JP2014515942A - 薬物送達デバイスと薬物送達デバイス用のカートリッジホルダ - Google Patents
薬物送達デバイスと薬物送達デバイス用のカートリッジホルダ Download PDFInfo
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- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical class [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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Abstract
Description
に協動するとき、回転運動はすでに行われている。回転運動は、普通のねじ山連結から知られているように、使用者に非常に馴染みのある動きである。このように、使用者は連結運動に非常に馴染みを感じることができる。特に、カートリッジホルダのこの連結運動は、使用者がカートリッジホルダとボディの安全な連結を容易に信頼できるようにすることに役立つ。このようにして、高い使用者快適性を含むデバイスの供給が容易にされる。
と機械的に協動するとき、90度の最大角度だけ回転し得る。カートリッジホルダは、相互作用部材が第二のセクションと機械的に協動するとき、例えば10と20度の間の角度だけ回転し得る。好ましくは、カートリッジホルダは、相互作用部材が第二のセクションと機械的に協動するとき、15度の角度だけ回転し得る。
通過する。
位端は矢印8によって示される。近位端は矢印9によって示される。用語「遠位端」は、薬物送達デバイス1又は薬物送達デバイス1の投薬末端に最も近くに配置される、若しくは配置しようとするその部材のその末端を指定する。用語「近位端」は、デバイス1又はデバイス1の投与末端から最も離れて配置される若しくは配置しようとするその部材のその末端を指定する。遠位端及び近位端は、軸方向においてお互いの間隔をあけている。軸は、デバイス1の縦軸14になり得る(図1参照)。
ここで一つの実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、酵素、抗体、若しくはこのフラグメント、ホルモン、若しくはオリゴヌクレオチド、又は上記の薬学的に活性な化合物の混合物であり、
ここで更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチの治療、及び/又は、予防に有用である。
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の治療、及び/又は、予防のための、少なくとも1つのペプチドを含む。
ここで、更なる実施態様において、薬学的に活性な化合物は、少なくとも1つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセンジン−3又はエキセンジン−4、若しくはエキセンジン−3又はエキセンジン−4の類似体若しくは誘導体を含む。
インスリン;B29−N−(N−リトコリル−γ−グルタミル)−des(B30)ヒトインスリン;B29−N−(ω−カルボキシヘプタデカノイル)−des(B30)ヒトインスリン、及びB29−N−(ω−カルボキシヘプタデカノイル)ヒトインスリンである。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と連結してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)
−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,
Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のいずれかのエキセンジン−4誘導体の薬学的に許容可能な塩若しくは溶媒和物;
から選択される。
抗体では同一である。各重鎖の可変領域は約110のアミノ酸長があり、そして単一Igドメインから成っている。
は、薬物11の用量を投薬するためにボディ3に対して遠位方向にピストンロッド17を駆動する。駆動機構4,10,19は、用量設定運動中にボディ3に対してピストンロッド17の近位方向への動きを防止する。軸受部材15は、栓7の近位面に隣接するためにピストンロッド17の遠位端に設置される。
ッジホルダ2の軸方向運動が、第二のセクション12Bの遠位及び近位壁22,23と相互作用部材13の機械的協働によって防止されている。
2: カートリッジホルダ;
3: ボディ;
4: 駆動機構;
5: 係合手段;
6: カートリッジ;
7: 栓;
8: 遠位端;
9: 近位端;
10: 駆動機構;
11: 薬物;
12; ガイドトラック;
12A:第一のセクション;
12B:第二のセクション;
13: 相互作用部材;
14: 縦軸;
15: 軸受部材;
16: 窪み;
17: ピストンロッド;
19: 駆動機構;
20: 角のある端止め部;
21: キャップ;
22: 近位壁;
23: 遠位壁;
Claims (14)
- −少なくとも1つのガイドトラック(12)を含むカートリッジホルダ(2)、
−少なくとも1つのガイドトラック(12)と機械的に協動するように適合されそして配置された少なくとも1つの相互作用部材(13)を含むボディ(3)、
を含んでなる薬物送達デバイス(1)であって、
ここで、ガイドトラック(12)は、第一のセクション(12A)及び第二のセクション(12B)を含み、ここで、第一のセクション(12A)によって画成される経路は、デバイス(1)の縦軸(14)と角度を成し、ここで、縦軸(14)と、第一のセクション(12A)によって画成される経路によって囲まれた角度は、縦軸(14)と、第二のセクション(12B)によって画成された経路によって囲まれる角度より小さく、
ここで、カートリッジホルダ(2)をボディ(3)に連結するために、相互作用部材(13)は、カートリッジホルダ(2)を軸方向に移動し、そしてボディ(3)に対して回転するように、第一のセクション(12A)と機械的に協動するように構成され、そして相互作用部材(13)は、カートリッジホルダ(2)をボディ(3)に対して回転するように、第二のセクション(12B)と機械的に協動するように構成され、これによって、ボディ(3)に対してカートリッジホルダ(2)の軸方向運動が防止される、上記薬物送達デバイス(1)。 - カートリッジホルダ(2)は、相互作用部材(13)の第一及び第二のセクション(12A,12B)との機械的協動中、ボディ(3)に対して第一の方向に回転する、請求項1に記載の薬物送達デバイス(1)。
- 第二のセクション(12B)は、角のある端止め部(20)の相互作用部材(13)との機械的協動によって第一の方向へカートリッジホルダ(2)とボディ(3)の更なる相対的回転を防止するように適合されそして配置された角のある端止め部(20)を含む、請求項2に記載の薬物送達デバイス。
- 請求項1〜3のいずれか1項に記載の薬物送達デバイスであって、
