JP2014513084A5 - - Google Patents
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- JP2014513084A5 JP2014513084A5 JP2014505375A JP2014505375A JP2014513084A5 JP 2014513084 A5 JP2014513084 A5 JP 2014513084A5 JP 2014505375 A JP2014505375 A JP 2014505375A JP 2014505375 A JP2014505375 A JP 2014505375A JP 2014513084 A5 JP2014513084 A5 JP 2014513084A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- oxo
- halo
- membered heterocycloalkyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000005843 halogen group Chemical group 0.000 claims 24
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 19
- 125000000217 alkyl group Chemical group 0.000 claims 17
- -1 C 1 -C 6 alkoxyl Chemical group 0.000 claims 16
- 229910052799 carbon Inorganic materials 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 claims 3
- FZNGSNUBJOVDRX-UHFFFAOYSA-N 3,5-diacetamido-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]benzamide Chemical compound CC(=O)NC1=CC(NC(C)=O)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C1 FZNGSNUBJOVDRX-UHFFFAOYSA-N 0.000 claims 2
- CJPMZAQWTRKEEE-UHFFFAOYSA-N 3-bromo-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-5-methoxy-4-propoxybenzamide Chemical compound C1=C(OC)C(OCCC)=C(Br)C=C1C(=O)NCC1=C(C)C=C(C)NC1=O CJPMZAQWTRKEEE-UHFFFAOYSA-N 0.000 claims 2
- FWRVYJLUPPGAOX-UHFFFAOYSA-N 4-(2-amino-2-oxoethoxy)-3-chloro-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-5-methoxybenzamide Chemical compound ClC1=C(OCC(N)=O)C(OC)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C1 FWRVYJLUPPGAOX-UHFFFAOYSA-N 0.000 claims 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- ZHBSEXHHJLGRKX-UHFFFAOYSA-N n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-3,4,5-trimethoxybenzamide Chemical compound COC1=C(OC)C(OC)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C1 ZHBSEXHHJLGRKX-UHFFFAOYSA-N 0.000 claims 2
- CJOOKLCQRFMKCZ-UHFFFAOYSA-N n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-3-(2,2-dimethylpropanoylamino)benzamide Chemical compound O=C1NC(C)=CC(C)=C1CNC(=O)C1=CC=CC(NC(=O)C(C)(C)C)=C1 CJOOKLCQRFMKCZ-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000003566 oxetanyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 1
- QOSIYIZOWFDFTH-UHFFFAOYSA-N 3-chloro-n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-4-hydroxy-5-methoxybenzamide Chemical compound ClC1=C(O)C(OC)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C1 QOSIYIZOWFDFTH-UHFFFAOYSA-N 0.000 claims 1
- FSPIBFKGESGOLU-UHFFFAOYSA-N 4,6-dimethyl-1h-pyridin-2-one Chemical compound CC1=CC(C)=NC(O)=C1 FSPIBFKGESGOLU-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- TVFIYRKPCACCNL-UHFFFAOYSA-N furan-2-carboxamide Chemical compound NC(=O)C1=CC=CO1 TVFIYRKPCACCNL-UHFFFAOYSA-N 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- BAQLUVXNKOTTHU-UHFFFAOYSA-N metofenazate Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OCCN2CCN(CCCN3C4=CC(Cl)=CC=C4SC4=CC=CC=C43)CC2)=C1 BAQLUVXNKOTTHU-UHFFFAOYSA-N 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- JFEXNEMJRIPESK-UHFFFAOYSA-N n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-3,5-dimethoxybenzamide Chemical compound COC1=CC(OC)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C1 JFEXNEMJRIPESK-UHFFFAOYSA-N 0.000 claims 1
- DYBOTOAIZGPJFS-UHFFFAOYSA-N n-[5-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methylcarbamoyl]-2-methylphenyl]furan-2-carboxamide Chemical compound O=C1NC(C)=CC(C)=C1CNC(=O)C1=CC=C(C)C(NC(=O)C=2OC=CC=2)=C1 DYBOTOAIZGPJFS-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- DSSYMJCATJNMOZ-UHFFFAOYSA-N spiro[3H-furo[3,4-c]pyridine-1,1'-cyclohexane] Chemical compound C12(OCC=3C=NC=CC=31)CCCCC2 DSSYMJCATJNMOZ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474825P | 2011-04-13 | 2011-04-13 | |
