JP2016105097A5 - - Google Patents
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- JP2016105097A5 JP2016105097A5 JP2015253708A JP2015253708A JP2016105097A5 JP 2016105097 A5 JP2016105097 A5 JP 2016105097A5 JP 2015253708 A JP2015253708 A JP 2015253708A JP 2015253708 A JP2015253708 A JP 2015253708A JP 2016105097 A5 JP2016105097 A5 JP 2016105097A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acids
- terminal
- tau
- degradation product
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 22
- 239000000090 biomarker Substances 0.000 claims 10
- 239000007857 degradation product Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 210000004899 c-terminal region Anatomy 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 6
- 102000013498 tau Proteins Human genes 0.000 claims 6
- 108010026424 tau Proteins Proteins 0.000 claims 6
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 4
- 101100480719 Rattus norvegicus Mapt gene Proteins 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 102000057063 human MAPT Human genes 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 230000000926 neurological effect Effects 0.000 claims 3
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000017004 dementia pugilistica Diseases 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24212309P | 2009-09-14 | 2009-09-14 | |
| US61/242,123 | 2009-09-14 | ||
| US35450410P | 2010-06-14 | 2010-06-14 | |
| US61/354,504 | 2010-06-14 | ||
| US35577910P | 2010-06-17 | 2010-06-17 | |
| US61/355,779 | 2010-06-17 | ||
| US38015810P | 2010-09-03 | 2010-09-03 | |
| US61/380,158 | 2010-09-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Division JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017111070A Division JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016105097A JP2016105097A (ja) | 2016-06-09 |
| JP2016105097A5 true JP2016105097A5 (enExample) | 2016-12-01 |
Family
ID=43733138
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Active JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Active JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130022982A1 (enExample) |
| EP (1) | EP2478360B1 (enExample) |
| JP (3) | JP5909447B2 (enExample) |
| AU (2) | AU2010291933B2 (enExample) |
| CA (1) | CA2774173A1 (enExample) |
| ES (1) | ES2687469T3 (enExample) |
| HU (1) | HUE040281T2 (enExample) |
| WO (1) | WO2011032155A2 (enExample) |
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-
2010
- 2010-09-14 AU AU2010291933A patent/AU2010291933B2/en not_active Expired - Fee Related
- 2010-09-14 WO PCT/US2010/048789 patent/WO2011032155A2/en not_active Ceased
- 2010-09-14 CA CA2774173A patent/CA2774173A1/en not_active Abandoned
- 2010-09-14 ES ES10816275T patent/ES2687469T3/es active Active
- 2010-09-14 HU HUE10816275A patent/HUE040281T2/hu unknown
- 2010-09-14 US US13/395,931 patent/US20130022982A1/en not_active Abandoned
- 2010-09-14 EP EP10816275.1A patent/EP2478360B1/en not_active Revoked
- 2010-09-14 JP JP2012528991A patent/JP5909447B2/ja active Active
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2015
- 2015-12-25 JP JP2015253708A patent/JP2016105097A/ja active Pending
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2016
- 2016-12-07 AU AU2016269481A patent/AU2016269481B2/en not_active Ceased
- 2016-12-27 US US15/391,755 patent/US10041959B2/en active Active
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2017
- 2017-06-05 JP JP2017111070A patent/JP6469760B2/ja active Active
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2018
- 2018-08-01 US US16/052,512 patent/US20190064188A1/en not_active Abandoned
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