JP2014221801A5 - - Google Patents
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- Publication number
- JP2014221801A5 JP2014221801A5 JP2014142904A JP2014142904A JP2014221801A5 JP 2014221801 A5 JP2014221801 A5 JP 2014221801A5 JP 2014142904 A JP2014142904 A JP 2014142904A JP 2014142904 A JP2014142904 A JP 2014142904A JP 2014221801 A5 JP2014221801 A5 JP 2014221801A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- helix
- enhanced
- modified
- helix polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9906308P | 2008-09-22 | 2008-09-22 | |
| US61/099,063 | 2008-09-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Division JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016159624A Division JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014221801A JP2014221801A (ja) | 2014-11-27 |
| JP2014221801A5 true JP2014221801A5 (enExample) | 2015-09-10 |
| JP6067626B2 JP6067626B2 (ja) | 2017-01-25 |
Family
ID=41611441
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Expired - Fee Related JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
| JP2014142904A Expired - Fee Related JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Expired - Fee Related JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8524653B2 (enExample) |
| EP (1) | EP2342222B1 (enExample) |
| JP (3) | JP5711128B2 (enExample) |
| CN (1) | CN102482336B (enExample) |
| AU (1) | AU2009294877C1 (enExample) |
| BR (1) | BRPI0918948A2 (enExample) |
| CA (1) | CA2737922A1 (enExample) |
| ES (1) | ES2666458T3 (enExample) |
| IL (1) | IL211836A0 (enExample) |
| WO (1) | WO2010034034A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| EP1680443B9 (en) * | 2003-11-05 | 2014-09-03 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides and uses thereof |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| CA2686827C (en) * | 2006-12-14 | 2014-09-16 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CN109627287A (zh) | 2007-02-23 | 2019-04-16 | 爱勒让治疗公司 | 三唑大环系统 |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| WO2009110952A2 (en) * | 2007-12-31 | 2009-09-11 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| BRPI0907754A2 (pt) | 2008-02-08 | 2015-07-21 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos terapêuticos |
| US20110144303A1 (en) * | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| EP2356139A4 (en) * | 2008-07-23 | 2013-01-09 | Harvard College | LIGURE COMBINED POLYPEPTIDES |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| US8524653B2 (en) | 2008-09-22 | 2013-09-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2010060112A1 (en) | 2008-11-24 | 2010-05-27 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with improved properties |
| EP2376100B1 (en) | 2009-01-14 | 2017-10-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| BR112012008831A2 (pt) * | 2009-10-14 | 2019-09-24 | Aileron Therapeutics Inc | macrociclos de peptideomiméticos aprimorados. |
| SI2603600T1 (sl) * | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| WO2012051405A1 (en) | 2010-10-13 | 2012-04-19 | Bristol-Myers Squibb Company | Methods for preparing macrocycles and macrocycle stabilized peptides |
| EP2637680B1 (en) | 2010-11-12 | 2017-03-01 | Dana-Farber Cancer Institute, Inc. | Cancer therapies |
| US9029332B2 (en) | 2010-12-15 | 2015-05-12 | The Research Foundation For The State University Of New York | Cross-linked peptides and proteins, methods of making same, and uses thereof |
| WO2012174423A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of rab gtpase function |
| WO2012174409A1 (en) * | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized variant maml peptides and uses thereof |
| IN2014CN02398A (enExample) * | 2011-08-31 | 2015-06-19 | Univ New York | |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CA3113959A1 (en) | 2012-09-26 | 2014-04-03 | President And Fellows Of Harvard College | Proline-locked stapled peptides and uses thereof |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| WO2014113792A1 (en) * | 2013-01-19 | 2014-07-24 | New York University | Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation |
| EP3782638A1 (en) | 2013-03-13 | 2021-02-24 | President and Fellows of Harvard College | Stapled and stitched polypeptides and uses thereof |
| WO2014201370A1 (en) | 2013-06-14 | 2014-12-18 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
| WO2015038938A1 (en) | 2013-09-13 | 2015-03-19 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| US10039809B2 (en) | 2013-12-18 | 2018-08-07 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| CN114805527A (zh) | 2014-05-21 | 2022-07-29 | 哈佛大学的校长及成员们 | Ras抑制肽和其用途 |
| BR112017005598A2 (pt) * | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
| JP2018503595A (ja) | 2014-09-24 | 2018-02-08 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその製剤 |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| JP6729579B2 (ja) * | 2015-06-25 | 2020-07-22 | Ａｇｃ株式会社 | 撥水剤組成物、撥水剤組成物の製造方法および物品 |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
| CN108541221B (zh) | 2015-12-15 | 2023-02-28 | 格礼卡姆股份公司 | Hmo的混合物 |
| WO2017165299A2 (en) * | 2016-03-21 | 2017-09-28 | Aileron Therapeutics, Inc. | Companion diagnostic tool for peptidomimetic macrocycles |
| WO2018085208A1 (en) | 2016-11-02 | 2018-05-11 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction |
| BR112020004555A2 (pt) | 2017-09-07 | 2020-09-24 | Fog Pharmaceuticals, Inc. | agentes que modulam funções de beta-catenina e métodos dos mesmos |
| CN120118207A (zh) | 2017-12-15 | 2025-06-10 | 丹娜-法伯癌症研究院有限公司 | 稳定肽-介导的靶向蛋白降解 |
| EP3749678A1 (en) | 2018-02-07 | 2020-12-16 | Dana Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EP4069726A4 (en) | 2019-12-04 | 2024-03-20 | The Scripps Research Institute | GLP2 RECEPTOR AGONISTS AND METHOD OF USE |
