JP2014504508A5 - - Google Patents
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- Publication number
- JP2014504508A5 JP2014504508A5 JP2013552630A JP2013552630A JP2014504508A5 JP 2014504508 A5 JP2014504508 A5 JP 2014504508A5 JP 2013552630 A JP2013552630 A JP 2013552630A JP 2013552630 A JP2013552630 A JP 2013552630A JP 2014504508 A5 JP2014504508 A5 JP 2014504508A5
- Authority
- JP
- Japan
- Prior art keywords
- coa
- crotonyl
- reductase
- alcohol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 33
- 102000004316 Oxidoreductases Human genes 0.000 claims 32
- 108090000854 Oxidoreductases Proteins 0.000 claims 32
- 108010011384 acyl-CoA dehydrogenase (NADP+) Proteins 0.000 claims 24
- WCASXYBKJHWFMY-NSCUHMNNSA-N 2-Buten-1-ol Chemical compound C\C=C\CO WCASXYBKJHWFMY-NSCUHMNNSA-N 0.000 claims 20
- MLUCVPSAIODCQM-NSCUHMNNSA-N crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 claims 20
- MLUCVPSAIODCQM-UHFFFAOYSA-N crotonaldehyde Natural products CC=CC=O MLUCVPSAIODCQM-UHFFFAOYSA-N 0.000 claims 20
- WCASXYBKJHWFMY-UHFFFAOYSA-N gamma-methylallyl alcohol Natural products CC=CCO WCASXYBKJHWFMY-UHFFFAOYSA-N 0.000 claims 20
- 244000005700 microbiome Species 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 230000037361 pathway Effects 0.000 claims 16
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical group O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 15
- 230000015572 biosynthetic process Effects 0.000 claims 15
- 102000003960 Ligases Human genes 0.000 claims 12
- 108090000364 Ligases Proteins 0.000 claims 12
- 102000004357 Transferases Human genes 0.000 claims 12
- 108090000992 Transferases Proteins 0.000 claims 12
- 150000001299 aldehydes Chemical class 0.000 claims 12
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 108010031139 3-aminobutyryl-CoA deaminase Proteins 0.000 claims 8
- 108030005660 3-hydroxybutyryl-CoA dehydratases Proteins 0.000 claims 8
- 102100026105 3-ketoacyl-CoA thiolase, mitochondrial Human genes 0.000 claims 8
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims 8
- 108010003902 Acetyl-CoA C-acyltransferase Proteins 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 8
- 108090000790 Enzymes Proteins 0.000 claims 8
- 108010015451 Glutaryl-CoA Dehydrogenase Proteins 0.000 claims 8
- 102100028603 Glutaryl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 8
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims 8
- 108010068207 Glutaconyl-CoA decarboxylase Proteins 0.000 claims 6
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 claims 4
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 1
- KFWWCMJSYSSPSK-PAXLJYGASA-N crotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)/C=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KFWWCMJSYSSPSK-PAXLJYGASA-N 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438947P | 2011-02-02 | 2011-02-02 | |
| US61/438,947 | 2011-02-02 | ||
| PCT/US2012/023632 WO2012106516A1 (en) | 2011-02-02 | 2012-02-02 | Microorganisms and methods for the biosynthesis of butadiene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124920A Division JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504508A JP2014504508A (ja) | 2014-02-24 |
| JP2014504508A5 true JP2014504508A5 (cg-RX-API-DMAC7.html) | 2015-03-26 |
| JP5960729B2 JP5960729B2 (ja) | 2016-08-02 |
Family
ID=46603080
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552630A Active JP5960729B2 (ja) | 2011-02-02 | 2012-02-02 | ブタジエンの生合成のための微生物および方法 |
| JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
| JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
| JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9321701B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2670852A4 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5960729B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140145935A (cg-RX-API-DMAC7.html) |
| CN (2) | CN106191132A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012212118B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013019811A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2826293A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX348334B (cg-RX-API-DMAC7.html) |
| MY (2) | MY162964A (cg-RX-API-DMAC7.html) |
| PH (1) | PH12013501630A1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG192614A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012106516A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (45)
