JP2014531213A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014531213A5 JP2014531213A5 JP2014533357A JP2014533357A JP2014531213A5 JP 2014531213 A5 JP2014531213 A5 JP 2014531213A5 JP 2014533357 A JP2014533357 A JP 2014533357A JP 2014533357 A JP2014533357 A JP 2014533357A JP 2014531213 A5 JP2014531213 A5 JP 2014531213A5
- Authority
- JP
- Japan
- Prior art keywords
- cpg site
- absence
- methylation
- kit
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091029430 CpG site Proteins 0.000 claims 17
- 229940121647 egfr inhibitor Drugs 0.000 claims 13
- 238000000034 method Methods 0.000 claims 13
- 210000004881 tumor cell Anatomy 0.000 claims 12
- 230000007067 DNA methylation Effects 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 230000011987 methylation Effects 0.000 claims 8
- 238000007069 methylation reaction Methods 0.000 claims 8
- 102100026098 Claudin-7 Human genes 0.000 claims 7
- -1 ESPR1 Proteins 0.000 claims 7
- 102100034227 Grainyhead-like protein 2 homolog Human genes 0.000 claims 7
- 102100020759 Homeobox protein Hox-C4 Human genes 0.000 claims 7
- 101000912652 Homo sapiens Claudin-7 Proteins 0.000 claims 7
- 101001069929 Homo sapiens Grainyhead-like protein 2 homolog Proteins 0.000 claims 7
- 101001002994 Homo sapiens Homeobox protein Hox-C4 Proteins 0.000 claims 7
- 101001106413 Homo sapiens Macrophage-stimulating protein receptor Proteins 0.000 claims 7
- 101000911769 Homo sapiens Protein FAM110A Proteins 0.000 claims 7
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 7
- 101000652500 Homo sapiens Tubulin-specific chaperone D Proteins 0.000 claims 7
- 102100021435 Macrophage-stimulating protein receptor Human genes 0.000 claims 7
- 102100027039 Protein FAM110A Human genes 0.000 claims 7
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 7
- 108010090763 Shiga Toxin 2 Proteins 0.000 claims 7
- 102100035936 Syntaxin-2 Human genes 0.000 claims 7
- 102100030290 Tubulin-specific chaperone D Human genes 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 108020004414 DNA Proteins 0.000 claims 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 238000012175 pyrosequencing Methods 0.000 claims 4
- 230000004614 tumor growth Effects 0.000 claims 4
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 3
- 229960005395 cetuximab Drugs 0.000 claims 3
- 229960001433 erlotinib Drugs 0.000 claims 3
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 3
- 229960001972 panitumumab Drugs 0.000 claims 3
- 102100028447 Galanin receptor type 1 Human genes 0.000 claims 2
- 101001061554 Homo sapiens Galanin receptor type 1 Proteins 0.000 claims 2
- 101000987689 Homo sapiens PEX5-related protein Proteins 0.000 claims 2
- 101000735376 Homo sapiens Protocadherin-8 Proteins 0.000 claims 2
- 101000723833 Homo sapiens Zinc finger E-box-binding homeobox 2 Proteins 0.000 claims 2
- 102100029578 PEX5-related protein Human genes 0.000 claims 2
- 102100034958 Protocadherin-8 Human genes 0.000 claims 2
- 102100028458 Zinc finger E-box-binding homeobox 2 Human genes 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000012188 paraffin wax Substances 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical group FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542141P | 2011-09-30 | 2011-09-30 | |
| US61/542,141 | 2011-09-30 | ||
| PCT/US2012/057777 WO2013055530A1 (en) | 2011-09-30 | 2012-09-28 | Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014531213A JP2014531213A (ja) | 2014-11-27 |
