CL2014000268A1 - Compuestos sustancialmente puros con formulas quimicas definidas, metabolitos del trans-clomifeno; composicion farmaceutica y usos de los mismos en el tratamiento de hipogonadismo secundario o un trastorno asociado con este en un paciente humano masculino. - Google Patents

Compuestos sustancialmente puros con formulas quimicas definidas, metabolitos del trans-clomifeno; composicion farmaceutica y usos de los mismos en el tratamiento de hipogonadismo secundario o un trastorno asociado con este en un paciente humano masculino.

Info

Publication number
CL2014000268A1
CL2014000268A1 CL2014000268A CL2014000268A CL2014000268A1 CL 2014000268 A1 CL2014000268 A1 CL 2014000268A1 CL 2014000268 A CL2014000268 A CL 2014000268A CL 2014000268 A CL2014000268 A CL 2014000268A CL 2014000268 A1 CL2014000268 A1 CL 2014000268A1
Authority
CL
Chile
Prior art keywords
trans
treatment
pharmaceutical composition
substantially pure
human patient
Prior art date
Application number
CL2014000268A
Other languages
English (en)
Spanish (es)
Inventor
Ronald D Wiehle
Joseph S Podolski
Original Assignee
Repros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46724628&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014000268(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Repros Therapeutics Inc filed Critical Repros Therapeutics Inc
Publication of CL2014000268A1 publication Critical patent/CL2014000268A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CL2014000268A 2011-08-04 2014-02-03 Compuestos sustancialmente puros con formulas quimicas definidas, metabolitos del trans-clomifeno; composicion farmaceutica y usos de los mismos en el tratamiento de hipogonadismo secundario o un trastorno asociado con este en un paciente humano masculino. CL2014000268A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161515278P 2011-08-04 2011-08-04

Publications (1)

Publication Number Publication Date
CL2014000268A1 true CL2014000268A1 (es) 2014-11-14

Family

ID=46724628

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014000268A CL2014000268A1 (es) 2011-08-04 2014-02-03 Compuestos sustancialmente puros con formulas quimicas definidas, metabolitos del trans-clomifeno; composicion farmaceutica y usos de los mismos en el tratamiento de hipogonadismo secundario o un trastorno asociado con este en un paciente humano masculino.

Country Status (21)

Country Link
US (1) US9981906B2 (enExample)
EP (2) EP3351527A1 (enExample)
JP (2) JP6433785B2 (enExample)
KR (1) KR20140054110A (enExample)
CN (1) CN103702975B (enExample)
AU (2) AU2012289964B2 (enExample)
BR (1) BR112014000908A2 (enExample)
CA (1) CA2841572C (enExample)
CL (1) CL2014000268A1 (enExample)
CO (1) CO6862154A2 (enExample)
CR (1) CR20140124A (enExample)
EA (1) EA201490416A1 (enExample)
IL (1) IL230287B (enExample)
MX (1) MX355316B (enExample)
MY (2) MY191802A (enExample)
NI (1) NI201400008A (enExample)
PH (1) PH12014500144A1 (enExample)
SG (1) SG10201606425WA (enExample)
UA (1) UA113291C2 (enExample)
WO (1) WO2013020017A1 (enExample)
ZA (1) ZA201400406B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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MX363640B (es) 2012-05-31 2019-03-28 Repros Therapeutics Inc Formulaciones y metodos para la administracion vaginal de antiprogestinas.
ES2688821T3 (es) 2012-11-02 2018-11-07 Repros Therapeutics Inc. Métodos y composiciones para tratar afecciones dependientes de la progesterona
HK1216502A1 (zh) * 2012-11-02 2016-11-18 Repros Therapeutics Inc. 用於癌症治療的反式-克羅米芬
EP3402471A4 (en) * 2016-01-12 2019-08-28 Repros Therapeutics Inc. TRANS-CLOMIPHENE-BASED POLY THERAPY AND PROGESTERONE RECEPTOR ANTAGONIST FOR THE TREATMENT OF HORMONE-DEPENDENT PATHOLOGICAL CONDITIONS
US20190054044A1 (en) * 2016-02-25 2019-02-21 Aspen Park Pharmaceuticals, Inc. Oral dosage form of both clomiphene isomers and method of using same to treat secondary hypogonadism and minimize drug side effects in men
WO2017182097A1 (en) 2016-04-22 2017-10-26 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit.

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Also Published As

Publication number Publication date
CO6862154A2 (es) 2014-02-10
SG10201606425WA (en) 2016-09-29
CR20140124A (es) 2014-05-13
NI201400008A (es) 2015-12-10
AU2012289964A1 (en) 2014-01-30
US9981906B2 (en) 2018-05-29
UA113291C2 (xx) 2017-01-10
CA2841572A1 (en) 2013-02-07
MX355316B (es) 2018-04-16
KR20140054110A (ko) 2014-05-08
BR112014000908A2 (pt) 2017-02-21
PH12014500144A1 (en) 2014-02-24
EA201490416A1 (ru) 2014-11-28
US20140163114A1 (en) 2014-06-12
CA2841572C (en) 2020-10-13
ZA201400406B (en) 2014-11-26
MY170718A (en) 2019-08-27
CN103702975A (zh) 2014-04-02
JP6433785B2 (ja) 2018-12-05
IL230287B (en) 2019-07-31
AU2012289964B2 (en) 2017-03-23
HK1196349A1 (zh) 2014-12-12
NZ621892A (en) 2016-03-31
JP2019023210A (ja) 2019-02-14
MY191802A (en) 2022-07-15
MX2014000825A (es) 2014-02-27
IL230287A0 (en) 2014-03-06
AU2017204171A1 (en) 2017-07-13
CN103702975B (zh) 2016-03-16
EP2744777A1 (en) 2014-06-25
EP3351527A1 (en) 2018-07-25
WO2013020017A1 (en) 2013-02-07
JP2014529584A (ja) 2014-11-13

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