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| BRPI0913901A2 (pt) | 2008-06-17 | 2016-12-13 | Genomatica Inc | micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
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| EP2510102A4 (en) | 2009-12-10 | 2014-01-22 | Genomatica Inc | METHODS AND ORGANIZATIONS FOR THE CONVERSION OF SYNTHESIS GAS OR OTHER CARBONACEOUS GAS SOURCES AND METHANOL TO 1,3-BUTANEDIOL |
| AU2011248182A1 (en) * | 2010-05-05 | 2012-11-15 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| MY162964A (en) * | 2011-02-02 | 2017-07-31 | Genomatica Inc | Microorganisms and methods for the biosynthesis of butadiene |
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
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| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| BR112014008061A2 (pt) * | 2011-10-19 | 2017-04-11 | Scientist Of Fortune Sa | método para a produção enzimática de butadieno |
| WO2013071074A1 (en) * | 2011-11-11 | 2013-05-16 | Invista North America S.A. R.L. | Methods of producing butadiene |
| CN104903455A (zh) | 2012-11-28 | 2015-09-09 | 英威达技术有限责任公司 | 用于异丁烯生物合成的方法 |
| US20150329877A1 (en) | 2012-12-07 | 2015-11-19 | Global Bioenergies | Fermentation method |
| CN105143457B (zh) | 2012-12-07 | 2018-10-30 | 环球生物能源公司 | 发酵生产烃 |
| JP2014161252A (ja) * | 2013-02-22 | 2014-09-08 | Sekisui Chem Co Ltd | 組換え細胞 |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| BR112016002625A2 (pt) | 2013-08-05 | 2017-09-12 | Invista Tech Sarl | método para sintetizar enzimaticamente isopreno e hospedeiro recombinante produtor de isopreno |
| CN105683384A (zh) | 2013-08-05 | 2016-06-15 | 英威达技术有限责任公司 | 用于生物合成异丁烯的方法 |
| EP4296364B1 (en) | 2013-12-03 | 2025-12-03 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| CN106062178B (zh) | 2013-12-27 | 2021-07-27 | 基因组股份公司 | 具有增加的碳通量效率的方法和生物 |
| BR112016029471A2 (pt) | 2014-06-16 | 2017-10-24 | Invista Tech Sarl | método para biosintetizar éster de metil glutarato em um hospedeiro recombinante, método para preparar glutarato, célula hospedeira recombinante, hospedeiro recombinante, produto bioderivado, produto de base biológica ou produto derivado de fermentação e método para aumentar a atividade de um polipeptídeo tendo atividade carboxilato reductase sobre um ácido dicarboxílico c4-c8 substituído ou não-substituído |
| WO2016004334A1 (en) | 2014-07-03 | 2016-01-07 | Genomatica, Inc. | Microorganisms for producing 4c-5c compounds with unsaturation and methods related thereto |
| WO2016007196A1 (en) * | 2014-07-07 | 2016-01-14 | Cobalt Technologies, Inc. | Biomass conversion to butadiene |
| WO2016044713A1 (en) | 2014-09-18 | 2016-03-24 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| CN104298866B (zh) * | 2014-09-30 | 2017-06-06 | 杭州电子科技大学 | 一种克劳斯硫磺回收过程中反应炉动态建模方法 |
| WO2016066869A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Catalizador microporoso con encapsulación selectiva de óxidos metálicos útil para producir precursores de butadieno |
| WO2016066873A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Óxidos mixtos que comprenden magnesio y boro, y su uso como catalizadores para producir precursores de butadieno |
| ES2857324T3 (es) * | 2015-02-23 | 2021-09-28 | Versalis Spa | Procedimiento para la producción de dienos |
| WO2016164586A1 (en) | 2015-04-09 | 2016-10-13 | Genomatica, Inc. | Engineered microorganisms & methods for improved crotyl alcohol production |
| WO2016196233A1 (en) | 2015-05-30 | 2016-12-08 | Genomatica, Inc. | Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and/ crotyl alcohol dehydratases and methods for making and using them |
| WO2017035141A2 (en) * | 2015-08-24 | 2017-03-02 | White Dog Labs, Inc. | Microbial organisms for converting acetyl-coa into crotyl alcohol and methods for producing crotyl alcohol |
| SG11201803164SA (en) | 2015-10-30 | 2018-05-30 | Genomatica Inc | Methanol dehydrogenase fusion proteins |
| KR101929631B1 (ko) | 2016-12-20 | 2018-12-14 | 서강대학교산학협력단 | 미생물 발효를 이용한 1,3-부타디엔의 제조 방법 |
| EA201891926A1 (ru) * | 2017-02-03 | 2019-04-30 | Киверди, Инк. | Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1 |
