JP2003519668A5 - - Google Patents
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- Publication number
- JP2003519668A5 JP2003519668A5 JP2001551504A JP2001551504A JP2003519668A5 JP 2003519668 A5 JP2003519668 A5 JP 2003519668A5 JP 2001551504 A JP2001551504 A JP 2001551504A JP 2001551504 A JP2001551504 A JP 2001551504A JP 2003519668 A5 JP2003519668 A5 JP 2003519668A5
- Authority
- JP
- Japan
- Prior art keywords
- heat shock
- shock protein
- binding domain
- protein
- atp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 24
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 24
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 20
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 20
- 238000000034 method Methods 0.000 description 14
- 239000000427 antigen Substances 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 11
- 108091007433 antigens Proteins 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 125000000539 amino acid group Chemical group 0.000 description 6
- 244000045947 parasite Species 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 108090000288 Glycoproteins Proteins 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000002538 fungal effect Effects 0.000 description 3
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 description 2
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 description 2
- 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 description 2
- 101150031823 HSP70 gene Proteins 0.000 description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 101150052825 dnaK gene Proteins 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 101150086609 groEL2 gene Proteins 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241000186366 Mycobacterium bovis Species 0.000 description 1
- 108700009457 Mycobacterium tuberculosis HSP70 Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17614300P | 2000-01-14 | 2000-01-14 | |
| US60/176,143 | 2000-01-14 | ||
| PCT/US2000/032831 WO2001051081A1 (en) | 2000-01-14 | 2000-12-01 | In vivo ctl elicitation by heat shock protein fusion proteins maps to a discrete atp binding domain and is cd4+ t cell-independent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519668A JP2003519668A (ja) | 2003-06-24 |
| JP2003519668A5 true JP2003519668A5 (enExample) | 2008-01-17 |
Family
ID=22643163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551504A Pending JP2003519668A (ja) | 2000-01-14 | 2000-12-01 | 熱ショックタンパク質融合タンパク質による、ｃｄ４＋ｔ細胞非依存性のインビボｃｔｌ惹起による個別ａｔｐ結合ドメインのマッピング |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6875435B2 (enExample) |
| EP (1) | EP1253939B1 (enExample) |
| JP (1) | JP2003519668A (enExample) |
| AT (1) | ATE438408T1 (enExample) |
| AU (2) | AU1814101A (enExample) |
| CA (1) | CA2396384A1 (enExample) |
| DE (1) | DE60042704D1 (enExample) |
| WO (1) | WO2001051081A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69429723T2 (de) * | 1993-06-04 | 2002-09-26 | Whitehead Institute For Biomedical Research, Cambridge | Stressproteine und ihre verwendung |
| DE60042704D1 (de) | 2000-01-14 | 2009-09-17 | Whitehead Biomedical Inst | Induktion zytotoxischer lymphozyten durch hitzeschockprotein-fusionsproteine hängt von der atp-bindungsdomäne in hsp ab und is cd4+ unabhängig |
| EP1267618A1 (en) * | 2000-03-28 | 2003-01-02 | The Regents Of The University Of California | Methods for increasing a cytotoxic t lymphocyte response in vivo |
| US20050267020A1 (en) * | 2001-09-27 | 2005-12-01 | Olivier Faure | Polypeptides derived from inducible hsp70 and pharmaceutical compositions containing the same |
| WO2003068941A2 (en) * | 2002-02-13 | 2003-08-21 | Duke University | Modulation of immune response by non-peptide binding stress response polypeptides |
