JP2004508065A5 - - Google Patents
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- Publication number
- JP2004508065A5 JP2004508065A5 JP2002526418A JP2002526418A JP2004508065A5 JP 2004508065 A5 JP2004508065 A5 JP 2004508065A5 JP 2002526418 A JP2002526418 A JP 2002526418A JP 2002526418 A JP2002526418 A JP 2002526418A JP 2004508065 A5 JP2004508065 A5 JP 2004508065A5
- Authority
- JP
- Japan
- Prior art keywords
- vector according
- antigen
- adenyl cyclase
- proteinaceous vector
- proteinaceous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013598 vector Substances 0.000 description 34
- 102000030621 adenylate cyclase Human genes 0.000 description 18
- 108060000200 adenylate cyclase Proteins 0.000 description 18
- 239000000427 antigen Substances 0.000 description 17
- 102000036639 antigens Human genes 0.000 description 17
- 108091007433 antigens Proteins 0.000 description 17
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 16
- 102100022338 Integrin alpha-M Human genes 0.000 description 16
- 210000004027 cell Anatomy 0.000 description 16
- 241001135529 Bordetella sp. Species 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 241000588807 Bordetella Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000002121 endocytic effect Effects 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 210000004443 dendritic cell Anatomy 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
- 210000000172 cytosol Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000006450 immune cell response Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000588832 Bordetella pertussis Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 210000003161 choroid Anatomy 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00402562A EP1188446B1 (en) | 2000-09-15 | 2000-09-15 | Proteinaceous vectors for molecule delivery to CD11b expressing cells |
| PCT/EP2001/011315 WO2002022169A2 (en) | 2000-09-15 | 2001-09-14 | VECTORS FOR MOLECULE DELIVERY TO CD11b EXPRESSING CELLS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004508065A JP2004508065A (ja) | 2004-03-18 |
| JP2004508065A5 true JP2004508065A5 (enExample) | 2011-12-01 |
Family
ID=8173866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526418A Pending JP2004508065A (ja) | 2000-09-15 | 2001-09-14 | ＣＤ１１ｂ発現細胞に対する分子送達用ベクター |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20040001867A1 (enExample) |
| EP (2) | EP1188446B1 (enExample) |
| JP (1) | JP2004508065A (enExample) |
| KR (2) | KR100953364B1 (enExample) |
| AT (2) | ATE438409T1 (enExample) |
| AU (2) | AU2001293855B2 (enExample) |
| BR (1) | BR0113915A (enExample) |
| CA (1) | CA2422603A1 (enExample) |
| CZ (1) | CZ2003726A3 (enExample) |
| DE (1) | DE60042687D1 (enExample) |
| ES (1) | ES2331348T3 (enExample) |
| HU (1) | HUP0303126A3 (enExample) |
| PL (1) | PL208864B1 (enExample) |
| PT (1) | PT1188446E (enExample) |
| RU (1) | RU2312143C2 (enExample) |
| WO (1) | WO2002022169A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2646776B1 (fr) | 1989-05-12 | 1994-06-03 | Pasteur Institut | Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella |
| PT1188446E (pt) | 2000-09-15 | 2009-11-10 | Pasteur Institut | Vectores proteinácios para a distribuição da molécula a células que expressam cd11b |
| EP1489092A1 (en) | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof |
| AU2004279621A1 (en) * | 2003-10-14 | 2005-04-21 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease |
| WO2005053738A1 (en) | 2003-11-21 | 2005-06-16 | Institut Pasteur | Recombinant adenylate cyclase toxin of bordetella induces t cell responses against tumoral antigens |
| SI1576967T1 (sl) | 2004-03-18 | 2008-02-29 | Pasteur Institut | Rekombinantni protein, ki nosi epitope humanega papilomavirusa, vstavljene v adenilat ciklazni protein ali njegov fragment, in njegove terapevtske uporabe |