ここで、カートリッジホルダ(2)は、相互作用部材(13)が第一のセクションと機械的に協動したとき、ボディ(3)に対して1回未満の回転数だけ回転し、ここで、カートリッジホルダ(2)は、相互作用部材(13)が第二のセクション(12B)と機械的に協動したとき、ボディ(3)に対して1回未満の回転数だけ回転する、上記薬物送達デバイス。 - カートリッジホルダ(2)は、相互作用部材(13)が第二のセクション(12B)と機械的に協動するときよりも、相互作用部材(13)が第一のセクション(12A)と機械的に協動するとき、ボディ(3)に対してより大きな角度だけ回転する、請求項1〜4のいずれか1項に記載の薬物送達デバイス(1)。
- カートリッジホルダ(2)とボディ(3)の連結を解除するために、相互作用部材(13)は、カートリッジホルダ(2)がボディ(3)に対して、第一の方向と反対になる第二の方向に回転するように、ガイドトラック(12)の第二のセクション(12B)及び第一のセクション(12A)と機械的に協動するように構成される、請求項2〜5のいずれか1項に記載の薬物送達デバイス(1)。
- ガイドトラック(12)の第一のセクション(12A)及び第二のセクション(12B)が、互いの中に通り越す、請求項1〜6のいずれか1項に記載の薬物送達デバイス(1)。
- 少なくとも1つのガイドトラック(12)は、カートリッジホルダ(2)の外面に配置される、請求項1〜7のいずれか1項に記載の薬物送達デバイス(1)。
- 請求項1〜8のいずれか1項に記載の薬物送達デバイス(1)であって、
ここで、ガイドトラック(12)は、カートリッジホルダ(2)の近位端セクションに配置され、ここで、近位端セクションは、少なくとも1つの窪み(16)を含み、ガイドトラック(12)は、窪み(16)の遠位端がガイドトラック(12)の第一のセクション(12A)の近位端に通り越すように配置される、上記薬物送達デバイス(1)。 - 少なくとも1つの相互作用部材(13)は、ボディ(3)の内面に配置される、請求項1〜9のいずれか1項に記載の薬物送達デバイス(1)。
- 少なくとも1つの相互作用部材(13)は突出部を含む、請求項1〜10のいずれか1項に記載の薬物送達デバイス(1)。
- 少なくとも1つのガイドトラック(12)は溝を含む、請求項1〜11のいずれか1項に記載の薬物送達デバイス(1)。
- 請求項1〜12のいずれか1項に記載の薬物送達デバイス(1)であって、
ここで、カートリッジホルダ(2)は、2つの異なるガイドトラック(12)を含み、ガイドトラック(12)は、互いに対して反対側に配置され、そして、ここで、ボディ(3)は、2つの異なる相互作用部材(13)を含み、相互作用部材(13)は、互いに対して反対側に配置される、上記薬物送達デバイス(1)。 - 薬物送達デバイス(1)用のカートリッジホルダ(2)であって、カートリッジホルダ(2)は少なくとも1つのガイドトラック(12)を含んでなり、ここで、ガイドトラック(12)は、カートリッジホルダ(2)の縦軸に対して斜めに伸びる第一のセクション(12A)を含み、そしてここで、ガイドトラック(12)は、カートリッジホルダ(2)の縦軸に対して、第一のセクション(12A)よりも小さい傾きで伸びる第二のセクションを含む、上記薬物送達デバイス(1)用のカートリッジホルダ(2)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP11165047.9 | 2011-05-06 | ||
EP11165047 | 2011-05-06 | ||
PCT/EP2012/058182 WO2012152668A1 (en) | 2011-05-06 | 2012-05-04 | Drug delivery device and cartridge holder for a drug delivery device |
Publications (2)
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JP2014515942A true JP2014515942A (ja) | 2014-07-07 |
JP6442283B2 JP6442283B2 (ja) | 2018-12-19 |
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JP2014508811A Active JP6442283B2 (ja) | 2011-05-06 | 2012-05-04 | 薬物送達デバイスと薬物送達デバイス用のカートリッジホルダ |
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US (3) | US9492617B2 (ja) |
EP (2) | EP2704777B1 (ja) |
JP (1) | JP6442283B2 (ja) |
KR (1) | KR102042981B1 (ja) |
CN (1) | CN103648554B (ja) |
AR (1) | AR086257A1 (ja) |
AU (1) | AU2012252538B2 (ja) |
BR (1) | BR112013028475B1 (ja) |
CA (1) | CA2832880A1 (ja) |
DE (1) | DE202012013243U1 (ja) |
DK (2) | DK2907538T3 (ja) |
IL (1) | IL228694A (ja) |
MX (1) | MX357832B (ja) |
MY (1) | MY163399A (ja) |
RU (1) | RU2605422C2 (ja) |
SG (1) | SG194159A1 (ja) |
TW (1) | TWI538707B (ja) |
WO (1) | WO2012152668A1 (ja) |
ZA (1) | ZA201307393B (ja) |
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Patent Citations (4)
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US2461481A (en) * | 1944-05-26 | 1949-02-08 | Roberts Mfg Company | Hypodermic syringe |
JPS57168673A (en) * | 1980-12-30 | 1982-10-18 | Zarusuteezu Barutaa | Blood extractor |
US6090082A (en) * | 1998-02-23 | 2000-07-18 | Becton, Dickinson And Company | Vial retainer interface to a medication delivery pen |
JP2010510011A (ja) * | 2006-11-21 | 2010-04-02 | ノボ・ノルデイスク・エー/エス | L字型の溝を備えたロックリングを備える医療用送達システム |
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