| JP2014531213A5 true JP2014531213A5 (enExample) | 2015-07-23 |
Family
ID=47071458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014533357A Pending JP2014531213A (ja) | 2011-09-30 | 2012-09-28 | 上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるｅｇｆｒキナーゼ阻害薬に対する応答 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130084287A1 (enExample) |
| EP (1) | EP2761025A1 (enExample) |
| JP (1) | JP2014531213A (enExample) |
| KR (1) | KR20140066783A (enExample) |
| CN (1) | CN104066851A (enExample) |
| AU (1) | AU2012321248A1 (enExample) |
| BR (1) | BR112014007569A2 (enExample) |
| CA (1) | CA2849120A1 (enExample) |
| IL (1) | IL231590A0 (enExample) |
| MX (1) | MX2014003698A (enExample) |
| RU (1) | RU2014110228A (enExample) |
| SG (1) | SG11201400996SA (enExample) |
| WO (1) | WO2013055530A1 (enExample) |
| ZA (1) | ZA201401968B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013082123A2 (en) * | 2011-11-28 | 2013-06-06 | University Of Chicago | Method, system, software and medium for advanced image-based arrays for analysis and display of biomedical information |
| AU2014274276A1 (en) * | 2013-05-31 | 2015-12-03 | Onconova Therapeutics, Inc. | Methods and compositions for predicting therapeutic efficacy of kinase inhibitors in patients with myelodysplastic syndrome or related disorders |
| CA2952390A1 (en) * | 2013-06-20 | 2014-12-24 | The Trustees Of The University Of Pennsylvania | Methods for diagnosing pancreatic cancer |
| US10233465B2 (en) * | 2013-11-04 | 2019-03-19 | Dow Agrosciences Llc | Optimal soybean loci |
| WO2016018087A1 (ko) * | 2014-07-29 | 2016-02-04 | 재단법인 아산사회복지재단 | Egfr-표적제제에 대한 감수성 예측용 신규한 바이오 마커 및 이의 용도 |
| US20170356051A1 (en) * | 2014-10-17 | 2017-12-14 | Tohoku University | Method for estimating sensitivity to drug therapy for colorectal cancer |
| CN113981057A (zh) | 2014-12-12 | 2022-01-28 | 精密科学公司 | 用于进行甲基化检测测定的组合物和方法 |
| EP3230476B1 (en) | 2014-12-12 | 2020-02-05 | Exact Sciences Development Company, LLC | Zdhhc1 for normalizing methylation detection assays |
| EP3303626B1 (en) * | 2015-05-29 | 2020-04-01 | Vito NV | Epigenetic markers for respiratory allergy |
| WO2018009709A1 (en) * | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Lung cancer methylation markers and uses thereof |
| TWI859118B (zh) * | 2017-03-29 | 2024-10-21 | 大陸商中美冠科生物技術（太倉）有限公司 | 測定對胃癌之西妥昔單抗（ｃｅｔｕｘｉｍａｂ）敏感性的系統及方法 |
| CN107144695B (zh) * | 2017-04-19 | 2019-02-26 | 南昌大学 | Arl13b蛋白在癌症诊断中的应用 |
| WO2018216009A1 (en) * | 2017-05-22 | 2018-11-29 | The National Institute For Biotechnology In The Negev Ltd. Ben-Gurion University Of The Negev | Biomarkers for diagnosis of lung cancer |
| CN110055313B (zh) | 2018-01-18 | 2024-03-08 | 纽克莱克斯有限公司 | 用于诊断肺癌的方法 |
| EP3775285B1 (en) * | 2018-06-15 | 2021-10-06 | Unilever IP Holdings B.V. | Epigenetic method to assess sun exposure |
| MX2021005963A (es) * | 2018-11-27 | 2021-08-24 | Exact Sciences Dev Co Llc | Caracterizacion de adn metilado, arn y proteinas en la deteccion de neoplasia pulmonar. |
| CN111521810B (zh) * | 2019-02-02 | 2024-06-21 | 中国科学院上海药物研究所 | 癌症患者根据脾酪氨酸激酶进行分层 |
| IL265451B (en) | 2019-03-18 | 2020-01-30 | Frumkin Dan | Methods and systems for the detection of methylation changes in DNA samples |
| CN110283910B (zh) * | 2019-06-21 | 2021-04-20 | 浙江大学 | 目标基因dna甲基化作为分子标志物在制备判别结直肠组织癌变进展试剂盒中的应用 |
| CN111304305B (zh) * | 2020-03-30 | 2023-05-30 | 陕西科技大学 | 一种用于检测egfr基因甲基化的试剂盒及方法 |
| CN111676286B (zh) * | 2020-05-29 | 2023-04-14 | 武汉爱基百客生物科技有限公司 | 肺癌血浆游离dna甲基化检测用的多重pcr引物系统、检测方法及应用 |
