JP6273200B2 - 脂質含有ｐｓａ組成物、その単離の方法および使用の方法 - Google Patents
脂質含有ｐｓａ組成物、その単離の方法および使用の方法 Download PDFInfo
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Families Citing this family (17)
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| US20110002965A1 (en) * | 2007-11-09 | 2011-01-06 | Round June L | Immunomodulating compounds and related compositions and methods |
| EP2217250A4 (en) | 2007-11-09 | 2011-01-05 | California Inst Of Techn | IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS |
| HUE040658T2 (hu) | 2010-04-07 | 2019-03-28 | California Inst Of Techn | Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek |
| US20110287048A1 (en) | 2010-05-20 | 2011-11-24 | Round June L | Antigen Specific Tregs and related compositions, methods and systems |
| EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR |
| WO2014182966A1 (en) | 2013-05-10 | 2014-11-13 | California Institute Of Technology | Probiotic prevention and treatment of colon cancer |
| US11331335B2 (en) | 2015-06-10 | 2022-05-17 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| JP6918365B2 (ja) * | 2015-08-19 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 脂質化ｐｓａ組成物および方法 |
| US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| CN109481472A (zh) * | 2017-09-11 | 2019-03-19 | 广州知易生物科技有限公司 | 脆弱拟杆菌提取物在制备防治炎症性肠病的药物或食品中的应用 |
| CN109481474A (zh) * | 2017-09-11 | 2019-03-19 | 广州知易生物科技有限公司 | 脆弱拟杆菌在制备防治鼻炎的药物或食品中的应用 |
| CN113730443B (zh) * | 2017-09-11 | 2022-10-04 | 广州知易生物科技有限公司 | 脆弱拟杆菌及其提取物在制备防治肠易激综合征的药物中的应用 |
| CN109776690B (zh) * | 2017-11-13 | 2021-04-30 | 石家庄普维生物科技有限公司 | 脆弱拟杆菌荚膜多糖硫酸酯及其制备方法和应用 |
| CN109897117B (zh) * | 2017-12-08 | 2021-08-06 | 广州知易生物科技有限公司 | 磷酸化tp2多糖及其制备方法和应用 |
| CN109954005B (zh) * | 2017-12-14 | 2021-07-09 | 广州知易生物科技有限公司 | 脆弱拟杆菌提取物在制备防治过敏性皮炎的组合物中的应用 |
| CN109954004B (zh) * | 2017-12-14 | 2021-07-09 | 广州知易生物科技有限公司 | 脆弱拟杆菌提取物在制备防治银屑病的组合物中的应用 |
| CN110025636B (zh) * | 2018-01-12 | 2021-07-23 | 石家庄普维生物科技有限公司 | 脆弱拟杆菌提取物在制备增强免疫力的组合物中的应用 |
Family Cites Families (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| US3723506A (en) | 1971-08-11 | 1973-03-27 | Univ Sherbrooke | Oxidation of sugars |
| DE2917104A1 (de) | 1979-04-27 | 1980-11-06 | Hoechst Ag | Verfahren zur viskositaetserniedrigung von celluloseethern durch ozon und seine verwendung |
| JPS56128721U (enExample) | 1980-02-29 | 1981-09-30 | ||
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| JPS618945A (ja) | 1984-06-25 | 1986-01-16 | Nec Corp | 半導体集積回路装置 |
| SE456346B (sv) | 1984-07-23 | 1988-09-26 | Pharmacia Ab | Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning |
| US4619995A (en) | 1984-12-24 | 1986-10-28 | Nova Chem Limited | N,O-carboxymethyl chitosan and preparative method therefor |
| DE3650242T2 (de) | 1985-07-12 | 1995-06-14 | Univ New York | Mit dem plasmodium-vivax-circumsporozoit-protein übereinstimmendes immunogenes peptidantigen. |
| US4684727A (en) | 1985-07-29 | 1987-08-04 | Schering Corporation | Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents |
| ATE107697T1 (de) | 1986-03-26 | 1994-07-15 | Genexpress Aps | Biologische eindämmung. |
| US4775626A (en) | 1986-05-23 | 1988-10-04 | Syntex (U.S.A.) Inc. | Method and compositions for protecting anerobic microorganisms |
| US4819617A (en) | 1986-09-04 | 1989-04-11 | University Of Florida | Viscoelastic material for ophthalmic surgery |
| US5514581A (en) | 1986-11-04 | 1996-05-07 | Protein Polymer Technologies, Inc. | Functional recombinantly prepared synthetic protein polymer |
