MX355316B - Metabolitos de trans - clomifeno y usos de los mismos. - Google Patents
Metabolitos de trans - clomifeno y usos de los mismos.Info
- Publication number
- MX355316B MX355316B MX2014000825A MX2014000825A MX355316B MX 355316 B MX355316 B MX 355316B MX 2014000825 A MX2014000825 A MX 2014000825A MX 2014000825 A MX2014000825 A MX 2014000825A MX 355316 B MX355316 B MX 355316B
- Authority
- MX
- Mexico
- Prior art keywords
- metabolites
- cancer
- clomiphene
- trans
- elevated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Pregnancy & Childbirth (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a metabolitos de trans-clomifeno sustancialmente puros. La invención también se refiere a composiciones farmacéuticas que comprenden estos metabolitos y su uso en el tratamiento de trastornos incluyendo hipogonadismo secundario, diabetes tipo 2, colesterol elevado, triglicéridos elevados, emaciación, lipodistrofia, infertilidad femenina y masculina, hipertrofia benigna de la próstata, cáncer de próstata, cáncer de mama, cáncer de ovarios y cáncer de endometrio.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161515278P | 2011-08-04 | 2011-08-04 | |
PCT/US2012/049451 WO2013020017A1 (en) | 2011-08-04 | 2012-08-03 | Trans-clomiphene metabolites and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014000825A MX2014000825A (es) | 2014-02-27 |
MX355316B true MX355316B (es) | 2018-04-16 |
Family
ID=46724628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014000825A MX355316B (es) | 2011-08-04 | 2012-08-03 | Metabolitos de trans - clomifeno y usos de los mismos. |
Country Status (21)
Country | Link |
---|---|
US (1) | US9981906B2 (es) |
EP (2) | EP2744777A1 (es) |
JP (2) | JP6433785B2 (es) |
KR (1) | KR20140054110A (es) |
CN (1) | CN103702975B (es) |
AU (2) | AU2012289964B2 (es) |
BR (1) | BR112014000908A2 (es) |
CA (1) | CA2841572C (es) |
CL (1) | CL2014000268A1 (es) |
CO (1) | CO6862154A2 (es) |
CR (1) | CR20140124A (es) |
EA (1) | EA201490416A1 (es) |
HK (1) | HK1196349A1 (es) |
IL (1) | IL230287B (es) |
MX (1) | MX355316B (es) |
MY (2) | MY170718A (es) |
NI (1) | NI201400008A (es) |
SG (1) | SG10201606425WA (es) |
UA (1) | UA113291C2 (es) |
WO (1) | WO2013020017A1 (es) |
ZA (1) | ZA201400406B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120284764A1 (en) * | 2011-05-05 | 2012-11-08 | Keith Ball | Method and system for requesting services by a media device |
UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
NZ702467A (en) | 2012-05-31 | 2016-07-29 | Repros Therapeutics Inc | Formulations and methods for vaginal delivery of antiprogestins |
CN104994877A (zh) | 2012-11-02 | 2015-10-21 | 利普生物药剂公司 | 用于癌症治疗的反式-克罗米芬 |
EP2914268B1 (en) | 2012-11-02 | 2018-07-04 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
EP3402471A4 (en) * | 2016-01-12 | 2019-08-28 | Repros Therapeutics Inc. | TRANS-CLOMIPHENE-BASED POLY THERAPY AND PROGESTERONE RECEPTOR ANTAGONIST FOR THE TREATMENT OF HORMONE-DEPENDENT PATHOLOGICAL CONDITIONS |
WO2017147264A1 (en) * | 2016-02-25 | 2017-08-31 | Aspen Park Pharmaceuticals, Inc. | Oral dosage form of both clomiphene isomers and method of using same to treat secondary hypogonadism |
