ZA201401968B - Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells - Google Patents
Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cellsInfo
- Publication number
- ZA201401968B ZA201401968B ZA2014/01968A ZA201401968A ZA201401968B ZA 201401968 B ZA201401968 B ZA 201401968B ZA 2014/01968 A ZA2014/01968 A ZA 2014/01968A ZA 201401968 A ZA201401968 A ZA 201401968A ZA 201401968 B ZA201401968 B ZA 201401968B
- Authority
- ZA
- South Africa
- Prior art keywords
- tumours
- epithelial
- response
- kinase inhibitor
- tumour cells
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940121647 egfr inhibitor Drugs 0.000 title 1
- 230000011987 methylation Effects 0.000 title 1
- 238000007069 methylation reaction Methods 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542141P | 2011-09-30 | 2011-09-30 | |
| PCT/US2012/057777 WO2013055530A1 (en) | 2011-09-30 | 2012-09-28 | Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201401968B true ZA201401968B (en) | 2018-05-30 |
Family
ID=47071458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/01968A ZA201401968B (en) | 2011-09-30 | 2014-03-18 | Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130084287A1 (enExample) |
| EP (1) | EP2761025A1 (enExample) |
| JP (1) | JP2014531213A (enExample) |
| KR (1) | KR20140066783A (enExample) |
| CN (1) | CN104066851A (enExample) |
| AU (1) | AU2012321248A1 (enExample) |
| BR (1) | BR112014007569A2 (enExample) |
| CA (1) | CA2849120A1 (enExample) |
| IL (1) | IL231590A0 (enExample) |
| MX (1) | MX2014003698A (enExample) |
| RU (1) | RU2014110228A (enExample) |
| SG (1) | SG11201400996SA (enExample) |
| WO (1) | WO2013055530A1 (enExample) |
| ZA (1) | ZA201401968B (enExample) |
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| US20140375671A1 (en) * | 2011-11-28 | 2014-12-25 | University Of Chicago | Method, system, software and medium for advanced image-based arrays for analysis and display of biomedical information |
| EP3004387A4 (en) * | 2013-05-31 | 2017-04-12 | Onconova Therapeutics, Inc. | Methods and compositions for predicting therapeutic efficacy of kinase inhibitors in patients with myelodysplastic syndrome or related disorders |
| EP3159695A3 (en) * | 2013-06-20 | 2017-07-05 | The Trustees of The University of Pennsylvania | Methods for diagnosing pancreatic cancer |
| UY35814A (es) * | 2013-11-04 | 2015-05-29 | Dow Agrosciences Llc | ?lugares óptimos para la soja?. |
| JP6779858B2 (ja) * | 2014-07-29 | 2020-11-04 | ウェルマーカー バイオ カンパニー リミテッド | Ｅｇｆｒ−標的製剤に対する感受性予測用の新規なバイオマーカー及びその用途 |
| WO2016060278A1 (ja) * | 2014-10-17 | 2016-04-21 | 国立大学法人東北大学 | 大腸癌に対する薬物療法の感受性を予測する方法 |
| WO2016094839A2 (en) | 2014-12-12 | 2016-06-16 | Exact Sciences Corporation | Compositions and methods for performing methylation detection assays |
| US10465248B2 (en) | 2014-12-12 | 2019-11-05 | Exact Sciences Development Company, Llc | Method of characterizing ZDHHC1 DNA |
| US10683547B2 (en) * | 2015-05-29 | 2020-06-16 | Vito Nv | Epigenetic markers for respiratory allergy |
| KR20250073555A (ko) | 2015-10-30 | 2025-05-27 | 이그잭트 사이언시즈 코포레이션 | 복합 증폭 검출 분석 및 혈장으로부터 dna의 분리 및 검출 방법 |
| CN116064796A (zh) | 2016-05-05 | 2023-05-05 | 精密科学公司 | 通过分析甲基化dna来检测肺肿瘤 |
| WO2018009709A1 (en) | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Lung cancer methylation markers and uses thereof |
| TWI859118B (zh) * | 2017-03-29 | 2024-10-21 | 大陸商中美冠科生物技術（太倉）有限公司 | 測定對胃癌之西妥昔單抗（ｃｅｔｕｘｉｍａｂ）敏感性的系統及方法 |
| CN107144695B (zh) * | 2017-04-19 | 2019-02-26 | 南昌大学 | Arl13b蛋白在癌症诊断中的应用 |
| US11408887B2 (en) | 2017-05-22 | 2022-08-09 | The National Institute for Biotechnology in the Negev Ltd. | Biomarkers for diagnosis of lung cancer |
| CN110055313B (zh) | 2018-01-18 | 2024-03-08 | 纽克莱克斯有限公司 | 用于诊断肺癌的方法 |
| WO2019238792A1 (en) * | 2018-06-15 | 2019-12-19 | Unilever Plc | Epigenetic method to assess sun exposure |