| ES2291071B1 (es) * | 2005-06-13 | 2009-03-16 | Proyecto De Biomedicina Cima, S.L. | Agentes y metodos basados en el uso del dominio eda de la fibronectina. |
| ES2331271B1 (es) * | 2007-06-29 | 2010-10-14 | Universidad Del Pais Vasco | Metodo para la internalizacion de bacterias no invasivas en celulas eucariotas. |
| BRPI0913108A2 (pt) * | 2008-05-29 | 2017-06-20 | Trangene S A | método ex-vivo para testar se um paciente responderá terapeuticamente a um método de tratamento, uso de níveis de células exterminadores naturais ativadas como um biomarcador, e, kit |
| CN105602924A (zh) * | 2009-03-23 | 2016-05-25 | 巴斯德研究院 | 适合将免疫原性分子递送到细胞中的突变CyaA多肽及多肽衍生物 |
| PT2233569E (pt) | 2009-03-23 | 2014-10-06 | Pasteur Institut | Polipéptidos mutantes de cyaa e derivados de polipéptidos adequados para a entrega de moléculas imunogénicas numa célula |
| GB201003920D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| EP2478915A1 (en) * | 2011-01-24 | 2012-07-25 | Genticel | CyaA-carried polypeptide(s) and use to induce both therapeutic and prophylactic immune responses |
| EP2689786A1 (en) | 2012-07-23 | 2014-01-29 | Genticel | HPV/CYAA-based chimeric proteins and their uses in the induction of immune responses against HPV infection and HPV-induced disorders |
| EP2690172A1 (en) * | 2012-07-23 | 2014-01-29 | Genticel | CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses |
| EP2975120A1 (en) | 2014-07-17 | 2016-01-20 | Institut Pasteur | Monomeric and functional adenylate cyclase CyaA toxin |
| EP3323426A1 (en) | 2016-11-17 | 2018-05-23 | Ecole Nationale Vétérinaire de Toulouse | Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection |
| WO2018091613A1 (en) | 2016-11-17 | 2018-05-24 | Ecole Nationale Vétérinaire de Toulouse | Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection |
| EP3342421A1 (en) | 2016-12-27 | 2018-07-04 | Genticel | Immunogenic composition comprising cyaa-derived polypeptide promoting a th1/th17-oriented immune response |
| EP3703677A4 (en) * | 2017-11-03 | 2021-08-25 | MacKay Memorial Hospital | METHOD OF MODULATING TUMOR ASSOCIATED MYELOID CELLS AND IMPROVING IMMUNE CHECKPOINT BLOCKAGE |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2597605B1 (fr) * | 1986-04-16 | 1989-06-23 | Merieux Inst | Nouveau materiau pour chromatographie d'affinite et son application a la separation et a la purification des antigenes proteiques des bacteries du genre bordetella |
| FR2601679B1 (fr) * | 1986-07-15 | 1990-05-25 | Sanofi Sa | Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant |
| US5182211A (en) | 1987-08-07 | 1993-01-26 | Institut Pasteur | Plasmid vectors encoding a protein of a picornavirus |
| US5312902A (en) | 1988-06-09 | 1994-05-17 | Institut Pasteur | Dimer of the precursor of HIV-2 envelope glycoprotein |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| FR2638169B1 (fr) | 1988-10-25 | 1991-01-11 | Pasteur Institut | Derives d'adenyl cyclase et leurs utilisations biologiques |
| ATE123065T1 (de) | 1989-07-07 | 1995-06-15 | Takeda Chemical Industries Ltd | Proteine und deren herstellung. |
| NO175188C (no) | 1990-06-27 | 1994-09-14 | Sjur Olsnes | Fremgangsmåte for fremstilling av et peptidkonjugat med evne til å trenge inn i cellecytosol |
| US5935580A (en) * | 1992-04-21 | 1999-08-10 | Institut Pasteur | Recombinant mutants for inducing specific immune responses |
| DE69334155T2 (de) * | 1992-04-21 | 2008-02-14 | Institut Pasteur | Rekombinante mutanten zur induktion spezifischer immunantworten |
| EP0831817B1 (en) * | 1995-06-07 | 2001-03-14 | Joel K. Swadesh | Antigen-processing cell-targeted conjugates comprising a polyamino acid backbone and a non-steroidal anti-inflammatory agent |
