JP2014512808A5 - - Google Patents
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- JP2014512808A5 JP2014512808A5 JP2013556905A JP2013556905A JP2014512808A5 JP 2014512808 A5 JP2014512808 A5 JP 2014512808A5 JP 2013556905 A JP2013556905 A JP 2013556905A JP 2013556905 A JP2013556905 A JP 2013556905A JP 2014512808 A5 JP2014512808 A5 JP 2014512808A5
- Authority
- JP
- Japan
- Prior art keywords
- proteins
- disease
- transcription factor
- mammal
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 28
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 102000040945 Transcription factor Human genes 0.000 claims 14
- 108091023040 Transcription factor Proteins 0.000 claims 14
- 239000003446 ligand Substances 0.000 claims 14
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- 241000124008 Mammalia Species 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 11
- 102000003951 Erythropoietin Human genes 0.000 claims 9
- 108090000394 Erythropoietin Proteins 0.000 claims 9
- 229940105423 erythropoietin Drugs 0.000 claims 9
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 9
- 230000001419 dependent effect Effects 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 7
- 208000002815 pulmonary hypertension Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 241000702421 Dependoparvovirus Species 0.000 claims 4
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims 4
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 claims 4
- 102000003996 Interferon-beta Human genes 0.000 claims 4
- 108090000467 Interferon-beta Proteins 0.000 claims 4
- 239000012190 activator Substances 0.000 claims 4
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims 4
- 229960001388 interferon-beta Drugs 0.000 claims 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims 3
- 206010019860 Hereditary angioedema Diseases 0.000 claims 3
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 102100027637 Plasma protease C1 inhibitor Human genes 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000002685 pulmonary effect Effects 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 102000011690 Adiponectin Human genes 0.000 claims 2
- 108010076365 Adiponectin Proteins 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 101710085045 B2 bradykinin receptor Proteins 0.000 claims 2
- 102400000967 Bradykinin Human genes 0.000 claims 2
- 101800004538 Bradykinin Proteins 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 102000003814 Interleukin-10 Human genes 0.000 claims 2
- 108090000174 Interleukin-10 Proteins 0.000 claims 2
- 102000016267 Leptin Human genes 0.000 claims 2
- 108010092277 Leptin Proteins 0.000 claims 2
- 208000031964 Other metabolic disease Diseases 0.000 claims 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 claims 2
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 229940076144 interleukin-10 Drugs 0.000 claims 2
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 2
- 229940039781 leptin Drugs 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 206010003178 Arterial thrombosis Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108010028774 Complement C1 Proteins 0.000 claims 1
- 102100025406 Complement C1s subcomponent Human genes 0.000 claims 1
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 claims 1
- 101000975003 Homo sapiens Kallistatin Proteins 0.000 claims 1
- 101001077723 Homo sapiens Serine protease inhibitor Kazal-type 6 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 229940127379 Kallikrein Inhibitors Drugs 0.000 claims 1
- 229940122920 Kallikrein inhibitor Drugs 0.000 claims 1
- 102100023012 Kallistatin Human genes 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 208000031467 Pulmonary capillary hemangiomatosis Diseases 0.000 claims 1
- 206010068690 Pulmonary vein occlusion Diseases 0.000 claims 1
