JP2012503026A5 - - Google Patents
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- Publication number
- JP2012503026A5 JP2012503026A5 JP2011528084A JP2011528084A JP2012503026A5 JP 2012503026 A5 JP2012503026 A5 JP 2012503026A5 JP 2011528084 A JP2011528084 A JP 2011528084A JP 2011528084 A JP2011528084 A JP 2011528084A JP 2012503026 A5 JP2012503026 A5 JP 2012503026A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- enhanced
- helix
- helical
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 91
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 89
- 229920001184 polypeptide Polymers 0.000 claims description 88
- 238000000034 method Methods 0.000 claims description 81
- 150000001413 amino acids Chemical class 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 239000003431 cross linking reagent Substances 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 13
- 102000004506 Blood Proteins Human genes 0.000 claims description 10
- 108010017384 Blood Proteins Proteins 0.000 claims description 10
- 210000000170 cell membrane Anatomy 0.000 claims description 9
- 230000001419 dependent effect Effects 0.000 claims description 9
- 230000003834 intracellular effect Effects 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 230000003463 hyperproliferative effect Effects 0.000 claims description 7
- 239000012466 permeate Substances 0.000 claims description 7
- 238000003556 assay Methods 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 101100455978 Arabidopsis thaliana MAM1 gene Proteins 0.000 claims description 4
- 102000051485 Bcl-2 family Human genes 0.000 claims description 4
- 108700038897 Bcl-2 family Proteins 0.000 claims description 4
- 102100031633 Chorionic somatomammotropin hormone-like 1 Human genes 0.000 claims description 4
- 108010016626 Dipeptides Proteins 0.000 claims description 4
- 101000940558 Homo sapiens Chorionic somatomammotropin hormone-like 1 Proteins 0.000 claims description 4
- 102000005650 Notch Receptors Human genes 0.000 claims description 4
- 108010070047 Notch Receptors Proteins 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 230000003993 interaction Effects 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 230000001413 cellular effect Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000012202 endocytosis Effects 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 230000001594 aberrant effect Effects 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9906308P | 2008-09-22 | 2008-09-22 | |
| US61/099,063 | 2008-09-22 | ||
| PCT/US2009/057934 WO2010034034A1 (en) | 2008-09-22 | 2009-09-22 | Peptidomimetic macrocycles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142904A Division JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503026A JP2012503026A (ja) | 2012-02-02 |
| JP2012503026A5 true JP2012503026A5 (enExample) | 2013-05-16 |
| JP5711128B2 JP5711128B2 (ja) | 2015-04-30 |
Family
ID=41611441
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Expired - Fee Related JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
| JP2014142904A Expired - Fee Related JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142904A Expired - Fee Related JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8524653B2 (enExample) |
| EP (1) | EP2342222B1 (enExample) |
| JP (3) | JP5711128B2 (enExample) |
| CN (1) | CN102482336B (enExample) |
| AU (1) | AU2009294877C1 (enExample) |
| BR (1) | BRPI0918948A2 (enExample) |
| CA (1) | CA2737922A1 (enExample) |
| ES (1) | ES2666458T3 (enExample) |
| IL (1) | IL211836A0 (enExample) |
| WO (1) | WO2010034034A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| CN103467588B (zh) | 2003-11-05 | 2016-12-28 | 达纳-法伯癌症研究所股份有限公司 | 稳定的α螺旋肽及其用途 |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| EP3170835A1 (en) * | 2006-12-14 | 2017-05-24 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EP2564862B1 (en) * | 2007-02-23 | 2017-08-02 | Aileron Therapeutics, Inc. | Substituted amino acids for preparing triazole linked macrocyclic peptides |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| WO2009110952A2 (en) * | 2007-12-31 | 2009-09-11 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| CN104474529A (zh) | 2008-02-08 | 2015-04-01 | 爱勒让治疗公司 | 治疗性的拟肽大环化合物 |
| US20110144303A1 (en) * | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| WO2010011313A2 (en) | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| CN102482336B (zh) | 2008-09-22 | 2015-05-06 | 爱勒让治疗公司 | 拟肽大环化合物 |
| WO2010034032A2 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutic, Inc. | Methods for preparing purified polypeptide compositions |
| JP2012509902A (ja) * | 2008-11-24 | 2012-04-26 | エルロン・セラピューティクス・インコーポレイテッド | 改善された特性を有するペプチド模倣大環状分子 |