| WO2022081827A1 (en) | 2020-10-14 | 2022-04-21 | Dana-Farber Cancer Institute, Inc. | Chimeric conjugates for degradation of viral and host proteins and methods of use |
| CA3209603A1 (en) * | 2021-01-28 | 2022-08-04 | Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center | Treatment of integrin-related disorders with stapled peptides |
| AU2022289610A1 (en) | 2021-06-09 | 2024-01-25 | The Scripps Research Institute | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811515A (en) | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| CA2363077A1 (en) | 1999-03-01 | 2000-09-08 | Variagenics, Inc. | Methods for targeting rna molecules |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| EP3167935B1 (en) * | 2003-05-01 | 2018-07-18 | Cornell Research Foundation, Inc. | Method and carrier complexes for delivering molecules to cells |
| EP1680443B9 (en) | 2003-11-05 | 2014-09-03 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides and uses thereof |
| WO2005089790A2 (en) | 2004-03-17 | 2005-09-29 | 7Tm Pharma A/S | Y2/y4 selective receptor agonists for therapeutic interventions |
| US8193310B2 (en) | 2004-03-19 | 2012-06-05 | The University Of Queensland | Alpha helical mimics, their uses and methods for their production |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| US7084248B2 (en) * | 2004-07-14 | 2006-08-01 | Gene Tools, Llc | Peptide composition and method for delivering substances into the cytosol of cells |
| WO2006103666A2 (en) | 2005-03-28 | 2006-10-05 | Yeda Research And Development Co. Ltd. | Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis |
| JP2010510236A (ja) | 2006-11-15 | 2010-04-02 | ダナ−ファーバー キャンサー インスティテュート インク． | 安定化させたｍａｍｌペプチドおよびその使用法 |
| CA2686827C (en) | 2006-12-14 | 2014-09-16 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US7981998B2 (en) | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CN109627287A (zh) * | 2007-02-23 | 2019-04-16 | 爱勒让治疗公司 | 三唑大环系统 |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| US10716828B2 (en) | 2007-05-02 | 2020-07-21 | Dana-Farber Cancer Institute, Inc. | Methods of modulating cellular homeostatic pathways and cellular survival |
| WO2009110952A2 (en) | 2007-12-31 | 2009-09-11 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| JP5788178B2 (ja) | 2008-01-23 | 2015-09-30 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | ウィルス感染症の治療のための組成物及び方法 |
| BRPI0907754A2 (pt) * | 2008-02-08 | 2015-07-21 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos terapêuticos |
| US20110144303A1 (en) | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| US20090326192A1 (en) | 2008-04-08 | 2009-12-31 | Aileron Therapeutics, Inc. | Biologically active peptidomimetic macrocycles |
| WO2009149214A2 (en) | 2008-06-03 | 2009-12-10 | Aileron Therapeutics, Inc. | Compositions and methods for enhancing cellular transport of biomolecules |
| EP2356139A4 (en) | 2008-07-23 | 2013-01-09 | Harvard College | LIGURE COMBINED POLYPEPTIDES |
| US9399666B2 (en) | 2008-09-18 | 2016-07-26 | New York University | Inhibiting interaction between the HIF-1ALPHA and p300/CBP with hydrogen bond surrogate-based helices |
| CN102884074A (zh) | 2008-09-22 | 2013-01-16 | 爱勒让治疗公司 | 拟肽大环化合物 |
| US8524653B2 (en) | 2008-09-22 | 2013-09-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CA2737918A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CA2737916A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| AU2009294869A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2010060112A1 (en) | 2008-11-24 | 2010-05-27 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with improved properties |
| EP2376100B1 (en) | 2009-01-14 | 2017-10-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| BR112012008831A2 (pt) | 2009-10-14 | 2019-09-24 | Aileron Therapeutics Inc | macrociclos de peptideomiméticos aprimorados. |
| SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| ES2586411T3 (es) | 2011-03-04 | 2016-10-14 | New York University | Macrociclos sustitutos de enlace de hidrógeno como moduladores de Ras |
| WO2012173846A2 (en) | 2011-06-06 | 2012-12-20 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| IN2014CN02398A (enExample) | 2011-08-31 | 2015-06-19 | Univ New York | |
| WO2013059530A2 (en) | 2011-10-18 | 2013-04-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
-
2009
- 2009-09-22 US US12/564,910 patent/US8524653B2/en not_active Expired - Fee Related
- 2009-09-22 JP JP2011528084A patent/JP5711128B2/ja not_active Expired - Fee Related
- 2009-09-22 BR BRPI0918948A patent/BRPI0918948A2/pt not_active Application Discontinuation
- 2009-09-22 EP EP09736335.2A patent/EP2342222B1/en not_active Not-in-force
- 2009-09-22 ES ES09736335.2T patent/ES2666458T3/es active Active
- 2009-09-22 WO PCT/US2009/057934 patent/WO2010034034A1/en not_active Ceased
- 2009-09-22 AU AU2009294877A patent/AU2009294877C1/en not_active Ceased
- 2009-09-22 CA CA2737922A patent/CA2737922A1/en not_active Abandoned
- 2009-09-22 CN CN200980142223.9A patent/CN102482336B/zh not_active Expired - Fee Related
-
2011
- 2011-03-21 IL IL211836A patent/IL211836A0/en active IP Right Grant
-
2012
- 2012-02-03 US US13/366,113 patent/US8399405B2/en not_active Expired - Fee Related
-
2013
- 2013-08-02 US US13/957,667 patent/US9175045B2/en not_active Expired - Fee Related
-
2014
- 2014-07-11 JP JP2014142904A patent/JP6067626B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-25 US US14/866,445 patent/US20160096873A1/en not_active Abandoned
-
2016
- 2016-08-16 JP JP2016159624A patent/JP2016190882A/ja active Pending
- 2016-09-06 US US15/257,807 patent/US20170299576A1/en not_active Abandoned