JP2018197237A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018197237A5 JP2018197237A5 JP2018126516A JP2018126516A JP2018197237A5 JP 2018197237 A5 JP2018197237 A5 JP 2018197237A5 JP 2018126516 A JP2018126516 A JP 2018126516A JP 2018126516 A JP2018126516 A JP 2018126516A JP 2018197237 A5 JP2018197237 A5 JP 2018197237A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- immunogenic composition
- amino acid
- antigen
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002163 immunogen Effects 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 102000043871 biotin binding protein Human genes 0.000 claims 16
- 108700021042 biotin binding protein Proteins 0.000 claims 16
- 230000000890 antigenic effect Effects 0.000 claims 15
- 150000004676 glycans Chemical class 0.000 claims 14
- 229920001282 polysaccharide Polymers 0.000 claims 14
- 239000005017 polysaccharide Substances 0.000 claims 14
- 108020001507 fusion proteins Proteins 0.000 claims 13
- 102000037865 fusion proteins Human genes 0.000 claims 13
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 230000028993 immune response Effects 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 230000005867 T cell response Effects 0.000 claims 4
- 230000036039 immunity Effects 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 241000588923 Citrobacter Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000005875 antibody response Effects 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000036755 cellular response Effects 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000002949 hemolytic effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- -1 1-cyano-4-dimethylaminopyridinium tetrafluoroborate Chemical compound 0.000 claims 1
- 241001112696 Clostridia Species 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 108010034143 Inflammasomes Proteins 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 229960002235 anthrax antigen Drugs 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000002421 cell wall Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000001932 seasonal effect Effects 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020026905A JP7336402B2 (ja) | 2011-05-11 | 2020-02-20 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2023133790A JP7679431B2 (ja) | 2011-05-11 | 2023-08-21 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161484934P | 2011-05-11 | 2011-05-11 | |
| US61/484,934 | 2011-05-11 | ||
| US201261608168P | 2012-03-08 | 2012-03-08 | |
| US61/608,168 | 2012-03-08 | ||
| US201261609974P | 2012-03-13 | 2012-03-13 | |
| US61/609,974 | 2012-03-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510498A Division JP6366501B2 (ja) | 2011-05-11 | 2012-05-11 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020026905A Division JP7336402B2 (ja) | 2011-05-11 | 2020-02-20 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018197237A JP2018197237A (ja) | 2018-12-13 |
| JP2018197237A5 true JP2018197237A5 (enExample) | 2019-02-28 |
| JP6666389B2 JP6666389B2 (ja) | 2020-03-13 |
Family
ID=47139675
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510498A Active JP6366501B2 (ja) | 2011-05-11 | 2012-05-11 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2014510481A Active JP6152378B2 (ja) | 2011-05-11 | 2012-05-11 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2017105191A Active JP6502420B2 (ja) | 2011-05-11 | 2017-05-29 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2018126516A Active JP6666389B2 (ja) | 2011-05-11 | 2018-07-03 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2019052175A Pending JP2019104758A (ja) | 2011-05-11 | 2019-03-20 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2020026905A Active JP7336402B2 (ja) | 