| AU2019389008A1 (en) * | 2018-11-27 | 2021-06-03 | Exact Sciences Corporation | Characterizing methylated DNA, RNA, and proteins in the detection of lung neoplasia |
| CN111521810B (zh) * | 2019-02-02 | 2024-06-21 | 中国科学院上海药物研究所 | 癌症患者根据脾酪氨酸激酶进行分层 |
| IL265451B (en) | 2019-03-18 | 2020-01-30 | Frumkin Dan | Methods and systems for the detection of methylation changes in DNA samples |
| CN110283910B (zh) * | 2019-06-21 | 2021-04-20 | 浙江大学 | 目标基因dna甲基化作为分子标志物在制备判别结直肠组织癌变进展试剂盒中的应用 |
| CN111304305B (zh) * | 2020-03-30 | 2023-05-30 | 陕西科技大学 | 一种用于检测egfr基因甲基化的试剂盒及方法 |
| CN111676286B (zh) * | 2020-05-29 | 2023-04-14 | 武汉爱基百客生物科技有限公司 | 肺癌血浆游离dna甲基化检测用的多重pcr引物系统、检测方法及应用 |
| CN114354927B (zh) * | 2021-03-18 | 2025-04-22 | 中国人民解放军陆军特色医学中心 | 唾液酸转移酶st3gal4作为egfr-tki耐药标志物的新应用 |
| CN115772565B (zh) * | 2021-09-08 | 2023-09-05 | 广州市基准医疗有限责任公司 | 用于辅助检测肺癌体细胞egfr基因突变的甲基化位点及其应用 |
| CN114525281B (zh) * | 2022-03-14 | 2024-03-12 | 右江民族医学院 | Esrp1启动子报告基因转录活性可视化及在去甲基化抗癌药物筛选中的应用 |
| CN115651984B (zh) * | 2022-10-20 | 2023-04-14 | 山东大学 | 一种生物标志物在评价肿瘤紫杉类化疗耐药性的应用 |
| WO2026086863A1 (en) * | 2024-10-24 | 2026-04-30 | The Chinese University Of Hong Kong | Methylation markers for coronary heart disease |
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| ATE477495T1 (de) | 2005-03-16 | 2010-08-15 | Osi Pharm Inc | Biologische marker prediktiv für das ansprechen von krebs auf inhibitoren der kinase des rezeptors für epidermalen wachstumsfaktor |
| DK2059533T3 (da) | 2006-08-30 | 2013-02-25 | Genentech Inc | Multispecifikke antistoffer |
| RU2547596C2 (ru) | 2008-09-03 | 2015-04-10 | Дженентек, Инк. | Полиспецифические антитела |
| US8642834B2 (en) * | 2009-02-27 | 2014-02-04 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| WO2010099138A2 (en) * | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| SG10201402742YA (en) | 2009-03-20 | 2014-08-28 | Genentech Inc | Bispecific anti-her antibodies |
| JP2012524280A (ja) * | 2009-04-17 | 2012-10-11 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 上皮成長因子受容体キナーゼ阻害剤に対する抗がん反応を予測するための生物学的マーカー |
| WO2012061510A2 (en) * | 2010-11-03 | 2012-05-10 | Merck Sharp & Dohme Corp. | Methods of predicting cancer cell response to therapeutic agents |
-
2012
- 2012-09-28 WO PCT/US2012/057777 patent/WO2013055530A1/en not_active Ceased
- 2012-09-28 CN CN201280058401.1A patent/CN104066851A/zh active Pending
- 2012-09-28 RU RU2014110228/10A patent/RU2014110228A/ru not_active Application Discontinuation
- 2012-09-28 CA CA2849120A patent/CA2849120A1/en not_active Abandoned
- 2012-09-28 KR KR1020147011145A patent/KR20140066783A/ko not_active Ceased
- 2012-09-28 MX MX2014003698A patent/MX2014003698A/es unknown
- 2012-09-28 US US13/630,363 patent/US20130084287A1/en not_active Abandoned
- 2012-09-28 JP JP2014533357A patent/JP2014531213A/ja active Pending
- 2012-09-28 EP EP12775890.2A patent/EP2761025A1/en not_active Ceased
- 2012-09-28 AU AU2012321248A patent/AU2012321248A1/en not_active Abandoned
- 2012-09-28 BR BR112014007569A patent/BR112014007569A2/pt not_active IP Right Cessation
- 2012-09-28 SG SG11201400996SA patent/SG11201400996SA/en unknown
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2014
- 2014-03-18 ZA ZA2014/01968A patent/ZA201401968B/en unknown
- 2014-03-19 IL IL231590A patent/IL231590A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014003698A (es) | 2014-07-28 |
| AU2012321248A1 (en) | 2014-04-24 |
| EP2761025A1 (en) | 2014-08-06 |
| CA2849120A1 (en) | 2013-04-18 |
| RU2014110228A (ru) | 2015-11-10 |
| US20130084287A1 (en) | 2013-04-04 |
| CN104066851A (zh) | 2014-09-24 |
| IL231590A0 (en) | 2014-05-28 |
| WO2013055530A1 (en) | 2013-04-18 |
| JP2014531213A (ja) | 2014-11-27 |
| KR20140066783A (ko) | 2014-06-02 |
| BR112014007569A2 (pt) | 2017-04-18 |
| SG11201400996SA (en) | 2014-04-28 |
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