JP2014529328A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014529328A5 JP2014529328A5 JP2014514909A JP2014514909A JP2014529328A5 JP 2014529328 A5 JP2014529328 A5 JP 2014529328A5 JP 2014514909 A JP2014514909 A JP 2014514909A JP 2014514909 A JP2014514909 A JP 2014514909A JP 2014529328 A5 JP2014529328 A5 JP 2014529328A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- retinoid
- group
- composition according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494710P | 2011-06-08 | 2011-06-08 | |
| US201161494840P | 2011-06-08 | 2011-06-08 | |
| US61/494,840 | 2011-06-08 | ||
| US61/494,710 | 2011-06-08 | ||
| PCT/US2012/041753 WO2012170952A2 (en) | 2011-06-08 | 2012-06-08 | Compounds for targeting drug delivery and enhancing sirna activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006249A Division JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529328A JP2014529328A (ja) | 2014-11-06 |
| JP2014529328A5 true JP2014529328A5 (enExample) | 2015-07-23 |
| JP5873553B2 JP5873553B2 (ja) | 2016-03-01 |
Family
ID=46317540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514909A Active JP5873553B2 (ja) | 2011-06-08 | 2012-06-08 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2016006249A Active JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2017203199A Active JP6590888B2 (ja) | 2011-06-08 | 2017-10-20 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006249A Active JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2017203199A Active JP6590888B2 (ja) | 2011-06-08 | 2017-10-20 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP2998289B1 (enExample) |
| JP (3) | JP5873553B2 (enExample) |
| KR (3) | KR102038300B1 (enExample) |
| CN (3) | CN107043334B (enExample) |
| AU (2) | AU2012267467B8 (enExample) |
| CA (2) | CA3094645C (enExample) |
| CY (2) | CY1117433T1 (enExample) |
| DK (2) | DK2718261T3 (enExample) |
| ES (2) | ES2743540T3 (enExample) |
| HR (1) | HRP20191463T8 (enExample) |
| HU (1) | HUE045821T2 (enExample) |
| LT (1) | LT2998289T (enExample) |
| PL (2) | PL2998289T3 (enExample) |
| PT (1) | PT2998289T (enExample) |
| RS (1) | RS59380B1 (enExample) |
| RU (2) | RU2769872C2 (enExample) |
| SI (1) | SI2998289T1 (enExample) |
| SM (1) | SMT201900523T1 (enExample) |
| TW (2) | TWI712422B (enExample) |
| WO (1) | WO2012170952A2 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102933233A (zh) * | 2010-06-17 | 2013-02-13 | 日东电工株式会社 | 肾纤维化处理剂 |
| US9011903B2 (en) | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| CN103906503B (zh) * | 2011-11-04 | 2016-12-14 | 日东电工株式会社 | 用于无菌制备脂质-核酸颗粒的单次使用系统 |
| BR112014030714B1 (pt) * | 2012-06-08 | 2020-12-22 | Nitto Denko Corporation | composto de lipídeo ionizável, composição, veículo de fármaco e formulação farmacêutica |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| JP6076076B2 (ja) | 2012-12-21 | 2017-02-08 | 日東電工株式会社 | 組織再生促進剤 |
| KR102095085B1 (ko) | 2013-11-18 | 2020-03-31 | 아크투루스 쎄라퓨틱스, 인크. | Rna 전달을 위한 이온화가능한 양이온성 지질 |
| US9365610B2 (en) | 2013-11-18 | 2016-06-14 | Arcturus Therapeutics, Inc. | Asymmetric ionizable cationic lipid for RNA delivery |
| ES2821966T3 (es) | 2014-04-02 | 2021-04-28 | Nitto Denko Corp | Molécula de direccionamiento derivada de RBP y utilización de la misma |