2011-05-11 | 2020-02-20 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2023133790A Active JP7679431B2 (ja) | 2011-05-11 | 2023-08-21 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510498A Active JP6366501B2 (ja) | 2011-05-11 | 2012-05-11 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2014510481A Active JP6152378B2 (ja) | 2011-05-11 | 2012-05-11 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2017105191A Active JP6502420B2 (ja) | 2011-05-11 | 2017-05-29 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019052175A Pending JP2019104758A (ja) | 2011-05-11 | 2019-03-20 | 多重抗原提示免疫原性組成物、ならびにその方法および使用 |
| JP2020026905A Active JP7336402B2 (ja) | 2011-05-11 | 2020-02-20 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
| JP2023133790A Active JP7679431B2 (ja) | 2011-05-11 | 2023-08-21 | 修飾ビオチン結合タンパク質、その融合タンパク質、および用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (9) | US9499593B2 (enExample) |
| EP (4) | EP3881836A1 (enExample) |
| JP (7) | JP6366501B2 (enExample) |
| KR (4) | KR20140146993A (enExample) |
| CN (4) | CN108714212B (enExample) |
| AU (2) | AU2012253359B2 (enExample) |
| BR (2) | BR112013028892B1 (enExample) |
| CA (2) | CA2835628C (enExample) |
| ES (2) | ES2864764T3 (enExample) |
| MX (2) | MX2013013112A (enExample) |
| RU (2) | RU2632651C2 (enExample) |
| WO (2) | WO2012155007A1 (enExample) |
| ZA (2) | ZA201308461B (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101139590B (zh) * | 2000-02-28 | 2012-07-18 | 启龙股份公司 | 奈瑟球菌蛋白质的杂交表达 |
| US9125863B2 (en) * | 2008-05-22 | 2015-09-08 | Children's Medical Center Corporation | Synergistic immunogenic fusion protein-polysaccharide conjugate |
| WO2011112906A2 (en) | 2010-03-12 | 2011-09-15 | Children's Medical Center Corporation | Novel immunogens and methods for discovery and screening thereof |
| ES2864764T3 (es) | 2011-05-11 | 2021-10-14 | Childrens Medical Center | Composición inmunogénica que presenta múltiples antígenos, y métodos y usos de la misma |
| US10500283B2 (en) * | 2011-05-30 | 2019-12-10 | National Institute Of Immunology | Vaccine composition capable of inducing memory antibody response from single point immunization |
| WO2013043643A1 (en) * | 2011-09-21 | 2013-03-28 | St. Jude Children's Research Hospital | Live, attenuated streptococcus pneumoniae strain and vaccine for protection against pneumococcal disease |
| US9274430B2 (en) | 2012-10-10 | 2016-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and devices for molecule sensing and method of manufacturing thereof |
| WO2014124228A1 (en) | 2013-02-07 | 2014-08-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| US9981997B2 (en) | 2013-10-31 | 2018-05-29 | Arizona Board Of Regents On Behalf Of Arizona State University | Chemical reagents for attaching affinity molecules on surfaces |
| WO2016044588A1 (en) | 2014-09-19 | 2016-03-24 | The Regents Of The University Of Michigan | Staphylococcus aureus materials and methods |
| CN104548101B (zh) * | 2015-01-31 | 2017-02-22 | 广东海大畜牧兽医研究院有限公司 | 一种诱导哺乳动物乳腺黏膜产生IgA的免疫增强剂及其制备方法和应用 |
| CN105646681B (zh) * | 2016-01-21 | 2021-07-16 | 浙江海隆生物科技有限公司 | 一种奶牛金黄色葡萄球菌α-溶血素亚单位疫苗的制备方法及应用 |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| US20190119332A1 (en) * | 2016-05-04 | 2019-04-25 | The Children's Medical Center Corporation | Methods to purify avidin-like proteins and fusion proteins thereof |
| US10751398B2 (en) * | 2016-10-07 | 2020-08-25 | Loyola University Chicago | Inflammasome activators and methods of use to treat tumors |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| US20180161433A1 (en) * | 2017-03-22 | 2018-06-14 | Timothy Andrew Erickson | Size tunable microbial mimetics for immunotherapy of thyroid carcinomas and solid tumors |
