CN104066851A - 肿瘤或肿瘤细胞中上皮或间充质表型的诊断性甲基化标志物和对egfr激酶抑制剂的响应 - Google Patents

肿瘤或肿瘤细胞中上皮或间充质表型的诊断性甲基化标志物和对egfr激酶抑制剂的响应 Download PDF

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CN104066851A
CN104066851A CN201280058401.1A CN201280058401A CN104066851A CN 104066851 A CN104066851 A CN 104066851A CN 201280058401 A CN201280058401 A CN 201280058401A CN 104066851 A CN104066851 A CN 104066851A
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dna
inhibitor
cancer
egfr
cell
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D.夏姆斯
T.M.霍尔科姆
K.沃尔特
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Genentech Inc
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201280058401.1A 2011-09-30 2012-09-28 肿瘤或肿瘤细胞中上皮或间充质表型的诊断性甲基化标志物和对egfr激酶抑制剂的响应 Pending CN104066851A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161542141P 2011-09-30 2011-09-30
US61/542,141 2011-09-30
PCT/US2012/057777 WO2013055530A1 (en) 2011-09-30 2012-09-28 Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells

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US (1) US20130084287A1 (enExample)
EP (1) EP2761025A1 (enExample)
JP (1) JP2014531213A (enExample)
KR (1) KR20140066783A (enExample)
CN (1) CN104066851A (enExample)
AU (1) AU2012321248A1 (enExample)
BR (1) BR112014007569A2 (enExample)
CA (1) CA2849120A1 (enExample)
IL (1) IL231590A0 (enExample)
MX (1) MX2014003698A (enExample)
RU (1) RU2014110228A (enExample)
SG (1) SG11201400996SA (enExample)
WO (1) WO2013055530A1 (enExample)
ZA (1) ZA201401968B (enExample)

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CN107144695A (zh) * 2017-04-19 2017-09-08 南昌大学 Arl13b蛋白在癌症诊断中的应用
CN110283910A (zh) * 2019-06-21 2019-09-27 浙江大学 目标基因dna甲基化作为分子标志物在制备判别结直肠组织癌变进展试剂盒中的应用
CN111304305A (zh) * 2020-03-30 2020-06-19 陕西科技大学 一种用于检测egfr基因甲基化的试剂盒及方法
CN111521810A (zh) * 2019-02-02 2020-08-11 中国科学院上海药物研究所 癌症患者根据脾酪氨酸激酶进行分层
CN111676286A (zh) * 2020-05-29 2020-09-18 武汉爱基百客生物科技有限公司 肺癌血浆游离dna甲基化检测用的多重pcr引物系统、检测方法及应用
CN112166202A (zh) * 2018-06-15 2021-01-01 荷兰联合利华有限公司 评估阳光照射的表观遗传方法
CN114525281A (zh) * 2022-03-14 2022-05-24 右江民族医学院 Esrp1启动子报告基因转录活性可视化及在去甲基化抗癌药物筛选中的应用
CN115772565A (zh) * 2021-09-08 2023-03-10 广州市基准医疗有限责任公司 用于辅助检测肺癌体细胞egfr基因突变的甲基化位点及其应用

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WO2014205374A1 (en) * 2013-06-20 2014-12-24 The Trustees Of The University Of Pennsylvania Methods for diagnosing pancreatic cancer
WO2015066634A2 (en) * 2013-11-04 2015-05-07 Dow Agrosciences Llc Optimal soybean loci
CN107517590B (zh) * 2014-07-29 2021-11-12 威马克生物有限公司 与表皮生长因子受体-靶制剂有关的感受性预测用新型生物标志物及其用途
WO2016060278A1 (ja) * 2014-10-17 2016-04-21 国立大学法人東北大学 大腸癌に対する薬物療法の感受性を予測する方法
CN107208135B (zh) 2014-12-12 2021-10-15 精密科学公司 用于进行甲基化检测测定的组合物和方法
ES2879964T3 (es) 2014-12-12 2021-11-23 Exact Sciences Dev Co Llc Composiciones y métodos para realizar ensayos de detección de metilación
WO2016193151A1 (en) * 2015-05-29 2016-12-08 Vito Nv Epigenetic markers for respiratory allergy
EP3481954A4 (en) * 2016-07-06 2020-04-15 Youhealth Biotech, Limited SPECIFIC METHYLATION MARKERS OF LUNG CANCER AND USES OF THE SAME
EP3601602B1 (en) * 2017-03-29 2024-04-10 Crown Bioscience, Inc. (Taicang) System and method for determining cetuximab sensitivity on gastric cancer
US11408887B2 (en) 2017-05-22 2022-08-09 The National Institute for Biotechnology in the Negev Ltd. Biomarkers for diagnosis of lung cancer
CN110055313B (zh) * 2018-01-18 2024-03-08 纽克莱克斯有限公司 用于诊断肺癌的方法
CA3119329A1 (en) * 2018-11-27 2020-06-04 Exact Sciences Development Company, Llc Characterizing methylated dna, rna, and proteins in the detection of lung neoplasia
IL265451B (en) 2019-03-18 2020-01-30 Frumkin Dan Methods and systems for the detection of methylation changes in DNA samples
CN114354927B (zh) * 2021-03-18 2025-04-22 中国人民解放军陆军特色医学中心 唾液酸转移酶st3gal4作为egfr-tki耐药标志物的新应用
CN115651984B (zh) * 2022-10-20 2023-04-14 山东大学 一种生物标志物在评价肿瘤紫杉类化疗耐药性的应用

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