DE60325696D1 - Synthese von lipopolysaccharid-protein konjugatvaccinen über die lipid-a region nach entfernung des glycosidischen phosphatresidüs - Google Patents
Synthese von lipopolysaccharid-protein konjugatvaccinen über die lipid-a region nach entfernung des glycosidischen phosphatresidüsInfo
- Publication number
- DE60325696D1 DE60325696D1 DE60325696T DE60325696T DE60325696D1 DE 60325696 D1 DE60325696 D1 DE 60325696D1 DE 60325696 T DE60325696 T DE 60325696T DE 60325696 T DE60325696 T DE 60325696T DE 60325696 D1 DE60325696 D1 DE 60325696D1
- Authority
- DE
- Germany
- Prior art keywords
- lipopolysaccharide
- lipid
- region
- protein conjugate
- phosphatesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002158 endotoxin Substances 0.000 title abstract 3
- 229920006008 lipopolysaccharide Polymers 0.000 title abstract 3
- 108010060123 Conjugate Vaccines Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 229940031348 multivalent vaccine Drugs 0.000 abstract 2
- 229920001542 oligosaccharide Polymers 0.000 abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229940031670 conjugate vaccine Drugs 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical group O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35838402P | 2002-02-22 | 2002-02-22 | |
| PCT/CA2003/000254 WO2003070282A2 (en) | 2002-02-22 | 2003-02-24 | Synthesis of lipopolysaccharide-protein conjugate vaccines via the lipid a region following removal of the glycosidic phosphate residue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60325696D1 true DE60325696D1 (de) | 2009-02-26 |
Family
ID=27757735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60325696T Expired - Lifetime DE60325696D1 (de) | 2002-02-22 | 2003-02-24 | Synthese von lipopolysaccharid-protein konjugatvaccinen über die lipid-a region nach entfernung des glycosidischen phosphatresidüs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050147624A1 (de) |
| EP (1) | EP1476197B1 (de) |
| AT (1) | ATE419873T1 (de) |
| AU (1) | AU2003206532A1 (de) |
| CA (1) | CA2477068A1 (de) |
| DE (1) | DE60325696D1 (de) |
| ES (1) | ES2320334T3 (de) |
| WO (1) | WO2003070282A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7749511B2 (en) | 2000-04-18 | 2010-07-06 | Endobiologics, Incorporated | Anti-sepsis conjugate vaccine |
| WO2001078787A2 (en) * | 2000-04-18 | 2001-10-25 | Endobiologics, Incorporated | Lipopolysaccharide-conjugate vaccine for sepsis treatment |
| AU2005243548A1 (en) * | 2004-05-14 | 2005-11-24 | National Research Council Canada | Conserved inner core lipopolysaccharide epitopes as multi-species vaccine candidates |
| US8975043B2 (en) | 2005-11-23 | 2015-03-10 | National Research Council Of Canada | Enzymatic degradation of lipid A fatty acids of bacterial LPS |
| US8795680B2 (en) * | 2006-07-21 | 2014-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for conjugation of oligosaccharides or polysaccharides to protein carriers through oxime linkages via 3-deoxy-D-manno-octulsonic acid |
| WO2008133645A2 (en) * | 2006-10-31 | 2008-11-06 | President And Fellows Of Harvard College | Combination vaccine for prevention of tularemia |
| JP2011503104A (ja) | 2007-11-09 | 2011-01-27 | カリフォルニア インスティテュート オブ テクノロジー | 免疫調節化合物ならびに関連組成物および方法 |
| EP2326671A4 (de) * | 2008-09-05 | 2012-10-03 | Ca Nat Research Council | Auf lps basierende impfstoffe |
| JP5597245B2 (ja) | 2009-03-24 | 2014-10-01 | ノバルティス アーゲー | アジュバント添加した髄膜炎菌ｈ因子結合タンパク質 |
| WO2010109324A1 (en) | 2009-03-24 | 2010-09-30 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| WO2011014771A1 (en) * | 2009-07-31 | 2011-02-03 | Wayne State University | Monophosphorylated lipid a derivatives |
| US9259476B2 (en) | 2009-07-31 | 2016-02-16 | Wayne State University | Monophosphorylated lipid A derivatives |
| WO2011024071A1 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| US20130071422A1 (en) | 2010-03-18 | 2013-03-21 | Michele Pallaoro | Adjuvanted vaccines for serogroup b meningococcus |
| JP6027961B2 (ja) * | 2010-04-07 | 2016-11-16 | シェン, ユエSHEN, Yue | 粘膜へ化合物を送るための媒体、それに関連する組成物、方法、及びシステム |
| EP2585106A1 (de) | 2010-06-25 | 2013-05-01 | Novartis AG | Kombinationen aus meningokokken-faktor-h-bindenden proteinen |
| JP6273200B2 (ja) | 2011-07-12 | 2018-01-31 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | 脂質含有ｐｓａ組成物、その単離の方法および使用の方法 |
| CA2862247A1 (en) | 2011-12-29 | 2013-07-04 | Novartis Ag | Adjuvanted combinations of meningococcal factor h binding proteins |
| US11052142B2 (en) * | 2013-06-04 | 2021-07-06 | Petr G. Aparin | Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
| US11331335B2 (en) | 2015-06-10 | 2022-05-17 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
| WO2017031431A1 (en) * | 2015-08-19 | 2017-02-23 | President And Fellows Of Harvard College | Lipidated psa compositions and methods |
| WO2018014012A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US6416763B1 (en) * | 1998-08-28 | 2002-07-09 | Hawaii Biotechnology Group, Inc. | Recombinant nonstructural protein subunit vaccine against flaviviral infection |
| US6531131B1 (en) * | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| WO2001078787A2 (en) * | 2000-04-18 | 2001-10-25 | Endobiologics, Incorporated | Lipopolysaccharide-conjugate vaccine for sepsis treatment |
| US7537766B2 (en) * | 2004-08-30 | 2009-05-26 | Wyeth | Neisseria meningitidis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof |
| JP4546846B2 (ja) * | 2005-01-24 | 2010-09-22 | 株式会社リコー | 画像形成装置 |
-
2003
- 2003-02-24 AU AU2003206532A patent/AU2003206532A1/en not_active Abandoned
- 2003-02-24 ES ES03704133T patent/ES2320334T3/es not_active Expired - Lifetime
- 2003-02-24 US US10/505,276 patent/US20050147624A1/en not_active Abandoned
- 2003-02-24 AT AT03704133T patent/ATE419873T1/de not_active IP Right Cessation
- 2003-02-24 DE DE60325696T patent/DE60325696D1/de not_active Expired - Lifetime
- 2003-02-24 EP EP03704133A patent/EP1476197B1/de not_active Expired - Lifetime
- 2003-02-24 WO PCT/CA2003/000254 patent/WO2003070282A2/en not_active Application Discontinuation
- 2003-02-24 CA CA002477068A patent/CA2477068A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1476197B1 (de) | 2009-01-07 |
| EP1476197A2 (de) | 2004-11-17 |
| CA2477068A1 (en) | 2003-08-28 |
| ES2320334T3 (es) | 2009-05-21 |
| ATE419873T1 (de) | 2009-01-15 |
| AU2003206532A1 (en) | 2003-09-09 |
| WO2003070282A2 (en) | 2003-08-28 |
| WO2003070282A3 (en) | 2004-02-05 |
| US20050147624A1 (en) | 2005-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |