JP2014529328A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014529328A5 JP2014529328A5 JP2014514909A JP2014514909A JP2014529328A5 JP 2014529328 A5 JP2014529328 A5 JP 2014529328A5 JP 2014514909 A JP2014514909 A JP 2014514909A JP 2014514909 A JP2014514909 A JP 2014514909A JP 2014529328 A5 JP2014529328 A5 JP 2014529328A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- retinoid
- group
- composition according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494710P | 2011-06-08 | 2011-06-08 | |
| US201161494840P | 2011-06-08 | 2011-06-08 | |
| US61/494,710 | 2011-06-08 | ||
| US61/494,840 | 2011-06-08 | ||
| PCT/US2012/041753 WO2012170952A2 (en) | 2011-06-08 | 2012-06-08 | Compounds for targeting drug delivery and enhancing sirna activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006249A Division JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529328A JP2014529328A (ja) | 2014-11-06 |
| JP2014529328A5 true JP2014529328A5 (cg-RX-API-DMAC7.html) | 2015-07-23 |
| JP5873553B2 JP5873553B2 (ja) | 2016-03-01 |
Family
ID=46317540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514909A Active JP5873553B2 (ja) | 2011-06-08 | 2012-06-08 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2016006249A Active JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2017203199A Active JP6590888B2 (ja) | 2011-06-08 | 2017-10-20 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016006249A Active JP6232083B2 (ja) | 2011-06-08 | 2016-01-15 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
| JP2017203199A Active JP6590888B2 (ja) | 2011-06-08 | 2017-10-20 | 薬物送達を標的化しｓｉＲＮＡ活性を増強する化合物 |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP2998289B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5873553B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR102038300B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN103857654B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2012267467B8 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2837101C (cg-RX-API-DMAC7.html) |
| CY (2) | CY1117433T1 (cg-RX-API-DMAC7.html) |
| DK (2) | DK2718261T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2570184T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20191463T8 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE045821T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2998289T (cg-RX-API-DMAC7.html) |
| PL (2) | PL2998289T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2998289T (cg-RX-API-DMAC7.html) |
| RS (1) | RS59380B1 (cg-RX-API-DMAC7.html) |
| RU (2) | RU2632888C2 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2998289T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT201900523T1 (cg-RX-API-DMAC7.html) |
| TW (2) | TWI712422B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012170952A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI549691B (zh) * | 2010-06-17 | 2016-09-21 | 日東電工股份有限公司 | 腎纖維症處置劑 |
| US9011903B2 (en) | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
| EP3673898A1 (en) * | 2011-11-04 | 2020-07-01 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| CA2876148C (en) | 2012-06-08 | 2021-01-12 | Nitto Denko Corporation | Lipids for therapeutic agent delivery formulations |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| JP6076076B2 (ja) | 2012-12-21 | 2017-02-08 | 日東電工株式会社 | 組織再生促進剤 |
