JP2014520932A5 - - Google Patents

Download PDF

Info

Publication number
JP2014520932A5
JP2014520932A5 JP2014520302A JP2014520302A JP2014520932A5 JP 2014520932 A5 JP2014520932 A5 JP 2014520932A5 JP 2014520302 A JP2014520302 A JP 2014520302A JP 2014520302 A JP2014520302 A JP 2014520302A JP 2014520932 A5 JP2014520932 A5 JP 2014520932A5
Authority
JP
Japan
Prior art keywords
psa
pharmaceutical composition
composition according
lipid
lipidated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014520302A
Other languages
English (en)
Japanese (ja)
Other versions
JP6273200B2 (ja
JP2014520932A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/046384 external-priority patent/WO2013009945A1/en
Publication of JP2014520932A publication Critical patent/JP2014520932A/ja
Publication of JP2014520932A5 publication Critical patent/JP2014520932A5/ja
Application granted granted Critical
Publication of JP6273200B2 publication Critical patent/JP6273200B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014520302A 2011-07-12 2012-07-12 脂質含有ｐｓａ組成物、その単離の方法および使用の方法 Expired - Fee Related JP6273200B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161507074P 2011-07-12 2011-07-12
US61/507,074 2011-07-12
PCT/US2012/046384 WO2013009945A1 (en) 2011-07-12 2012-07-12 Lipid-containing psa compositions, methods of isolation and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018000392A Division JP2018109180A (ja) 2011-07-12 2018-01-05 脂質含有ｐｓａ組成物、その単離の方法および使用の方法

Publications (3)

Publication Number Publication Date
JP2014520932A JP2014520932A (ja) 2014-08-25
JP2014520932A5 true JP2014520932A5 (enExample) 2015-08-27
JP6273200B2 JP6273200B2 (ja) 2018-01-31

Family

ID=47506521

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014520302A Expired - Fee Related JP6273200B2 (ja) 2011-07-12 2012-07-12 脂質含有ｐｓａ組成物、その単離の方法および使用の方法
JP2018000392A Pending JP2018109180A (ja) 2011-07-12 2018-01-05 脂質含有ｐｓａ組成物、その単離の方法および使用の方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018000392A Pending JP2018109180A (ja) 2011-07-12 2018-01-05 脂質含有ｐｓａ組成物、その単離の方法および使用の方法

Country Status (4)

Country Link
US (1) US9539281B2 (enExample)
EP (1) EP2731617A4 (enExample)
JP (2) JP6273200B2 (enExample)
WO (1) WO2013009945A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110002965A1 (en) * 2007-11-09 2011-01-06 Round June L Immunomodulating compounds and related compositions and methods
EP2217250A4 (en) 2007-11-09 2011-01-05 California Inst Of Techn IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS
HUE040658T2 (hu) 2010-04-07 2019-03-28 California Inst Of Techn Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek
US20110287048A1 (en) 2010-05-20 2011-11-24 Round June L Antigen Specific Tregs and related compositions, methods and systems
EP2731617A4 (en) 2011-07-12 2015-07-01 Brigham & Womens Hospital LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR
WO2014182966A1 (en) 2013-05-10 2014-11-13 California Institute Of Technology Probiotic prevention and treatment of colon cancer
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
JP6918365B2 (ja) * 2015-08-19 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 脂質化ｐｓａ組成物および方法
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
CN109481472A (zh) * 2017-09-11 2019-03-19 广州知易生物科技有限公司 脆弱拟杆菌提取物在制备防治炎症性肠病的药物或食品中的应用
CN109481474A (zh) * 2017-09-11 2019-03-19 广州知易生物科技有限公司 脆弱拟杆菌在制备防治鼻炎的药物或食品中的应用
CN113730443B (zh) * 2017-09-11 2022-10-04 广州知易生物科技有限公司 脆弱拟杆菌及其提取物在制备防治肠易激综合征的药物中的应用
CN109776690B (zh) * 2017-11-13 2021-04-30 石家庄普维生物科技有限公司 脆弱拟杆菌荚膜多糖硫酸酯及其制备方法和应用
CN109897117B (zh) * 2017-12-08 2021-08-06 广州知易生物科技有限公司 磷酸化tp2多糖及其制备方法和应用
CN109954005B (zh) * 2017-12-14 2021-07-09 广州知易生物科技有限公司 脆弱拟杆菌提取物在制备防治过敏性皮炎的组合物中的应用
CN109954004B (zh) * 2017-12-14 2021-07-09 广州知易生物科技有限公司 脆弱拟杆菌提取物在制备防治银屑病的组合物中的应用
CN110025636B (zh) * 2018-01-12 2021-07-23 石家庄普维生物科技有限公司 脆弱拟杆菌提取物在制备增强免疫力的组合物中的应用

