JP2014500879A - Bcma発現に相関性を有する疾患を治療する因子及び方法 - Google Patents
Bcma発現に相関性を有する疾患を治療する因子及び方法 Download PDFInfo
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- JP2014500879A JP2014500879A JP2013539249A JP2013539249A JP2014500879A JP 2014500879 A JP2014500879 A JP 2014500879A JP 2013539249 A JP2013539249 A JP 2013539249A JP 2013539249 A JP2013539249 A JP 2013539249A JP 2014500879 A JP2014500879 A JP 2014500879A
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- Prior art keywords
- binding
- bcma
- bispecific
- antibody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10191418.2 | 2010-11-16 | ||
| EP10191418 | 2010-11-16 | ||
| PCT/EP2011/070301 WO2012066058A1 (en) | 2010-11-16 | 2011-11-16 | Agents and methods for treating diseases that correlate with bcma expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016234174A Division JP2017093437A (ja) | 2010-11-16 | 2016-12-01 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2014500879A true JP2014500879A (ja) | 2014-01-16 |
Family
ID=43769116
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539249A Pending JP2014500879A (ja) | 2010-11-16 | 2011-11-16 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
| JP2016234174A Pending JP2017093437A (ja) | 2010-11-16 | 2016-12-01 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
| JP2018224988A Pending JP2019030338A (ja) | 2010-11-16 | 2018-11-30 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
| JP2020209835A Pending JP2021042257A (ja) | 2010-11-16 | 2020-12-18 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016234174A Pending JP2017093437A (ja) | 2010-11-16 | 2016-12-01 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
| JP2018224988A Pending JP2019030338A (ja) | 2010-11-16 | 2018-11-30 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
| JP2020209835A Pending JP2021042257A (ja) | 2010-11-16 | 2020-12-18 | Bcma発現に相関性を有する疾患を治療する因子及び方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130273055A1 (https=) |
| EP (2) | EP3974453A3 (https=) |
| JP (4) | JP2014500879A (https=) |
| WO (1) | WO2012066058A1 (https=) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017515470A (ja) * | 2014-04-30 | 2017-06-15 | マックス−デルブリュック−ツェントルム フューア モレキュラーレ メディツィン イン デア ヘルムホルツ−ゲマインシャフト | Cd269(bcma)に対するヒト化抗体 |
| JP2018515107A (ja) * | 2015-05-13 | 2018-06-14 | アブリンクス エン.ヴェー. | Cd3反応性に基づくt細胞リクルートポリペプチド |
| JP2018516068A (ja) * | 2015-04-13 | 2018-06-21 | ファイザー・インク | 治療抗体およびその使用 |
| JP2018532766A (ja) * | 2015-08-03 | 2018-11-08 | エンクマフ エスアーエールエル | Bcmaに対するモノクローナル抗体 |
| JP2019506406A (ja) * | 2016-01-25 | 2019-03-07 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハーAMGEN Research(Munich)GmbH | 二重特異性抗体コンストラクトを含む医薬組成物 |
| KR20190086477A (ko) * | 2016-11-02 | 2019-07-22 | 잉맵 에스에이알엘 | 다발성 골수종 치료를 위한 bcma 및 cd3에 대응하는 이중 특이적 항체 및 면역학적 약물의 복합용도 |
| JP2020524000A (ja) * | 2017-06-20 | 2020-08-13 | テネオワン, インコーポレイテッド | 抗bcma重鎖のみ抗体 |
| JP2020524506A (ja) * | 2017-06-20 | 2020-08-20 | テネオバイオ, インコーポレイテッド | 抗bcma重鎖のみ抗体 |
| JP2020525032A (ja) * | 2017-06-27 | 2020-08-27 | ナンキン レジェンド バイオテック カンパニー リミテッド | キメラ抗体免疫エフェクター細胞エンゲージャー及びその使用方法 |
| JP2020534255A (ja) * | 2017-09-15 | 2020-11-26 | アムジエン・インコーポレーテツド | 治療用タンパク質の凍結乾燥医薬配合物のためのプロセス |
| JP2020535181A (ja) * | 2017-09-29 | 2020-12-03 | ヤンセン バイオテツク,インコーポレーテツド | 低用量抗体組成物を安定化する新規製剤 |
| JP2021021734A (ja) * | 2014-04-04 | 2021-02-18 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 精密分子質量を用いた免疫グロブリンのアイソタイピング |