| US9365610B2 (en) | 2013-11-18 | 2016-06-14 | Arcturus Therapeutics, Inc. | Asymmetric ionizable cationic lipid for RNA delivery |
| AU2014348212C1 (en) * | 2013-11-18 | 2018-11-29 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| US9976142B2 (en) | 2014-04-02 | 2018-05-22 | Nitto Denko Corporation | Targeting molecule and a use thereof |
| US10093931B2 (en) | 2014-06-17 | 2018-10-09 | Nitto Denko Corporation | Apoptosis inducer |
| EP2966068A1 (en) * | 2014-07-08 | 2016-01-13 | Incella GmbH | Synthesis and use of amino lipids |
| CN104174034A (zh) * | 2014-08-20 | 2014-12-03 | 南京大学 | 肝星状细胞靶向的基因药物输送载体及其制备方法和应用 |
| WO2016068160A1 (ja) * | 2014-10-30 | 2016-05-06 | Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 | 局所投与用リポプレックスの新規製造方法及び該リポプレックスを使用する抗腫瘍剤 |
| PL3221293T3 (pl) * | 2014-11-18 | 2023-07-10 | Arcturus Therapeutics, Inc. | Jonizowalny kationowy lipid do dostarczania rna |
| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
| AU2016281685B2 (en) * | 2015-06-24 | 2021-08-12 | Nitto Denko Corporation | Ionizable compounds and compositions and uses thereof |
| JP7041616B2 (ja) * | 2015-09-14 | 2022-03-24 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | リポカチオン性デンドリマーおよびその使用 |
| CN105194689A (zh) * | 2015-10-10 | 2015-12-30 | 湖南中楚博生物科技有限公司 | 一种基于siRNA的双偶联复合物 |
| EP3458074B1 (en) * | 2016-05-16 | 2024-04-17 | Board of Regents of the University of Texas System | COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH |
| CA3024129A1 (en) * | 2016-05-16 | 2017-11-23 | The Board Of Regents Of The University Of Texas System | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
| JP6833456B2 (ja) | 2016-11-02 | 2021-02-24 | 日東電工株式会社 | 皮膚線維症処置剤 |
| US10526284B2 (en) | 2016-12-21 | 2020-01-07 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| US10383952B2 (en) | 2016-12-21 | 2019-08-20 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| CN110831586B (zh) * | 2017-05-23 | 2023-06-13 | 密执安大学评议会 | 二甲基-壬四烯基-三甲基-环己基化合物及其用途 |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| CA3071968A1 (en) | 2017-08-04 | 2019-02-07 | Kyowa Kirin Co., Ltd. | Nucleic acid-containing lipid nanoparticle |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| US11298371B2 (en) | 2017-10-11 | 2022-04-12 | Nitto Denko Corporation | Regulation of nucleic acid molecule expression |
| WO2019090359A1 (en) | 2017-11-06 | 2019-05-09 | Nitto Denko Corporation | Fusogenic compounds for delivery of biologically active molecules |
| CN112437674A (zh) * | 2018-04-11 | 2021-03-02 | 新墨西哥科技大学研究园公司 | 用于药物递送的脂质前药 |
| PL3805198T3 (pl) | 2018-06-08 | 2024-02-12 | Fujifilm Corporation | Związek, jego sól i cząstki lipidowe |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| JP7453145B2 (ja) * | 2018-08-22 | 2024-03-19 | 日東電工株式会社 | Ｈｓｐ４７の阻害物質を用いた、化学療法剤感受性の増強 |
| GB2606038B (en) | 2018-09-04 | 2023-05-03 | Univ Texas | Compositions and methods for organ specific delivery of nucleic acids |
| CN112930198A (zh) | 2018-09-04 | 2021-06-08 | 德克萨斯大学系统董事会 | 用于核酸的器官特异性递送的组合物和方法 |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| CN110124049B (zh) * | 2019-04-29 | 2023-09-22 | 大连医科大学 | 聚乙二醇化芬维a胺前体药物及其用途 |
| EP3981435B1 (en) | 2019-06-07 | 2023-08-16 | FUJIFILM Corporation | Lipid composition |
| KR102228271B1 (ko) | 2019-07-16 | 2021-03-17 | 한국과학기술연구원 | 항암활성을 갖는 면역조절 단백질-siRNA 복합체 |
| CN111248152A (zh) * | 2020-03-17 | 2020-06-09 | 上海市中医医院 | 一种肝硬化腹水动物模型及其构建方法 |
