EP2422200A4 - Methods and systems for identifying immunomodulatory substances - Google Patents

Methods and systems for identifying immunomodulatory substances

Info

Publication number
EP2422200A4
EP2422200A4 EP10767863A EP10767863A EP2422200A4 EP 2422200 A4 EP2422200 A4 EP 2422200A4 EP 10767863 A EP10767863 A EP 10767863A EP 10767863 A EP10767863 A EP 10767863A EP 2422200 A4 EP2422200 A4 EP 2422200A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
immunomodulatory substances
identifying
identifying immunomodulatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10767863A
Other languages
German (de)
French (fr)
Other versions
EP2422200A2 (en
Inventor
June L Round
Yue Shen
Sarkis K Mazmanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of EP2422200A2 publication Critical patent/EP2422200A2/en
Publication of EP2422200A4 publication Critical patent/EP2422200A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP10767863A 2009-04-23 2010-04-23 Methods and systems for identifying immunomodulatory substances Withdrawn EP2422200A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17210109P 2009-04-23 2009-04-23
PCT/US2010/032300 WO2010124256A2 (en) 2009-04-23 2010-04-23 Methods and systems for identifying immunomodulatory substances

Publications (2)

Publication Number Publication Date
EP2422200A2 EP2422200A2 (en) 2012-02-29
EP2422200A4 true EP2422200A4 (en) 2013-02-27

Family

ID=42993293

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10767863A Withdrawn EP2422200A4 (en) 2009-04-23 2010-04-23 Methods and systems for identifying immunomodulatory substances

Country Status (4)

Country Link
US (2) US20100275282A1 (en)
EP (1) EP2422200A4 (en)
JP (2) JP2012524910A (en)
WO (1) WO2010124256A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
EP2217250A4 (en) 2007-11-09 2011-01-05 California Inst Of Techn Immunomodulating compounds and related compositions and methods
HUE040658T2 (en) * 2010-04-07 2019-03-28 California Inst Of Techn Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
EP2571982A4 (en) 2010-05-20 2014-01-01 California Inst Of Techn Antigen specific tregs and related compositions, methods and systems
WO2011151941A1 (en) 2010-06-04 2011-12-08 国立大学法人東京大学 Composition having activity of inducing proliferation or accumulation of regulatory t cell
WO2012103532A1 (en) * 2011-01-28 2012-08-02 Mazmanian Sarkis K Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease
EP2731617A4 (en) * 2011-07-12 2015-07-01 Brigham & Womens Hospital Lipid-containing psa compositions, methods of isolation and methods of use thereof
WO2013019896A1 (en) * 2011-08-01 2013-02-07 Symbiotix Biotherapies, Inc. Platform for identifying and/or characterizing immunomodulatory agents
US9057070B2 (en) 2011-10-03 2015-06-16 California Institute Of Technology Generation of Bacteriodes fragilis capsular polysaccharide A-only producing mutant strain
JP6306507B2 (en) 2011-12-01 2018-04-18 国立大学法人 東京大学 Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
CA2911826C (en) 2013-05-10 2022-08-23 California Institute Of Technology Probiotic prevention and treatment of colon cancer
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
US10857177B2 (en) 2015-08-19 2020-12-08 President And Fellows Of Harvard College Lipidated PSA compositions and methods
EP3484441A4 (en) 2016-07-15 2020-03-18 President and Fellows of Harvard College Glycolipid compositions and methods of use
WO2018023088A1 (en) 2016-07-29 2018-02-01 Confer Health, Inc. Gel electrophoresis diagnostic kit and methods of using the same
WO2018119437A2 (en) 2016-12-23 2018-06-28 Confer Health, Inc. Electrophoresis diagnostic methods and kits
JP6836756B2 (en) * 2017-09-21 2021-03-03 光博 岡野 How to predict the composition ratio in the oral bacterial flora

