JP2014505096A5 - - Google Patents
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- JP2014505096A5 JP2014505096A5 JP2013553014A JP2013553014A JP2014505096A5 JP 2014505096 A5 JP2014505096 A5 JP 2014505096A5 JP 2013553014 A JP2013553014 A JP 2013553014A JP 2013553014 A JP2013553014 A JP 2013553014A JP 2014505096 A5 JP2014505096 A5 JP 2014505096A5
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 93
- 239000003814 drug Substances 0.000 claims 23
- 150000003943 catecholamines Chemical class 0.000 claims 21
- 229940079593 drug Drugs 0.000 claims 19
- 230000037406 food intake Effects 0.000 claims 18
- 235000012631 food intake Nutrition 0.000 claims 18
- 150000002148 esters Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 12
- 229910019142 PO4 Inorganic materials 0.000 claims 9
- 235000021317 phosphate Nutrition 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 208000018737 Parkinson disease Diseases 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 208000015114 central nervous system disease Diseases 0.000 claims 8
- 208000027232 peripheral nervous system disease Diseases 0.000 claims 8
- 238000011282 treatment Methods 0.000 claims 8
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 7
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 7
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 6
- 208000016285 Movement disease Diseases 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 229960004502 levodopa Drugs 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000010452 phosphate Substances 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000003435 aroyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 125000004001 thioalkyl group Chemical group 0.000 claims 4
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 3
- 150000003014 phosphoric acid esters Chemical class 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 claims 2
- 229960000911 benserazide Drugs 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 239000011630 iodine Chemical group 0.000 claims 2
- 229910052740 iodine Chemical group 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- ASOADIZOVZTJSR-UHFFFAOYSA-N opicapone Chemical compound CC1=C(Cl)C(C)=[N+]([O-])C(Cl)=C1C1=NOC(C=2C=C(C(O)=C(O)C=2)[N+]([O-])=O)=N1 ASOADIZOVZTJSR-UHFFFAOYSA-N 0.000 claims 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000004962 physiological condition Effects 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000005000 thioaryl group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- -1 phosphate ester Chemical class 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical group [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 claims 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161441988P | 2011-02-11 | 2011-02-11 | |
| US61/441,988 | 2011-02-11 | ||
| PCT/GB2011/052056 WO2012107708A1 (en) | 2011-02-11 | 2011-10-21 | Administration regime for nitrocatechols |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016220958A Division JP6389498B2 (ja) | 2011-02-11 | 2016-11-11 | ニトロカテコールの投与計画 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505096A JP2014505096A (ja) | 2014-02-27 |
| JP2014505096A5 true JP2014505096A5 (enExample) | 2014-12-18 |
| JP6148985B2 JP6148985B2 (ja) | 2017-06-14 |
Family
ID=44999798
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553014A Active JP6148985B2 (ja) | 2011-02-11 | 2011-10-21 | ニトロカテコールの投与計画 |
| JP2016220958A Active JP6389498B2 (ja) | 2011-02-11 | 2016-11-11 | ニトロカテコールの投与計画 |
| JP2018153722A Active JP6568274B2 (ja) | 2011-02-11 | 2018-08-17 | ニトロカテコールの投与計画 |
| JP2019142271A Active JP6843930B2 (ja) | 2011-02-11 | 2019-08-01 | ニトロカテコールの投与計画 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016220958A Active JP6389498B2 (ja) | 2011-02-11 | 2016-11-11 | ニトロカテコールの投与計画 |
| JP2018153722A Active JP6568274B2 (ja) | 2011-02-11 | 2018-08-17 | ニトロカテコールの投与計画 |
| JP2019142271A Active JP6843930B2 (ja) | 2011-02-11 | 2019-08-01 | ニトロカテコールの投与計画 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20140045900A1 (enExample) |
| EP (2) | EP3831382A1 (enExample) |
| JP (4) | JP6148985B2 (enExample) |
| AU (1) | AU2011358842B2 (enExample) |
| BR (2) | BR112013007380A2 (enExample) |
| CA (1) | CA2826080C (enExample) |
| CY (1) | CY1124022T1 (enExample) |
| DK (1) | DK2672973T3 (enExample) |
| ES (1) | ES2855162T3 (enExample) |
| HR (1) | HRP20210474T1 (enExample) |
| HU (1) | HUE054072T2 (enExample) |
| LT (1) | LT2672973T (enExample) |
| PL (1) | PL2672973T3 (enExample) |
| PT (1) | PT2672973T (enExample) |
| RS (1) | RS61643B1 (enExample) |
| RU (1) | RU2639131C2 (enExample) |
| SI (1) | SI2672973T1 (enExample) |
| WO (1) | WO2012107708A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007013830A1 (en) | 2005-07-26 | 2007-02-01 | Portela & Ca. S.A. | Nitrocatechol derivatives as comt inhibitors |
| EP1845097A1 (en) | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| DK2481410T3 (en) | 2007-01-31 | 2016-10-24 | Bial - Portela & Ca S A | Nitrocatecholderivater as COMT inhibitors administered in a specific dosage regimen |