- 208000014777 Pulmonary venoocclusive disease Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000007214 atherothrombosis Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 229940009550 c1 esterase inhibitor Drugs 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 239000002329 esterase inhibitor Substances 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 238000005534 hematocrit Methods 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 208000018875 hypoxemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000005980 lung dysfunction Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 201000008312 primary pulmonary hypertension Diseases 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 210000001147 pulmonary artery Anatomy 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449536P | 2011-03-04 | 2011-03-04 | |
| US61/449,536 | 2011-03-04 | ||
| US201161478881P | 2011-04-25 | 2011-04-25 | |
| US61/478,881 | 2011-04-25 | ||
| US201161490535P | 2011-05-26 | 2011-05-26 | |
| US61/490,535 | 2011-05-26 | ||
| US201161562342P | 2011-11-21 | 2011-11-21 | |
| US61/562,342 | 2011-11-21 | ||
| PCT/US2012/027515 WO2012122025A2 (en) | 2011-03-04 | 2012-03-02 | Vectors conditionally expressing protein |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044305A Division JP2017141245A (ja) | 2011-03-04 | 2017-03-08 | タンパク質を条件的に発現するベクター |
| JP2017125428A Division JP2017212995A (ja) | 2011-03-04 | 2017-06-27 | タンパク質を条件的に発現するベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512808A JP2014512808A (ja) | 2014-05-29 |
| JP2014512808A5 true JP2014512808A5 (https=) | 2015-04-16 |
| JP6189754B2 JP6189754B2 (ja) | 2017-08-30 |
Family
ID=46798719
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013556905A Expired - Fee Related JP6189754B2 (ja) | 2011-03-04 | 2012-03-02 | タンパク質を条件的に発現するベクター |
| JP2017044305A Withdrawn JP2017141245A (ja) | 2011-03-04 | 2017-03-08 | タンパク質を条件的に発現するベクター |
| JP2017125428A Withdrawn JP2017212995A (ja) | 2011-03-04 | 2017-06-27 | タンパク質を条件的に発現するベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044305A Withdrawn JP2017141245A (ja) | 2011-03-04 | 2017-03-08 | タンパク質を条件的に発現するベクター |
| JP2017125428A Withdrawn JP2017212995A (ja) | 2011-03-04 | 2017-06-27 | タンパク質を条件的に発現するベクター |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9402919B2 (https=) |
| EP (2) | EP2681327B1 (https=) |
| JP (3) | JP6189754B2 (https=) |
| CN (1) | CN103534355A (https=) |
| AU (1) | AU2012225749B2 (https=) |
| CA (1) | CA2828411A1 (https=) |
| SG (2) | SG10201600912SA (https=) |
| TW (1) | TWI582108B (https=) |
| WO (1) | WO2012122025A2 (https=) |
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| WO2013158871A1 (en) * | 2012-04-20 | 2013-10-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of erythropoietin and derivatives for treating hypertension |
| HUE050681T2 (hu) * | 2014-04-24 | 2020-12-28 | Univ Florida | AAV-alapú génterápia szklerózis multiplexre |
| WO2015164723A1 (en) * | 2014-04-25 | 2015-10-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treating metastatic breast cancer and other cancers in the brain |
| CN106794243A (zh) * | 2014-08-26 | 2017-05-31 | 哈斯福制药公司 | 新型免疫剂及其使用方法 |
| JP6383621B2 (ja) * | 2014-09-24 | 2018-08-29 | 太陽インキ製造株式会社 | 硬化性組成物、ドライフィルム、硬化物、プリント配線板およびプリント配線板の製造方法 |
| HK1250623A1 (zh) * | 2015-05-28 | 2019-01-11 | Cornell University | 腺相关病毒介导的c1ei递送作为用於血管性水肿的疗法 |
| JP6573991B2 (ja) * | 2015-05-28 | 2019-09-11 | コーネル ユニヴァーシティー | 血管性浮腫の治療としてのｃ１ｅｉのアデノ随伴ウイルス介在性送達 |
| ES2938089T3 (es) * | 2015-08-13 | 2023-04-04 | Takeda Pharmaceuticals Co | Tubos de extracción de sangre al vacío que contienen inhibidores de proteasa para la evaluación de la activación del sistema de contacto |
| SG11201802912PA (en) | 2015-10-10 | 2018-05-30 | Intrexon Corp | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| WO2017083750A1 (en) | 2015-11-11 | 2017-05-18 | Intrexon Corporation | Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| EP3235516B1 (en) * | 2016-04-22 | 2019-06-26 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | Regulatable adeno-associated virus (aav) vector |
