JP2014500725A5 - - Google Patents

Info

Publication number

JP2014500725A5

JP2014500725A5 JP2013539286A JP2013539286A JP2014500725A5 JP 2014500725 A5 JP2014500725 A5 JP 2014500725A5 JP 2013539286 A JP2013539286 A JP 2013539286A JP 2013539286 A JP2013539286 A JP 2013539286A JP 2014500725 A5 JP2014500725 A5 JP 2014500725A5

Authority

JP

Japan

Prior art keywords

seq

antibody

collection

functional fragment

variable heavy

Prior art date

2011-11-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000012634 fragment Substances 0.000 claims 53
• 238000000034 method Methods 0.000 claims 53
• 108090000623 proteins and genes Proteins 0.000 claims 41
• 210000004602 germ cell Anatomy 0.000 claims 40
• 102000004169 proteins and genes Human genes 0.000 claims 39
• 239000000178 monomer Substances 0.000 claims 20
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 3
• 210000003719 b-lymphocyte Anatomy 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 230000004048 modification Effects 0.000 claims 3
• 238000012986 modification Methods 0.000 claims 3
• 230000004481 post-translational protein modification Effects 0.000 claims 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 239000002299 complementary DNA Substances 0.000 claims 2
• 230000002194 synthesizing effect Effects 0.000 claims 2
• 101710145634 Antigen 1 Proteins 0.000 claims 1
• 238000012408 PCR amplification Methods 0.000 claims 1
• 238000010367 cloning Methods 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000012163 sequencing technique Methods 0.000 claims 1