JP2018528303A5 - - Google Patents

Download PDF

Info

Publication number
JP2018528303A5
JP2018528303A5 JP2018508753A JP2018508753A JP2018528303A5 JP 2018528303 A5 JP2018528303 A5 JP 2018528303A5 JP 2018508753 A JP2018508753 A JP 2018508753A JP 2018508753 A JP2018508753 A JP 2018508753A JP 2018528303 A5 JP2018528303 A5 JP 2018528303A5
Authority
JP
Japan
Prior art keywords
acyl chains
psa
composition
polysaccharide
glycolipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018508753A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018528303A (ja
JP6918365B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/047787 external-priority patent/WO2017031431A1/en
Publication of JP2018528303A publication Critical patent/JP2018528303A/ja
Publication of JP2018528303A5 publication Critical patent/JP2018528303A5/ja
Priority to JP2021116481A priority Critical patent/JP2021178967A/ja
Application granted granted Critical
Publication of JP6918365B2 publication Critical patent/JP6918365B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018508753A 2015-08-19 2016-08-19 脂質化psa組成物および方法 Expired - Fee Related JP6918365B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021116481A JP2021178967A (ja) 2015-08-19 2021-07-14 脂質化psa組成物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562207360P 2015-08-19 2015-08-19
US62/207,360 2015-08-19
PCT/US2016/047787 WO2017031431A1 (en) 2015-08-19 2016-08-19 Lipidated psa compositions and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021116481A Division JP2021178967A (ja) 2015-08-19 2021-07-14 脂質化psa組成物および方法

Publications (3)

Publication Number Publication Date
JP2018528303A JP2018528303A (ja) 2018-09-27
JP2018528303A5 true JP2018528303A5 (enExample) 2019-10-03
JP6918365B2 JP6918365B2 (ja) 2021-08-11

Family

ID=58051049

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018508753A Expired - Fee Related JP6918365B2 (ja) 2015-08-19 2016-08-19 脂質化psa組成物および方法
JP2021116481A Pending JP2021178967A (ja) 2015-08-19 2021-07-14 脂質化psa組成物および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021116481A Pending JP2021178967A (ja) 2015-08-19 2021-07-14 脂質化psa組成物および方法

Country Status (5)

Country Link
US (2) US10857177B2 (enExample)
EP (1) EP3337321A4 (enExample)
JP (2) JP6918365B2 (enExample)
CN (2) CN108135167B (enExample)
WO (1) WO2017031431A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6918365B2 (ja) * 2015-08-19 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 脂質化psa組成物および方法
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
CN109481472A (zh) * 2017-09-11 2019-03-19 广州知易生物科技有限公司 脆弱拟杆菌提取物在制备防治炎症性肠病的药物或食品中的应用