| CN114354927B (zh) * | 2021-03-18 | 2025-04-22 | 中国人民解放军陆军特色医学中心 | 唾液酸转移酶st3gal4作为egfr-tki耐药标志物的新应用 |
| CN115772565B (zh) * | 2021-09-08 | 2023-09-05 | 广州市基准医疗有限责任公司 | 用于辅助检测肺癌体细胞egfr基因突变的甲基化位点及其应用 |
| CN114525281B (zh) * | 2022-03-14 | 2024-03-12 | 右江民族医学院 | Esrp1启动子报告基因转录活性可视化及在去甲基化抗癌药物筛选中的应用 |
| CN115651984B (zh) * | 2022-10-20 | 2023-04-14 | 山东大学 | 一种生物标志物在评价肿瘤紫杉类化疗耐药性的应用 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| AU658646B2 (en) | 1991-05-10 | 1995-04-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| US6033854A (en) | 1991-12-16 | 2000-03-07 | Biotronics Corporation | Quantitative PCR using blocking oligonucleotides |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| WO1995006137A1 (en) | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
| WO1995009647A1 (en) | 1993-10-07 | 1995-04-13 | The George Washington University Medical Center | METHOD OF TREATING SEPTIC SHOCK USING THYMOSIN-α¿1? |
| US5656643A (en) | 1993-11-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| WO1995024190A2 (en) | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
| DK0682027T3 (da) | 1994-05-03 | 1998-05-04 | Ciba Geigy Ag | Pyrrolopyrimidinderivater med antiproliferativ virkning |
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| AU711592B2 (en) | 1995-04-03 | 1999-10-14 | Novartis Ag | Pyrazole derivatives and processes for the preparation thereof |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5650415A (en) | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
| DK0836605T3 (da) | 1995-07-06 | 2002-05-13 | Novartis Ag | Pyrrolopyrimidiner og fremgangsmåder til deres fremstilling |
| DK9500262U4 (da) | 1995-07-07 | 1996-10-07 | Bonus Energy As | Bundramme til vindmøllehus samt vindmølle omfattende samme |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| JP4275733B2 (ja) | 1996-01-23 | 2009-06-10 | ノバルティス アクチエンゲゼルシャフト | ピロロピリミジンおよびその製造法 |
| JP3406763B2 (ja) | 1996-01-30 | 2003-05-12 | 東レ・ダウコーニング・シリコーン株式会社 | シリコーンゴム組成物 |
| GB9603097D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| DE19608588A1 (de) | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE19629652A1 (de) | 1996-03-06 | 1998-01-29 | Thomae Gmbh Dr K | 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| EP0888353B1 (de) | 1996-03-15 | 2003-07-09 | Novartis AG | N-7 HETEROCYCLYL-PYRROLO[ 2,3-d]PYRIMIDINE UND IHRE VERWENDUNG |
| SK284073B6 (sk) | 1996-04-12 | 2004-09-08 | Warner-Lambert Company | Polycyklické zlúčeniny, ich použitie a farmaceutické kompozície na ich báze |
| GB9607729D0 (en) | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| WO1997049688A1 (en) | 1996-06-24 | 1997-12-31 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
| DE69718472T2 (de) | 1996-07-13 | 2003-11-06 | Glaxo Group Ltd., Greenford | Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| WO1998007726A1 (en) | 1996-08-23 | 1998-02-26 | Novartis Ag | Substituted pyrrolopyrimidines and processes for their preparation |
| JP4205168B2 (ja) | 1996-10-02 | 2009-01-07 | ノバルティス アクチエンゲゼルシヤフト | ピリミジン誘導体およびその製造法 |
| AU4779897A (en) | 1996-10-02 | 1998-04-24 | Novartis Ag | Fused pyrazole derivatives and processes for their preparation |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| GB9621757D0 (en) | 1996-10-18 | 1996-12-11 | Ciba Geigy Ag | Phenyl-substituted bicyclic heterocyclyl derivatives and their use |
| ES2301194T3 (es) | 1997-02-05 | 2008-06-16 | Warner-Lambert Company Llc | Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular. |