| CN110730670A (zh) * | 2017-03-28 | 2020-01-24 | 儿童医疗中心有限公司 | 基于多抗原提呈系统(maps)的金黄色葡萄球菌疫苗、免疫原性组合物以及它们的用途 |
| WO2018217564A1 (en) * | 2017-05-22 | 2018-11-29 | The Children's Medical Center Corporation | Combined vaccine against mycobacterium tuberculosis |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| CN111132691A (zh) | 2017-06-10 | 2020-05-08 | 创赏有限公司 | 提供改善的免疫原性和亲合力的具有二价或多价缀合物多糖的多价缀合物疫苗 |
| JP2020525540A (ja) | 2017-06-23 | 2020-08-27 | ノソコミアル ヴァクスィーン コーポレイション | 免疫原性組成物 |
| WO2019018635A1 (en) * | 2017-07-19 | 2019-01-24 | Children's Medical Center Corporation | COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH IMPRESSIVE FAULT |
| US11541110B2 (en) | 2017-10-13 | 2023-01-03 | The Research Foundation For The State University Of New York | Comprehensive vaccine design for commensal disease progression |
| US12053486B2 (en) | 2018-03-09 | 2024-08-06 | Therazure LLC | Compositions for the treatment of infections in feet |
| CN108339115B (zh) * | 2018-05-11 | 2020-07-10 | 武汉博沃生物科技有限公司 | 使用重组载体蛋白的肺炎球菌联合疫苗及其制备方法 |
| WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| JP2021535921A (ja) | 2018-09-12 | 2021-12-23 | アフィニバックス、インコーポレイテッド | 多価肺炎球菌ワクチン |
| JP7535791B2 (ja) * | 2018-09-12 | 2024-08-19 | ザ チルドレンズ メディカル センター コーポレーション | 肺炎球菌融合タンパク質ワクチン |
| WO2020086742A1 (en) | 2018-10-24 | 2020-04-30 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| CN109400704B (zh) * | 2018-11-14 | 2020-07-21 | 珠海泰诺麦博生物技术有限公司 | 一种抗金黄色葡萄球菌α-溶血素的抗体及其应用 |
| KR20210149251A (ko) | 2019-03-08 | 2021-12-08 | 옵시디안 테라퓨틱스, 인크. | 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법 |
| WO2020223240A1 (en) * | 2019-04-29 | 2020-11-05 | The Broad Institute, Inc. | Affinity-based multiplexing for live-cell monitoring of complex cell populations |
| EP3983538A1 (en) | 2019-06-12 | 2022-04-20 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2020252404A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| CN111518822B (zh) * | 2019-07-02 | 2022-08-09 | 江南大学 | 一种硫酸软骨素abc裂解酶突变体及其分泌表达的方法 |
| JP2021029171A (ja) * | 2019-08-23 | 2021-03-01 | 国立大学法人東京農工大学 | ブレビバチルス菌を用いた表層提示法 |
| US20220348937A1 (en) | 2019-09-06 | 2022-11-03 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| WO2021092206A1 (en) * | 2019-11-05 | 2021-05-14 | Beth Israel Deaconess Medical Center, Inc. | Mycobacterial compositions and biomarkers for use in treatment and monitoring of therapeutic responsiveness |
| US20230340402A1 (en) * | 2019-12-27 | 2023-10-26 | Amolifescience Co., Ltd. | Cell culture substrate and manufacturing method thereof |
| JP2023508478A (ja) * | 2019-12-27 | 2023-03-02 | アモライフサイエンス カンパニー リミテッド | 細胞培養基材及びその製造方法 |
| EP4192499A4 (en) | 2020-08-10 | 2024-09-25 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| WO2022053016A1 (zh) * | 2020-09-14 | 2022-03-17 | 神州细胞工程有限公司 | 通过糖-冠状病毒rbd抗原缀合物提高免疫原性的方法 |
| US20240197853A1 (en) * | 2021-04-06 | 2024-06-20 | The Board Of Trustees Of The University Of Illinois | Multivalent cholera multiepitope fusion antigen (mefa) and methods of use |
| US20230233667A1 (en) | 2021-09-08 | 2023-07-27 | Affinivax, Inc. | Coronavirus vaccine |
| WO2023039223A1 (en) | 2021-09-09 | 2023-03-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
| WO2023069278A1 (en) * | 2021-10-20 | 2023-04-27 | Fina Biosolutions, Llc | Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines |
| MX2024005327A (es) | 2021-11-02 | 2024-05-21 | Arvada Therapeutics Inc | Composiciones y metodos de dsg2. |
| US20250064910A1 (en) * | 2021-12-02 | 2025-02-27 | The Children's Medical Center Corporation | A maps vaccine targeting salmonella enterica serovars |
| WO2023192997A2 (en) * | 2022-03-31 | 2023-10-05 | The Children's Medical Center Corporation | Immunogenic compositions for b-cell recall response to a polysaccharide antigen |