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids
US3723506A (en) 1971-08-11 1973-03-27 Univ Sherbrooke Oxidation of sugars
DE2917104A1 (de) 1979-04-27 1980-11-06 Hoechst Ag Verfahren zur viskositaetserniedrigung von celluloseethern durch ozon und seine verwendung
JPS56128721A (en) 1980-03-12 1981-10-08 Eisai Co Ltd Antiallergic agent
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
JPS60501259A (ja) 1983-05-06 1985-08-08 ウイスコンシン・アルムニ・リサ−チ・フアンデ−シヨン 免疫刺激活性をもつ単糖類化合物
JPS618945A (ja) 1984-06-25 1986-01-16 Nec Corp 半導体集積回路装置
SE456346B (sv) 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4619995A (en) 1984-12-24 1986-10-28 Nova Chem Limited N,O-carboxymethyl chitosan and preparative method therefor
DE3650242T2 (de) 1985-07-12 1995-06-14 Univ New York Mit dem plasmodium-vivax-circumsporozoit-protein übereinstimmendes immunogenes peptidantigen.
US4684727A (en) 1985-07-29 1987-08-04 Schering Corporation Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents
ATE107697T1 (de) 1986-03-26 1994-07-15 Genexpress Aps Biologische eindämmung.
US4775626A (en) 1986-05-23 1988-10-04 Syntex (U.S.A.) Inc. Method and compositions for protecting anerobic microorganisms
US4819617A (en) 1986-09-04 1989-04-11 University Of Florida Viscoelastic material for ophthalmic surgery
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
DE3704389A1 (de) 1987-02-12 1988-08-25 Blutspendedienst Dt Rote Kreuz Verfahren zur herstellung von lymphokinen durch induktion lymphoider zellen
US4835252A (en) 1987-02-26 1989-05-30 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
US5215896A (en) 1987-03-20 1993-06-01 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4937270A (en) 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5140016A (en) 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
DE3840044A1 (de) 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US5196510A (en) 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
FI895708A7 (fi) 1989-02-10 1990-08-11 Alko Ab Oy Vesiliukoinen hajoamistuote
US4952524A (en) 1989-05-05 1990-08-28 At&T Bell Laboratories Semiconductor device manufacture including trench formation
US5158939A (en) 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
ATE121947T1 (de) 1989-12-14 1995-05-15 Ca Nat Research Council Verbessertes meningokokkale polysaccharidkonjugatvakzin.
US5268454A (en) 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
US5130417A (en) 1990-04-30 1992-07-14 Washington University Entamoeba histolytical immunogenic protein and cdna clone
US5331573A (en) 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
KR940006696B1 (ko) 1991-01-16 1994-07-25 금성일렉트론 주식회사 반도체 소자의 격리막 형성방법
CA2059693C (en) 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
GB2254083A (en) 1991-03-28 1992-09-30 Italfarmaco Spa Anticoagulants from e.coli saccharide
GR920100122A (el) 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
US5705178A (en) 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5936076A (en) 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
US20050181021A1 (en) 1992-02-14 2005-08-18 Robert Lamb Vitamin E phosphate/phosphatidycholine liposomes to protect from or ameliorate cell damage
US5350941A (en) 1992-09-23 1994-09-27 Texas Instruments Incorporated Trench isolation structure having a trench formed in a LOCOS structure and a channel stop region on the sidewalls of the trench
IL107103A (en) 1992-09-24 2001-03-19 Brigham & Womens Hospital Multivalent vaccine based on conjugated molecule comprising a capsular polysaccharide linked to a protein and a method for the preparation thereof
US5433794A (en) 1992-12-10 1995-07-18 Micron Technology, Inc. Spacers used to form isolation trenches with improved corners
US5728385A (en) 1993-08-12 1998-03-17 Classen Immunotherapies, Inc. Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae
JPH09505603A (ja) 1993-11-26 1997-06-03 ヘンドリー,ローレンス,ビー. レセプター−リガンド−dna相互作用に係わる薬剤の設計
IL113812A (en) 1994-05-24 2000-06-29 Yeda Res & Dev Copolymer-1 pharmaceutical compositions containing it and its use
JPH07326664A (ja) 1994-05-31 1995-12-12 Fuji Electric Co Ltd ウエハの誘電体分離溝の充填方法
US5565204A (en) 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
US5679654A (en) 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5700787A (en) 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
NZ296748A (en) 1994-11-02 1999-11-29 Univ New York State Res Found Peripheral nervous system specific sodium channel proteins, DNA coding therefor, compositions and methods
US5858964A (en) 1995-04-14 1999-01-12 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
US5679658A (en) 1995-05-08 1997-10-21 Chitogenics, Inc. N,O-carbonxymethylchitosan for prevention of surgical adhesions
US5851808A (en) 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
