JP2014517835A5 - - Google Patents
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- JP2014517835A5 JP2014517835A5 JP2014510498A JP2014510498A JP2014517835A5 JP 2014517835 A5 JP2014517835 A5 JP 2014517835A5 JP 2014510498 A JP2014510498 A JP 2014510498A JP 2014510498 A JP2014510498 A JP 2014510498A JP 2014517835 A5 JP2014517835 A5 JP 2014517835A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- fusion protein
- seq
- biotin
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims 21
- 102000036639 antigens Human genes 0.000 claims 21
- 108091007433 antigens Proteins 0.000 claims 21
- 108020001507 fusion proteins Proteins 0.000 claims 14
- 102000037865 fusion proteins Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 102000043871 biotin binding protein Human genes 0.000 claims 8
- 108700021042 biotin binding protein Proteins 0.000 claims 8
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 4
- 230000036755 cellular response Effects 0.000 claims 3
- 230000002949 hemolytic effect Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 230000005875 antibody response Effects 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- 241000588923 Citrobacter Species 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229960002235 anthrax antigen Drugs 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000001932 seasonal effect Effects 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161484934P | 2011-05-11 | 2011-05-11 | |
| US61/484,934 | 2011-05-11 | ||
| US201261608168P | 2012-03-08 | 2012-03-08 | |
| US61/608,168 | 2012-03-08 | ||
| US201261609974P | 2012-03-13 | 2012-03-13 | |
| US61/609,974 | 2012-03-13 | ||
| PCT/US2012/037541 WO2012155053A1 (en) | 2011-05-11 | 2012-05-11 | Modified biotin-binding protein, fusion proteins thereof and applications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018126516A Division JP6666389B2 (ja) | 2011-05-11 | 2018-07-03 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517835A JP2014517835A (ja) | 2014-07-24 |
| JP2014517835A5 true JP2014517835A5 (enExample) | 2015-06-25 |
| JP6366501B2 JP6366501B2 (ja) | 2018-08-01 |
Family
ID=47139675
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510498A Active JP6366501B2 (ja) | 2011-05-11 | 2012-05-11 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2014510481A Active JP6152378B2 (ja) | 2011-05-11 | 2012-05-11 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2017105191A Active JP6502420B2 (ja) | 2011-05-11 | 2017-05-29 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2018126516A Active JP6666389B2 (ja) | 2011-05-11 | 2018-07-03 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2019052175A Pending JP2019104758A (ja) | 2011-05-11 | 2019-03-20 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2020026905A Active JP7336402B2 (ja) | 2011-05-11 | 2020-02-20 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2023133790A Active JP7679431B2 (ja) | 2011-05-11 | 2023-08-21 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510481A Active JP6152378B2 (ja) | 2011-05-11 | 2012-05-11 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2017105191A Active JP6502420B2 (ja) | 2011-05-11 | 2017-05-29 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2018126516A Active JP6666389B2 (ja) | 2011-05-11 | 2018-07-03 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2019052175A Pending JP2019104758A (ja) | 2011-05-11 | 2019-03-20 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2020026905A Active JP7336402B2 (ja) | 2011-05-11 | 2020-02-20 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2023133790A Active JP7679431B2 (ja) | 2011-05-11 | 2023-08-21 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (9) | US9499593B2 (enExample) |
| EP (4) | EP3881836A1 (enExample) |
| JP (7) | JP6366501B2 (enExample) |
| KR (4) | KR20140146993A (enExample) |
| CN (4) | CN108714212B (enExample) |
| AU (2) | AU2012253359B2 (enExample) |
| BR (2) | BR112013028892B1 (enExample) |
| CA (2) | CA2835628C (enExample) |
| ES (2) | ES2864764T3 (enExample) |
| MX (2) | MX2013013112A (enExample) |
| RU (2) | RU2632651C2 (enExample) |
| WO (2) | WO2012155007A1 (enExample) |
| ZA (2) | ZA201308461B (enExample) |
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| WO2011112906A2 (en) | 2010-03-12 | 2011-09-15 | Children's Medical Center Corporation | Novel immunogens and methods for discovery and screening thereof |
| ES2864764T3 (es) | 2011-05-11 | 2021-10-14 | Childrens Medical Center | Composición inmunogénica que presenta múltiples antígenos, y métodos y usos de la misma |
| US10500283B2 (en) * | 2011-05-30 | 2019-12-10 | National Institute Of Immunology | Vaccine composition capable of inducing memory antibody response from single point immunization |
| WO2013043643A1 (en) * | 2011-09-21 | 2013-03-28 | St. Jude Children's Research Hospital | Live, attenuated streptococcus pneumoniae strain and vaccine for protection against pneumococcal disease |
| US9274430B2 (en) | 2012-10-10 | 2016-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and devices for molecule sensing and method of manufacturing thereof |
| WO2014124228A1 (en) | 2013-02-07 | 2014-08-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| US9981997B2 (en) | 2013-10-31 | 2018-05-29 | Arizona Board Of Regents On Behalf Of Arizona State University | Chemical reagents for attaching affinity molecules on surfaces |
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