NO175188C - Fremgangsmåte for fremstilling av et peptidkonjugat med evne til å trenge inn i cellecytosol - Google Patents
Fremgangsmåte for fremstilling av et peptidkonjugat med evne til å trenge inn i cellecytosolInfo
- Publication number
- NO175188C NO175188C NO902871A NO902871A NO175188C NO 175188 C NO175188 C NO 175188C NO 902871 A NO902871 A NO 902871A NO 902871 A NO902871 A NO 902871A NO 175188 C NO175188 C NO 175188C
- Authority
- NO
- Norway
- Prior art keywords
- preparing
- ability
- peptide conjugate
- cell cytosol
- penetrate cell
- Prior art date
Links
- 210000000172 cytosol Anatomy 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000863 peptide conjugate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO902871A NO175188C (no) | 1990-06-27 | 1990-06-27 | Fremgangsmåte for fremstilling av et peptidkonjugat med evne til å trenge inn i cellecytosol |
PCT/NO1991/000093 WO1992000099A1 (en) | 1990-06-27 | 1991-06-26 | Method of introducing a peptide into the cytosol |
AU80001/91A AU653158C (en) | 1990-06-27 | 1991-06-26 | Method of introducing a peptide into the cytosol |
JP3510777A JPH06503552A (ja) | 1990-06-27 | 1991-06-26 | 細胞質ゾル内にペプチドを導入する方法 |
EP91911315A EP0542756A1 (en) | 1990-06-27 | 1991-06-26 | Method of introducing a peptide into the cytosol |
CA002086342A CA2086342A1 (en) | 1990-06-27 | 1991-06-26 | Method of introducing a peptide into a cytosol |
HU924125A HUT63061A (en) | 1990-06-27 | 1991-06-26 | Process for entering peptide in cytosol |
FI925869A FI925869A0 (fi) | 1990-06-27 | 1992-12-23 | Foerfarande foer infoerande av en peptid i cytosol |
LTIP835A LTIP835A (en) | 1990-06-27 | 1993-08-03 | Method of introducting a peptide into the cytosol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO902871A NO175188C (no) | 1990-06-27 | 1990-06-27 | Fremgangsmåte for fremstilling av et peptidkonjugat med evne til å trenge inn i cellecytosol |
Publications (4)
Publication Number | Publication Date |
---|---|
NO902871D0 NO902871D0 (no) | 1990-06-27 |
NO902871L NO902871L (no) | 1991-12-30 |
NO175188B NO175188B (no) | 1994-06-06 |
NO175188C true NO175188C (no) | 1994-09-14 |
Family
ID=19893304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO902871A NO175188C (no) | 1990-06-27 | 1990-06-27 | Fremgangsmåte for fremstilling av et peptidkonjugat med evne til å trenge inn i cellecytosol |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0542756A1 (no) |
JP (1) | JPH06503552A (no) |
CA (1) | CA2086342A1 (no) |
FI (1) | FI925869A0 (no) |
HU (1) | HUT63061A (no) |
LT (1) | LTIP835A (no) |
NO (1) | NO175188C (no) |
WO (1) | WO1992000099A1 (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043057A (en) * | 1988-09-16 | 2000-03-28 | Vitec Aktiebolag | Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides |
US5314813A (en) * | 1992-02-19 | 1994-05-24 | Scripps Research Institute | Drosophila cell lines expressing genes encoding MHC class I antigens and B2-microglobulin and capable of assembling empty complexes and methods of making said cell lines |
ES2290950T3 (es) * | 1992-04-21 | 2008-02-16 | Institut Pasteur | Mutantes recombinantes para inducir respuestas inmunitarias especificas. |
US5935580A (en) * | 1992-04-21 | 1999-08-10 | Institut Pasteur | Recombinant mutants for inducing specific immune responses |
US6455673B1 (en) * | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
US6777546B2 (en) | 1997-10-07 | 2004-08-17 | Loma Linda University | Methods and substances for preventing and treating autoimmune disease |
US7422747B2 (en) | 1997-10-07 | 2008-09-09 | Loma Linda University | Transgenic plant-based vaccines |
US6004815A (en) * | 1998-08-13 | 1999-12-21 | The Regents Of The University Of California | Bacteria expressing nonsecreted cytolysin as intracellular microbial delivery vehicles to eukaryotic cells |
WO2001055169A1 (en) * | 2000-01-27 | 2001-08-02 | Loma Linda University | Transgenic plant-based vaccines |
EP1188446B1 (en) | 2000-09-15 | 2009-08-05 | Institut Pasteur | Proteinaceous vectors for molecule delivery to CD11b expressing cells |
GB0524408D0 (en) * | 2005-11-30 | 2006-01-11 | Glaxosmithkline Biolog Sa | Vaccines |
KR102430891B1 (ko) * | 2016-03-10 | 2022-08-09 | 더 존스 홉킨스 유니버시티 | 응집체-비함유 단량체성 디프테리아 독소 융합 단백질의 제조 방법 및 치료적 용도 |
US11965009B2 (en) | 2016-03-10 | 2024-04-23 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3369466D1 (en) * | 1982-05-12 | 1987-03-05 | Harvard College | Fused genes encoding hybrid proteins, cloning vectors containing them and the use thereof |
FR2532850B1 (fr) * | 1982-09-15 | 1985-12-20 | Pasteur Institut | Conjugues immunogenes entre un haptene et une molecule porteuse derivee d'une toxine, les vaccins les composant et procede pour leur obtention |
US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
IL89504A0 (en) * | 1988-03-08 | 1989-09-10 | Univ Wyoming | Diphtheria toxin derivative,process for the preparation thereof and pharmaceutical composition containing the same |
FR2636842B1 (fr) * | 1988-09-27 | 1994-06-10 | Liege Universite Etat | Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion |
JPH05502880A (ja) * | 1989-12-22 | 1993-05-20 | セラジェン・インコーポレーテッド | トランスロケーション領域および細胞結合領域を有するハイブリッド分子 |
-
1990
- 1990-06-27 NO NO902871A patent/NO175188C/no unknown
-
1991
- 1991-06-26 JP JP3510777A patent/JPH06503552A/ja active Pending
- 1991-06-26 CA CA002086342A patent/CA2086342A1/en not_active Abandoned
- 1991-06-26 EP EP91911315A patent/EP0542756A1/en not_active Withdrawn
- 1991-06-26 HU HU924125A patent/HUT63061A/hu unknown
- 1991-06-26 WO PCT/NO1991/000093 patent/WO1992000099A1/en not_active Application Discontinuation
-
1992
- 1992-12-23 FI FI925869A patent/FI925869A0/fi unknown
-
1993
- 1993-08-03 LT LTIP835A patent/LTIP835A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0542756A1 (en) | 1993-05-26 |
NO902871L (no) | 1991-12-30 |
LTIP835A (en) | 1995-02-27 |
AU653158B2 (en) | 1994-09-22 |
HU9204125D0 (en) | 1993-04-28 |
WO1992000099A1 (en) | 1992-01-09 |
FI925869A (fi) | 1992-12-23 |
CA2086342A1 (en) | 1991-12-28 |
JPH06503552A (ja) | 1994-04-21 |
NO175188B (no) | 1994-06-06 |
NO902871D0 (no) | 1990-06-27 |
FI925869A0 (fi) | 1992-12-23 |
AU8000191A (en) | 1992-01-23 |
HUT63061A (en) | 1993-07-28 |
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