JP2014529584A5 - - Google Patents
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- Publication number
- JP2014529584A5 JP2014529584A5 JP2014524097A JP2014524097A JP2014529584A5 JP 2014529584 A5 JP2014529584 A5 JP 2014529584A5 JP 2014524097 A JP2014524097 A JP 2014524097A JP 2014524097 A JP2014524097 A JP 2014524097A JP 2014529584 A5 JP2014529584 A5 JP 2014529584A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treatment
- administered
- pharmaceutically acceptable
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 5
- 206010059594 Secondary hypogonadism Diseases 0.000 claims description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 4
- 201000003368 hypogonadotropic hypogonadism Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 208000000509 infertility Diseases 0.000 claims description 3
- 231100000535 infertility Toxicity 0.000 claims description 3
- 230000036512 infertility Effects 0.000 claims description 3
- 206010046766 uterine cancer Diseases 0.000 claims description 3
- 201000005670 Anovulation Diseases 0.000 claims description 2
- 206010002659 Anovulatory cycle Diseases 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 2
- 206010064919 Hypospermia Diseases 0.000 claims description 2
- 231100000552 anovulation Toxicity 0.000 claims description 2
- 206010003883 azoospermia Diseases 0.000 claims description 2
- 230000037182 bone density Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 229960003604 testosterone Drugs 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims 3
- 230000002513 anti-ovulatory effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 16
- 208000001145 Metabolic Syndrome Diseases 0.000 description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 208000006132 lipodystrophy Diseases 0.000 description 1
- 230000011599 ovarian follicle development Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- GKIRPKYJQBWNGO-QPLCGJKRSA-N zuclomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-QPLCGJKRSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161515278P | 2011-08-04 | 2011-08-04 | |
| US61/515,278 | 2011-08-04 | ||
| PCT/US2012/049451 WO2013020017A1 (en) | 2011-08-04 | 2012-08-03 | Trans-clomiphene metabolites and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018186696A Division JP2019023210A (ja) | 2011-08-04 | 2018-10-01 | トランス−クロミフェン代謝物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529584A JP2014529584A (ja) | 2014-11-13 |
| JP2014529584A5 true JP2014529584A5 (enExample) | 2015-07-02 |
| JP6433785B2 JP6433785B2 (ja) | 2018-12-05 |
Family
ID=46724628
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014524097A Expired - Fee Related JP6433785B2 (ja) | 2011-08-04 | 2012-08-03 | トランス−クロミフェン代謝物およびその使用 |
| JP2018186696A Pending JP2019023210A (ja) | 2011-08-04 | 2018-10-01 | トランス−クロミフェン代謝物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018186696A Pending JP2019023210A (ja) | 2011-08-04 | 2018-10-01 | トランス−クロミフェン代謝物およびその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9981906B2 (enExample) |
| EP (2) | EP3351527A1 (enExample) |
| JP (2) | JP6433785B2 (enExample) |
| KR (1) | KR20140054110A (enExample) |
| CN (1) | CN103702975B (enExample) |
| AU (2) | AU2012289964B2 (enExample) |
| BR (1) | BR112014000908A2 (enExample) |
| CA (1) | CA2841572C (enExample) |
| CL (1) | CL2014000268A1 (enExample) |
| CO (1) | CO6862154A2 (enExample) |
| CR (1) | CR20140124A (enExample) |
| EA (1) | EA201490416A1 (enExample) |
| IL (1) | IL230287B (enExample) |
| MX (1) | MX355316B (enExample) |
| MY (2) | MY170718A (enExample) |
| NI (1) | NI201400008A (enExample) |
| PH (1) | PH12014500144A1 (enExample) |
| SG (1) | SG10201606425WA (enExample) |
| UA (1) | UA113291C2 (enExample) |
| WO (1) | WO2013020017A1 (enExample) |
| ZA (1) | ZA201400406B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120284764A1 (en) * | 2011-05-05 | 2012-11-08 | Keith Ball | Method and system for requesting services by a media device |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| EP2854763B1 (en) | 2012-05-31 | 2018-09-26 | Repros Therapeutics Inc. | Formulations for vaginal delivery of antiprogestins |
| WO2014070523A1 (en) * | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
| CN104755087A (zh) | 2012-11-02 | 2015-07-01 | 利普生物药剂公司 | 治疗孕酮依赖性病况的方法和组合物 |
| EP3402471A4 (en) * | 2016-01-12 | 2019-08-28 | Repros Therapeutics Inc. | TRANS-CLOMIPHENE-BASED POLY THERAPY AND PROGESTERONE RECEPTOR ANTAGONIST FOR THE TREATMENT OF HORMONE-DEPENDENT PATHOLOGICAL CONDITIONS |
| CN108883083A (zh) * | 2016-02-25 | 2018-11-23 | 艾森潘帕克制药股份有限公司 | 两种氯米芬异构体的口服剂型及使用其治疗继发性腺功能减退症的方法 |
