AU2011331129B2 - A collection and methods for its use - Google Patents

A collection and methods for its use Download PDF

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Publication number
AU2011331129B2
AU2011331129B2 AU2011331129A AU2011331129A AU2011331129B2 AU 2011331129 B2 AU2011331129 B2 AU 2011331129B2 AU 2011331129 A AU2011331129 A AU 2011331129A AU 2011331129 A AU2011331129 A AU 2011331129A AU 2011331129 B2 AU2011331129 B2 AU 2011331129B2
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AU
Australia
Prior art keywords
seq
antibodies
pairs
light chain
heavy chain
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AU2011331129A
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English (en)
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AU2011331129A1 (en
Inventor
Ingrid Schuster
Yvonne Stark
Thomas Tiller
Stefanie Urlinger
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Morphosys AG
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Morphosys AG
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Publication of AU2011331129A1 publication Critical patent/AU2011331129A1/en
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Publication of AU2011331129B2 publication Critical patent/AU2011331129B2/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2011331129A 2010-11-19 2011-11-18 A collection and methods for its use Active AU2011331129B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41536710P 2010-11-19 2010-11-19
EP10191910 2010-11-19
EP10191910.8 2010-11-19
US61/415,367 2010-11-19
US201161494452P 2011-06-08 2011-06-08
US61/494,452 2011-06-08
PCT/EP2011/070473 WO2012066129A1 (en) 2010-11-19 2011-11-18 A collection and methods for its use

Publications (2)

Publication Number Publication Date
AU2011331129A1 AU2011331129A1 (en) 2013-05-23
AU2011331129B2 true AU2011331129B2 (en) 2016-10-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011331129A Active AU2011331129B2 (en) 2010-11-19 2011-11-18 A collection and methods for its use

Country Status (18)

Country Link
US (3) US8367586B2 (cg-RX-API-DMAC7.html)
EP (1) EP2640742B1 (cg-RX-API-DMAC7.html)
JP (1) JP6253986B2 (cg-RX-API-DMAC7.html)
KR (1) KR101938021B1 (cg-RX-API-DMAC7.html)
CN (1) CN103237809B (cg-RX-API-DMAC7.html)
AU (1) AU2011331129B2 (cg-RX-API-DMAC7.html)
CA (1) CA2816558C (cg-RX-API-DMAC7.html)
DK (1) DK2640742T3 (cg-RX-API-DMAC7.html)
ES (1) ES2696548T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20181811T1 (cg-RX-API-DMAC7.html)
IL (1) IL226364B (cg-RX-API-DMAC7.html)
MX (1) MX353795B (cg-RX-API-DMAC7.html)
NZ (1) NZ609707A (cg-RX-API-DMAC7.html)
PL (1) PL2640742T3 (cg-RX-API-DMAC7.html)
RU (1) RU2603080C2 (cg-RX-API-DMAC7.html)
SG (2) SG10201509257VA (cg-RX-API-DMAC7.html)
WO (1) WO2012066129A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201303566B (cg-RX-API-DMAC7.html)

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CN102993305B (zh) 2012-11-16 2015-05-13 上海赛伦生物技术有限公司 人源抗人表皮生长因子受体抗体及其编码基因与应用
KR20200103882A (ko) * 2013-09-18 2020-09-02 리제너론 파마슈티칼스 인코포레이티드 히스티딘 엔지니어링된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-인간 동물
EP3080158A4 (en) 2013-12-09 2018-03-21 Adimab, LLC Polyclonal mixtures of antibodies, and methods of making and using them
CN106029682B (zh) * 2013-12-27 2021-04-13 中外制药株式会社 等电点低的抗体的纯化方法
WO2017140831A1 (en) 2016-02-19 2017-08-24 Morphosys Ag Antibodies for il-17c
EP3443087B1 (en) * 2016-04-12 2024-09-18 Medimmune, LLC Immune repertoire mining
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WO2019099454A2 (en) 2017-11-15 2019-05-23 Philippe Valadon Highly functional antibody libraries
IL278323B2 (en) 2018-05-16 2025-05-01 Morphosys Ag Antibodies directed against glycoprotein IV
KR102115300B1 (ko) 2018-06-01 2020-05-26 재단법인 목암생명과학연구소 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법
US20230183675A1 (en) 2020-05-20 2023-06-15 Institut Curie Synthetic Single Domain Library
EP4154004A1 (en) 2020-06-08 2023-03-29 Immundiagnostik AG Improved method and test system for in-vitro determination of drug antibodies in blood
AU2021350342A1 (en) 2020-09-24 2023-03-09 Morphosys Ag Novel human antibodies binding to human CD3 epsilon
AU2023240297A1 (en) 2022-03-22 2024-10-03 Morphosys Ag Deimmunized antibodies specific for cd3
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Also Published As

Publication number Publication date
IL226364B (en) 2020-11-30
US8367586B2 (en) 2013-02-05
US20130236902A1 (en) 2013-09-12
CA2816558A1 (en) 2012-05-24
US20120129717A1 (en) 2012-05-24
MX353795B (es) 2018-01-30
WO2012066129A1 (en) 2012-05-24
JP6253986B2 (ja) 2017-12-27
ES2696548T3 (es) 2019-01-16
SG10201509257VA (en) 2015-12-30
RU2603080C2 (ru) 2016-11-20
IL226364A0 (en) 2013-07-31
US8728981B2 (en) 2014-05-20
CN103237809A (zh) 2013-08-07
HRP20181811T1 (hr) 2018-12-28
NZ609707A (en) 2014-12-24
ZA201303566B (en) 2014-07-30
CA2816558C (en) 2020-12-29
US9541559B2 (en) 2017-01-10
DK2640742T3 (en) 2018-12-03
EP2640742A1 (en) 2013-09-25
SG189950A1 (en) 2013-06-28
MX2013005614A (es) 2013-11-21
RU2013126025A (ru) 2014-12-27
KR101938021B1 (ko) 2019-01-11
KR20140015274A (ko) 2014-02-06
EP2640742B1 (en) 2018-08-15
CN103237809B (zh) 2016-09-07
US20140206575A1 (en) 2014-07-24
JP2014500725A (ja) 2014-01-16
AU2011331129A1 (en) 2013-05-23
PL2640742T3 (pl) 2019-01-31

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