JP2014534233A5 - - Google Patents
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- JP2014534233A5 JP2014534233A5 JP2014540611A JP2014540611A JP2014534233A5 JP 2014534233 A5 JP2014534233 A5 JP 2014534233A5 JP 2014540611 A JP2014540611 A JP 2014540611A JP 2014540611 A JP2014540611 A JP 2014540611A JP 2014534233 A5 JP2014534233 A5 JP 2014534233A5
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- 239000000427 antigen Substances 0.000 claims 21
- 102000036639 antigens Human genes 0.000 claims 21
- 108091007433 antigens Proteins 0.000 claims 21
- 239000012634 fragment Substances 0.000 claims 21
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 17
- 150000001413 amino acids Chemical group 0.000 claims 16
- 235000001014 amino acid Nutrition 0.000 claims 13
- 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000004472 Lysine Substances 0.000 claims 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 5
- 239000002254 cytotoxic agent Substances 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 231100000599 cytotoxic agent Toxicity 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical group CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- KAHJVVNKEWQPJI-JXJGXUGVSA-N (2S)-2-acetamido-6-aminohexanoic acid (2S)-2-amino-3-methylbutanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC(=O)N[C@@H](CCCCN)C(O)=O KAHJVVNKEWQPJI-JXJGXUGVSA-N 0.000 claims 1
- -1 1,3-thiazol-2-yl Chemical group 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 102100027212 Tumor-associated calcium signal transducer 2 Human genes 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 125000003588 lysine group Chemical class [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000005443 oral cavity cancer Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 230000005751 tumor progression Effects 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Images
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559015P | 2011-11-11 | 2011-11-11 | |
| US61/559,015 | 2011-11-11 | ||
| US201261640641P | 2012-04-30 | 2012-04-30 | |
| US61/640,641 | 2012-04-30 | ||
| US201261717288P | 2012-10-23 | 2012-10-23 | |
| US61/717,288 | 2012-10-23 | ||
| PCT/IB2012/056234 WO2013068946A2 (en) | 2011-11-11 | 2012-11-07 | Antibodies specific for trop-2 and their uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015240754A Division JP6157575B2 (ja) | 2011-11-11 | 2015-12-10 | Ｔｒｏｐ−２に対して特異的な抗体およびこれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534233A JP2014534233A (ja) | 2014-12-18 |
| JP2014534233A5 true JP2014534233A5 (cg-RX-API-DMAC10.html) | 2015-02-05 |
| JP5936702B2 JP5936702B2 (ja) | 2016-06-22 |
Family
ID=47216378
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540611A Expired - Fee Related JP5936702B2 (ja) | 2011-11-11 | 2012-11-07 | Ｔｒｏｐ−２に対して特異的な抗体およびこれらの使用 |
| JP2015240754A Expired - Fee Related JP6157575B2 (ja) | 2011-11-11 | 2015-12-10 | Ｔｒｏｐ−２に対して特異的な抗体およびこれらの使用 |
| JP2017049125A Expired - Fee Related JP6475277B2 (ja) | 2011-11-11 | 2017-03-14 | Ｔｒｏｐ−２に対して特異的な抗体およびこれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015240754A Expired - Fee Related JP6157575B2 (ja) | 2011-11-11 | 2015-12-10 | Ｔｒｏｐ−２に対して特異的な抗体およびこれらの使用 |
| JP2017049125A Expired - Fee Related JP6475277B2 (ja) | 2011-11-11 | 2017-03-14 | Ｔｒｏｐ−２に対して特異的な抗体およびこれらの使用 |
Country Status (20)
Families Citing this family (168)
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| US8435529B2 (en) | 2002-06-14 | 2013-05-07 | Immunomedics, Inc. | Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy |
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| EP3252076B1 (en) | 2011-01-14 | 2019-09-04 | The Regents Of The University Of California | Diagnostic use of antibodies against ror-1 protein |
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| US10195288B2 (en) | 2012-10-11 | 2019-02-05 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
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| EP2916872B1 (en) | 2012-11-09 | 2019-02-27 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
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