| DE3704389A1 (de) | 1987-02-12 | 1988-08-25 | Blutspendedienst Dt Rote Kreuz | Verfahren zur herstellung von lymphokinen durch induktion lymphoider zellen |
| US4835252A (en) | 1987-02-26 | 1989-05-30 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Vasoactive intestinal peptide analogs |
| US5215896A (en) | 1987-03-20 | 1993-06-01 | Creative Biomolecules, Inc. | Leader sequences for the production of recombinant proteins |
| US4937270A (en) | 1987-09-18 | 1990-06-26 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| US5140016A (en) | 1988-05-31 | 1992-08-18 | University Of Florida | Method and composition for preventing surgical adhesions using a dilute solution of polymer |
| US5126141A (en) | 1988-11-16 | 1992-06-30 | Mediventures Incorporated | Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides |
| DE3840044A1 (de) | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
| US5196510A (en) | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
| FI895708A7 (fi) | 1989-02-10 | 1990-08-11 | Alko Ab Oy | Vesiliukoinen hajoamistuote |
| US4952524A (en) | 1989-05-05 | 1990-08-28 | At&T Bell Laboratories | Semiconductor device manufacture including trench formation |
| US5158939A (en) | 1989-07-21 | 1992-10-27 | Wisconsin Alumni Research Foundation | Method of stimulating the immune systems of animals and compositions useful therefor |
| ATE121947T1 (de) | 1989-12-14 | 1995-05-15 | Ca Nat Research Council | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| US5130417A (en) | 1990-04-30 | 1992-07-14 | Washington University | Entamoeba histolytical immunogenic protein and cdna clone |
| US5331573A (en) | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
| KR940006696B1 (ko) | 1991-01-16 | 1994-07-25 | 금성일렉트론 주식회사 | 반도체 소자의 격리막 형성방법 |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| GB2254083A (en) | 1991-03-28 | 1992-09-30 | Italfarmaco Spa | Anticoagulants from e.coli saccharide |
| GR920100122A (el) | 1991-04-05 | 1993-03-16 | Ethicon Inc | Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως. |
| US5605938A (en) | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
| US5705178A (en) | 1991-05-31 | 1998-01-06 | Gliatech, Inc. | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers |
| US20050181021A1 (en) | 1992-02-14 | 2005-08-18 | Robert Lamb | Vitamin E phosphate/phosphatidycholine liposomes to protect from or ameliorate cell damage |
| US5350941A (en) | 1992-09-23 | 1994-09-27 | Texas Instruments Incorporated | Trench isolation structure having a trench formed in a LOCOS structure and a channel stop region on the sidewalls of the trench |
| IL107103A (en) | 1992-09-24 | 2001-03-19 | Brigham & Womens Hospital | Multivalent vaccine based on conjugated molecule comprising a capsular polysaccharide linked to a protein and a method for the preparation thereof |
| US5433794A (en) | 1992-12-10 | 1995-07-18 | Micron Technology, Inc. | Spacers used to form isolation trenches with improved corners |
| US5728385A (en) | 1993-08-12 | 1998-03-17 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
| JPH09505603A (ja) | 1993-11-26 | 1997-06-03 | ヘンドリー，ローレンス，ビー． | レセプター−リガンド−ｄｎａ相互作用に係わる薬剤の設計 |
| IL113812A (en) | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| JPH07326664A (ja) | 1994-05-31 | 1995-12-12 | Fuji Electric Co Ltd | ウエハの誘電体分離溝の充填方法 |