| EP4139280A4 (en) * | 2020-04-23 | 2024-08-07 | Purdue Research Foundation | LINKS TO TREATMENT OF SARS |
| KR102361479B1 (ko) * | 2020-06-18 | 2022-02-11 | 고려대학교 산학협력단 | ｓｉＲＮＡ의 생성 및 기능 증진 활성을 갖는 ＣＭＴＲ１의 신규용도 |
| IL299263A (en) * | 2020-06-24 | 2023-02-01 | Bristol Myers Squibb Co | A process for the synthesis of lipids |
| WO2021262745A1 (en) | 2020-06-24 | 2021-12-30 | Bristol-Myers Squibb Company | Process for synthesizing cationic lipids |
| WO2021262743A1 (en) | 2020-06-24 | 2021-12-30 | Bristol-Myers Squibb Company | Process for synthesizing targeting molecules |
| US20230277457A1 (en) * | 2020-08-06 | 2023-09-07 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| WO2022034946A1 (ko) | 2020-08-14 | 2022-02-17 | 한국과학기술연구원 | 항암활성을 갖는 면역조절 단백질-siRNA 복합체 |
| CN114391008B (zh) * | 2020-08-20 | 2024-05-03 | 苏州艾博生物科技有限公司 | 脂质化合物和脂质纳米颗粒组合物 |
| CN114306278A (zh) * | 2021-12-30 | 2022-04-12 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种EV装载CPP-siRNA纳米颗粒的制备方法及其产品和应用 |
| CN114805113B (zh) * | 2022-01-22 | 2023-09-15 | 苏州天澜生物材料科技有限公司 | 一种安全高效的可降解脂质纳米颗粒及其制备方法和应用 |
| CN114522244B (zh) * | 2022-01-28 | 2023-09-01 | 浙江大学医学院附属第四医院 | 视黄酸修饰的lytac分子及其制备方法和应用 |
| EP4487854A1 (en) | 2022-03-03 | 2025-01-08 | Kyushu University, National University Corporation | Pharmaceutical composition for treatment or prevention of fibrotic disease |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024160826A1 (en) * | 2023-01-31 | 2024-08-08 | BioNTech SE | Compositions and methods |
| EP4480943A1 (en) * | 2023-06-22 | 2024-12-25 | Oz Biosciences | New class of lipids for delivering active ingredients into cells |
| WO2025006799A1 (en) | 2023-06-27 | 2025-01-02 | Capstan Therapeutics, Inc. | Extracorporeal and ex vivo engineering of select cell populations from peripheral blood |
| CN117185942B (zh) * | 2023-07-04 | 2025-09-12 | 清华大学 | 一种可用于靶向肺部递送广谱中和抗体的脂质纳米颗粒及其制备方法与应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| JPS6189286A (ja) * | 1984-10-08 | 1986-05-07 | Tokuyama Soda Co Ltd | 液晶組成物 |
| JPS61136584A (ja) * | 1984-12-07 | 1986-06-24 | Tokuyama Soda Co Ltd | 液晶組成物 |
| US6153737A (en) | 1990-01-11 | 2000-11-28 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| US5214136A (en) | 1990-02-20 | 1993-05-25 | Gilead Sciences, Inc. | Anthraquinone-derivatives oligonucleotides |
| US5138045A (en) | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US6235886B1 (en) | 1993-09-03 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Methods of synthesis and use |
| JP3029354B2 (ja) * | 1992-12-22 | 2000-04-04 | 三菱電機株式会社 | ディジタルビデオ信号符号化装置および復号化装置 |
| DE69433036T2 (de) | 1993-09-03 | 2004-05-27 | Isis Pharmaceuticals, Inc., Carlsbad | Aminoderivatisierte nukleoside und oligonukleoside |
| FR2714382B1 (fr) * | 1993-12-27 | 1996-02-02 | Roussel Uclaf | Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques. |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| DE69535703T2 (de) | 1994-04-13 | 2009-02-19 | The Rockefeller University | AAV-vermittelte Zufuhr von DNA an Zellen des Nervensystems |
| US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| DE19640092A1 (de) * | 1996-09-28 | 1998-04-16 | Beiersdorf Ag | Strukturen mit Lipid-Doppelmembranen, in deren lipophilen Bereich längerkettige Moleküle eintauchen oder durch hydrophobe Wechselwirkungen an solche Moleküle angedockt sind |