JP2001519817A (ja) 1997-03-26 2001-10-23 ブリガム アンド ウイメンズ ホスピタル 糖断片生成法
ATE229038T1 (de) 1997-04-04 2002-12-15 Fidia Advanced Biopolymers Srl N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
US6749831B1 (en) 1997-05-16 2004-06-15 Medical Defense Technology, Llc Vaccine against lipopolysaccharide core
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
EP0908179A1 (en) 1997-08-23 1999-04-14 Werner Bollag Treatment of cell-mediated immune diseases
US6015787A (en) 1997-11-04 2000-01-18 New England Medical Center Hospitals, Inc. Cell-permeable protein inhibitors of calpain
AU3066599A (en) 1998-03-03 1999-10-18 University Of Southern California Use of cytokines and mitogens to inhibit graft versus host disease
AU752942B2 (en) 1998-04-13 2002-10-03 Massachusetts Institute Of Technology Comb copolymers for regulating cell-surface interactions
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
CA2366895A1 (en) 1999-04-02 2000-10-12 Brigham And Women's Hospital, Inc. Immunomodulating polymers
US7083777B1 (en) 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
EP1459757A1 (en) 1999-04-02 2004-09-22 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
JP2001055335A (ja) 1999-08-18 2001-02-27 Toshio Sato アレルギー性皮膚疾患治療剤
US6995237B1 (en) 1999-10-27 2006-02-07 Cel-Sci Corporation Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
CA2416120A1 (en) 2000-07-17 2002-01-24 Svend Laulund Methods and formulations with probiotic microorganisms and medicaments
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
US6670146B2 (en) 2000-10-04 2003-12-30 Schering Corporation Regulatory T cells; methods
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
CN1496266A (zh) 2001-01-12 2004-05-12 ������ҩ��ʽ���� 抗变态反应剂
EP1361863A2 (en) 2001-02-13 2003-11-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carotenoid-loaded liposomes
ATE489968T1 (de) 2001-03-09 2010-12-15 Id Biomedical Corp Quebec Proteosom-liposaccharid-vakzine-adjuvans
US20050101012A1 (en) 2001-03-12 2005-05-12 Gerold Schuler CD4+CD25+ regulatory T cells from human blood
EP1409009A1 (en) * 2001-06-15 2004-04-21 Nordic Vaccine Technology A/S Therapeutical vaccination
EP1308167A1 (de) 2001-11-06 2003-05-07 Pickl, Winfried, Ao. Univ. Prof. Dr. Antigenpräsentierende Vesikel
GB0130123D0 (en) 2001-12-17 2002-02-06 Microbiological Res Agency Outer membrane vesicle vaccine and its preparation
US20030147865A1 (en) 2002-02-07 2003-08-07 Benoit Salomon Cell therapy using immunoregulatory T-cells
ES2320334T3 (es) * 2002-02-22 2009-05-21 National Research Council Of Canada Uso de analogos de acidos grasos para el tratamiento y/o prevencion de enfermedades proliferativas de la piel.
US7629313B2 (en) 2002-03-08 2009-12-08 Eli Lilly And Company Immunomodulatory polymeric antigens for treating inflammatory pathologies
CA2479246C (en) 2002-03-13 2017-05-09 Laurie E. Comstock Method for overexpression of zwitterionic polysaccharides
US7829289B2 (en) 2002-05-14 2010-11-09 Institut National De La Sante Et De Recherche Medicale T cell subpopulation regulating gut immunity
GB0213622D0 (en) 2002-06-13 2002-07-24 Glaxosmithkline Biolog Sa Vaccine Corporation
DK1531832T3 (da) 2002-06-28 2009-07-27 Glykos Finland Oy Terapeutiske sammensætninger til anvendelse ved profylakse eller behandling af diarré
US20060160153A1 (en) 2002-12-03 2006-07-20 Jean-Pierre Abastado Method to measure a t cell response and its uses to qualify antigen-presenting cells
US20040219160A1 (en) 2003-03-31 2004-11-04 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
NZ543467A (en) 2003-04-10 2008-07-31 Novartis Vaccines & Diagnostic The severe acute respiratory syndrome coronavirus
US20050048587A1 (en) 2003-07-17 2005-03-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor
US6846807B1 (en) 2003-07-25 2005-01-25 Board Of Regents, The University Of Texas System Colorectal neoplasia prophylaxis
JP2007518394A (ja) 2003-08-14 2007-07-12 ザ バイオ バランス コーポレイション 細菌菌株、該細菌菌株を含む組成物、およびそのプロバイオティクス使用
DE10353593A1 (de) 2003-11-17 2005-06-23 Klinikum der Universität München Großhadern-Innenstadt Leptinantagonist und Verfahren zur quantitativen Messung von Leptin
CA2549001A1 (en) 2003-12-10 2005-06-30 Activbiotics, Inc. Rifamycin analogs and uses thereof
WO2006060117A2 (en) 2004-11-02 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Methods for inhibition of nkt cells
US8426146B2 (en) 2005-06-03 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Multiparameteric method for assessing immune system status
AU2006297896B2 (en) 2005-10-06 2011-12-08 Probi Ab Use of lactobacillus for treatment of autoimmune diseases
AU2006335256B2 (en) 2005-11-22 2012-10-18 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
CN100366737C (zh) 2006-03-01 2008-02-06 哈尔滨美华生物技术股份有限公司 固定化乳糖酶生产方法