Family Cites Families (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
US3723506A (en) 1971-08-11 1973-03-27 Univ Sherbrooke Oxidation of sugars
DE2917104A1 (de) 1979-04-27 1980-11-06 Hoechst Ag Verfahren zur viskositaetserniedrigung von celluloseethern durch ozon und seine verwendung
JPS56128721U (enExample) 1980-02-29 1981-09-30
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
JPS618945A (ja) 1984-06-25 1986-01-16 Nec Corp 半導体集積回路装置
SE456346B (sv) 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4619995A (en) 1984-12-24 1986-10-28 Nova Chem Limited N,O-carboxymethyl chitosan and preparative method therefor
DE3650242T2 (de) 1985-07-12 1995-06-14 Univ New York Mit dem plasmodium-vivax-circumsporozoit-protein übereinstimmendes immunogenes peptidantigen.
US4684727A (en) 1985-07-29 1987-08-04 Schering Corporation Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents
ATE107697T1 (de) 1986-03-26 1994-07-15 Genexpress Aps Biologische eindämmung.
US4775626A (en) 1986-05-23 1988-10-04 Syntex (U.S.A.) Inc. Method and compositions for protecting anerobic microorganisms
US4819617A (en) 1986-09-04 1989-04-11 University Of Florida Viscoelastic material for ophthalmic surgery
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
DE3704389A1 (de) 1987-02-12 1988-08-25 Blutspendedienst Dt Rote Kreuz Verfahren zur herstellung von lymphokinen durch induktion lymphoider zellen
US4835252A (en) 1987-02-26 1989-05-30 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
US5215896A (en) 1987-03-20 1993-06-01 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
US4937270A (en) 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5140016A (en) 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
DE3840044A1 (de) 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US5196510A (en) 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
FI895708A7 (fi) 1989-02-10 1990-08-11 Alko Ab Oy Vesiliukoinen hajoamistuote
US4952524A (en) 1989-05-05 1990-08-28 At&T Bell Laboratories Semiconductor device manufacture including trench formation
US5158939A (en) 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
ATE121947T1 (de) 1989-12-14 1995-05-15 Ca Nat Research Council Verbessertes meningokokkale polysaccharidkonjugatvakzin.
US5268454A (en) 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
US5130417A (en) 1990-04-30 1992-07-14 Washington University Entamoeba histolytical immunogenic protein and cdna clone
US5331573A (en) 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
KR940006696B1 (ko) 1991-01-16 1994-07-25 금성일렉트론 주식회사 반도체 소자의 격리막 형성방법
CA2059693C (en) 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
GB2254083A (en) 1991-03-28 1992-09-30 Italfarmaco Spa Anticoagulants from e.coli saccharide
GR920100122A (el) 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
US5605938A (en) 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US20050181021A1 (en) 1992-02-14 2005-08-18 Robert Lamb Vitamin E phosphate/phosphatidycholine liposomes to protect from or ameliorate cell damage
US5350941A (en) 1992-09-23 1994-09-27 Texas Instruments Incorporated Trench isolation structure having a trench formed in a LOCOS structure and a channel stop region on the sidewalls of the trench
IL107103A (en) 1992-09-24 2001-03-19 Brigham & Womens Hospital Multivalent vaccine based on conjugated molecule comprising a capsular polysaccharide linked to a protein and a method for the preparation thereof
US5433794A (en) 1992-12-10 1995-07-18 Micron Technology, Inc. Spacers used to form isolation trenches with improved corners
US5728385A (en) 1993-08-12 1998-03-17 Classen Immunotherapies, Inc. Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae
JPH09505603A (ja) 1993-11-26 1997-06-03 ヘンドリー，ローレンス，ビー． レセプター−リガンド−ｄｎａ相互作用に係わる薬剤の設計
IL113812A (en) 1994-05-24 2000-06-29 Yeda Res & Dev Copolymer-1 pharmaceutical compositions containing it and its use
JPH07326664A (ja) 1994-05-31 1995-12-12 Fuji Electric Co Ltd ウエハの誘電体分離溝の充填方法
US5565204A (en) 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
US5679654A (en) 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5700787A (en) 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
NZ296748A (en) 1994-11-02 1999-11-29 Univ New York State Res Found Peripheral nervous system specific sodium channel proteins, DNA coding therefor, compositions and methods