| WO2024081906A1 (en) * | 2022-10-14 | 2024-04-18 | The Children's Medical Center Corporation | A maps vaccine targeting group b streptococcus (gbs) |
| WO2024081871A1 (en) * | 2022-10-14 | 2024-04-18 | The Children's Medical Center Corporation | Shigella multiple antigen presenting immunogenic composition and fusion proteins thereof |
| IL321062A (en) | 2022-11-22 | 2025-07-01 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN115819624B (zh) * | 2022-12-16 | 2023-12-15 | 深圳华腾生物医药科技有限公司 | 一种重组融合蛋白及其制备方法和应用 |
| CN120826235A (zh) * | 2023-03-16 | 2025-10-21 | 艾芬尼维克斯公司 | 免疫原性组合物 |
| AU2024246082A1 (en) | 2023-03-30 | 2025-10-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN121057590A (zh) | 2023-04-14 | 2025-12-02 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024229176A1 (en) | 2023-05-04 | 2024-11-07 | Affinivax, Inc. | Rhizavidin variants |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025080776A2 (en) * | 2023-10-13 | 2025-04-17 | The Children's Medical Center Corporation | Vaccine compositions comprising sialic acid binding domain (sbd) proteins and use thereof to enhance immune response |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025193903A1 (en) | 2024-03-15 | 2025-09-18 | Affinivax, Inc. | Pneumococcal polysaccharide compositions and uses thereof |
| WO2025219908A2 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Media and fermentation methods for polysaccharide production in bacterial cell culture |
| CN118421577B (zh) * | 2024-06-28 | 2024-10-01 | 华南理工大学 | 酪氨酸酶突变体及其用途 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US244420A (en) | 1881-07-19 | Stove pipe threadeb and beader | ||
| US3887699A (en) | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| PH19942A (en) | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4673641A (en) | 1982-12-16 | 1987-06-16 | Molecular Genetics Research And Development Limited Partnership | Co-aggregate purification of proteins |
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| DE3413608A1 (de) | 1984-04-11 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Implantierbare zubereitungen von regulatorischen peptiden mit gesteuerter freisetzung und verfahren zu ihrer herstellung |
| US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| WO1988001513A1 (fr) | 1986-08-28 | 1988-03-10 | Teijin Limited | Complexe d'anticorps cytocide et procede de production |
| NZ224422A (en) | 1987-05-05 | 1990-11-27 | Molecular Eng Ass | Composition adapted for intranasal immunisation against viral infection comprising a glycoprotein complexed with a lipid |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| US5179007A (en) | 1989-07-07 | 1993-01-12 | The Texas A & M University System | Method and vector for the purification of foreign proteins |
| FR2664905B1 (fr) | 1990-07-18 | 1994-08-12 | Agronomique Inst Nat Rech | Baculovirus modifie, son procede d'obtention, et vecteurs d'expression obtenus a partir dudit baculovirus. |
| US5516657A (en) | 1992-05-11 | 1996-05-14 | Cambridge Biotech Corporation | Baculovirus vectors for expression of secretory and membrane-bound proteins |
| US5390111A (en) | 1993-11-12 | 1995-02-14 | General Electric Company | Method and system for processing cone beam data for reconstructing free of boundary-induced artifacts a three dimensional computerized tomography image |
| WO1995017515A1 (en) | 1993-12-23 | 1995-06-29 | University Technologies International Inc. | Methods of expressing proteins in insect cells and methods of killing insects |
| IL112372A (en) | 1994-02-07 | 2001-08-26 | Res Dev Foundation | Non-viral vector for the delivery of genetic information to cells |