| JP6727765B2 (ja) | 2014-06-17 | 2020-07-22 | 日東電工株式会社 | アポトーシス誘導剤 |
| EP2966068A1 (en) * | 2014-07-08 | 2016-01-13 | Incella GmbH | Synthesis and use of amino lipids |
| CN104174034A (zh) * | 2014-08-20 | 2014-12-03 | 南京大学 | 肝星状细胞靶向的基因药物输送载体及其制备方法和应用 |
| US9855345B2 (en) * | 2014-10-30 | 2018-01-02 | Delta-Fly Pharma, Inc. | Method for producing lipoplex for topical administration and antitumor agent using such lipoplex |
| LT3221293T (lt) * | 2014-11-18 | 2023-03-27 | Arcturus Therapeutics, Inc. | Jonizuojamas katijoninis lipidas, skirtas rnr pristatymui |
| US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| KR102659774B1 (ko) * | 2015-06-24 | 2024-04-23 | 닛토덴코 가부시키가이샤 | 이온화성 화합물 및 조성물 및 그 용도 |
| CN116640316A (zh) * | 2015-09-14 | 2023-08-25 | 得克萨斯州大学系统董事会 | 亲脂阳离子树枝状聚合物及其用途 |
| CN105194689A (zh) * | 2015-10-10 | 2015-12-30 | 湖南中楚博生物科技有限公司 | 一种基于siRNA的双偶联复合物 |
| CN114656378A (zh) | 2016-05-16 | 2022-06-24 | 得克萨斯州大学系统董事会 | 阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质 |
| PL3458074T3 (pl) * | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| JP6833456B2 (ja) | 2016-11-02 | 2021-02-24 | 日東電工株式会社 | 皮膚線維症処置剤 |
| US10383952B2 (en) | 2016-12-21 | 2019-08-20 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| US10526284B2 (en) | 2016-12-21 | 2020-01-07 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| JP7178715B2 (ja) | 2017-05-23 | 2022-11-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ジメチル－ノナテトラエニル－トリメチル－シクロヘキシル化合物およびその使用 |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| EP3662913A4 (en) | 2017-08-04 | 2021-06-30 | Kyowa Kirin Co., Ltd. | Nucleic-acid-containing lipid nanoparticles |
| CN111315359A (zh) | 2017-08-31 | 2020-06-19 | 摩登纳特斯有限公司 | 制备脂质纳米颗粒的方法 |
| JP7208911B2 (ja) | 2017-10-11 | 2023-01-19 | 日東電工株式会社 | 核酸分子発現の調節 |
| KR102751412B1 (ko) * | 2017-11-06 | 2025-01-09 | 닛토덴코 가부시키가이샤 | 생물학적 활성 분자의 전달을 위한 융합성 화합물 |
| WO2019200043A1 (en) * | 2018-04-11 | 2019-10-17 | New Mexico Tech University Research Park Coporation | Lipid prodrugs for use in drug delivery |
| CN116172975B (zh) | 2018-06-08 | 2025-03-28 | 富士胶片株式会社 | 脂质颗粒、包含该脂质颗粒的核酸药物以及核酸递送用组合物 |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| JP7453145B2 (ja) * | 2018-08-22 | 2024-03-19 | 日東電工株式会社 | Ｈｓｐ４７の阻害物質を用いた、化学療法剤感受性の増強 |
| AU2019336679B2 (en) | 2018-09-04 | 2025-05-29 | The Board Of Regents Of The University Of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| WO2020051220A1 (en) | 2018-09-04 | 2020-03-12 | The Board of the Regents of the University of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| CN110124049B (zh) * | 2019-04-29 | 2023-09-22 | 大连医科大学 | 聚乙二醇化芬维a胺前体药物及其用途 |
| CA3143865A1 (en) | 2019-06-07 | 2020-12-10 | Fujifilm Corporation | Lipid composition |
| KR102228271B1 (ko) | 2019-07-16 | 2021-03-17 | 한국과학기술연구원 | 항암활성을 갖는 면역조절 단백질-siRNA 복합체 |
| CN111248152A (zh) * | 2020-03-17 | 2020-06-09 | 上海市中医医院 | 一种肝硬化腹水动物模型及其构建方法 |
| BR112022021381A2 (pt) * | 2020-04-23 | 2022-12-06 | Purdue Research Foundation | Compostos para o tratamento de sars |
| KR102361479B1 (ko) * | 2020-06-18 | 2022-02-11 | 고려대학교 산학협력단 | ｓｉＲＮＡ의 생성 및 기능 증진 활성을 갖는 ＣＭＴＲ１의 신규용도 |
| WO2021262746A1 (en) * | 2020-06-24 | 2021-12-30 | Bristol-Myers Squibb Company | Process for synthesizing lipids |