| US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| US5679654A (en) | 1994-09-02 | 1997-10-21 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5700787A (en) | 1994-09-02 | 1997-12-23 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| NZ296748A (en) | 1994-11-02 | 1999-11-29 | Univ New York State Res Found | Peripheral nervous system specific sodium channel proteins, DNA coding therefor, compositions and methods |
| US5858964A (en) | 1995-04-14 | 1999-01-12 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD |
| US5679658A (en) | 1995-05-08 | 1997-10-21 | Chitogenics, Inc. | N,O-carbonxymethylchitosan for prevention of surgical adhesions |
| US5851808A (en) | 1997-02-28 | 1998-12-22 | Baylor College Of Medicine | Rapid subcloning using site-specific recombination |
| JP2001519817A (ja) | 1997-03-26 | 2001-10-23 | ブリガム アンド ウイメンズ ホスピタル | 糖断片生成法 |
| ATE229038T1 (de) | 1997-04-04 | 2002-12-15 | Fidia Advanced Biopolymers Srl | N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung |
| US5929049A (en) | 1997-08-08 | 1999-07-27 | Dade Behring Marburg Gmbh | Polysaccharide conjugates of biomolecules |
| EP0908179A1 (en) | 1997-08-23 | 1999-04-14 | Werner Bollag | Treatment of cell-mediated immune diseases |
| US6015787A (en) | 1997-11-04 | 2000-01-18 | New England Medical Center Hospitals, Inc. | Cell-permeable protein inhibitors of calpain |
| AU3066599A (en) | 1998-03-03 | 1999-10-18 | University Of Southern California | Use of cytokines and mitogens to inhibit graft versus host disease |
| AU752942B2 (en) | 1998-04-13 | 2002-10-03 | Massachusetts Institute Of Technology | Comb copolymers for regulating cell-surface interactions |
| ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| US7083777B1 (en) | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| EP1459757A1 (en) * | 1999-04-02 | 2004-09-22 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| CA2366895A1 (en) * | 1999-04-02 | 2000-10-12 | Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| JP2001055335A (ja) | 1999-08-18 | 2001-02-27 | Toshio Sato | アレルギー性皮膚疾患治療剤 |
| US6995237B1 (en) | 1999-10-27 | 2006-02-07 | Cel-Sci Corporation | Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| CA2416120A1 (en) | 2000-07-17 | 2002-01-24 | Svend Laulund | Methods and formulations with probiotic microorganisms and medicaments |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| US6670146B2 (en) | 2000-10-04 | 2003-12-30 | Schering Corporation | Regulatory T cells; methods |
| SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| CN1496266A (zh) | 2001-01-12 | 2004-05-12 | ������ҩ��ʽ���� | 抗变态反应剂 |
| EP1361863A2 (en) | 2001-02-13 | 2003-11-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Carotenoid-loaded liposomes |
| ATE489968T1 (de) | 2001-03-09 | 2010-12-15 | Id Biomedical Corp Quebec | Proteosom-liposaccharid-vakzine-adjuvans |
| US20050101012A1 (en) | 2001-03-12 | 2005-05-12 | Gerold Schuler | CD4+CD25+ regulatory T cells from human blood |
| EP1308167A1 (de) | 2001-11-06 | 2003-05-07 | Pickl, Winfried, Ao. Univ. Prof. Dr. | Antigenpräsentierende Vesikel |
| GB0130123D0 (en) | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| US20030147865A1 (en) | 2002-02-07 | 2003-08-07 | Benoit Salomon | Cell therapy using immunoregulatory T-cells |
| ES2320334T3 (es) | 2002-02-22 | 2009-05-21 | National Research Council Of Canada | Uso de analogos de acidos grasos para el tratamiento y/o prevencion de enfermedades proliferativas de la piel. |
| US7629313B2 (en) | 2002-03-08 | 2009-12-08 | Eli Lilly And Company | Immunomodulatory polymeric antigens for treating inflammatory pathologies |
| CA2479246C (en) | 2002-03-13 | 2017-05-09 | Laurie E. Comstock | Method for overexpression of zwitterionic polysaccharides |
