007-07-25 | Recepticon ApS | Use of compounds for the prevention of drug-induced cell toxicity |
| WO2006050501A2 (en) | 2004-11-03 | 2006-05-11 | University Of Kansas | Novobiocin analogues as anticancer agents |
| US7622451B2 (en) | 2004-11-03 | 2009-11-24 | University Of Kansas | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders |
| TW200637839A (en) | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
| JP5264183B2 (ja) * | 2005-02-23 | 2013-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換（（ヘテロ）アリールエチニル−ベンジル）−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体２（ｓｇｌｔ２）インヒビターとしてのそれらの使用 |
| CN101160315A (zh) | 2005-03-25 | 2008-04-09 | 印斯拜尔药品股份有限公司 | 细胞骨架的活性化合物，组合物及用途 |
| US20060240496A1 (en) | 2005-04-21 | 2006-10-26 | Lakshmi Anne | Immunogens, derivatives and immunoassay for ethyl glucuronide |
| US7723309B2 (en) | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
| WO2007025943A2 (en) | 2005-08-30 | 2007-03-08 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
| US8253752B2 (en) | 2006-07-20 | 2012-08-28 | Qualcomm Incorporated | Method and apparatus for encoder assisted pre-processing |
| JP5452223B2 (ja) | 2006-07-24 | 2014-03-26 | テトラロジック ファーマシューティカルズ コーポレーション | Ｉａｐ阻害剤 |
| TWI499414B (zh) * | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法 |
| US20080107744A1 (en) * | 2006-11-06 | 2008-05-08 | Jack Fa-De Chu | Injectable hollow tissue filler |
| US7846945B2 (en) | 2007-03-08 | 2010-12-07 | Lexicon Pharmaceuticals, Inc. | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use |
| PT2183263E (pt) | 2007-07-26 | 2012-01-11 | Lexicon Pharmaceuticals Inc | Processos e compostos úteis na preparação de inibidores do co-transportador 2 de glucose e sódio |
| US8015005B2 (en) | 2008-02-15 | 2011-09-06 | Motorola Mobility, Inc. | Method and apparatus for voice searching for stored content using uniterm discovery |
| TWI472521B (zh) | 2008-07-17 | 2015-02-11 | Lexicon Pharmaceuticals Inc | （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法 |
| US9200025B2 (en) * | 2012-11-20 | 2015-12-01 | Lexicon Pharmaceuticals, Inc. | Inhibitors of sodium glucose cotransporter 1 |
-
2007
- 2007-09-19 TW TW096134994A patent/TWI499414B/zh active
- 2007-09-27 AT AT07843301T patent/ATE496888T1/de active
- 2007-09-27 AU AU2007304971A patent/AU2007304971B2/en active Active
- 2007-09-27 DK DK07843301.8T patent/DK2089361T5/da active
- 2007-09-27 DE DE602007012292T patent/DE602007012292D1/de active Active
- 2007-09-27 PT PT101940633T patent/PT2308841E/pt unknown
- 2007-09-27 KR KR1020097008685A patent/KR101492277B1/ko active Active
- 2007-09-27 PL PL10194063T patent/PL2308841T3/pl unknown
- 2007-09-27 KR KR1020147033635A patent/KR20150002889A/ko not_active Withdrawn
- 2007-09-27 CA CA2664688A patent/CA2664688C/en active Active
- 2007-09-27 US US11/862,690 patent/US7781577B2/en active Active
- 2007-09-27 NZ NZ575811A patent/NZ575811A/en unknown
- 2007-09-27 BR BRPI0717156A patent/BRPI0717156B8/pt active IP Right Grant
- 2007-09-27 PL PL07843301T patent/PL2089361T4/pl unknown
- 2007-09-27 DK DK10194063.3T patent/DK2308841T3/da active
- 2007-09-27 EP EP10194063.3A patent/EP2308841B1/en active Active
- 2007-09-27 WO PCT/US2007/079654 patent/WO2008042688A2/en not_active Ceased
- 2007-09-27 MX MX2009003305A patent/MX2009003305A/es active IP Right Grant
- 2007-09-27 EA EA200970337A patent/EA016511B1/ru not_active IP Right Cessation
- 2007-09-27 PT PT07843301T patent/PT2089361E/pt unknown
- 2007-09-27 JP JP2009530593A patent/JP5283625B2/ja active Active
- 2007-09-27 EP EP07843301A patent/EP2089361B1/en active Active
- 2007-09-27 ES ES10194063.3T patent/ES2477216T3/es active Active
- 2007-09-28 AR ARP070104306A patent/AR063047A1/es active IP Right Grant
-
2009
- 2009-03-26 IL IL197836A patent/IL197836A/en active IP Right Grant
- 2009-04-28 NO NO20091700A patent/NO345139B1/no unknown
-
2010
- 2010-08-18 US US12/858,666 patent/US8476413B2/en active Active
-
2012
- 2012-11-20 JP JP2012254023A patent/JP5701845B2/ja active Active
-
2013
- 2013-06-25 US US13/925,981 patent/US9365602B2/en active Active
-
2015
- 2015-02-17 JP JP2015028510A patent/JP5889453B2/ja active Active
-
2016
- 2016-05-16 US US15/155,780 patent/US20170087172A1/en not_active Abandoned
-
2018
- 2018-03-27 US US15/937,496 patent/US20190099436A1/en not_active Abandoned
-
2019
- 2019-08-15 HU HUS1900038C patent/HUS1900038I1/hu unknown
- 2019-08-30 NL NL301003C patent/NL301003I2/nl unknown
- 2019-09-19 FR FR19C1053C patent/FR19C1053I2/fr active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015120736A5 (https=) | ||
| JP2016041701A5 (https=) | ||
| JP2014515013A5 (https=) | ||
| JP2013525444A5 (https=) | ||
| JP2015525757A5 (https=) | ||
| JP2016515522A5 (https=) | ||
| JP2015078220A5 (https=) | ||
| JP2013032389A5 (https=) | ||
| JP2013530958A5 (https=) | ||
| JP2017506627A5 (https=) | ||
| JP2013519675A5 (https=) | ||
| CY1118839T1 (el) | Επικαλυμμενη φαρμακευτικη συνθεση που περιεχει ρεγοραφενιμπη | |
| JP2010513478A5 (https=) | ||
| JP2014501780A5 (https=) | ||
| JP2014167010A5 (https=) | ||
| CN103717571B8 (zh) | 9‑氨基甲基取代的四环素类化合物 | |
| JP2016523260A5 (https=) | ||
| WO2013041519A9 (en) | Ror gamma modulators | |
| WO2013057251A3 (en) | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | |
| EA201490026A1 (ru) | Производное инданона, его фармацевтически приемлемая соль или энантиомер, способ его получения и содержащая его фармацевтическая композиция для профилактики или лечения вирусного заболевания | |
| JP2016535082A5 (https=) | ||
| WO2016057658A8 (en) | Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof | |
| RU2017139002A (ru) | Пироглутамат вортиоксетина | |
| JP2016532632A5 (https=) | ||
| RU2016112257A (ru) | Композиция для лечения гипертензии и/или фиброза |