| JP2023532011A (ja) * | 2020-06-24 | 2023-07-26 | ブリストル－マイヤーズ スクイブ カンパニー | 標的分子の合成方法 |
| JP2023532014A (ja) * | 2020-06-24 | 2023-07-26 | ブリストル－マイヤーズ スクイブ カンパニー | カチオン性脂質の合成方法 |
| IL300404A (en) * | 2020-08-06 | 2023-04-01 | Modernatx Inc | Methods for preparing fat nanoparticles |
| WO2022034946A1 (ko) | 2020-08-14 | 2022-02-17 | 한국과학기술연구원 | 항암활성을 갖는 면역조절 단백질-siRNA 복합체 |
| CN114391008B (zh) * | 2020-08-20 | 2024-05-03 | 苏州艾博生物科技有限公司 | 脂质化合物和脂质纳米颗粒组合物 |
| CN114306278A (zh) * | 2021-12-30 | 2022-04-12 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种EV装载CPP-siRNA纳米颗粒的制备方法及其产品和应用 |
| CN114805113B (zh) * | 2022-01-22 | 2023-09-15 | 苏州天澜生物材料科技有限公司 | 一种安全高效的可降解脂质纳米颗粒及其制备方法和应用 |
| CN114522244B (zh) * | 2022-01-28 | 2023-09-01 | 浙江大学医学院附属第四医院 | 视黄酸修饰的lytac分子及其制备方法和应用 |
| US20250197865A1 (en) | 2022-03-03 | 2025-06-19 | Kyushu University, National University Corporation | Pharmaceutical composition for treatment or prevention of fibrotic disease |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024160829A1 (en) * | 2023-01-31 | 2024-08-08 | BioNTech SE | Compositions and methods |
| EP4480943A1 (en) * | 2023-06-22 | 2024-12-25 | Oz Biosciences | New class of lipids for delivering active ingredients into cells |
| WO2025006799A1 (en) | 2023-06-27 | 2025-01-02 | Capstan Therapeutics, Inc. | Extracorporeal and ex vivo engineering of select cell populations from peripheral blood |
| CN117185942B (zh) * | 2023-07-04 | 2025-09-12 | 清华大学 | 一种可用于靶向肺部递送广谱中和抗体的脂质纳米颗粒及其制备方法与应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| JPS6189286A (ja) * | 1984-10-08 | 1986-05-07 | Tokuyama Soda Co Ltd | 液晶組成物 |
| JPS61136584A (ja) * | 1984-12-07 | 1986-06-24 | Tokuyama Soda Co Ltd | 液晶組成物 |
| US6153737A (en) | 1990-01-11 | 2000-11-28 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| US5214136A (en) | 1990-02-20 | 1993-05-25 | Gilead Sciences, Inc. | Anthraquinone-derivatives oligonucleotides |
| US5138045A (en) | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US6235886B1 (en) | 1993-09-03 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Methods of synthesis and use |
| JP3029354B2 (ja) * | 1992-12-22 | 2000-04-04 | 三菱電機株式会社 | ディジタルビデオ信号符号化装置および復号化装置 |
| DE69433036T2 (de) | 1993-09-03 | 2004-05-27 | Isis Pharmaceuticals, Inc., Carlsbad | Aminoderivatisierte nukleoside und oligonukleoside |
| FR2714382B1 (fr) * | 1993-12-27 | 1996-02-02 | Roussel Uclaf | Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques. |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| ATE386131T1 (de) | 1994-04-13 | 2008-03-15 | Univ Rockefeller | Aav-vermittelte überbringung von dna in zellen des nervensystems |
| US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| DE19640092A1 (de) * | 1996-09-28 | 1998-04-16 | Beiersdorf Ag | Strukturen mit Lipid-Doppelmembranen, in deren lipophilen Bereich längerkettige Moleküle eintauchen oder durch hydrophobe Wechselwirkungen an solche Moleküle angedockt sind |
| DE19641672A1 (de) * | 1996-10-10 | 1998-04-16 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6586524B2 (en) | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| ATE359829T1 (de) * | 2001-10-30 | 2007-05-15 | Nektar Therapeutics Al Corp | Wasserlösliche polymerkonjugate von retinoesäure |
