JP2014531213A - 上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるｅｇｆｒキナーゼ阻害薬に対する応答 - Google Patents

上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるｅｇｆｒキナーゼ阻害薬に対する応答 Download PDF

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JP2014531213A
JP2014531213A JP2014533357A JP2014533357A JP2014531213A JP 2014531213 A JP2014531213 A JP 2014531213A JP 2014533357 A JP2014533357 A JP 2014533357A JP 2014533357 A JP2014533357 A JP 2014533357A JP 2014531213 A JP2014531213 A JP 2014531213A
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methylation
dna
tumor
cancer
egfr
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JP2014531213A5 (enExample
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デーヴィッド シェームズ，
デーヴィッド シェームズ，
トーマス エム． ホーカム，
トーマス エム． ホーカム，
キンバリー ウォルター，
キンバリー ウォルター，
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Genentech Inc
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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JP2014533357A 2011-09-30 2012-09-28 上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるｅｇｆｒキナーゼ阻害薬に対する応答 Pending JP2014531213A (ja)

Applications Claiming Priority (3)

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US201161542141P 2011-09-30 2011-09-30
US61/542,141 2011-09-30
PCT/US2012/057777 WO2013055530A1 (en) 2011-09-30 2012-09-28 Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells

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JP2014531213A true JP2014531213A (ja) 2014-11-27
JP2014531213A5 JP2014531213A5 (enExample) 2015-07-23

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US (1) US20130084287A1 (enExample)
EP (1) EP2761025A1 (enExample)
JP (1) JP2014531213A (enExample)
KR (1) KR20140066783A (enExample)
CN (1) CN104066851A (enExample)
AU (1) AU2012321248A1 (enExample)
BR (1) BR112014007569A2 (enExample)
CA (1) CA2849120A1 (enExample)
IL (1) IL231590A0 (enExample)
MX (1) MX2014003698A (enExample)
RU (1) RU2014110228A (enExample)
SG (1) SG11201400996SA (enExample)
WO (1) WO2013055530A1 (enExample)
ZA (1) ZA201401968B (enExample)

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WO2016018087A1 (ko) * 2014-07-29 2016-02-04 재단법인 아산사회복지재단 Egfr-표적제제에 대한 감수성 예측용 신규한 바이오 마커 및 이의 용도
US20170356051A1 (en) * 2014-10-17 2017-12-14 Tohoku University Method for estimating sensitivity to drug therapy for colorectal cancer
CN113981057A (zh) 2014-12-12 2022-01-28 精密科学公司 用于进行甲基化检测测定的组合物和方法
EP3230476B1 (en) 2014-12-12 2020-02-05 Exact Sciences Development Company, LLC Zdhhc1 for normalizing methylation detection assays
EP3303626B1 (en) * 2015-05-29 2020-04-01 Vito NV Epigenetic markers for respiratory allergy
WO2018009709A1 (en) * 2016-07-06 2018-01-11 Youhealth Biotech, Limited Lung cancer methylation markers and uses thereof
TWI859118B (zh) * 2017-03-29 2024-10-21 大陸商中美冠科生物技術（太倉）有限公司 測定對胃癌之西妥昔單抗（ｃｅｔｕｘｉｍａｂ）敏感性的系統及方法
CN107144695B (zh) * 2017-04-19 2019-02-26 南昌大学 Arl13b蛋白在癌症诊断中的应用
WO2018216009A1 (en) * 2017-05-22 2018-11-29 The National Institute For Biotechnology In The Negev Ltd. Ben-Gurion University Of The Negev Biomarkers for diagnosis of lung cancer
CN110055313B (zh) 2018-01-18 2024-03-08 纽克莱克斯有限公司 用于诊断肺癌的方法
EP3775285B1 (en) * 2018-06-15 2021-10-06 Unilever IP Holdings B.V. Epigenetic method to assess sun exposure
MX2021005963A (es) * 2018-11-27 2021-08-24 Exact Sciences Dev Co Llc Caracterizacion de adn metilado, arn y proteinas en la deteccion de neoplasia pulmonar.
CN111521810B (zh) * 2019-02-02 2024-06-21 中国科学院上海药物研究所 癌症患者根据脾酪氨酸激酶进行分层
IL265451B (en) 2019-03-18 2020-01-30 Frumkin Dan Methods and systems for the detection of methylation changes in DNA samples
CN110283910B (zh) * 2019-06-21 2021-04-20 浙江大学 目标基因dna甲基化作为分子标志物在制备判别结直肠组织癌变进展试剂盒中的应用
CN111304305B (zh) * 2020-03-30 2023-05-30 陕西科技大学 一种用于检测egfr基因甲基化的试剂盒及方法
CN111676286B (zh) * 2020-05-29 2023-04-14 武汉爱基百客生物科技有限公司 肺癌血浆游离dna甲基化检测用的多重pcr引物系统、检测方法及应用
CN114354927B (zh) * 2021-03-18 2025-04-22 中国人民解放军陆军特色医学中心 唾液酸转移酶st3gal4作为egfr-tki耐药标志物的新应用
CN115772565B (zh) * 2021-09-08 2023-09-05 广州市基准医疗有限责任公司 用于辅助检测肺癌体细胞egfr基因突变的甲基化位点及其应用
CN114525281B (zh) * 2022-03-14 2024-03-12 右江民族医学院 Esrp1启动子报告基因转录活性可视化及在去甲基化抗癌药物筛选中的应用
CN115651984B (zh) * 2022-10-20 2023-04-14 山东大学 一种生物标志物在评价肿瘤紫杉类化疗耐药性的应用

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