US5858964A (en) 1995-04-14 1999-01-12 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
US5679658A (en) 1995-05-08 1997-10-21 Chitogenics, Inc. N,O-carbonxymethylchitosan for prevention of surgical adhesions
US5851808A (en) 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
JP2001519817A (ja) 1997-03-26 2001-10-23 ブリガム アンド ウイメンズ ホスピタル 糖断片生成法
ATE229038T1 (de) 1997-04-04 2002-12-15 Fidia Advanced Biopolymers Srl N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
EP0908179A1 (en) 1997-08-23 1999-04-14 Werner Bollag Treatment of cell-mediated immune diseases
US6015787A (en) 1997-11-04 2000-01-18 New England Medical Center Hospitals, Inc. Cell-permeable protein inhibitors of calpain
AU3066599A (en) 1998-03-03 1999-10-18 University Of Southern California Use of cytokines and mitogens to inhibit graft versus host disease
AU752942B2 (en) 1998-04-13 2002-10-03 Massachusetts Institute Of Technology Comb copolymers for regulating cell-surface interactions
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US7083777B1 (en) 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
EP1459757A1 (en) * 1999-04-02 2004-09-22 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
CA2366895A1 (en) * 1999-04-02 2000-10-12 Brigham And Women's Hospital, Inc. Immunomodulating polymers
JP2001055335A (ja) 1999-08-18 2001-02-27 Toshio Sato アレルギー性皮膚疾患治療剤
US6995237B1 (en) 1999-10-27 2006-02-07 Cel-Sci Corporation Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
CA2416120A1 (en) 2000-07-17 2002-01-24 Svend Laulund Methods and formulations with probiotic microorganisms and medicaments
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
US6670146B2 (en) 2000-10-04 2003-12-30 Schering Corporation Regulatory T cells; methods
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
CN1496266A (zh) 2001-01-12 2004-05-12 ������ҩ��ʽ���� 抗变态反应剂
EP1361863A2 (en) 2001-02-13 2003-11-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carotenoid-loaded liposomes
ATE489968T1 (de) 2001-03-09 2010-12-15 Id Biomedical Corp Quebec Proteosom-liposaccharid-vakzine-adjuvans
US20050101012A1 (en) 2001-03-12 2005-05-12 Gerold Schuler CD4+CD25+ regulatory T cells from human blood
EP1308167A1 (de) 2001-11-06 2003-05-07 Pickl, Winfried, Ao. Univ. Prof. Dr. Antigenpräsentierende Vesikel
GB0130123D0 (en) 2001-12-17 2002-02-06 Microbiological Res Agency Outer membrane vesicle vaccine and its preparation
US20030147865A1 (en) 2002-02-07 2003-08-07 Benoit Salomon Cell therapy using immunoregulatory T-cells
ES2320334T3 (es) 2002-02-22 2009-05-21 National Research Council Of Canada Uso de analogos de acidos grasos para el tratamiento y/o prevencion de enfermedades proliferativas de la piel.
US7629313B2 (en) 2002-03-08 2009-12-08 Eli Lilly And Company Immunomodulatory polymeric antigens for treating inflammatory pathologies
CA2479246C (en) 2002-03-13 2017-05-09 Laurie E. Comstock Method for overexpression of zwitterionic polysaccharides
US7829289B2 (en) 2002-05-14 2010-11-09 Institut National De La Sante Et De Recherche Medicale T cell subpopulation regulating gut immunity
GB0213622D0 (en) 2002-06-13 2002-07-24 Glaxosmithkline Biolog Sa Vaccine Corporation
DK1531832T3 (da) 2002-06-28 2009-07-27 Glykos Finland Oy Terapeutiske sammensætninger til anvendelse ved profylakse eller behandling af diarré
US20060160153A1 (en) 2002-12-03 2006-07-20 Jean-Pierre Abastado Method to measure a t cell response and its uses to qualify antigen-presenting cells
US20040219160A1 (en) 2003-03-31 2004-11-04 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
NZ543467A (en) 2003-04-10 2008-07-31 Novartis Vaccines & Diagnostic The severe acute respiratory syndrome coronavirus
US20050048587A1 (en) 2003-07-17 2005-03-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor
US6846807B1 (en) 2003-07-25 2005-01-25 Board Of Regents, The University Of Texas System Colorectal neoplasia prophylaxis
JP2007518394A (ja) 2003-08-14 2007-07-12 ザ バイオ バランス コーポレイション 細菌菌株、該細菌菌株を含む組成物、およびそのプロバイオティクス使用
DE10353593A1 (de) 2003-11-17 2005-06-23 Klinikum der Universität München Großhadern-Innenstadt Leptinantagonist und Verfahren zur quantitativen Messung von Leptin
CA2549001A1 (en) 2003-12-10 2005-06-30 Activbiotics, Inc. Rifamycin analogs and uses thereof