WO2017182097A1 (en) | 2016-04-22 | 2017-10-26 | F.I.S. - Fabbrica Italiana Sintetici S.P.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
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UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
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-
2012
- 2012-03-08 UA UAA201402168A patent/UA113291C2/uk unknown
- 2012-08-03 BR BR112014000908A patent/BR112014000908A2/pt active Search and Examination
- 2012-08-03 EP EP12750508.9A patent/EP2744777A1/en not_active Withdrawn
- 2012-08-03 JP JP2014524097A patent/JP6433785B2/ja not_active Expired - Fee Related
- 2012-08-03 WO PCT/US2012/049451 patent/WO2013020017A1/en active Application Filing
- 2012-08-03 AU AU2012289964A patent/AU2012289964B2/en not_active Ceased
- 2012-08-03 EP EP18161551.9A patent/EP3351527A1/en not_active Withdrawn
- 2012-08-03 MY MYPI2014000022A patent/MY170718A/en unknown
- 2012-08-03 CA CA2841572A patent/CA2841572C/en not_active Expired - Fee Related
- 2012-08-03 EA EA201490416A patent/EA201490416A1/ru unknown
- 2012-08-03 CN CN201280038230.6A patent/CN103702975B/zh not_active Expired - Fee Related
- 2012-08-03 SG SG10201606425WA patent/SG10201606425WA/en unknown
- 2012-08-03 US US14/236,868 patent/US9981906B2/en not_active Expired - Fee Related
- 2012-08-03 MY MYPI2017001676A patent/MY191802A/en unknown
- 2012-08-03 MX MX2014000825A patent/MX355316B/es active IP Right Grant
- 2012-08-03 KR KR1020147004588A patent/KR20140054110A/ko not_active IP Right Cessation
-
2014
- 2014-01-02 IL IL230287A patent/IL230287B/en active IP Right Grant
- 2014-01-17 ZA ZA2014/00406A patent/ZA201400406B/en unknown
- 2014-01-24 CO CO14014339A patent/CO6862154A2/es unknown
- 2014-01-30 NI NI201400008A patent/NI201400008A/es unknown
- 2014-02-03 CL CL2014000268A patent/CL2014000268A1/es unknown
- 2014-03-13 CR CR20140124A patent/CR20140124A/es unknown
- 2014-09-26 HK HK14109682.8A patent/HK1196349A1/zh not_active IP Right Cessation
-
2017
- 2017-06-20 AU AU2017204171A patent/AU2017204171A1/en not_active Abandoned
-
2018
- 2018-10-01 JP JP2018186696A patent/JP2019023210A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CL2014000268A1 (es) | 2014-11-14 |
US20140163114A1 (en) | 2014-06-12 |
KR20140054110A (ko) | 2014-05-08 |
US9981906B2 (en) | 2018-05-29 |
EP2744777A1 (en) | 2014-06-25 |
MX2014000825A (es) | 2014-02-27 |
MY170718A (en) | 2019-08-27 |
AU2012289964A1 (en) | 2014-01-30 |
AU2012289964B2 (en) | 2017-03-23 |
NZ621892A (en) | 2016-03-31 |
BR112014000908A2 (pt) | 2017-02-21 |
SG10201606425WA (en) | 2016-09-29 |
MY191802A (en) | 2022-07-15 |
JP2014529584A (ja) | 2014-11-13 |
JP2019023210A (ja) | 2019-02-14 |
AU2017204171A1 (en) | 2017-07-13 |
EA201490416A1 (ru) | 2014-11-28 |
CA2841572A1 (en) | 2013-02-07 |
CN103702975B (zh) | 2016-03-16 |
UA113291C2 (xx) | 2017-01-10 |
EP3351527A1 (en) | 2018-07-25 |
CN103702975A (zh) | 2014-04-02 |
CO6862154A2 (es) | 2014-02-10 |
IL230287B (en) | 2019-07-31 |
CR20140124A (es) | 2014-05-13 |
NI201400008A (es) | 2015-12-10 |
JP6433785B2 (ja) | 2018-12-05 |
CA2841572C (en) | 2020-10-13 |
HK1196349A1 (zh) | 2014-12-12 |
ZA201400406B (en) | 2014-11-26 |
IL230287A0 (en) | 2014-03-06 |
WO2013020017A1 (en) | 2013-02-07 |
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