LTIP835A - Method of introducting a peptide into the cytosol - Google Patents
Method of introducting a peptide into the cytosolInfo
- Publication number
- LTIP835A LTIP835A LTIP835A LTIP835A LTIP835A LT IP835 A LTIP835 A LT IP835A LT IP835 A LTIP835 A LT IP835A LT IP835 A LTIP835 A LT IP835A LT IP835 A LTIP835 A LT IP835A
- Authority
- LT
- Lithuania
- Prior art keywords
- introducting
- cytosol
- peptide
- Prior art date
Links
- 210000000172 cytosol Anatomy 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO902871A NO175188C (en) | 1990-06-27 | 1990-06-27 | Process for Preparing a Peptide Conjugate with the ability to penetrate cell cytosol |
Publications (1)
Publication Number | Publication Date |
---|---|
LTIP835A true LTIP835A (en) | 1995-02-27 |
Family
ID=19893304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP835A LTIP835A (en) | 1990-06-27 | 1993-08-03 | Method of introducting a peptide into the cytosol |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0542756A1 (en) |
JP (1) | JPH06503552A (en) |
CA (1) | CA2086342A1 (en) |
FI (1) | FI925869A0 (en) |
HU (1) | HUT63061A (en) |
LT (1) | LTIP835A (en) |
NO (1) | NO175188C (en) |
WO (1) | WO1992000099A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043057A (en) * | 1988-09-16 | 2000-03-28 | Vitec Aktiebolag | Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides |
US5314813A (en) * | 1992-02-19 | 1994-05-24 | Scripps Research Institute | Drosophila cell lines expressing genes encoding MHC class I antigens and B2-microglobulin and capable of assembling empty complexes and methods of making said cell lines |
US5935580A (en) * | 1992-04-21 | 1999-08-10 | Institut Pasteur | Recombinant mutants for inducing specific immune responses |
CA2133999A1 (en) * | 1992-04-21 | 1993-10-28 | Daniel Ladant | Recombinant mutants for inducing specific immune responses |
US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
US6777546B2 (en) | 1997-10-07 | 2004-08-17 | Loma Linda University | Methods and substances for preventing and treating autoimmune disease |
US7422747B2 (en) | 1997-10-07 | 2008-09-09 | Loma Linda University | Transgenic plant-based vaccines |
US6004815A (en) * | 1998-08-13 | 1999-12-21 | The Regents Of The University Of California | Bacteria expressing nonsecreted cytolysin as intracellular microbial delivery vehicles to eukaryotic cells |
WO2001055169A1 (en) * | 2000-01-27 | 2001-08-02 | Loma Linda University | Transgenic plant-based vaccines |
EP1188446B1 (en) | 2000-09-15 | 2009-08-05 | Institut Pasteur | Proteinaceous vectors for molecule delivery to CD11b expressing cells |
GB0524408D0 (en) * | 2005-11-30 | 2006-01-11 | Glaxosmithkline Biolog Sa | Vaccines |
US11965009B2 (en) | 2016-03-10 | 2024-04-23 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
BR112018068055A2 (en) * | 2016-03-10 | 2019-01-08 | Univ Johns Hopkins | methods for producing aggregate free monomeric diphtheria toxin fusion proteins and therapeutic uses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1203672B (en) * | 1982-05-12 | 1989-02-15 | Harvard College | HYBRID PROTEIN INCLUDING PROTEIN FRAGMENTS LINKED TO PEPTIDAL BONDS AND RELATED GENE OF MELTING COMPOSITION CONTAINING SUCH PROTEIN |
FR2532850B1 (en) * | 1982-09-15 | 1985-12-20 | Pasteur Institut | IMMUNOGENIC CONJUGATES BETWEEN A HAPTENA AND A CARRIER MOLECULE DERIVED FROM A TOXIN, THE VACCINES CONTAINING THEM AND PROCESS FOR OBTAINING THEM |
US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
IL89504A0 (en) * | 1988-03-08 | 1989-09-10 | Univ Wyoming | Diphtheria toxin derivative,process for the preparation thereof and pharmaceutical composition containing the same |
FR2636842B1 (en) * | 1988-09-27 | 1994-06-10 | Liege Universite Etat | FUSION PROTEIN OF A SEQUENCE DERIVED FROM CHOLERIC TOXIN B SUBUNIT B AND A HETEROLOGOUS ANTIGEN HAVING IMMUNOGENIC PROPERTIES, RECOMBINANT NUCLEIC ACID CONTAINING VACCINE COMPOSITIONS CONTAINING NUCLEOTIDITE CODING SEQUENCE |
CA2071969A1 (en) * | 1989-12-22 | 1991-06-23 | John R. Murphy | Hybrid molecules having translocation region and cell-binding region |
-
1990
- 1990-06-27 NO NO902871A patent/NO175188C/en unknown
-
1991
- 1991-06-26 CA CA002086342A patent/CA2086342A1/en not_active Abandoned
- 1991-06-26 WO PCT/NO1991/000093 patent/WO1992000099A1/en not_active Application Discontinuation
- 1991-06-26 EP EP91911315A patent/EP0542756A1/en not_active Withdrawn
- 1991-06-26 JP JP3510777A patent/JPH06503552A/en active Pending
- 1991-06-26 HU HU924125A patent/HUT63061A/en unknown
-
1992
- 1992-12-23 FI FI925869A patent/FI925869A0/en unknown
-
1993
- 1993-08-03 LT LTIP835A patent/LTIP835A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO175188B (en) | 1994-06-06 |
AU8000191A (en) | 1992-01-23 |
FI925869A (en) | 1992-12-23 |
JPH06503552A (en) | 1994-04-21 |
CA2086342A1 (en) | 1991-12-28 |
FI925869A0 (en) | 1992-12-23 |
NO902871L (en) | 1991-12-30 |
HUT63061A (en) | 1993-07-28 |
AU653158B2 (en) | 1994-09-22 |
WO1992000099A1 (en) | 1992-01-09 |
EP0542756A1 (en) | 1993-05-26 |
HU9204125D0 (en) | 1993-04-28 |
NO175188C (en) | 1994-09-14 |
NO902871D0 (en) | 1990-06-27 |
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