JP2016105097A5 - - Google Patents
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- JP2016105097A5 JP2016105097A5 JP2015253708A JP2015253708A JP2016105097A5 JP 2016105097 A5 JP2016105097 A5 JP 2016105097A5 JP 2015253708 A JP2015253708 A JP 2015253708A JP 2015253708 A JP2015253708 A JP 2015253708A JP 2016105097 A5 JP2016105097 A5 JP 2016105097A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acids
- terminal
- tau
- degradation product
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 22
- 239000000090 biomarker Substances 0.000 claims 10
- 239000007857 degradation product Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 210000004899 c-terminal region Anatomy 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 6
- 102000013498 tau Proteins Human genes 0.000 claims 6
- 108010026424 tau Proteins Proteins 0.000 claims 6
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 4
- 101100480719 Rattus norvegicus Mapt gene Proteins 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 102000057063 human MAPT Human genes 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 230000000926 neurological effect Effects 0.000 claims 3
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000017004 dementia pugilistica Diseases 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24212309P | 2009-09-14 | 2009-09-14 | |
| US61/242,123 | 2009-09-14 | ||
| US35450410P | 2010-06-14 | 2010-06-14 | |
| US61/354,504 | 2010-06-14 | ||
| US35577910P | 2010-06-17 | 2010-06-17 | |
| US61/355,779 | 2010-06-17 | ||
| US38015810P | 2010-09-03 | 2010-09-03 | |
| US61/380,158 | 2010-09-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Division JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017111070A Division JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016105097A JP2016105097A (ja) | 2016-06-09 |
| JP2016105097A5 true JP2016105097A5 (enExample) | 2016-12-01 |
Family
ID=43733138
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Active JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Active JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130022982A1 (enExample) |
| EP (1) | EP2478360B1 (enExample) |
| JP (3) | JP5909447B2 (enExample) |
| AU (2) | AU2010291933B2 (enExample) |
| CA (1) | CA2774173A1 (enExample) |
| ES (1) | ES2687469T3 (enExample) |
| HU (1) | HUE040281T2 (enExample) |
| WO (1) | WO2011032155A2 (enExample) |
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| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| US20140342381A1 (en) | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| WO2010019553A2 (en) | 2008-08-11 | 2010-02-18 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| WO2010059242A2 (en) | 2008-11-21 | 2010-05-27 | The Johns Hopkins University | Neurodegenerative disease diagnostic compositions and methods of use |
| EP2443461A4 (en) | 2009-06-19 | 2012-12-26 | Banyan Biomarkers Inc | BIOMARKER ASSAY FOR NERVES |
| US20170315136A9 (en) | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| WO2011011334A2 (en) | 2009-07-18 | 2011-01-27 | Banyan Biomarkers, Inc. | SYNERGISTIC BIOMARKER ASSAY OF NEUROLGICAL CONDITION USING S-100β |
| ES2687469T3 (es) | 2009-09-14 | 2018-10-25 | Banyan Biomarkers, Inc. | Marcadores autoanticuerpos para el diagnóstico de traumatismo craneoencefálico |
| US20130029362A1 (en) | 2010-04-01 | 2013-01-31 | Andreas Jeromin | Markers and assays for detection of neurotoxicity |
| WO2011160096A2 (en) | 2010-06-17 | 2011-12-22 | Banyan Biomarkers, Inc. | Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition |
| JP6061935B2 (ja) | 2011-09-14 | 2017-01-18 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン，インコーポレーテッド | 心的外傷後ストレス障害（ｐｔｓｄ）のための診断用バイオマーカーを検出及び監視するため、並びに同障害の自殺型と非自殺型とを識別するためのプロセス及びキット |
| US20140024053A1 (en) | 2012-07-20 | 2014-01-23 | Banyan Biomarkers, Inc. | Methods, kits and devices for detecting bii-spectrin, and breakdown products thereof, as biomarkers for the diagnosis of neural injury |
| US20140275294A1 (en) | 2013-03-15 | 2014-09-18 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of liver injury |
| WO2014194329A1 (en) | 2013-05-31 | 2014-12-04 | Banyan Biomarkers, Inc. | NEURAL SPECIFIC S100β FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION |
-
2010
- 2010-09-14 ES ES10816275T patent/ES2687469T3/es active Active
- 2010-09-14 WO PCT/US2010/048789 patent/WO2011032155A2/en not_active Ceased
- 2010-09-14 CA CA2774173A patent/CA2774173A1/en not_active Abandoned
- 2010-09-14 HU HUE10816275A patent/HUE040281T2/hu unknown
- 2010-09-14 AU AU2010291933A patent/AU2010291933B2/en not_active Expired - Fee Related
- 2010-09-14 JP JP2012528991A patent/JP5909447B2/ja active Active
- 2010-09-14 EP EP10816275.1A patent/EP2478360B1/en not_active Revoked
- 2010-09-14 US US13/395,931 patent/US20130022982A1/en not_active Abandoned
-
2015
- 2015-12-25 JP JP2015253708A patent/JP2016105097A/ja active Pending
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2016
- 2016-12-07 AU AU2016269481A patent/AU2016269481B2/en not_active Ceased
- 2016-12-27 US US15/391,755 patent/US10041959B2/en active Active
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2017
- 2017-06-05 JP JP2017111070A patent/JP6469760B2/ja active Active
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2018
- 2018-08-01 US US16/052,512 patent/US20190064188A1/en not_active Abandoned
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