| EP0814833B1 (en) | 1995-03-22 | 2003-05-28 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents |
| SE506793C2 (sv) | 1996-09-19 | 1998-02-09 | Atlas Copco Rocktech Ab | Kopplingsstycke för användning vid samtidig jord- och/eller bergborrning med en övre rotationsslaganordning och en undre slaganordning |
| WO1998018931A2 (en) | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| US6087328A (en) | 1997-04-24 | 2000-07-11 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Coupling of unmodified proteins to haloacyl or dihaloacyl derivatized polysaccharides for the preparation of protein-polysaccharide vaccines |
| US7060458B1 (en) * | 1997-08-14 | 2006-06-13 | Wyeth | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics |
| WO1999012416A1 (en) | 1997-09-09 | 1999-03-18 | The Trustees Of Columbia University In The City Of New York | T-independent conjugate-vaccines |
| SE9900496D0 (sv) | 1999-02-12 | 1999-02-12 | Pharmatrix Ab | Vaccine formulation |
| US6398774B1 (en) | 1999-09-29 | 2002-06-04 | Heska Corporation | Intranasal delivery system |
| US8246945B2 (en) | 2000-04-06 | 2012-08-21 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
| US6919187B2 (en) | 2000-04-21 | 2005-07-19 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| US20020051794A1 (en) | 2000-08-09 | 2002-05-02 | Alk-Abello A/S | Novel parenteral vaccine formulations and uses thereof |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| WO2003094960A2 (en) | 2002-05-14 | 2003-11-20 | Chiron Srl | Mucosal combination vaccines for bacterial meningitis |
| EP1603950A2 (en) * | 2003-03-17 | 2005-12-14 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
| EP2336357A1 (en) | 2003-04-15 | 2011-06-22 | Intercell AG | S. pneumoniae antigens |
| AU2004255526A1 (en) | 2003-05-07 | 2005-01-20 | Aventis Pasteur, Inc. | Method of enhanced immunogenicity to meningococcal vaccination |
| EP1670509A4 (en) * | 2003-09-03 | 2007-10-31 | Dendritherapeutics Inc | MULTIPLEX VACCINES |
| US7556814B2 (en) | 2003-10-23 | 2009-07-07 | Karp Nelson M | Immunogenic compositions comprising UV-irradiated, psoralen-inactivated, desialated human immunodeficiency virus (HIV) devoid of CD55 and CD59 in the viral membrane |
| EP1708741B1 (en) | 2003-12-24 | 2016-03-30 | Aduro Biotech | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
| WO2005103073A2 (en) | 2004-04-27 | 2005-11-03 | Intercell Ag | Td antigens |
| GB0410220D0 (en) * | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
| CA2576083A1 (en) | 2004-08-18 | 2006-02-23 | Joel Weiner | Protein production method utilizing yebf |
| FI20041396A0 (fi) * | 2004-10-29 | 2004-10-29 | Vesa Pekka Hytoenen | Uudet mikrobiavidiinit |
| US20090028891A1 (en) | 2004-11-11 | 2009-01-29 | Queensland University Of Technology | Chlamydia Antigens and Uses Thereof |
| GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
| JP2008530037A (ja) | 2005-02-11 | 2008-08-07 | エース バイオサイエンシズ エー／エス | 表面に位置したＳｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅのポリペプチド |
| US20090148894A1 (en) * | 2005-08-15 | 2009-06-11 | Broedel Sheldon E | Methods for optimizing the secretion of protein in prokaryotes |
| CN101287488B (zh) | 2005-09-01 | 2013-01-30 | 诺华疫苗和诊断有限两合公司 | 含血清群c脑膜炎球菌的多价疫苗 |
| MX2008007292A (es) | 2005-12-08 | 2008-10-17 | Univ Louisville Res Found | Composiciones inmunoestimuladoras y metodos. |
| WO2007081583A2 (en) | 2006-01-04 | 2007-07-19 | Children's Medical Center Corporation | Anti-pneumococcal preparations and methods of use |
| US7943133B2 (en) | 2006-02-02 | 2011-05-17 | Boston Biocom Llc | Mesothelin antibody protein fusions and methods of use |
| US20080032340A1 (en) | 2006-06-09 | 2008-02-07 | University Of Arizona | Peptide motifs for binding avidin or neutravidin |