| US5821122A (en) | 1995-06-07 | 1998-10-13 | Inserm (Institute Nat'l De La Sante Et De La Recherche . .) | Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof |
| AU2322097A (en) | 1996-03-27 | 1997-10-17 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| US6333154B1 (en) * | 1997-12-04 | 2001-12-25 | Institut Pasteur | Bacterial multi-hybrid system and applications thereof |
| US6673914B1 (en) | 1998-01-22 | 2004-01-06 | John Wayne Cancer Institute | Human tumor-associated gene |
| ATE418340T1 (de) * | 1999-05-06 | 2009-01-15 | Univ Wake Forest | Zusammensetzungen und methoden zur identifikation von antigenen, die eine immunantwort hervorrufen |
| JP2003512057A (ja) | 1999-10-19 | 2003-04-02 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Ｍａｇｅ−ａ１２抗原ペプチド及びその利用 |
| PT1188446E (pt) | 2000-09-15 | 2009-11-10 | Pasteur Institut | Vectores proteinácios para a distribuição da molécula a células que expressam cd11b |
| EP1489092A1 (en) * | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof |
| AU2004279621A1 (en) | 2003-10-14 | 2005-04-21 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease |
| WO2005053738A1 (en) | 2003-11-21 | 2005-06-16 | Institut Pasteur | Recombinant adenylate cyclase toxin of bordetella induces t cell responses against tumoral antigens |
| US20070026022A1 (en) | 2004-11-19 | 2007-02-01 | Gilles Dadaglio | Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens |
| SI1576967T1 (sl) | 2004-03-18 | 2008-02-29 | Pasteur Institut | Rekombinantni protein, ki nosi epitope humanega papilomavirusa, vstavljene v adenilat ciklazni protein ali njegov fragment, in njegove terapevtske uporabe |
| EP1894941A1 (en) | 2006-09-01 | 2008-03-05 | Institut Pasteur | Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens |
| US8017132B2 (en) * | 2009-03-23 | 2011-09-13 | Institut Pasteur | Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell |
-
2000
- 2000-09-15 PT PT00402562T patent/PT1188446E/pt unknown
- 2000-09-15 AT AT00402562T patent/ATE438409T1/de active
- 2000-09-15 DE DE60042687T patent/DE60042687D1/de not_active Expired - Lifetime
- 2000-09-15 EP EP00402562A patent/EP1188446B1/en not_active Expired - Lifetime
- 2000-09-15 ES ES00402562T patent/ES2331348T3/es not_active Expired - Lifetime
-
2001
- 2001-09-14 CA CA002422603A patent/CA2422603A1/en not_active Abandoned
- 2001-09-14 WO PCT/EP2001/011315 patent/WO2002022169A2/en not_active Ceased
- 2001-09-14 KR KR1020087015164A patent/KR100953364B1/ko not_active Expired - Fee Related
- 2001-09-14 JP JP2002526418A patent/JP2004508065A/ja active Pending
- 2001-09-14 RU RU2003110574/13A patent/RU2312143C2/ru not_active IP Right Cessation
- 2001-09-14 AT AT01974315T patent/ATE518880T1/de not_active IP Right Cessation
- 2001-09-14 KR KR1020037003818A patent/KR100879151B1/ko not_active Expired - Fee Related
- 2001-09-14 PL PL365743A patent/PL208864B1/pl unknown
- 2001-09-14 HU HU0303126A patent/HUP0303126A3/hu unknown
- 2001-09-14 EP EP01974315A patent/EP1317282B1/en not_active Expired - Lifetime
- 2001-09-14 BR BR0113915-0A patent/BR0113915A/pt not_active IP Right Cessation
- 2001-09-14 AU AU2001293855A patent/AU2001293855B2/en not_active Ceased
- 2001-09-14 CZ CZ2003726A patent/CZ2003726A3/cs unknown
- 2001-09-14 AU AU9385501A patent/AU9385501A/xx active Pending
-
2003
- 2003-03-14 US US10/387,486 patent/US20040001867A1/en not_active Abandoned
-
2005
- 2005-04-05 US US11/098,404 patent/US20050238637A1/en not_active Abandoned
-
2011
- 2011-06-27 US US13/169,605 patent/US9370564B2/en not_active Expired - Fee Related
-
2016
- 2016-06-08 US US15/177,029 patent/US10004794B2/en not_active Expired - Fee Related
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