| US6329375B1 (en) | 1997-08-05 | 2001-12-11 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| US6566131B1 (en) | 2000-10-04 | 2003-05-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of Smad6 expression |
| US6410323B1 (en) | 1999-08-31 | 2002-06-25 | Isis Pharmaceuticals, Inc. | Antisense modulation of human Rho family gene expression |
| US6107091A (en) | 1998-12-03 | 2000-08-22 | Isis Pharmaceuticals Inc. | Antisense inhibition of G-alpha-16 expression |
| US5981732A (en) | 1998-12-04 | 1999-11-09 | Isis Pharmaceuticals Inc. | Antisense modulation of G-alpha-13 expression |
| US6046321A (en) | 1999-04-09 | 2000-04-04 | Isis Pharmaceuticals Inc. | Antisense modulation of G-alpha-i1 expression |
| US6331393B1 (en) | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| KR20020000223A (ko) | 1999-05-14 | 2002-01-05 | 존 비. 랜디스 | 표피성장인자 수용체 길항제를 사용한 인간 난치성 종양의치료 방법 |
| US6180349B1 (en) | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
| UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
| US6365354B1 (en) | 2000-07-31 | 2002-04-02 | Isis Pharmaceuticals, Inc. | Antisense modulation of lysophospholipase I expression |
| US6566135B1 (en) | 2000-10-04 | 2003-05-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of caspase 6 expression |
| DE10130800B4 (de) | 2001-06-22 | 2005-06-23 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierung mit hoher Sensitivität |
| US20040132097A1 (en) | 2002-06-19 | 2004-07-08 | Bacus Sarah S. | Method for predicting response to epidermal growth factor receptor-directed therapy |
| CA2489360C (en) | 2002-06-26 | 2013-01-29 | Cold Spring Harbor Laboratory | Methods and compositions for determining methylation profiles |
| CA2506066A1 (en) | 2002-11-15 | 2004-06-03 | Genomic Health, Inc. | Gene expression profiling of egfr positive cancer |
| EP1597558A2 (en) | 2003-01-08 | 2005-11-23 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
| WO2004071572A2 (en) | 2003-02-06 | 2004-08-26 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| JP4453297B2 (ja) | 2003-05-27 | 2010-04-21 | トヨタ自動車株式会社 | 車両用遊星歯車式多段変速機 |
| CA2527321A1 (en) | 2003-05-30 | 2004-12-23 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| EP1664716A4 (en) | 2003-08-15 | 2008-08-13 | Smithkline Beecham Corp | CANCER BIOMARKERS |
| WO2006101925A2 (en) | 2005-03-16 | 2006-09-28 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors |
| ES2399075T3 (es) | 2006-08-30 | 2013-03-25 | Genentech, Inc. | Anticuerpos multiespecíficos |
| ES2628108T3 (es) | 2008-09-03 | 2017-08-01 | F. Hoffmann-La Roche Ag | Anticuerpos multiespecíficos |
| JP2012519281A (ja) * | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
| WO2010099138A2 (en) * | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| CN102356092B (zh) | 2009-03-20 | 2014-11-05 | 霍夫曼-拉罗奇有限公司 | 双特异性抗-her抗体 |
| JP2012524280A (ja) * | 2009-04-17 | 2012-10-11 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 上皮成長因子受容体キナーゼ阻害剤に対する抗がん反応を予測するための生物学的マーカー |
| US20140030255A1 (en) * | 2010-11-03 | 2014-01-30 | Merck Sharp & Dohme Corp. | Methods of predicting cancer cell response to therapeutic agents |
-
2012
- 2012-09-28 BR BR112014007569A patent/BR112014007569A2/pt not_active IP Right Cessation
- 2012-09-28 CN CN201280058401.1A patent/CN104066851A/zh active Pending
- 2012-09-28 JP JP2014533357A patent/JP2014531213A/ja active Pending
- 2012-09-28 US US13/630,363 patent/US20130084287A1/en not_active Abandoned
- 2012-09-28 CA CA2849120A patent/CA2849120A1/en not_active Abandoned