| WO2007149982A2 (en) | 2006-06-22 | 2007-12-27 | The Brigham And Women's Hospital, Inc. | Diagnosis of autoimmune disease |
| EP2041175A4 (en) * | 2006-06-23 | 2011-03-16 | Augmenta Biolog Llc | TARGETED IMMUNOJUGATE |
| US7452985B2 (en) | 2006-08-17 | 2008-11-18 | Visgeneer, Inc. | Human Ron-related gene variant associated with cancers |
| WO2008152448A2 (en) | 2006-12-21 | 2008-12-18 | Emergent Product Development Uk Limited | Streptococcus proteins, and their use in vaccination |
| CN100579152C (zh) | 2007-01-29 | 2010-01-06 | 华为技术有限公司 | 一种播放集团彩铃的方法、系统及装置 |
| EP2468869B1 (en) * | 2007-01-31 | 2015-03-18 | Pfenex Inc. | Bacterial leader sequences for increased expression |
| US8128939B2 (en) | 2007-04-13 | 2012-03-06 | The Board Of Regents Of The University Of Oklahoma | Mutants of cholesterol-dependent cytolysins and uses thereof |
| US9610339B2 (en) | 2007-06-26 | 2017-04-04 | Glaxosmithkline Biologicals, S.A. | Vaccine comprising Streptococcus pneumoniae capsular polysaccharide conjugates |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| WO2009020553A2 (en) | 2007-08-03 | 2009-02-12 | President And Fellows Of Harvard College | Chlamydia antigens |
| EP2176291A1 (en) | 2007-08-10 | 2010-04-21 | Wacker Chemie AG | Expression of full length igg and secretion into the culture medium of prokaryotic cells |
| CA2697538C (en) | 2007-08-31 | 2019-02-12 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
| BRPI0923649A2 (pt) | 2008-12-24 | 2016-01-19 | Netherlands Vaccine Inst | polipeptídeos de pneumolisina (ply) de streptococcus pneumoniae modificados. |
| EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| CA2758490C (en) | 2009-04-14 | 2023-05-02 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| US8828953B2 (en) | 2009-04-20 | 2014-09-09 | NaZura BioHealth, Inc. | Chemosensory receptor ligand-based therapies |
| MX2012000158A (es) | 2009-06-29 | 2012-06-08 | Genocea Biosciences Inc | Vacunas y composiciones contra streptococcus pneumoniae. |
| CN101797381B (zh) | 2010-01-29 | 2012-05-23 | 中国人民解放军第三军医大学 | 乙肝病毒抗原与路易斯寡糖的复合物及其制备方法和应用 |
| WO2011137354A2 (en) | 2010-04-30 | 2011-11-03 | Augmenta Biologicals, Llc | Delivery proteins |
| ES2864764T3 (es) | 2011-05-11 | 2021-10-14 | Childrens Medical Center | Composición inmunogénica que presenta múltiples antígenos, y métodos y usos de la misma |
| WO2014018904A1 (en) | 2012-07-26 | 2014-01-30 | Genocea Biosciences, Inc. | Fused antigen vaccines and compositions against streptococcus pneumoniae |
| WO2014124228A1 (en) | 2013-02-07 | 2014-08-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| CN110730670A (zh) | 2017-03-28 | 2020-01-24 | 儿童医疗中心有限公司 | 基于多抗原提呈系统(maps)的金黄色葡萄球菌疫苗、免疫原性组合物以及它们的用途 |
| JP2021535921A (ja) | 2018-09-12 | 2021-12-23 | アフィニバックス、インコーポレイテッド | 多価肺炎球菌ワクチン |
-
2012
- 2012-05-11 ES ES12781636T patent/ES2864764T3/es active Active
- 2012-05-11 JP JP2014510498A patent/JP6366501B2/ja active Active
- 2012-05-11 US US14/116,492 patent/US9499593B2/en active Active
- 2012-05-11 CN CN201810398905.7A patent/CN108714212B/zh active Active
- 2012-05-11 CN CN201810413217.3A patent/CN108840912B/zh active Active
- 2012-05-11 MX MX2013013112A patent/MX2013013112A/es unknown
- 2012-05-11 BR BR112013028892-2A patent/BR112013028892B1/pt active IP Right Grant
- 2012-05-11 CA CA2835628A patent/CA2835628C/en active Active
- 2012-05-11 EP EP21156431.5A patent/EP3881836A1/en active Pending
- 2012-05-11 JP JP2014510481A patent/JP6152378B2/ja active Active
- 2012-05-11 WO PCT/US2012/037412 patent/WO2012155007A1/en not_active Ceased
- 2012-05-11 RU RU2013154706A patent/RU2632651C2/ru active
- 2012-05-11 CA CA2835630A patent/CA2835630A1/en active Pending
- 2012-05-11 KR KR1020137032789A patent/KR20140146993A/ko not_active Ceased