| US7829289B2 (en) | 2002-05-14 | 2010-11-09 | Institut National De La Sante Et De Recherche Medicale | T cell subpopulation regulating gut immunity |
| GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| DK1531832T3 (da) | 2002-06-28 | 2009-07-27 | Glykos Finland Oy | Terapeutiske sammensætninger til anvendelse ved profylakse eller behandling af diarré |
| US20060160153A1 (en) | 2002-12-03 | 2006-07-20 | Jean-Pierre Abastado | Method to measure a t cell response and its uses to qualify antigen-presenting cells |
| US20040219160A1 (en) | 2003-03-31 | 2004-11-04 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
| NZ543467A (en) | 2003-04-10 | 2008-07-31 | Novartis Vaccines & Diagnostic | The severe acute respiratory syndrome coronavirus |
| US20050048587A1 (en) | 2003-07-17 | 2005-03-03 | Tolerrx, Inc. | Methods for identifying tolerance modulatory compounds and uses therefor |
| US6846807B1 (en) | 2003-07-25 | 2005-01-25 | Board Of Regents, The University Of Texas System | Colorectal neoplasia prophylaxis |
| JP2007518394A (ja) | 2003-08-14 | 2007-07-12 | ザ バイオ バランス コーポレイション | 細菌菌株、該細菌菌株を含む組成物、およびそのプロバイオティクス使用 |
| DE10353593A1 (de) | 2003-11-17 | 2005-06-23 | Klinikum der Universität München Großhadern-Innenstadt | Leptinantagonist und Verfahren zur quantitativen Messung von Leptin |
| CA2549001A1 (en) | 2003-12-10 | 2005-06-30 | Activbiotics, Inc. | Rifamycin analogs and uses thereof |
| WO2006060117A2 (en) | 2004-11-02 | 2006-06-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for inhibition of nkt cells |
| US8426146B2 (en) | 2005-06-03 | 2013-04-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multiparameteric method for assessing immune system status |
| AU2006297896B2 (en) | 2005-10-06 | 2011-12-08 | Probi Ab | Use of lactobacillus for treatment of autoimmune diseases |
| AU2006335256B2 (en) | 2005-11-22 | 2012-10-18 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
| US8206726B2 (en) | 2006-02-06 | 2012-06-26 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
| CN100366737C (zh) | 2006-03-01 | 2008-02-06 | 哈尔滨美华生物技术股份有限公司 | 固定化乳糖酶生产方法 |
| WO2007136719A2 (en) | 2006-05-18 | 2007-11-29 | Biobalance Llc | Biotherapeutic compositions comprising probiotic escherichia coli and uses thereof |
| EP2032695B1 (en) | 2006-05-31 | 2018-08-15 | The Regents of The University of California | Cd127 expression inversely correlates with foxp3 and suppressive function of cd4+ tregs |
| PT103495B (pt) | 2006-06-05 | 2017-05-12 | Faculdade De Farmácia Da Univ De Lisboa | Pró-fármacos de ácidos orgânicos e composições farmacêuticas contendo os referidos pró-fármacos |
| HUE030386T2 (en) | 2007-01-31 | 2017-05-29 | Yeda Res & Dev | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
| TW200904340A (en) | 2007-05-11 | 2009-02-01 | Mannatech Inc | Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same |
| US8092998B2 (en) | 2007-05-31 | 2012-01-10 | Abbott Laboratories | Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders |
| US20100221755A1 (en) | 2007-06-15 | 2010-09-02 | University Of Rochester | Use of antibody secreting cell elispot to assess antibody responses following antigen exposure |
| EP2217250A4 (en) | 2007-11-09 | 2011-01-05 | California Inst Of Techn | IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS |
| US20110002965A1 (en) * | 2007-11-09 | 2011-01-06 | Round June L | Immunomodulating compounds and related compositions and methods |
