JP2014512355A5 - - Google Patents

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JP2014512355A5
JP2014512355A5 JP2014502884A JP2014502884A JP2014512355A5 JP 2014512355 A5 JP2014512355 A5 JP 2014512355A5 JP 2014502884 A JP2014502884 A JP 2014502884A JP 2014502884 A JP2014502884 A JP 2014502884A JP 2014512355 A5 JP2014512355 A5 JP 2014512355A5
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pharmaceutically acceptable
acceptable salt
formula
cancer
compound
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JP2014512355A (ja
JP6147246B2 (ja
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Priority claimed from PCT/US2012/031716 external-priority patent/WO2012135779A1/en
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JP2014502884A 2011-04-01 2012-03-30 Akt及びmek阻害剤化合物の組み合わせ、及び使用方法 Active JP6147246B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161471038P 2011-04-01 2011-04-01
US61/471,038 2011-04-01
PCT/US2012/031716 WO2012135779A1 (en) 2011-04-01 2012-03-30 Combinations of akt and mek inhibitor compounds, and methods of use

Publications (3)

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JP2014512355A JP2014512355A (ja) 2014-05-22
JP2014512355A5 true JP2014512355A5 (enExample) 2015-05-21
JP6147246B2 JP6147246B2 (ja) 2017-06-14

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JP2014502884A Active JP6147246B2 (ja) 2011-04-01 2012-03-30 Akt及びmek阻害剤化合物の組み合わせ、及び使用方法

Country Status (16)

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US (1) US9682082B2 (enExample)
EP (1) EP2694073B1 (enExample)
JP (1) JP6147246B2 (enExample)
KR (1) KR20140022053A (enExample)
CN (2) CN103841976A (enExample)
AU (1) AU2012236164A1 (enExample)
BR (1) BR112013025397A2 (enExample)
CA (1) CA2831932A1 (enExample)
ES (1) ES2688809T3 (enExample)
IL (1) IL228643A0 (enExample)
MX (1) MX2013011333A (enExample)
PL (1) PL2694073T3 (enExample)
RU (1) RU2013148817A (enExample)
SG (1) SG194047A1 (enExample)
TR (1) TR201815685T4 (enExample)
WO (1) WO2012135779A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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PH12012500709A1 (en) * 2009-10-12 2012-10-29 Hoffmann La Roche Combinations of a pi3k inhibitor and a mek inhibitor
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AU2014315142B2 (en) * 2013-09-05 2020-07-02 Memorial Sloan-Kettering Cancer Center DDX43 as a biomarker of resistance to MEK1/2 inhibitors
JP2022515371A (ja) 2018-12-19 2022-02-18 ジェネンテック, インコーポレイテッド Akt阻害剤、タキサンおよびpd-l1阻害剤を含む併用療法を用いた乳癌の処置
MX2022012351A (es) * 2020-04-03 2023-03-13 Beigene Ltd Administracion conjunta de mirdametinib y lifirafenib para uso en el tratamiento de canceres.
US11084780B1 (en) 2021-02-17 2021-08-10 Springworks Therapeutics, Inc. Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof
US11066358B1 (en) * 2021-02-17 2021-07-20 Warner-Lambert Company Llc Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof
WO2024255830A1 (zh) * 2023-06-14 2024-12-19 南京正大天晴制药有限公司 Akt抑制剂在制备预防或治疗卵巢癌药物中的用途

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