- 2012-09-28 AU AU2012321248A patent/AU2012321248A1/en not_active Abandoned
- 2012-09-28 RU RU2014110228/10A patent/RU2014110228A/ru not_active Application Discontinuation
- 2012-09-28 SG SG11201400996SA patent/SG11201400996SA/en unknown
- 2012-09-28 KR KR1020147011145A patent/KR20140066783A/ko not_active Ceased
- 2012-09-28 MX MX2014003698A patent/MX2014003698A/es unknown
- 2012-09-28 WO PCT/US2012/057777 patent/WO2013055530A1/en not_active Ceased
- 2012-09-28 EP EP12775890.2A patent/EP2761025A1/en not_active Ceased
-
2014
- 2014-03-18 ZA ZA2014/01968A patent/ZA201401968B/en unknown
- 2014-03-19 IL IL231590A patent/IL231590A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014531213A5 (enExample) | ||
| RU2014110228A (ru) | Диагностические маркеры | |
| Zhou et al. | MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1 | |
| Xiao et al. | miR-206 functions as a novel cell cycle regulator and tumor suppressor in clear-cell renal cell carcinoma | |
| Tsang et al. | Long non‐coding RNA HOTTIP is frequently up‐regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR‐125b | |
| Zhang et al. | miR-221/222 promote malignant progression of glioma through activation of the Akt pathway | |
| Zhao et al. | EGFR/c-myc axis regulates TGFβ/Hippo/Notch pathway via epigenetic silencing miR-524 in gliomas | |
| Wang et al. | Up-regulation of p21WAF1/CIP1 by miRNAs and its implications in bladder cancer cells | |
| Stefanska et al. | Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets | |
| Cai et al. | miR-186 downregulation correlates with poor survival in lung adenocarcinoma, where it interferes with cell-cycle regulation | |
| Chen et al. | MiR-410 regulates MET to influence the proliferation and invasion of glioma | |
| Zhao et al. | Transcriptional downregulation of miR-4306 serves as a new therapeutic target for triple negative breast cancer | |
| Chacon-Cabrera et al. | MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1−/− and Parp-2−/− mice with lung cancer cachexia | |
| Cheng et al. | MeCP2: multifaceted roles in gene regulation and neural development | |
| CN108606982B (zh) | Vcp抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 | |
| Wu et al. | miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling | |
| Liang et al. | Porphyromonas gingivalis promotes the proliferation and migration of esophageal squamous cell carcinoma through the miR-194/GRHL3/PTEN/Akt axis | |
| Eoh et al. | MicroRNA-630 inhibitor sensitizes chemoresistant ovarian cancer to chemotherapy by enhancing apoptosis | |
| Deng et al. | Long non-coding RNA HOTTIP promotes tumor growth and inhibits cell apoptosis in lung cancer | |
| EA201500373A1 (ru) | Маситиниб или его соль для лечения рака, фармацевтическая композиция, лекарственное средство и набор | |
| Qiu et al. | microRNA-183 plays as oncogenes by increasing cell proliferation, migration and invasion via targeting protein phosphatase 2A in renal cancer cells | |
| Tarantelli et al. | BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance | |
| Wang et al. | The regulatory roles of miRNA and methylation on oncogene and tumor suppressor gene expression in pancreatic cancer cells | |
| Zhou et al. | Long noncoding RNA ZFAS1 promotes hepatocellular carcinoma proliferation by epigenetically repressing miR-193a-3p. | |
| Bai et al. | Serine/threonine kinase CHEK1-dependent transcriptional regulation of RAD54L promotes proliferation and radio resistance in glioblastoma |