| AU2017272104A1 (en) * | 2016-05-25 | 2018-12-13 | The Board Of Trustees Of The Leland Stanford Junior University | Activity-dependent expression constructs and methods of using the same |
| SG11201810640RA (en) | 2016-06-08 | 2018-12-28 | Intrexon Corp | Cd33 specific chimeric antigen receptors |
| UY37343A (es) | 2016-07-25 | 2018-02-28 | Intrexon Corp | Control del fenotipo en plantas |
| CN110139933B (zh) * | 2016-11-09 | 2024-03-08 | 英特瑞克斯顿股份有限公司 | 共济蛋白表达构建体 |
| KR20190102259A (ko) | 2017-01-10 | 2019-09-03 | 인트렉손 코포레이션 | 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절 |
| EP3635132A4 (en) | 2017-06-07 | 2021-05-26 | Intrexon Corporation | EXPRESSION OF NOVEL CELL MARKERS |
| US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
| CN111902164A (zh) | 2018-02-01 | 2020-11-06 | 同源药物公司 | 用于恢复pah基因功能的腺相关病毒组合物及其使用方法 |
| CN112041437A (zh) | 2018-02-19 | 2020-12-04 | 同源药物公司 | 用于恢复f8基因功能的腺相关病毒组合物和其使用方法 |
| WO2019173465A1 (en) | 2018-03-06 | 2019-09-12 | Intrexon Corporation | Human papillomavirus vaccines and uses of the same |
| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| CA3103372A1 (en) * | 2018-06-27 | 2020-01-02 | Precigen, Inc. | In vivo controlled combination therapy for treatment of cancer |
| EP3820484A4 (en) | 2018-07-10 | 2022-05-04 | Precigen, Inc. | ROR-1 SPECIFIC CHIMERA ANTIGEN RECEPTORS AND USES THEREOF |
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| AU2020223826A1 (en) * | 2019-02-18 | 2021-08-05 | The University Of Liverpool | Method of diagnosis |
| CN114174327A (zh) | 2019-03-08 | 2022-03-11 | 黑曜石疗法公司 | 用于可调整调控的cd40l组合物和方法 |
| WO2020206056A1 (en) | 2019-04-04 | 2020-10-08 | Greenvenus Llc | Peptides and methods of plant protection |
| WO2021142376A1 (en) | 2020-01-08 | 2021-07-15 | Obsidian Therapeutics, Inc. | Compositions and methods for tunable regulation of transcription |
| TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
| WO2021211614A1 (en) | 2020-04-14 | 2021-10-21 | University Of Florida Research Foundation, Incorporated | Aav-based gene therapies for treatment of autoimmune diseases |
| TW202204625A (zh) * | 2020-04-14 | 2022-02-01 | 美商佛羅里達大學研究基金會公司 | 多發性硬化之基因免疫治療與免疫抑制劑之增強功效 |
| TW202208632A (zh) | 2020-05-27 | 2022-03-01 | 美商同源醫藥公司 | 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法 |
| CN112741895A (zh) * | 2021-01-19 | 2021-05-04 | 中国人民解放军陆军军医大学 | Epo类似物在制备治疗脓毒症药物中的应用 |
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2012
- 2012-03-02 SG SG10201600912SA patent/SG10201600912SA/en unknown
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- 2012-03-02 JP JP2013556905A patent/JP6189754B2/ja not_active Expired - Fee Related
- 2012-03-02 CN CN201280021577.XA patent/CN103534355A/zh active Pending
- 2012-03-02 AU AU2012225749A patent/AU2012225749B2/en not_active Ceased
- 2012-03-02 SG SG2013063045A patent/SG192856A1/en unknown
- 2012-03-02 EP EP18188076.6A patent/EP3450568A3/en not_active Withdrawn
- 2012-03-02 US US14/001,943 patent/US9402919B2/en not_active Expired - Fee Related
- 2012-03-02 WO PCT/US2012/027515 patent/WO2012122025A2/en not_active Ceased
- 2012-03-02 CA CA2828411A patent/CA2828411A1/en not_active Abandoned
- 2012-03-03 TW TW101107160A patent/TWI582108B/zh not_active IP Right Cessation
-
2016
- 2016-05-11 US US15/151,947 patent/US20160317678A1/en not_active Abandoned
-
2017
- 2017-03-08 JP JP2017044305A patent/JP2017141245A/ja not_active Withdrawn
- 2017-06-27 JP JP2017125428A patent/JP2017212995A/ja not_active Withdrawn
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2018
- 2018-05-31 US US15/993,773 patent/US20180344876A1/en not_active Abandoned
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