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095606A2 (en) * 2002-05-14 2003-11-20 Institut National de la Santé et de la Recherche Médicale A t cell subpopulation regulating gut immunity
WO2004050909A2 (en) * 2002-12-03 2004-06-17 Dartmouth College Method to measure a t cell response and its uses to qualify antigen-presenting cells
WO2005010215A2 (en) * 2003-07-17 2005-02-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5679654A (en) * 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
SV2003000753A (en) * 2000-12-05 2003-06-16 Brigham & Womens Hospital USE OF ZWITTERIONIC POLYSACARIDS FOR THE SPECIFIC MODULATION OF IMMUNE PROGRESS
JP4137640B2 (en) * 2001-03-09 2008-08-20 アイディー バイオメディカル コーポレイション オブ ケベック Novel proteosome-liposaccharide vaccine adjuvant
JP2003204796A (en) * 2001-11-08 2003-07-22 Japan Science & Technology Corp Non-human gene-modified animal and utilization thereof
EP1638581A2 (en) * 2003-03-31 2006-03-29 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
JPWO2005094571A1 (en) * 2004-03-31 2008-02-14 独立行政法人科学技術振興機構 Genetically modified heterozygous animal and method for measuring exocytosis using the animal
US8426146B2 (en) * 2005-06-03 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Multiparameteric method for assessing immune system status
JP2007119414A (en) * 2005-10-31 2007-05-17 Univ Nagoya Immunosuppressant for enhancing immunosuppression activity of cd8+ cd122+ t-cell
WO2007092451A2 (en) * 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
US8092998B2 (en) * 2007-05-31 2012-01-10 Abbott Laboratories Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095606A2 (en) * 2002-05-14 2003-11-20 Institut National de la Santé et de la Recherche Médicale A t cell subpopulation regulating gut immunity
WO2004050909A2 (en) * 2002-12-03 2004-06-17 Dartmouth College Method to measure a t cell response and its uses to qualify antigen-presenting cells
WO2005010215A2 (en) * 2003-07-17 2005-02-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ESTELLE BETTELLI ET AL: "Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells", NATURE, vol. 441, no. 7090, 11 May 2006 (2006-05-11), pages 235 - 238, XP055049368, ISSN: 0028-0836, DOI: 10.1038/nature04753 *
FINK LISBETH N ET AL: "Human antigen-presenting cells respond differently to gut-derived probiotic bacteria but mediate similar strain-dependent NK and T cell activation", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, vol. 51, no. 3, 1 December 2007 (2007-12-01), pages 535 - 546, XP008093591, ISSN: 0928-8244, [retrieved on 20070928], DOI: 10.1111/J.1574-695X.2007.00333.X *
HORI S ET AL: "Control of regulatory T cell development by the transcription factor Foxp3", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 299, no. 5609, 14 February 2003 (2003-02-14), pages 1057 - 1061, XP002316905, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1079490 *
META J KUEHN ET AL: "Bacterial outer membrane vesicles and the host-pathogen interaction", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 19, no. 22, 1 January 2005 (2005-01-01), pages 2645 - 2655, XP008155452, ISSN: 0890-9369, DOI: 10.1101/GAD.1299905 *
TANAKA H ET AL: "Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors: role of stimulator/responder ratio", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 192, no. 3, 7 August 2000 (2000-08-07), pages 405 - 411, XP002959593, ISSN: 0022-1007, DOI: 10.1084/JEM.192.3.405 *
TIMOTHY L DENNING ET AL: "Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses", NATURE IMMUNOLOGY, vol. 8, no. 10, 1 October 2007 (2007-10-01), pages 1086 - 1094, XP055049229, ISSN: 1529-2908, DOI: 10.1038/ni1511 *

Also Published As

Publication number Publication date
US20100275282A1 (en) 2010-10-28
EP2422200A2 (en) 2012-02-29
US20170003274A1 (en) 2017-01-05
JP2016014660A (en) 2016-01-28
WO2010124256A3 (en) 2011-03-31
JP2012524910A (en) 2012-10-18
WO2010124256A2 (en) 2010-10-28

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Ipc: G01N 33/569 20060101AFI20130118BHEP

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