US8802419B2 (en) 2006-03-02 2014-08-12 University Of Massachusetts Modified pathogens for use as vaccines
WO2007136719A2 (en) 2006-05-18 2007-11-29 Biobalance Llc Biotherapeutic compositions comprising probiotic escherichia coli and uses thereof
EP2032695B1 (en) 2006-05-31 2018-08-15 The Regents of The University of California Cd127 expression inversely correlates with foxp3 and suppressive function of cd4+ tregs
PT103495B (pt) 2006-06-05 2017-05-12 Faculdade De Farmácia Da Univ De Lisboa Pró-fármacos de ácidos orgânicos e composições farmacêuticas contendo os referidos pró-fármacos
KR101378872B1 (ko) 2006-09-26 2014-04-11 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) 합성 애주번트를 함유하는 백신 조성물
HUE030386T2 (en) 2007-01-31 2017-05-29 Yeda Res & Dev Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
TW200904340A (en) 2007-05-11 2009-02-01 Mannatech Inc Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same
US8092998B2 (en) 2007-05-31 2012-01-10 Abbott Laboratories Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders
US20100221755A1 (en) 2007-06-15 2010-09-02 University Of Rochester Use of antibody secreting cell elispot to assess antibody responses following antigen exposure
WO2009035528A2 (en) * 2007-09-07 2009-03-19 University Of Georgia Research Foundation, Inc. Synthetic lipid a derivative
US20110002965A1 (en) 2007-11-09 2011-01-06 Round June L Immunomodulating compounds and related compositions and methods
EP2217250A4 (en) 2007-11-09 2011-01-05 California Inst Of Techn IMMUNOMODULATING COMPOUNDS AND RELEVANT COMPOSITIONS AND METHODS
TWI468188B (zh) 2008-01-30 2015-01-11 Univ Tokushima Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation
FR2930264B1 (fr) 2008-04-18 2013-02-22 Gervais Danone Sa Nouvelle souche de lactobacillus paracasei subsp. paracasei dotee de proprietes antimicrobiennes et immunomodulatrices.
WO2009149149A1 (en) 2008-06-04 2009-12-10 Trustees Of Dartmouth College Prevention or treatment of immune-relevant disease by modification of microfloral populations
EP2326671A4 (en) 2008-09-05 2012-10-03 Ca Nat Research Council LIPOPOLYOSIDIC VACCINES
US20100081956A1 (en) 2008-09-30 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, composition, and system to control pH in pulmonary tissue of a subject
JP2012524910A (ja) 2009-04-23 2012-10-18 カリフォルニア インスティチュート オブ テクノロジー 免疫調節物質の同定方法及びシステム
US8580278B2 (en) 2009-06-03 2013-11-12 Trustees Of Dartmouth College Nutraceutical composition and methods for preventing or treating multiple sclerosis
US20100311686A1 (en) 2009-06-03 2010-12-09 Kasper Lloyd H Nutraceutical composition and methods for preventing or treating multiple sclerosis
HUE040658T2 (hu) 2010-04-07 2019-03-28 California Inst Of Techn Vivõanyag vegyület mukózus membránhoz juttatásához és kapcsolódó készítmények, eljárások és rendszerek
US20110287048A1 (en) 2010-05-20 2011-11-24 Round June L Antigen Specific Tregs and related compositions, methods and systems
WO2011153226A2 (en) 2010-06-01 2011-12-08 Moore Research Enterprises Llc Cellular constituents from bacteroides, compositions thereof, and therapeutic methods employing bacteroides or cellular constituents thereof
US20140030807A1 (en) 2010-07-20 2014-01-30 Trustees Of Dartmouth College Method for stimulating foxp3+ regulatory t cell expression of cd39
HUE038600T2 (hu) 2010-10-07 2018-10-29 California Inst Of Techn Probiotikus terápiák autizmushoz
US20130064859A1 (en) 2011-01-28 2013-03-14 Sarkis K. Mazmanian Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease
EP2731617A4 (en) 2011-07-12 2015-07-01 Brigham & Womens Hospital LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR
WO2013019896A1 (en) 2011-08-01 2013-02-07 Symbiotix Biotherapies, Inc. Platform for identifying and/or characterizing immunomodulatory agents
WO2013036290A1 (en) 2011-09-09 2013-03-14 Yale University Compositions and methods for assessing and treating inflammatory diseases and disorders
EP2764090B1 (en) 2011-10-03 2017-12-13 California Institute of Technology Generation of psa-only producing mutant strain
US20140072534A1 (en) 2012-08-30 2014-03-13 California Institute Of Technology Novel therapy for multiple sclerosis using vitamin d and gut bacteria
WO2014182966A1 (en) 2013-05-10 2014-11-13 California Institute Of Technology Probiotic prevention and treatment of colon cancer
BR112016021692A2 (pt) 2014-03-25 2017-08-15 The Government Of The Us Secretary Of The Army Métodos de preparação de uma composição imunogênica e de aperfeiçoamento de potência imunoestimuladora de vacinas adsorvidas em sal de alumínio, composição imunogênica e uso de uma composição de l(mpla)
JP6918365B2 (ja) 2015-08-19 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 脂質化psa組成物および方法
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use