| US20090118173A1 (en) * | 2006-01-24 | 2009-05-07 | Universiteit Utrecht Uu Holding B.V. | Treatment and prevention of inflammatory bowel diseases |
| RU2333767C2 (ru) * | 2006-03-31 | 2008-09-20 | Автономная некоммерческая организация "Институт молекулярной диагностики" (АНО "ИнМоДи") | Вакцинные композиции, способы их применения для профилактики и лечения меланомы и генетические конструкции для получения действующих компонентов композиции |
| JP2010532785A (ja) * | 2007-07-06 | 2010-10-14 | ウニベルジテイト・ウトレヒト・ホールディング・ビー．ブイ． | 炎症性疾患および自己免疫疾患の治療および予防 |
| CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| WO2017156461A2 (en) * | 2016-03-10 | 2017-09-14 | Aperisys, Inc. | Antigen-binding fusion proteins with modified hsp70 domains |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666847A (en) * | 1981-01-16 | 1987-05-19 | Collaborative Research, Inc. | Recombinant DNA means and method |
| US4557931A (en) | 1982-12-02 | 1985-12-10 | Regents Of The University Of California | Antigenic compositions and methods for using same |
| NO172595C (no) | 1983-02-07 | 1993-08-11 | Battelle Memorial Institute | Fremgangsmaate og ekspresjonsplasmid for fremstilling av hemagglutinin under kontroll av drosophila hsp-promoter |
| US4797359A (en) * | 1983-05-10 | 1989-01-10 | Board Of Regents, The University Of Texas System | Heat shock regulated production of selected and fused proteins in yeast |
| GB8404280D0 (en) | 1984-02-17 | 1984-03-21 | Stanford J L | Biological preparations |
| IL71683A0 (en) | 1984-04-27 | 1984-09-30 | Yeda Res & Dev | Pharmaceutical compositions for treating arthritis type diseases comprising fractions obtained from mycobacteria |
| US4918164A (en) * | 1987-09-10 | 1990-04-17 | Oncogen | Tumor immunotherapy using anti-idiotypic antibodies |
| US4784941A (en) * | 1985-04-08 | 1988-11-15 | Genetic Systems Corporation | Expression and diagnostic use of pENV-3 encoded peptides which are immunologically reactive with antibodies to LAV |
| JPS62164696A (ja) | 1986-01-06 | 1987-07-21 | エフ．ホフマン ― ラ ロシュ アーゲー | ＨＴＬＶ−３ｇａｇ遺伝子の発現 |
| US4734362A (en) * | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
| US4906742A (en) | 1986-07-31 | 1990-03-06 | Whitehead Institute For Biomedical Research | Encoding antigens of M. Leprae |
| NL8701163A (nl) | 1986-09-09 | 1988-04-05 | Nederlanden Staat | Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits. |
| AU1548388A (en) | 1987-02-02 | 1988-08-24 | Whitehead Institute For Biomedical Research | Mycobacterium tuberculosis genes and encoding protein antigens |
| US4952395A (en) | 1987-02-26 | 1990-08-28 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
| US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
| US4918166A (en) | 1987-04-10 | 1990-04-17 | Oxford Gene Systems Limited | Particulate hybrid HIV antigens |
| US5256767A (en) * | 1987-06-10 | 1993-10-26 | The Immune Response Corporation | Retroviral antigens |
| NL8703107A (nl) | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
| US5204259A (en) * | 1988-05-06 | 1993-04-20 | Pharmacia Genetic Engineering, Inc. | Methods and systems for producing HIV antigens |
| CA1338778C (en) | 1988-06-15 | 1996-12-10 | Richard A. Young | Stress proteins and uses therefor |
| US5114844A (en) | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
| WO1990012030A1 (en) | 1989-04-06 | 1990-10-18 | Washington State University Research Foundation, Inc. | Rickettsial antigens for vaccination and diagnosis |
| AU5848090A (en) | 1989-06-19 | 1991-01-08 | Whitehead Institute For Biomedical Research | Vector-mediated genomic insertion and expression of dna in bcg |