| DE19641672A1 (de) * | 1996-10-10 | 1998-04-16 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6586524B2 (en) | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| KR20050042013A (ko) * | 2001-10-30 | 2005-05-04 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | 레티노산의 수용성 중합체 콘쥬게이트 |
| AUPR894201A0 (en) | 2001-11-19 | 2001-12-13 | Women's And Children's Hospital | Respiratory delivery for gene therapy and lentiviral delivery particle |
| US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| CA2521407A1 (en) * | 2003-03-31 | 2004-10-21 | Vectramed, Inc. | Polymeric drug agents for the treatment of fibrotic disorders |
| JP2006254877A (ja) * | 2005-03-18 | 2006-09-28 | Fukuoka Prefecture | 糖脂質を含んだキャリア及びそれを用いた遺伝子導入法 |
| EP2476756A1 (en) * | 2005-06-15 | 2012-07-18 | Massachusetts Institute of Technology | Amine-containing lipids and uses thereof |
| WO2008001505A1 (en) * | 2006-06-30 | 2008-01-03 | Hokkaido System Science Co., Ltd. | Composition for nucleic-acid introduction |
| JP2010527914A (ja) | 2007-04-26 | 2010-08-19 | クォーク ファーマシューティカルズ インコーポレーティッド | 呼吸器系への抑制性核酸分子の治療的送達 |
| CN101970012A (zh) * | 2007-09-14 | 2011-02-09 | 日东电工株式会社 | 药物载体 |
| WO2009059450A1 (en) * | 2007-11-05 | 2009-05-14 | Shanghai Jiaotong University | Peptide ligand directed drug delivery |
| US20100028416A1 (en) * | 2008-07-30 | 2010-02-04 | Nitto Denko Corporation | Drug carriers |
| RU2596495C2 (ru) * | 2008-09-12 | 2016-09-10 | Нитто Денко Корпорейшн | Визуализирующие агенты для фиброзных заболеваний |
| WO2010061880A1 (ja) * | 2008-11-26 | 2010-06-03 | 中外製薬株式会社 | ベシクル製剤 |
| CA2774168C (en) * | 2009-09-15 | 2021-02-23 | Ronald Erwin Boch | Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle |
| TWI658830B (zh) * | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Ｈｓｐ47表現調控強化用類視色素脂質體 |
| JP6301742B2 (ja) * | 2014-06-05 | 2018-03-28 | ヨシモトポール株式会社 | 鋼管ポールおよびその設置方法 |
-
2012
- 2012-06-08 ES ES12728010T patent/ES2570184T3/es active Active
- 2012-06-08 EP EP15181729.3A patent/EP2998289B1/en active Active
- 2012-06-08 CA CA2837101A patent/CA2837101C/en active Active
- 2012-06-08 PL PL15181729T patent/PL2998289T3/pl unknown
- 2012-06-08 CN CN201280027912.7A patent/CN103857654B/zh active Active
- 2012-06-08 RU RU2013158456A patent/RU2632888C2/ru active
- 2012-06-08 WO PCT/US2012/041753 patent/WO2012170952A2/en not_active Ceased
- 2012-06-08 KR KR1020147000573A patent/KR102038300B1/ko active Active
- 2012-06-08 KR KR1020187034794A patent/KR102029657B1/ko active Active
- 2012-06-08 DK DK12728010.5T patent/DK2718261T3/en active
- 2012-06-08 DK DK15181729.3T patent/DK2998289T3/da active
- 2012-06-08 SI SI201231655T patent/SI2998289T1/sl unknown
- 2012-06-08 RU RU2017135548A patent/RU2769872C2/ru active
- 2012-06-08 HU HUE15181729A patent/HUE045821T2/hu unknown
- 2012-06-08 ES ES15181729T patent/ES2743540T3/es active Active
- 2012-06-08 PL PL12728010T patent/PL2718261T3/pl unknown
- 2012-06-08 PT PT15181729T patent/PT2998289T/pt unknown
- 2012-06-08 LT LT15181729T patent/LT2998289T/lt unknown
- 2012-06-08 JP JP2014514909A patent/JP5873553B2/ja active Active
- 2012-06-08 RS RSP20191142 patent/RS59380B1/sr unknown
- 2012-06-08 SM SM20190523T patent/SMT201900523T1/it unknown
- 2012-06-08 KR KR1020187034790A patent/KR102029654B1/ko active Active
- 2012-06-08 CN CN201710081858.9A patent/CN107082747B/zh active Active
- 2012-06-08 CN CN201710081577.3A patent/CN107043334B/zh active Active