| AUPR894201A0 (en) | 2001-11-19 | 2001-12-13 | Women's And Children's Hospital | Respiratory delivery for gene therapy and lentiviral delivery particle |
| US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| EP1608380A2 (en) * | 2003-03-31 | 2005-12-28 | Vectramed, Inc. | Polymeric drug agents for the treatment of fibrotic disorders |
| JP2006254877A (ja) * | 2005-03-18 | 2006-09-28 | Fukuoka Prefecture | 糖脂質を含んだキャリア及びそれを用いた遺伝子導入法 |
| JP5777846B2 (ja) * | 2005-06-15 | 2015-09-09 | マサチューセッツ インスティテュート オブ テクノロジー | アミン含有脂質およびその使用 |
| EP2034019B1 (en) * | 2006-06-30 | 2014-08-20 | Hokkaido System Science Co., Ltd. | Composition for nucleic-acid introduction |
| JP2010527914A (ja) | 2007-04-26 | 2010-08-19 | クォーク ファーマシューティカルズ インコーポレーティッド | 呼吸器系への抑制性核酸分子の治療的送達 |
| US8003621B2 (en) * | 2007-09-14 | 2011-08-23 | Nitto Denko Corporation | Drug carriers |
| WO2009059450A1 (en) * | 2007-11-05 | 2009-05-14 | Shanghai Jiaotong University | Peptide ligand directed drug delivery |
| RU2505315C2 (ru) * | 2008-07-30 | 2014-01-27 | Нитто Денко Корпорейшн | Носители лекарственных средств |
| KR20160095209A (ko) * | 2008-09-12 | 2016-08-10 | 닛토덴코 가부시키가이샤 | 섬유증 질환의 조영제 |
| CN102292069B (zh) * | 2008-11-26 | 2014-07-30 | 中外制药株式会社 | 囊泡制剂 |
| US20120178806A1 (en) * | 2009-09-15 | 2012-07-12 | Qlt Inc. | Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle |
| TWI658830B (zh) * | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Ｈｓｐ47表現調控強化用類視色素脂質體 |
| JP6301742B2 (ja) * | 2014-06-05 | 2018-03-28 | ヨシモトポール株式会社 | 鋼管ポールおよびその設置方法 |
-
2012
- 2012-06-08 EP EP15181729.3A patent/EP2998289B1/en active Active
- 2012-06-08 ES ES15181729T patent/ES2743540T3/es active Active
- 2012-06-08 CN CN201710081577.3A patent/CN107043334B/zh active Active
- 2012-06-08 DK DK12728010.5T patent/DK2718261T3/en active
- 2012-06-08 PL PL15181729T patent/PL2998289T3/pl unknown
- 2012-06-08 KR KR1020147000573A patent/KR102038300B1/ko active Active
- 2012-06-08 TW TW105140746A patent/TWI712422B/zh active
- 2012-06-08 ES ES12728010T patent/ES2570184T3/es active Active
- 2012-06-08 KR KR1020187034794A patent/KR102029657B1/ko active Active
- 2012-06-08 CN CN201280027912.7A patent/CN103857654B/zh active Active
- 2012-06-08 JP JP2014514909A patent/JP5873553B2/ja active Active
- 2012-06-08 PT PT15181729T patent/PT2998289T/pt unknown
- 2012-06-08 DK DK15181729.3T patent/DK2998289T3/da active
- 2012-06-08 RU RU2017135548A patent/RU2769872C2/ru active
- 2012-06-08 SI SI201231655T patent/SI2998289T1/sl unknown
- 2012-06-08 HU HUE15181729A patent/HUE045821T2/hu unknown
- 2012-06-08 TW TW101120844A patent/TWI569814B/zh active
- 2012-06-08 AU AU2012267467A patent/AU2012267467B8/en active Active
- 2012-06-08 CA CA3094645A patent/CA3094645C/en active Active
- 2012-06-08 EP EP12728010.5A patent/EP2718261B1/en active Active
- 2012-06-08 SM SM20190523T patent/SMT201900523T1/it unknown
- 2012-06-08 CA CA2837101A patent/CA2837101C/en active Active
- 2012-06-08 KR KR1020187034790A patent/KR102029654B1/ko active Active
- 2012-06-08 PL PL12728010T patent/PL2718261T3/pl unknown
- 2012-06-08 LT LT15181729T patent/LT2998289T/lt unknown
- 2012-06-08 RS RSP20191142 patent/RS59380B1/sr unknown
- 2012-06-08 WO PCT/US2012/041753 patent/WO2012170952A2/en not_active Ceased