| WO2010083347A2 (en) | 2009-01-14 | 2010-07-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CA2777700A1 (en) * | 2009-10-14 | 2011-04-21 | Aileron Therapeutics, Inc. | Improved peptidomimetic macrocycles |
| RU2016111360A (ru) | 2010-08-13 | 2018-11-27 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
| US8957026B2 (en) | 2010-09-22 | 2015-02-17 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| WO2012051405A1 (en) | 2010-10-13 | 2012-04-19 | Bristol-Myers Squibb Company | Methods for preparing macrocycles and macrocycle stabilized peptides |
| AU2011325910B2 (en) | 2010-11-12 | 2016-03-24 | Dana Farber Cancer Institute, Inc. | Cancer therapies and diagnostics |
| EP2651964B1 (en) | 2010-12-15 | 2018-02-28 | The Research Foundation of State University of New York | Cross-linked peptides and proteins, methods of making same, and uses thereof |
| EP2721061A4 (en) * | 2011-06-17 | 2014-11-05 | Harvard College | VARIANT STABILIZED MAML-PEPTIDES AND USES THEREOF |
| WO2012174423A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of rab gtpase function |
| WO2013033645A1 (en) * | 2011-08-31 | 2013-03-07 | New York University | Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| RU2017145921A (ru) | 2012-02-15 | 2019-02-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
| EP2920197B1 (en) | 2012-09-26 | 2021-03-17 | President and Fellows of Harvard College | Proline-locked stapled peptides and uses thereof |
| CN104812384B (zh) | 2012-11-01 | 2020-09-18 | 爱勒让治疗公司 | 二取代的氨基酸及其制备和使用方法 |
| US20140205681A1 (en) * | 2013-01-19 | 2014-07-24 | New York University | HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION |
| JP6568515B2 (ja) | 2013-03-13 | 2019-08-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステープルドおよびステッチドポリペプチドならびにその使用 |
| MX2015017274A (es) | 2013-06-14 | 2016-08-04 | Harvard College | Moduladores del receptor del polipéptido insulina estabilizados. |
| ES2927607T3 (es) | 2013-09-13 | 2022-11-08 | Scripps Research Inst | Agentes terapéuticos modificados y composiciones de los mismos |
| US10039809B2 (en) | 2013-12-18 | 2018-08-07 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| JP6759109B2 (ja) | 2014-05-21 | 2020-09-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Ｒａｓ抑制性ペプチドおよびその使用 |
| JP2017533889A (ja) | 2014-09-24 | 2017-11-16 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその使用 |
| MX389354B (es) | 2014-09-24 | 2025-03-20 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y formulaciones de los mismos. |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| KR102665898B1 (ko) * | 2015-06-25 | 2024-05-14 | 에이지씨 가부시키가이샤 | 발수제 조성물, 발수제 조성물의 제조 방법 및 물품 |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
| CN108541221B (zh) * | 2015-12-15 | 2023-02-28 | 格礼卡姆股份公司 | Hmo的混合物 |
| JP2019520304A (ja) * | 2016-03-21 | 2019-07-18 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子に関するコンパニオン診断ツール |
| US12059413B2 (en) | 2016-11-02 | 2024-08-13 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction |
| SG11202001162TA (en) | 2017-09-07 | 2020-03-30 | Fog Pharmaceuticals Inc | Agents modulating beta-catenin functions and methods thereof |
| WO2019118893A1 (en) | 2017-12-15 | 2019-06-20 | Dana-Farber Cancer Institute, Inc. | Stabilized peptide-mediated targeted protein degradation |
| EP3749678A1 (en) | 2018-02-07 | 2020-12-16 | Dana Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CA3193261A1 (en) | 2020-10-14 | 2022-04-21 | Dana-Farber Cancer Institute, Inc. | Chimeric conjugates for degradation of viral and host proteins and methods of use |
| CA3209603A1 (en) * | 2021-01-28 | 2022-08-04 | Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center | Treatment of integrin-related disorders with stapled peptides |
| IL309067A (en) | 2021-06-09 | 2024-02-01 | Scripps Research Inst | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811515A (en) * | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| WO2000052210A2 (en) | 1999-03-01 | 2000-09-08 | Variagenics, Inc. | Methods for targeting rna molecules |
| US7192713B1 (en) * | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| CA2524258C (en) * | 2003-05-01 | 2012-08-07 | Cornell Research Foundation, Inc. | Carrier complexes comprising cationic peptides for delivering molecules to cells |
| CN103467588B (zh) | 2003-11-05 | 2016-12-28 | 达纳-法伯癌症研究所股份有限公司 | 稳定的α螺旋肽及其用途 |
| EP1786458A2 (en) * | 2004-03-17 | 2007-05-23 | 7TM Pharma A/S | Y2/y4 selective receptor agonists for therapeutic interventions |
| WO2005090388A1 (en) * | 2004-03-19 | 2005-09-29 | The University Of Queensland | Alpha helical mimics, their uses and methods for their production |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| US7084248B2 (en) | 2004-07-14 | 2006-08-01 | Gene Tools, Llc | Peptide composition and method for delivering substances into the cytosol of cells |