- 2012-06-08 CA CA3094645A patent/CA3094645C/en active Active
- 2012-06-08 EP EP12728010.5A patent/EP2718261B1/en active Active
- 2012-06-08 AU AU2012267467A patent/AU2012267467B8/en active Active
- 2012-06-08 TW TW105140746A patent/TWI712422B/zh active
- 2012-06-08 TW TW101120844A patent/TWI569814B/zh active
-
2016
- 2016-01-15 JP JP2016006249A patent/JP6232083B2/ja active Active
- 2016-03-31 CY CY20161100261T patent/CY1117433T1/el unknown
-
2017
- 2017-05-09 AU AU2017203075A patent/AU2017203075B2/en active Active
- 2017-10-20 JP JP2017203199A patent/JP6590888B2/ja active Active
-
2019
- 2019-08-13 HR HRP20191463TT patent/HRP20191463T8/hr unknown
- 2019-09-05 CY CY20191100937T patent/CY1123807T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014529328A5 (cg-RX-API-DMAC7.html) | ||
| RU2014153658A (ru) | Липиды для композиций для доставки терапевтических агентов | |
| WO2012170952A4 (en) | Compounds for targeting drug delivery and enhancing sirna activity | |
| Yu et al. | Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery | |
| Bajaj et al. | Design, synthesis, and in vitro gene delivery efficacies of novel cholesterol-based gemini cationic lipids and their serum compatibility: A structure− activity investigation | |
| Sen et al. | Design, syntheses, and transfection biology of novel non-cholesterol-based guanidinylated cationic lipids | |
| US10081598B2 (en) | Cationic lipid | |
| CY1121232T1 (el) | Τριαλκυλο κατιονικα λιπιδια και μεθοδοι χρησης αυτων | |
| MX366055B (es) | Liposomas pegilados para admistracion de acido ribonucleico (arn) que codifica para inmunogeno. | |
| CY1123370T1 (el) | Σταθερη ενεσιμη φαρμακευτικη συνθεση ανταγωνιστη υποδοχεα νευροκινινης 1 και μεθοδος παρασκευης αυτης | |
| CY1122809T1 (el) | Εστερικα προ-φαρμακα της [3-(1-(1η-ιμιδαζολ-4-υλ)αιθυλο)-2-μεθυλοφαινυλο) μεθανολης για τη θεραπεια οφθαλμικων νοσηματων | |
| FI3303598T3 (fi) | Kohdennettuja lipidipartikkeleita nukleiinihappomolekyylien systeemiseen annosteluun leukosyyteille | |
| EA201200939A1 (ru) | Липиды, липидные композиции и способы их применения | |
| Dutta et al. | Charge‐conversion strategies for nucleic acid delivery | |
| MX341989B (es) | Liposomas pequeños para el suministro de arn que codifica el inmunogeno. | |
| HK1198629A1 (en) | High-loading water-soluble carrier-linked prodrugs | |
| BR112012008142A8 (pt) | conjugados de peptídeo/ polietilenoglicol ligados a dissulfeto para a transfecção de ácidos nucleicos | |
| WO2011141705A8 (en) | Novel cationic lipids and methods of use thereof | |
| WO2012170957A8 (en) | Retinoid-liposomes for enhancing modulation of hsp47 expression | |
| BR112015000106A2 (pt) | moduladores heterocíclicos de síntes de lipídio | |
| JP6389477B2 (ja) | カチオン性脂質 | |
| JP2014508804A5 (cg-RX-API-DMAC7.html) | ||
| Martínez-Negro et al. | Efficient cellular knockdown mediated by siRNA nanovectors of gemini cationic lipids having delocalizable headgroups and oligo-oxyethylene spacers | |
| Karmali et al. | In vitro gene transfer efficacies and serum compatibility profiles of novel mono-, di-, and tri-histidinylated cationic transfection lipids: a structure− activity investigation | |
| Karmali et al. | Design, syntheses and in vitro gene delivery efficacies of novel mono-, di-and trilysinated cationic lipids: a structure− activity investigation |