- 2012-06-08 RU RU2013158456A patent/RU2632888C2/ru active
- 2012-06-08 CN CN201710081858.9A patent/CN107082747B/zh active Active
-
2016
- 2016-01-15 JP JP2016006249A patent/JP6232083B2/ja active Active
- 2016-03-31 CY CY20161100261T patent/CY1117433T1/el unknown
-
2017
- 2017-05-09 AU AU2017203075A patent/AU2017203075B2/en active Active
- 2017-10-20 JP JP2017203199A patent/JP6590888B2/ja active Active
-
2019
- 2019-08-13 HR HRP20191463TT patent/HRP20191463T8/hr unknown
- 2019-09-05 CY CY20191100937T patent/CY1123807T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014529328A5 (enExample) | ||
| WO2012170952A3 (en) | Compounds for targeting drug delivery and enhancing sirna activity | |
| RU2014153658A (ru) | Липиды для композиций для доставки терапевтических агентов | |
| Yu et al. | Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery | |
| Bajaj et al. | Design, synthesis, and in vitro gene delivery efficacies of novel cholesterol-based gemini cationic lipids and their serum compatibility: A structure− activity investigation | |
| ES2613498T3 (es) | Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos | |
| Sen et al. | Design, syntheses, and transfection biology of novel non-cholesterol-based guanidinylated cationic lipids | |
| US10081598B2 (en) | Cationic lipid | |
| WO2021102411A8 (en) | Ionizable lipids and nanoparticle compositions thereof | |
| CY1121232T1 (el) | Τριαλκυλο κατιονικα λιπιδια και μεθοδοι χρησης αυτων | |
| MX366055B (es) | Liposomas pegilados para admistracion de acido ribonucleico (arn) que codifica para inmunogeno. | |
| CY1123370T1 (el) | Σταθερη ενεσιμη φαρμακευτικη συνθεση ανταγωνιστη υποδοχεα νευροκινινης 1 και μεθοδος παρασκευης αυτης | |
| CY1122809T1 (el) | Εστερικα προ-φαρμακα της [3-(1-(1η-ιμιδαζολ-4-υλ)αιθυλο)-2-μεθυλοφαινυλο) μεθανολης για τη θεραπεια οφθαλμικων νοσηματων | |
| FI3303598T3 (fi) | Kohdennettuja lipidipartikkeleita nukleiinihappomolekyylien systeemiseen annosteluun leukosyyteille | |
| BR112012015755A2 (pt) | lipideos composicoes de lipideos, e metodos de uso dos mesmos | |
| MX341989B (es) | Liposomas pequeños para el suministro de arn que codifica el inmunogeno. | |
| BR112012008142A8 (pt) | conjugados de peptídeo/ polietilenoglicol ligados a dissulfeto para a transfecção de ácidos nucleicos | |
| WO2011141705A8 (en) | Novel cationic lipids and methods of use thereof | |
| WO2012170957A3 (en) | Retinoid-liposomes for enhancing modulation of hsp47 expression | |
| BR112015000106A2 (pt) | moduladores heterocíclicos de síntes de lipídio | |
| WO2012107706A8 (en) | Phenothiazine diaminium salts and their use | |
| Martínez-Negro et al. | Efficient cellular knockdown mediated by siRNA nanovectors of gemini cationic lipids having delocalizable headgroups and oligo-oxyethylene spacers | |
| Karmali et al. | In vitro gene transfer efficacies and serum compatibility profiles of novel mono-, di-, and tri-histidinylated cationic transfection lipids: a structure− activity investigation | |
| Karmali et al. | Design, syntheses and in vitro gene delivery efficacies of novel mono-, di-and trilysinated cationic lipids: a structure− activity investigation | |
| BR112013011265A2 (pt) | derivados de triazol como ligantes para receptores gaba |