| WO2006103666A2 (en) | 2005-03-28 | 2006-10-05 | Yeda Research And Development Co. Ltd. | Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis |
| EP2091552A4 (en) * | 2006-11-15 | 2010-01-06 | Dana Farber Cancer Inst Inc | STABILIZED MAML-PEPTIDES AND ITS USES |
| EP3170835A1 (en) | 2006-12-14 | 2017-05-24 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| EP2564862B1 (en) * | 2007-02-23 | 2017-08-02 | Aileron Therapeutics, Inc. | Substituted amino acids for preparing triazole linked macrocyclic peptides |
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| JP5883220B2 (ja) | 2007-05-02 | 2016-03-09 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 細胞のホメオスタシス経路および細胞の生存を調節する方法 |
| WO2009110952A2 (en) | 2007-12-31 | 2009-09-11 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| WO2009108261A2 (en) | 2008-01-23 | 2009-09-03 | Dana Farber Cancer Institute | Compositions and methods for the treatment of viral infections |
| CN104474529A (zh) | 2008-02-08 | 2015-04-01 | 爱勒让治疗公司 | 治疗性的拟肽大环化合物 |
| US20110144303A1 (en) | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| WO2009126292A2 (en) | 2008-04-08 | 2009-10-15 | Aileron Therapeutics, Inc. | Biologically active peptidomimetic macrocycles |
| EP2285970A4 (en) | 2008-06-03 | 2011-10-12 | Aileron Therapeutics Inc | COMPOSITIONS AND METHODS FOR REINFORCING THE CELL TRANSPORT OF BIOMOLECULES |
| WO2010011313A2 (en) | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| JP2012503013A (ja) | 2008-09-18 | 2012-02-02 | ニューヨーク ユニバーシティ | ＨＩＦ−１αと水素結合代替ヘリックスを有するｐ３００／ＣＢＰの間の相互作用の阻害 |
| BRPI0920889A2 (pt) | 2008-09-22 | 2017-10-10 | Aileron Therapeutics Inc | macrociclos peptidomiméticos. |
| CN102482336B (zh) | 2008-09-22 | 2015-05-06 | 爱勒让治疗公司 | 拟肽大环化合物 |
| CA2737918A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2010034032A2 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutic, Inc. | Methods for preparing purified polypeptide compositions |
| CA2737914A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP2342214A1 (en) | 2008-09-22 | 2011-07-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP2012509902A (ja) * | 2008-11-24 | 2012-04-26 | エルロン・セラピューティクス・インコーポレイテッド | 改善された特性を有するペプチド模倣大環状分子 |
| WO2010083347A2 (en) | 2009-01-14 | 2010-07-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CA2777700A1 (en) | 2009-10-14 | 2011-04-21 | Aileron Therapeutics, Inc. | Improved peptidomimetic macrocycles |
| RU2016111360A (ru) | 2010-08-13 | 2018-11-27 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
| CA2828889A1 (en) | 2011-03-04 | 2012-09-13 | New York University | Hydrogen bond surrogate macrocycles as modulators of ras |
| WO2012173846A2 (en) | 2011-06-06 | 2012-12-20 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2013033645A1 (en) | 2011-08-31 | 2013-03-07 | New York University | Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics |
| WO2013059530A2 (en) | 2011-10-18 | 2013-04-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| RU2017145921A (ru) | 2012-02-15 | 2019-02-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
| CN104812384B (zh) | 2012-11-01 | 2020-09-18 | 爱勒让治疗公司 | 二取代的氨基酸及其制备和使用方法 |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
-
2009
- 2009-09-22 CN CN200980142223.9A patent/CN102482336B/zh not_active Expired - Fee Related
- 2009-09-22 BR BRPI0918948A patent/BRPI0918948A2/pt not_active Application Discontinuation
- 2009-09-22 JP JP2011528084A patent/JP5711128B2/ja not_active Expired - Fee Related
- 2009-09-22 CA CA2737922A patent/CA2737922A1/en not_active Abandoned
- 2009-09-22 ES ES09736335.2T patent/ES2666458T3/es active Active
- 2009-09-22 WO PCT/US2009/057934 patent/WO2010034034A1/en not_active Ceased
- 2009-09-22 EP EP09736335.2A patent/EP2342222B1/en not_active Not-in-force
- 2009-09-22 US US12/564,910 patent/US8524653B2/en not_active Expired - Fee Related
- 2009-09-22 AU AU2009294877A patent/AU2009294877C1/en not_active Ceased
-
2011
- 2011-03-21 IL IL211836A patent/IL211836A0/en active IP Right Grant
-
2012
- 2012-02-03 US US13/366,113 patent/US8399405B2/en not_active Expired - Fee Related
-
2013
- 2013-08-02 US US13/957,667 patent/US9175045B2/en not_active Expired - Fee Related
-
2014
- 2014-07-11 JP JP2014142904A patent/JP6067626B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-25 US US14/866,445 patent/US20160096873A1/en not_active Abandoned
-
2016
- 2016-08-16 JP JP2016159624A patent/JP2016190882A/ja active Pending
- 2016-09-06 US US15/257,807 patent/US20170299576A1/en not_active Abandoned
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