| WO2019006257A1 (en) | 2017-06-30 | 2019-01-03 | Invista North America .S.A.R.L. | METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| WO2019022083A1 (ja) * | 2017-07-24 | 2019-01-31 | 国立研究開発法人理化学研究所 | デカルボキシラーゼ、及びそれを用いた不飽和炭化水素化合物の製造方法 |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| JP2021528977A (ja) | 2018-06-26 | 2021-10-28 | ジェノマティカ， インコーポレイテッド | グリセルアルデヒド３−リン酸（ｇ３ｐ）を３−ホスホグリセリン酸（３ｐｇ）に変換する酵素および／またはフルクトース−１，６−ビスホスファターゼを有する組換え微生物（合成または増強されたメチロトロフィーを有するものを含む） |
| US20220282265A1 (en) * | 2019-08-12 | 2022-09-08 | Zymergen Inc. | Engineered biosynthetic pathways for production of 3-amino-4-hydroxybenzoic acid by fermentation |
| US12221543B2 (en) | 2019-10-24 | 2025-02-11 | Shin-Etsu Chemical Co., Ltd. | Thermally conductive silicone composition and production method therefor |
| EP4313917A1 (en) | 2021-04-01 | 2024-02-07 | Synthos Dwory 7 spolka z ograniczona odpowiedzialnoscia | Adiabatically conducted process for the production of 1,3-butadiene from mixtures of ethanol and acetaldehyde |
| WO2024257686A1 (ja) | 2023-06-15 | 2024-12-19 | 株式会社Ｃｏ２資源化研究所 | クロチルアルコールを生成するヒドロゲノフィラス属細菌形質転換体 |
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| GB525198A (en) | 1938-03-21 | 1940-08-23 | Melle Usines Sa | Improvements in or relating to the preparation of di-olefines |
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| US5849970A (en) | 1995-06-23 | 1998-12-15 | The Regents Of The University Of Colorado | Materials and methods for the bacterial production of isoprene |
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| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
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| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| EP2285948B1 (en) * | 2008-03-03 | 2014-01-08 | Joule Unlimited Technologies, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| SG192545A1 (en) | 2008-04-23 | 2013-08-30 | Danisco Us Inc | Isoprene synthase variants for improved microbial production of isoprene |
| US20110190513A1 (en) * | 2008-07-08 | 2011-08-04 | Lynch Michael D | Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol |
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| WO2010127319A2 (en) * | 2009-04-30 | 2010-11-04 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
| WO2011052718A1 (ja) | 2009-10-30 | 2011-05-05 | ダイセル化学工業株式会社 | １，３－ブタンジオール生産機能を付与された遺伝子組換え微生物及びその利用 |
| AU2011248182A1 (en) | 2010-05-05 | 2012-11-15 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| EP2653529A4 (en) * | 2010-12-17 | 2018-01-24 | Mitsubishi Chemical Corporation | Synthetic pathway constructing equipment, synthetic pathway constructing method, synthetic pathway constructing program, and processes for manufacturing 3-hydroxypropionic acid, crotonyl alcohol and butadiene |
| MY162964A (en) * | 2011-02-02 | 2017-07-31 | Genomatica Inc | Microorganisms and methods for the biosynthesis of butadiene |
| US9169486B2 (en) * | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
-
2012
- 2012-02-02 MY MYPI2013701358A patent/MY162964A/en unknown
- 2012-02-02 SG SG2013059167A patent/SG192614A1/en unknown
- 2012-02-02 AU AU2012212118A patent/AU2012212118B2/en not_active Ceased
- 2012-02-02 EP EP12742132.9A patent/EP2670852A4/en not_active Withdrawn
- 2012-02-02 CN CN201610552260.9A patent/CN106191132A/zh active Pending
- 2012-02-02 CA CA2826293A patent/CA2826293A1/en not_active Abandoned
- 2012-02-02 JP JP2013552630A patent/JP5960729B2/ja active Active
- 2012-02-02 WO PCT/US2012/023632 patent/WO2012106516A1/en not_active Ceased
- 2012-02-02 US US13/365,132 patent/US9321701B2/en active Active
- 2012-02-02 KR KR1020137023026A patent/KR20140145935A/ko not_active Ceased
- 2012-02-02 MX MX2013008988A patent/MX348334B/es active IP Right Grant
- 2012-02-02 CN CN201280016837.4A patent/CN103459602B/zh not_active Expired - Fee Related
- 2012-02-02 PH PH1/2013/501630A patent/PH12013501630A1/en unknown
- 2012-02-02 BR BR112013019811A patent/BR112013019811A2/pt not_active Application Discontinuation
-
2013
- 2013-08-01 MY MYPI2017702592A patent/MY179664A/en unknown
-
2016
- 2016-03-23 US US15/078,437 patent/US20170044572A1/en not_active Abandoned
- 2016-06-23 JP JP2016124920A patent/JP2016192974A/ja active Pending
-
2018
- 2018-03-09 US US15/917,411 patent/US20190048366A1/en not_active Abandoned
- 2018-06-27 JP JP2018122381A patent/JP2018166514A/ja active Pending
-
2020
- 2020-06-25 US US16/912,409 patent/US20210147881A1/en not_active Abandoned
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