- 2012-05-11 EP EP12781636.1A patent/EP2706991B1/en active Active
- 2012-05-11 KR KR1020137032751A patent/KR102084509B1/ko active Active
- 2012-05-11 KR KR1020217009127A patent/KR102494245B1/ko active Active
- 2012-05-11 CN CN201280034406.0A patent/CN103648489A/zh active Pending
- 2012-05-11 KR KR1020197025288A patent/KR102234933B1/ko active Active
- 2012-05-11 CN CN201280034719.6A patent/CN103732222B/zh active Active
- 2012-05-11 AU AU2012253359A patent/AU2012253359B2/en active Active
- 2012-05-11 RU RU2013154489A patent/RU2619176C2/ru active
- 2012-05-11 ES ES12782582T patent/ES2864765T3/es active Active
- 2012-05-11 MX MX2013013111A patent/MX2013013111A/es unknown
- 2012-05-11 US US14/116,402 patent/US10766932B2/en active Active
- 2012-05-11 WO PCT/US2012/037541 patent/WO2012155053A1/en not_active Ceased
- 2012-05-11 EP EP21156712.8A patent/EP3912619A1/en active Pending
- 2012-05-11 EP EP12782582.6A patent/EP2709603B1/en active Active
- 2012-05-11 AU AU2012253327A patent/AU2012253327B2/en active Active
- 2012-05-11 BR BR112013028887-6A patent/BR112013028887B1/pt active IP Right Grant
-
2013
- 2013-11-11 ZA ZA2013/08461A patent/ZA201308461B/en unknown
- 2013-11-11 ZA ZA2013/08465A patent/ZA201308465B/en unknown
-
2015
- 2015-11-19 US US14/946,372 patent/US10017548B2/en active Active
-
2017
- 2017-05-29 JP JP2017105191A patent/JP6502420B2/ja active Active
-
2018
- 2018-05-30 US US15/992,343 patent/US10611805B2/en active Active
- 2018-07-03 JP JP2018126516A patent/JP6666389B2/ja active Active
-
2019
- 2019-03-20 JP JP2019052175A patent/JP2019104758A/ja active Pending
-
2020
- 2020-02-10 US US16/785,937 patent/US11560410B2/en active Active
- 2020-02-20 JP JP2020026905A patent/JP7336402B2/ja active Active
- 2020-07-31 US US16/945,714 patent/US11981708B2/en active Active
-
2022
- 2022-10-13 US US18/046,485 patent/US11976097B2/en active Active
-
2023
- 2023-08-21 JP JP2023133790A patent/JP7679431B2/ja active Active
-
2024
- 2024-03-20 US US18/611,637 patent/US20240425553A1/en active Pending
- 2024-04-03 US US18/626,126 patent/US20250066429A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018197237A5 (enExample) | ||
| JP2020079300A5 (enExample) | ||
| JP2014517835A5 (enExample) | ||
| Kumar et al. | Bacterial protein toll-like-receptor agonists: a novel perspective on vaccine adjuvants | |
| CA2759583C (en) | A tuberculosis tb vaccine to prevent reactivation | |
| Mäkelä | Vaccines, coming of age after 200 years | |
| JP2023162283A5 (enExample) | ||
| Sijts et al. | Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies. | |
| JP2014514363A5 (enExample) | ||
| RU2013154706A (ru) | Модифицированный биотин-связывающий белок, слитые белки на его основе и их применение | |
| JP2011524737A5 (enExample) | ||
| Mader et al. | Endotoxicity does not limit the use of bacterial ghosts as candidate vaccines | |
| JP2013502918A5 (enExample) | ||
| JP2015536134A5 (enExample) | ||
| JP2004526405A5 (enExample) | ||
| Newman et al. | Immunological and formulation design considerations for subunit vaccines | |
| JP2012532626A5 (enExample) | ||
| JP2003519668A5 (enExample) | ||
| JP2013523084A5 (enExample) | ||
| ATE328085T1 (de) | Identifizierung und klonierung eines mycobakterien antigens der einer heparin- bindenden hemaglutinin entspricht | |
| de Velasco et al. | Synthetic peptides representing T-cell epitopes act as carriers in pneumococcal polysaccharide conjugate vaccines | |
| Ferreira et al. | A highly effective component vaccine against nontyphoidal Salmonella enterica infections | |
| JP2012526519A5 (enExample) | ||
| JP2004503217A5 (enExample) | ||
| Del Giudice | Hsp70: a carrier molecule with built-in adjuvanticity |