WO2006060117A2 (en) 2004-11-02 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Methods for inhibition of nkt cells
US8426146B2 (en) 2005-06-03 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Multiparameteric method for assessing immune system status
AU2006297896B2 (en) 2005-10-06 2011-12-08 Probi Ab Use of lactobacillus for treatment of autoimmune diseases
AU2006335256B2 (en) 2005-11-22 2012-10-18 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
CN100366737C (zh) 2006-03-01 2008-02-06 哈尔滨美华生物技术股份有限公司 固定化乳糖酶生产方法
WO2007136719A2 (en) 2006-05-18 2007-11-29 Biobalance Llc Biotherapeutic compositions comprising probiotic escherichia coli and uses thereof
EP2032695B1 (en) 2006-05-31 2018-08-15 The Regents of The University of California Cd127 expression inversely correlates with foxp3 and suppressive function of cd4+ tregs
PT103495B (pt) 2006-06-05 2017-05-12 Faculdade De Farmácia Da Univ De Lisboa Pró-fármacos de ácidos orgânicos e composições farmacêuticas contendo os referidos pró-fármacos
HUE030386T2 (en) 2007-01-31 2017-05-29 Yeda Res & Dev Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
TW200904340A (en) 2007-05-11 2009-02-01 Mannatech Inc Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same
US8092998B2 (en) 2007-05-31 2012-01-10 Abbott Laboratories Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders
US20100221755A1 (en) 2007-06-15 2010-09-02 University Of Rochester Use of antibody secreting cell elispot to assess antibody responses following antigen exposure
EP2217250A4 (en) 2007-11-09 2011-01-05 California Inst Of Techn IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS
US20110002965A1 (en) * 2007-11-09 2011-01-06 Round June L Immunomodulating compounds and related compositions and methods
TWI468188B (zh) 2008-01-30 2015-01-11 Univ Tokushima Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation
FR2930264B1 (fr) 2008-04-18 2013-02-22 Gervais Danone Sa Nouvelle souche de lactobacillus paracasei subsp. paracasei dotee de proprietes antimicrobiennes et immunomodulatrices.
WO2009149149A1 (en) 2008-06-04 2009-12-10 Trustees Of Dartmouth College Prevention or treatment of immune-relevant disease by modification of microfloral populations
US20100081956A1 (en) 2008-09-30 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, composition, and system to control pH in pulmonary tissue of a subject
JP2012524910A (ja) 2009-04-23 2012-10-18 カリフォルニア インスティチュート オブ テクノロジー 免疫調節物質の同定方法及びシステム
US20100311686A1 (en) 2009-06-03 2010-12-09 Kasper Lloyd H Nutraceutical composition and methods for preventing or treating multiple sclerosis
US8580278B2 (en) 2009-06-03 2013-11-12 Trustees Of Dartmouth College Nutraceutical composition and methods for preventing or treating multiple sclerosis
HUE040658T2 (hu) 2010-04-07 2019-03-28 California Inst Of Techn Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek
US20110287048A1 (en) 2010-05-20 2011-11-24 Round June L Antigen Specific Tregs and related compositions, methods and systems
WO2011153226A2 (en) 2010-06-01 2011-12-08 Moore Research Enterprises Llc Cellular constituents from bacteroides, compositions thereof, and therapeutic methods employing bacteroides or cellular constituents thereof
US20140030807A1 (en) 2010-07-20 2014-01-30 Trustees Of Dartmouth College Method for stimulating foxp3+ regulatory t cell expression of cd39
HUE038600T2 (hu) 2010-10-07 2018-10-29 California Inst Of Techn Probiotikus terápiák autizmushoz
US20130064859A1 (en) 2011-01-28 2013-03-14 Sarkis K. Mazmanian Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease
EP2731617A4 (en) 2011-07-12 2015-07-01 Brigham & Womens Hospital LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR
WO2013019896A1 (en) 2011-08-01 2013-02-07 Symbiotix Biotherapies, Inc. Platform for identifying and/or characterizing immunomodulatory agents
WO2013036290A1 (en) 2011-09-09 2013-03-14 Yale University Compositions and methods for assessing and treating inflammatory diseases and disorders
EP2764090B1 (en) 2011-10-03 2017-12-13 California Institute of Technology Generation of psa-only producing mutant strain
US20140072534A1 (en) 2012-08-30 2014-03-13 California Institute Of Technology Novel therapy for multiple sclerosis using vitamin d and gut bacteria
WO2014182966A1 (en) 2013-05-10 2014-11-13 California Institute Of Technology Probiotic prevention and treatment of colon cancer