| BRPI0908731A2 (pt) | 2008-03-17 | 2017-05-16 | Bial - Portela & C A S A | formas cristalinas de 5-[3-(2,5-dicloro-4,6-dimetil-1-óxi-piridina-3-il)[1,2,4]oxadiazol-5-il]-3-nitrobenzeno-1,2-diol |
| CN102448444B (zh) | 2009-04-01 | 2016-05-25 | 巴尔-波特拉及康邦亚股份有限公司 | 包括硝基儿茶酚衍生物的药物制剂及其制备方法 |
| US20140045900A1 (en) * | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| US9126988B2 (en) | 2011-12-13 | 2015-09-08 | Bial—Portela & Ca, S.A. | Intermediate for preparing a catechol-O-methyltransferase inhibitor |
| WO2016083863A1 (en) | 2014-11-28 | 2016-06-02 | Bial - Portela & Ca, S.A. | Medicaments for slowing parkinson's disease |
| AR106313A1 (es) | 2015-10-09 | 2018-01-03 | Teva Pharmaceuticals Int Gmbh | Combinación de levodopa deuterada con carbidopa y opicapona para el tratamiento de enfermedad de parkinson |
| CN105677240B (zh) * | 2015-12-30 | 2019-04-23 | 上海联影医疗科技有限公司 | 数据删除方法及系统 |
| EP3860603A1 (en) | 2018-10-05 | 2021-08-11 | Neurocrine Biosciences, Inc. | Methods for the administration of comt inhibitors |
| WO2020072884A1 (en) | 2018-10-05 | 2020-04-09 | Neurocrine Biosciences, Inc. | Methods for the administration of comt inhibitors |
| JP2020023540A (ja) * | 2019-10-11 | 2020-02-13 | ノヴィファーマ，エス．アー． | パーキンソン病を遅延させるための医薬 |
| JP7251026B2 (ja) | 2019-11-14 | 2023-04-04 | 国立大学法人九州大学 | ポリマー化合物およびコーティング組成物 |
| GB202016425D0 (en) * | 2020-10-16 | 2020-12-02 | Bial Portela & Ca Sa | Treatment regimens for parkinson's disease |
| WO2022131944A1 (en) * | 2020-12-17 | 2022-06-23 | Bial-Portela & Ca., S.A. | Treatment regimens for early idiopathic parkinson's disease |
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| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| JP2008162955A (ja) | 2006-12-28 | 2008-07-17 | Chugai Pharmaceut Co Ltd | バリン含有高密度顆粒剤 |
| DK2481410T3 (en) * | 2007-01-31 | 2016-10-24 | Bial - Portela & Ca S A | Nitrocatecholderivater as COMT inhibitors administered in a specific dosage regimen |
| AR065802A1 (es) | 2007-03-22 | 2009-07-01 | Schering Corp | Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas |
| US8222243B2 (en) | 2007-08-27 | 2012-07-17 | Dart Neuroscience (Cayman) Ltd | Therapeutic isoxazole compounds |
| EP2259777A2 (en) | 2008-02-28 | 2010-12-15 | BIAL - Portela & Ca., S.A. | Pharmaceutical composition for poorly soluble drugs |
| BRPI0908731A2 (pt) * | 2008-03-17 | 2017-05-16 | Bial - Portela & C A S A | formas cristalinas de 5-[3-(2,5-dicloro-4,6-dimetil-1-óxi-piridina-3-il)[1,2,4]oxadiazol-5-il]-3-nitrobenzeno-1,2-diol |
| BRPI0913913A2 (pt) * | 2008-07-29 | 2015-10-13 | Bial Portela & Ca Sa | regime de dosagem para nitrocatecóis |
| PT2413913T (pt) | 2009-04-01 | 2022-06-09 | Bial Portela & Ca Sa | Formulações farmacêuticas que compreendem derivados de nitrocatecol e métodos para os preparar |
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| WO2016083863A1 (en) | 2014-11-28 | 2016-06-02 | Bial - Portela & Ca, S.A. | Medicaments for slowing parkinson's disease |
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2011
- 2011-10-12 US US13/583,375 patent/US20140045900A1/en not_active Abandoned
- 2011-10-21 BR BR112013007380A patent/BR112013007380A2/pt not_active Application Discontinuation
- 2011-10-21 BR BR112013020424-9A patent/BR112013020424A2/pt not_active Application Discontinuation
- 2011-10-21 LT LTEP11785058.6T patent/LT2672973T/lt unknown
- 2011-10-21 PL PL11785058T patent/PL2672973T3/pl unknown
- 2011-10-21 PT PT117850586T patent/PT2672973T/pt unknown
- 2011-10-21 ES ES11785058T patent/ES2855162T3/es active Active
- 2011-10-21 RU RU2013139414A patent/RU2639131C2/ru active
- 2011-10-21 HR HRP20210474TT patent/HRP20210474T1/hr unknown
- 2011-10-21 DK DK11785058.6T patent/DK2672973T3/da active
- 2011-10-21 JP JP2013553014A patent/JP6148985B2/ja active Active
- 2011-10-21 RS RS20210351A patent/RS61643B1/sr unknown
- 2011-10-21 SI SI201131963T patent/SI2672973T1/sl unknown
- 2011-10-21 AU AU2011358842A patent/AU2011358842B2/en active Active
- 2011-10-21 CA CA2826080A patent/CA2826080C/en active Active
- 2011-10-21 HU HUE11785058A patent/HUE054072T2/hu unknown
- 2011-10-21 EP EP20217676.4A patent/EP3831382A1/en active Pending
- 2011-10-21 EP EP11785058.6A patent/EP2672973B1/en active Active
- 2011-10-21 WO PCT/GB2011/052056 patent/WO2012107708A1/en not_active Ceased
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2013
- 2013-08-09 US US13/963,621 patent/US10065944B2/en active Active
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2016
- 2016-11-11 JP JP2016220958A patent/JP6389498B2/ja active Active
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2018
- 2018-08-17 JP JP2018153722A patent/JP6568274B2/ja active Active
- 2018-08-28 US US16/114,430 patent/US12129247B2/en active Active
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2019
- 2019-08-01 JP JP2019142271A patent/JP6843930B2/ja active Active
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2021
- 2021-03-23 CY CY20211100250T patent/CY1124022T1/el unknown
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2024
- 2024-10-23 US US18/924,015 patent/US20250276963A1/en active Pending
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