| WO2017182097A1 (en) | 2016-04-22 | 2017-10-26 | F.I.S. - Fabbrica Italiana Sintetici S.P.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
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| US4061733A (en) | 1976-10-15 | 1977-12-06 | Narayan Vishwanath Gunjikar | Veterinary compositions for inducing estrus in animals and method |
| US4729999A (en) | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| ATE36312T1 (de) | 1985-06-08 | 1988-08-15 | Asta Pharma Ag | Neue derivate des 1,1,2,2-tetramethyl-1,2-bis-(2fluor-4-hydroxyphenyl)-ethans. |
| US4820736A (en) * | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
| GB8926171D0 (en) | 1989-11-20 | 1990-01-10 | Applied Research Systems | Treatment of infertility |
| JPH04312522A (ja) | 1991-04-08 | 1992-11-04 | Yoshiaki Kawashima | 徐放性錠剤の製造方法 |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| WO1994006762A1 (en) * | 1992-09-15 | 1994-03-31 | Merrell Dow Pharmaceuticals Inc. | Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors |
| US5776923A (en) | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
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| DE4435368A1 (de) | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| DE69617245T2 (de) | 1995-08-17 | 2002-07-25 | Csir, Pretoria | Produkte mit gesteuerter freisetzung |
| US5773031A (en) | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| IL120262A (en) | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
| PL191399B1 (pl) | 1996-10-28 | 2006-05-31 | Gen Mills Inc | Sposób kapsułkowania lub osadzania składnika w osnowie w procesie ciągłym, sposób kapsułkowania i/lub osadzania składników w osnowie opartej na węglowodanach, sposób kapsułkowania i/lub osadzania składników w osnowie oraz kapsułka |
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| EP2405270B1 (en) | 2006-06-30 | 2013-07-17 | Merck Sharp & Dohme Corp. | IGFBP2-Biomarker |
| CN101766000A (zh) | 2007-06-26 | 2010-06-30 | 传媒专利有限公司 | 管理组播组的方法和设备 |
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| TWI458478B (zh) | 2008-11-07 | 2014-11-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
| US20100144687A1 (en) | 2008-12-05 | 2010-06-10 | Glaser Rebecca L | Pharmaceutical compositions containing testosterone and an aromatase inhibitor |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| US20140235601A1 (en) | 2011-08-09 | 2014-08-21 | Kenneth W. Adams | Use of Aromatase Inhibitor Or Estrogen Blocker For Increasing Spermatogenesis Or Testosterone Levels In Males |
| EP2819676B1 (en) | 2012-02-29 | 2018-05-30 | Repros Therapeutics Inc. | Combination therapy for treating androgen deficiency |
| SG10201704820SA (en) | 2012-08-21 | 2017-07-28 | Repros Therapeutics Inc | Trans-clomiphene formulations and uses thereof |
| CN103351304B (zh) | 2013-07-01 | 2015-12-09 | 暨明医药科技（苏州）有限公司 | 一种克罗米芬的合成方法 |
-
2012
- 2012-03-08 UA UAA201402168A patent/UA113291C2/uk unknown
- 2012-08-03 KR KR1020147004588A patent/KR20140054110A/ko not_active Ceased
- 2012-08-03 SG SG10201606425WA patent/SG10201606425WA/en unknown
- 2012-08-03 CN CN201280038230.6A patent/CN103702975B/zh not_active Expired - Fee Related
- 2012-08-03 EA EA201490416A patent/EA201490416A1/ru unknown
- 2012-08-03 EP EP18161551.9A patent/EP3351527A1/en not_active Withdrawn
- 2012-08-03 MY MYPI2014000022A patent/MY170718A/en unknown
- 2012-08-03 BR BR112014000908A patent/BR112014000908A2/pt active Search and Examination
- 2012-08-03 MY MYPI2017001676A patent/MY191802A/en unknown
- 2012-08-03 US US14/236,868 patent/US9981906B2/en not_active Expired - Fee Related
- 2012-08-03 CA CA2841572A patent/CA2841572C/en not_active Expired - Fee Related
- 2012-08-03 EP EP12750508.9A patent/EP2744777A1/en not_active Withdrawn
- 2012-08-03 AU AU2012289964A patent/AU2012289964B2/en not_active Ceased
- 2012-08-03 JP JP2014524097A patent/JP6433785B2/ja not_active Expired - Fee Related
- 2012-08-03 PH PH1/2014/500144A patent/PH12014500144A1/en unknown
- 2012-08-03 MX MX2014000825A patent/MX355316B/es active IP Right Grant
- 2012-08-03 WO PCT/US2012/049451 patent/WO2013020017A1/en not_active Ceased
-
2014
- 2014-01-02 IL IL230287A patent/IL230287B/en active IP Right Grant
- 2014-01-17 ZA ZA2014/00406A patent/ZA201400406B/en unknown
- 2014-01-24 CO CO14014339A patent/CO6862154A2/es unknown
- 2014-01-30 NI NI201400008A patent/NI201400008A/es unknown
- 2014-02-03 CL CL2014000268A patent/CL2014000268A1/es unknown
- 2014-03-13 CR CR20140124A patent/CR20140124A/es unknown
-
2017
- 2017-06-20 AU AU2017204171A patent/AU2017204171A1/en not_active Abandoned
-
2018
- 2018-10-01 JP JP2018186696A patent/JP2019023210A/ja active Pending
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