| GB8919321D0 (en) | 1989-08-25 | 1989-10-11 | Univ London | Treatment of chronic inflammatory conditions |
| GB9007194D0 (en) | 1990-03-30 | 1990-05-30 | Wellcome Found | Live vaccines |
| GB9024320D0 (en) | 1990-11-08 | 1990-12-19 | Univ London | Treatment of uveitis |
| JPH06501479A (ja) | 1990-11-08 | 1994-02-17 | スタンフオード・ルツク・リミテツド | 抗原担体 |
| GB2251186A (en) | 1990-12-04 | 1992-07-01 | Randall Neal Gatz | Polypeptide for use in treatment of autoimmune disease |
| EP0521220A1 (en) | 1991-06-14 | 1993-01-07 | Institut Pasteur | Recombinant immunogenic actinomycetale |
| IT1262896B (it) * | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| US5580563A (en) | 1992-05-01 | 1996-12-03 | Tam; James P. | Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| DE69429723T2 (de) | 1993-06-04 | 2002-09-26 | Whitehead Institute For Biomedical Research, Cambridge | Stressproteine und ihre verwendung |
| AU686660B2 (en) * | 1993-08-11 | 1998-02-12 | Jenner Technologies | Prostatic cancer vaccine |
| US5961979A (en) | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| IL109790A0 (en) | 1994-05-25 | 1994-08-26 | Yeda Res & Dev | Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines |
| GB9419979D0 (en) | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| IL123219A0 (en) | 1995-08-18 | 1998-09-24 | Sloan Kettering Inst Cancer | Method for treatment of cancer and infectious diseases and compositions useful in same |
| US5935576A (en) * | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| WO1997026910A2 (de) * | 1996-01-27 | 1997-07-31 | Max-Delbrück-Centrum für Molekulare Medizin | Tumorimpfstoff für die immuntherapie von malignen tumoren |
| US6455493B1 (en) * | 1996-09-20 | 2002-09-24 | University Of New Mexico | Methods for using heat shock proteins |
| DK0941315T3 (da) | 1996-11-26 | 2006-05-15 | Stressgen Biotechnologies Corp | Fusionsproteiner indeholdende stressproteiner til induktion af immunreaktioner |
| WO1998035705A1 (en) * | 1997-02-18 | 1998-08-20 | Whitehead Institute For Biomedical Research | Use of heat shock proteins to deliver moieties into cells |
| PT1336621E (pt) * | 1997-08-05 | 2006-08-31 | Stressgen Biotechnologies Corp | Respostas imunitarias contra antigenios dos vph, suscitadas por composicoes que incorporam um antigenio de vph e uma proteina do stress ou um vector de expressao com aptidao para a expressao destas proteinas |
| EP1196772A2 (en) * | 1999-07-08 | 2002-04-17 | Stressgen Biotechnologies Corporation | Induction of a th1-like response in vitro |
| DE60042704D1 (de) | 2000-01-14 | 2009-09-17 | Whitehead Biomedical Inst | Induktion zytotoxischer lymphozyten durch hitzeschockprotein-fusionsproteine hängt von der atp-bindungsdomäne in hsp ab und is cd4+ unabhängig |
-
2000
- 2000-12-01 DE DE60042704T patent/DE60042704D1/de not_active Expired - Lifetime
- 2000-12-01 JP JP2001551504A patent/JP2003519668A/ja active Pending
- 2000-12-01 EP EP00980947A patent/EP1253939B1/en not_active Expired - Lifetime
- 2000-12-01 AU AU18141/01A patent/AU1814101A/en not_active Abandoned
- 2000-12-01 AT AT00980947T patent/ATE438408T1/de not_active IP Right Cessation
- 2000-12-01 CA CA002396384A patent/CA2396384A1/en not_active Abandoned
- 2000-12-01 WO PCT/US2000/032831 patent/WO2001051081A1/en not_active Ceased
-
2001
- 2001-01-16 US US09/761,534 patent/US6875435B2/en not_active Expired - Fee Related
-
2004
- 2004-07-01 US US10/885,523 patent/US7501125B2/en not_active Expired - Fee Related
-
2006
- 2006-03-17 AU AU2006201114A patent/AU2006201114B2/en not_active Ceased
-
2009
- 2009-03-09 US US12/400,774 patent/US20100040645A1/en not_active Abandoned
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