MX355316B - Metabolitos de trans - clomifeno y usos de los mismos. - Google Patents

Metabolitos de trans - clomifeno y usos de los mismos.

Info

Publication number
MX355316B
MX355316B MX2014000825A MX2014000825A MX355316B MX 355316 B MX355316 B MX 355316B MX 2014000825 A MX2014000825 A MX 2014000825A MX 2014000825 A MX2014000825 A MX 2014000825A MX 355316 B MX355316 B MX 355316B
Authority
MX
Mexico
Prior art keywords
metabolites
cancer
clomiphene
trans
elevated
Prior art date
Application number
MX2014000825A
Other languages
English (en)
Other versions
MX2014000825A (es
Inventor
S Podolski Joseph
D Wiehle Ronald
Original Assignee
Repros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46724628&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX355316(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Repros Therapeutics Inc filed Critical Repros Therapeutics Inc
Publication of MX2014000825A publication Critical patent/MX2014000825A/es
Publication of MX355316B publication Critical patent/MX355316B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a metabolitos de trans-clomifeno sustancialmente puros. La invención también se refiere a composiciones farmacéuticas que comprenden estos metabolitos y su uso en el tratamiento de trastornos incluyendo hipogonadismo secundario, diabetes tipo 2, colesterol elevado, triglicéridos elevados, emaciación, lipodistrofia, infertilidad femenina y masculina, hipertrofia benigna de la próstata, cáncer de próstata, cáncer de mama, cáncer de ovarios y cáncer de endometrio.
MX2014000825A 2011-08-04 2012-08-03 Metabolitos de trans - clomifeno y usos de los mismos. MX355316B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161515278P 2011-08-04 2011-08-04
PCT/US2012/049451 WO2013020017A1 (en) 2011-08-04 2012-08-03 Trans-clomiphene metabolites and uses thereof

Publications (2)

Publication Number Publication Date
MX2014000825A MX2014000825A (es) 2014-02-27
MX355316B true MX355316B (es) 2018-04-16

Family

ID=46724628

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000825A MX355316B (es) 2011-08-04 2012-08-03 Metabolitos de trans - clomifeno y usos de los mismos.

Country Status (21)

Country Link
US (1) US9981906B2 (es)
EP (2) EP2744777A1 (es)
JP (2) JP6433785B2 (es)
KR (1) KR20140054110A (es)
CN (1) CN103702975B (es)
AU (2) AU2012289964B2 (es)
BR (1) BR112014000908A2 (es)
CA (1) CA2841572C (es)
CL (1) CL2014000268A1 (es)
CO (1) CO6862154A2 (es)
CR (1) CR20140124A (es)
EA (1) EA201490416A1 (es)
HK (1) HK1196349A1 (es)
IL (1) IL230287B (es)
MX (1) MX355316B (es)
MY (2) MY170718A (es)
NI (1) NI201400008A (es)
SG (1) SG10201606425WA (es)
UA (1) UA113291C2 (es)
WO (1) WO2013020017A1 (es)
ZA (1) ZA201400406B (es)

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NZ702467A (en) 2012-05-31 2016-07-29 Repros Therapeutics Inc Formulations and methods for vaginal delivery of antiprogestins
CN104994877A (zh) 2012-11-02 2015-10-21 利普生物药剂公司 用于癌症治疗的反式-克罗米芬
EP2914268B1 (en) 2012-11-02 2018-07-04 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions
EP3402471A4 (en) * 2016-01-12 2019-08-28 Repros Therapeutics Inc. TRANS-CLOMIPHENE-BASED POLY THERAPY AND PROGESTERONE RECEPTOR ANTAGONIST FOR THE TREATMENT OF HORMONE-DEPENDENT PATHOLOGICAL CONDITIONS
WO2017147264A1 (en) * 2016-02-25 2017-08-31 Aspen Park Pharmaceuticals, Inc. Oral dosage form of both clomiphene isomers and method of using same to treat secondary hypogonadism
WO2017182097A1 (en) 2016-04-22 2017-10-26 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit.

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Also Published As

Publication number Publication date
CL2014000268A1 (es) 2014-11-14
US20140163114A1 (en) 2014-06-12
KR20140054110A (ko) 2014-05-08
US9981906B2 (en) 2018-05-29
EP2744777A1 (en) 2014-06-25
MX2014000825A (es) 2014-02-27
MY170718A (en) 2019-08-27
AU2012289964A1 (en) 2014-01-30
AU2012289964B2 (en) 2017-03-23
NZ621892A (en) 2016-03-31
BR112014000908A2 (pt) 2017-02-21
SG10201606425WA (en) 2016-09-29
MY191802A (en) 2022-07-15
JP2014529584A (ja) 2014-11-13
JP2019023210A (ja) 2019-02-14
AU2017204171A1 (en) 2017-07-13
EA201490416A1 (ru) 2014-11-28
CA2841572A1 (en) 2013-02-07
CN103702975B (zh) 2016-03-16
UA113291C2 (xx) 2017-01-10
EP3351527A1 (en) 2018-07-25
CN103702975A (zh) 2014-04-02
CO6862154A2 (es) 2014-02-10
IL230287B (en) 2019-07-31
CR20140124A (es) 2014-05-13
NI201400008A (es) 2015-12-10
JP6433785B2 (ja) 2018-12-05
CA2841572C (en) 2020-10-13
HK1196349A1 (zh) 2014-12-12
ZA201400406B (en) 2014-11-26
IL230287A0 (en) 2014-03-06
WO2013020017A1 (en) 2013-02-07

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