| US61/474,825 | 2011-04-13 | ||
| US201161505676P | 2011-07-08 | 2011-07-08 | |
| US61/505,676 | 2011-07-08 | ||
| PCT/US2012/033662 WO2012142513A1 (en) | 2011-04-13 | 2012-04-13 | Substituted benzene compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513084A JP2014513084A (ja) | 2014-05-29 |
| JP2014513084A5 true JP2014513084A5 (enExample) | 2015-06-11 |
Family
ID=46000399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505375A Pending JP2014513084A (ja) | 2011-04-13 | 2012-04-13 | 置換されたベンゼン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9376422B2 (enExample) |
| EP (3) | EP2697198B1 (enExample) |
| JP (1) | JP2014513084A (enExample) |
| KR (1) | KR101975613B1 (enExample) |
| CN (1) | CN104066718B (enExample) |
| AR (1) | AR086839A1 (enExample) |
| AU (2) | AU2012242604B2 (enExample) |
| BR (1) | BR112013026308B1 (enExample) |
| CA (1) | CA2832846C (enExample) |
| DK (1) | DK2697198T3 (enExample) |
| ES (1) | ES2590489T3 (enExample) |
| HK (1) | HK1202534A1 (enExample) |
| HU (1) | HUE030722T2 (enExample) |
| IL (1) | IL228746B (enExample) |
| MX (1) | MX344530B (enExample) |
| PL (1) | PL2697198T3 (enExample) |
| PT (1) | PT2697198T (enExample) |
| RU (2) | RU2017126990A (enExample) |
| TW (2) | TW201733984A (enExample) |
| WO (1) | WO2012142513A1 (enExample) |
Families Citing this family (85)
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| CA2841142C (en) | 2010-06-23 | 2020-12-15 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
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| EP2780013A4 (en) * | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| US9085583B2 (en) | 2012-02-10 | 2015-07-21 | Constellation—Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| PL3628670T3 (pl) | 2012-04-13 | 2023-02-20 | Epizyme, Inc. | Postać soli dla inhibicji ezh2 |
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-
2012
- 2012-04-12 TW TW106103833A patent/TW201733984A/zh unknown
- 2012-04-12 TW TW101112996A patent/TWI598336B/zh active
- 2012-04-13 PT PT127169688T patent/PT2697198T/pt unknown
- 2012-04-13 WO PCT/US2012/033662 patent/WO2012142513A1/en not_active Ceased
- 2012-04-13 DK DK12716968.8T patent/DK2697198T3/en active
- 2012-04-13 KR KR1020137029686A patent/KR101975613B1/ko active Active
- 2012-04-13 US US14/110,873 patent/US9376422B2/en active Active
- 2012-04-13 HK HK15103015.8A patent/HK1202534A1/xx unknown
- 2012-04-13 EP EP12716968.8A patent/EP2697198B1/en active Active
- 2012-04-13 BR BR112013026308-3A patent/BR112013026308B1/pt active IP Right Grant
- 2012-04-13 ES ES12716968.8T patent/ES2590489T3/es active Active
- 2012-04-13 MX MX2013011922A patent/MX344530B/es active IP Right Grant
- 2012-04-13 CA CA2832846A patent/CA2832846C/en active Active
- 2012-04-13 AU AU2012242604A patent/AU2012242604B2/en not_active Ceased
- 2012-04-13 RU RU2017126990A patent/RU2017126990A/ru not_active Application Discontinuation
- 2012-04-13 AR ARP120101289A patent/AR086839A1/es unknown
- 2012-04-13 EP EP18189032.8A patent/EP3470396A1/en not_active Withdrawn
- 2012-04-13 PL PL12716968.8T patent/PL2697198T3/pl unknown
- 2012-04-13 CN CN201280029120.3A patent/CN104066718B/zh active Active
- 2012-04-13 HU HUE12716968A patent/HUE030722T2/en unknown
- 2012-04-13 JP JP2014505375A patent/JP2014513084A/ja active Pending
- 2012-04-13 EP EP16173275.5A patent/EP3165520B1/en active Active
- 2012-04-13 RU RU2013150510A patent/RU2629118C2/ru active
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