| JP2024023252A (ja) * | 2016-09-14 | 2024-02-21 | テネオワン, インコーポレイテッド | Cd3結合抗体 |
| JP2024513559A (ja) * | 2021-04-09 | 2024-03-26 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規なDARPinベースのCD70エンゲージャー |
| JP2024095775A (ja) * | 2018-06-19 | 2024-07-10 | ナンジン レジェンド バイオテック カンパニー,リミテッド | 操作された細胞およびその使用 |
| US12371505B2 (en) | 2016-12-21 | 2025-07-29 | Teneobio, Inc. | Anti-BCMA heavy chain-only antibodies |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2833820C (en) * | 2011-05-27 | 2019-10-29 | Glaxo Group Limited | Bcma (cd269/tnfrsf17) -binding proteins |
| UA112434C2 (uk) | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
| JP6694712B2 (ja) | 2012-11-01 | 2020-05-20 | マックス−デルブルック−セントラム フアー モレキュラーレ メデジン | Cd269(bcma)に対する抗体 |
| TW201425336A (zh) * | 2012-12-07 | 2014-07-01 | Amgen Inc | Bcma抗原結合蛋白質 |
| US9243058B2 (en) | 2012-12-07 | 2016-01-26 | Amgen, Inc. | BCMA antigen binding proteins |
| JP6636803B2 (ja) * | 2013-02-05 | 2020-01-29 | エンクマフ エスアーエールエル | Bcmaに対する抗体の選択のための方法 |
| EP2762497A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP2762496A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Method for the selection of antibodies against BCMA |
| CN105143270B (zh) * | 2013-02-26 | 2019-11-12 | 罗切格利卡特公司 | 双特异性t细胞活化抗原结合分子 |
| EP3447072A3 (en) * | 2013-03-05 | 2019-05-22 | Baylor College of Medicine | Engager cells comprising cd3 scfv and an antigen recognition domain that binds a tumor antigen for immunotherapy |
| JP6279065B2 (ja) * | 2013-03-13 | 2018-02-14 | サノフイ | 抗cd38抗体およびカーフィルゾミブを含む組成物 |
| AR095374A1 (es) * | 2013-03-15 | 2015-10-14 | Amgen Res Munich Gmbh | Moléculas de unión para bcma y cd3 |
| GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
| CN106459990B (zh) | 2014-02-07 | 2021-06-01 | 麦克马斯特大学 | 三功能t细胞抗原偶联物及其制备方法和用途 |
| TWI750110B (zh) | 2014-07-21 | 2021-12-21 | 瑞士商諾華公司 | 使用人類化抗-bcma嵌合抗原受體治療癌症 |
| KR20170037625A (ko) | 2014-07-21 | 2017-04-04 | 노파르티스 아게 | Cll-1 키메라 항원 수용체를 사용한 암의 치료 |
| EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3023437A1 (en) * | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| KR20240135036A (ko) | 2014-12-05 | 2024-09-10 | 메모리얼 슬로안 케터링 캔서 센터 | B-세포 성숙화 항원을 표적화하는 항체 및 사용 방법 |
| AU2015357526B2 (en) * | 2014-12-05 | 2022-03-17 | Eureka Therapeutics, Inc. | Chimeric antigen receptors targeting B-cell maturation antigen and uses thereof |
| EP3283520B1 (en) | 2015-04-13 | 2020-05-06 | Pfizer Inc | Chimeric antigen receptors targeting b-cell maturation antigen |
| EA201792573A1 (ru) | 2015-05-21 | 2018-04-30 | Харпун Терапьютикс, Инк. | Триспецифические связанные белки и способы их применения |
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| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
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| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
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| US10072088B2 (en) | 2015-08-17 | 2018-09-11 | Janssen Pharmaceutica, Nv | Anti-BCMA antibodies and uses thereof |
| CN116063544A (zh) * | 2016-02-03 | 2023-05-05 | 安进研发(慕尼黑)股份有限公司 | Bcma和cd3双特异性t细胞接合抗体构建体 |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2019030338A (ja) | 2019-02-28 |
| US20130273055A1 (en) | 2013-10-17 |
| EP2640750A1 (en) | 2013-09-25 |
| WO2012066058A1 (en) | 2012-05-24 |
| JP2021042257A (ja) | 2021-03-18 |
| JP2017093437A (ja) | 2017-06-01 |
| EP3974453A3 (en) | 2022-08-03 |
| EP3974453A2 (en) | 2022-03-30 |
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