| TWI468188B (zh) | 2008-01-30 | 2015-01-11 | Univ Tokushima | Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation |
| FR2930264B1 (fr) | 2008-04-18 | 2013-02-22 | Gervais Danone Sa | Nouvelle souche de lactobacillus paracasei subsp. paracasei dotee de proprietes antimicrobiennes et immunomodulatrices. |
| WO2009149149A1 (en) | 2008-06-04 | 2009-12-10 | Trustees Of Dartmouth College | Prevention or treatment of immune-relevant disease by modification of microfloral populations |
| US20100081956A1 (en) | 2008-09-30 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, composition, and system to control pH in pulmonary tissue of a subject |
| JP2012524910A (ja) | 2009-04-23 | 2012-10-18 | カリフォルニア インスティチュート オブ テクノロジー | 免疫調節物質の同定方法及びシステム |
| US20100311686A1 (en) | 2009-06-03 | 2010-12-09 | Kasper Lloyd H | Nutraceutical composition and methods for preventing or treating multiple sclerosis |
| US8580278B2 (en) | 2009-06-03 | 2013-11-12 | Trustees Of Dartmouth College | Nutraceutical composition and methods for preventing or treating multiple sclerosis |
| HUE040658T2 (hu) | 2010-04-07 | 2019-03-28 | California Inst Of Techn | Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek |
| US20110287048A1 (en) | 2010-05-20 | 2011-11-24 | Round June L | Antigen Specific Tregs and related compositions, methods and systems |
| WO2011153226A2 (en) | 2010-06-01 | 2011-12-08 | Moore Research Enterprises Llc | Cellular constituents from bacteroides, compositions thereof, and therapeutic methods employing bacteroides or cellular constituents thereof |
| US20140030807A1 (en) | 2010-07-20 | 2014-01-30 | Trustees Of Dartmouth College | Method for stimulating foxp3+ regulatory t cell expression of cd39 |
| HUE038600T2 (hu) | 2010-10-07 | 2018-10-29 | California Inst Of Techn | Probiotikus terápiák autizmushoz |
| US20130064859A1 (en) | 2011-01-28 | 2013-03-14 | Sarkis K. Mazmanian | Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease |
| EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR |
| WO2013019896A1 (en) | 2011-08-01 | 2013-02-07 | Symbiotix Biotherapies, Inc. | Platform for identifying and/or characterizing immunomodulatory agents |
| WO2013036290A1 (en) | 2011-09-09 | 2013-03-14 | Yale University | Compositions and methods for assessing and treating inflammatory diseases and disorders |
| EP2764090B1 (en) | 2011-10-03 | 2017-12-13 | California Institute of Technology | Generation of psa-only producing mutant strain |
| US20140072534A1 (en) | 2012-08-30 | 2014-03-13 | California Institute Of Technology | Novel therapy for multiple sclerosis using vitamin d and gut bacteria |
| WO2014182966A1 (en) | 2013-05-10 | 2014-11-13 | California Institute Of Technology | Probiotic prevention and treatment of colon cancer |
-
2012
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- 2012-07-12 WO PCT/US2012/046384 patent/WO2013009945A1/en not_active Ceased
- 2012-07-12 JP JP2014520302A patent/JP6273200B2/ja not_active Expired - Fee Related
- 2012-07-12 US US14/131,812 patent/US9539281B2/en not_active Expired - Fee Related
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2018
- 2018-01-05 JP JP2018000392A patent/JP2018109180A/ja active Pending
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|---|---|
| WO2013009945A1 (en) | 2013-01-17 |
| JP2018109180A (ja) | 2018-07-12 |
| EP2731617A4 (en) | 2015-07-01 |
| US9539281B2 (en) | 2017-01-10 |
| US20140243285A1 (en) | 2014-08-28 |
| EP2731617A1 (en) | 2014-05-21 |
| JP2014520932A (ja) | 2014-08-25 |
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