Similar Documents

Publication Publication Date Title
Peng et al. Gastrointestinal microenvironment responsive nanoencapsulation of probiotics and drugs for synergistic therapy of intestinal diseases
JP6273200B2 (ja) 脂質含有ｐｓａ組成物、その単離の方法および使用の方法
ES2848538T3 (es) Composiciones de galacto-ramnogalacturonato para el tratamiento de enfermedades asociadas con elevada óxido nítrico sintasa inducible
CN1108572A (zh) 抗溃疡剂和幽门螺旋菌粘连抑制剂
GB2616153A (en) Preparation method for exosome-loaded polymer for use in oral colon-targeting drug delivery
Ngwuluka et al. Functions of bioactive and intelligent natural polymers in the optimization of drug delivery
US20030162732A1 (en) Combination of aminosugars and cysteine or cysteine derivatives
CN106243239B (zh) 一种用于提高肝炎患者免疫力的可溶性小分子β-1,3-葡聚糖
JP5622357B2 (ja) アレルギー性疾患の予防または治療薬
CN104398504B (zh) 一种去氧鬼臼毒素类药物的药物组合物及其制备方法和制剂
JP6082633B2 (ja) 多糖ナノゲルおよびその製造方法、ならびにそれを用いた創傷治癒剤
JP2004137183A (ja) グリコサミノグリカン又はその塩を含む経口投与用医薬品、健康食品又は栄養薬品組成物
JP2022534278A (ja) 血液脳関門（ｂｂｂ）の保護及び修復のための組成物
JP2018528303A5 (enExample)
CN109053927A (zh) 一种含维生素b12基团的两亲性海藻酸钠衍生物及其制备方法和应用
CN1425691A (zh) 乙酰甘露聚糖及其制备方法和应用
JP2010195728A (ja) 腸疾患治療剤
Ding et al. Oral delivery of infliximab via self-assembled nano-in-microspheres for enhanced inflammatory bowel disease therapy
JP2006298791A (ja) グリコサミノグリカン又はその塩を含む経口投与用医薬品、健康食品又は栄養薬品組成物。
US20110065911A1 (en) Method for producing a bioactive glucan product substantially free of endotoxin contamination
CN103494826B (zh) Phyllanthoid A在制备治疗鼻炎药物中的应用
JP5646164B2 (ja) 分岐キトサン誘導体
CN105362274A (zh) Biscarpamontamine A在制备治疗鼻炎药物中的应用
CN107722133A (zh) 一种提高猴头菇多糖免疫活性的羟乙基化方法
WO2023221977A1 (zh) 一种硫酸软骨素生物多胺复合物、其制备方法及用途