Similar Documents

Publication Publication Date Title
Liu et al. Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis by modulating gut microbiota and bile acid metabolism
Niu et al. Structural characterization and immunomodulatory activity of a mannose-rich polysaccharide isolated from bifidobacterium breve H4–2
FI110408B (fi) Menetelmä rakennetta antavan matriisin käsittävän farmaseuttisen koostumuksen valmistamiseksi
WO2022241163A1 (en) Methods of use of oligosaccharide compositions for modulating microbiota and their metabolic products, and as therapeutics for health applications
EP3341081B1 (en) Use of bifidobacterium longum and an exopolysaccharide produced thereby
US20120309711A1 (en) Modified pectins, compositions and methods related thereto
RU2744199C2 (ru) Композиция, содержащая олигосахариды грудного молока, применяемая для младенцев или детей младшего возраста в целях профилактики или лечения аллергических реакций
WO1996016973A1 (en) Keratan sulfate oligosaccharide fraction and drug containing the same
CN101835806A (zh) 外泌多糖
JP2014520932A5 (enExample)
JP2009528267A (ja) 治療を増強するグルカン
Wang et al. Astragalus polysaccharides: structure-immunomodulation relationships, multi-target pharmacological activities, and cutting-edge applications in immune modulation
CN109394692B (zh) 达沙替尼接枝型聚合物胶束、其冻干粉针剂及制备方法和应用
CN104031097B (zh) 一种含有唾液酸基团的脂质衍生物及其应用
KR102686373B1 (ko) 양친매성 진세노사이드를 포함하는 미셀 입자, 이를 포함하는 조성물 및 이의 제조 방법
CN1646554A (zh) 唾液酸化的碳水化合物
US20160220587A1 (en) Vitamin d complexes with de-vdbp and an unsaturated fatty acid, and their use in therapy
CN106008638A (zh) 盐酸氯胺酮的药物组合物及其在生物医药中的应用
CN113845603B (zh) 醇溶性均一多糖及其抗抑郁用途
US20030232785A1 (en) O-sulphated bacterial polysaccharides and their use
HU185315B (en) Siliconpolymer compositions for treating textile materials
JPH09176206A (ja) ミコバクテリウム・ツベルクロシスから抽出した複合多糖体およびその製造方法
US10736864B2 (en) Immunotherapeutic agent
US20150158956A1 (en) Multivalent antiviral compositions, methods of making, and uses thereof
EP3153163B1 (en) Pharmaceutical compound comprising 13 glycerides, formulation and application thereof