JP2017530373A5 - - Google Patents
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- Publication number
- JP2017530373A5 JP2017530373A5 JP2017533721A JP2017533721A JP2017530373A5 JP 2017530373 A5 JP2017530373 A5 JP 2017530373A5 JP 2017533721 A JP2017533721 A JP 2017533721A JP 2017533721 A JP2017533721 A JP 2017533721A JP 2017530373 A5 JP2017530373 A5 JP 2017530373A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- soluble
- sample
- misfolded
- soluble misfolded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 131
- 108090000623 proteins and genes Proteins 0.000 claims 131
- 239000000523 sample Substances 0.000 claims 53
- 238000000034 method Methods 0.000 claims 34
- 238000011534 incubation Methods 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 32
- 239000000178 monomer Substances 0.000 claims 27
- 230000003321 amplification Effects 0.000 claims 11
- 238000003199 nucleic acid amplification method Methods 0.000 claims 11
- -1 m-I-stilbene Chemical compound 0.000 claims 8
- 206010012289 Dementia Diseases 0.000 claims 5
- 230000001149 cognitive effect Effects 0.000 claims 5
- 238000012360 testing method Methods 0.000 claims 5
- 102000029797 Prion Human genes 0.000 claims 4
- 108091000054 Prion Proteins 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000013060 biological fluid Substances 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 4
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims 4
- 239000013068 control sample Substances 0.000 claims 4
- 238000000159 protein binding assay Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- JADVWWSKYZXRGX-UHFFFAOYSA-M thioflavine T Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C1=[N+](C)C2=CC=C(C)C=C2S1 JADVWWSKYZXRGX-UHFFFAOYSA-M 0.000 claims 4
- 238000004220 aggregation Methods 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 claims 2
- IAVCEBMLYVGBLA-UHFFFAOYSA-N 2-[1-[6-[2-fluoroethyl(methyl)amino]naphthalen-2-yl]ethylidene]propanedinitrile Chemical compound C1=C(C(C)=C(C#N)C#N)C=CC2=CC(N(CCF)C)=CC=C21 IAVCEBMLYVGBLA-UHFFFAOYSA-N 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 2
- AJTVSSFTXWNIRG-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanesulfonic acid Chemical compound OCC[NH+](CCO)CCS([O-])(=O)=O AJTVSSFTXWNIRG-UHFFFAOYSA-N 0.000 claims 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 2
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 claims 2
- 206010003445 Ascites Diseases 0.000 claims 2
- 239000007992 BES buffer Substances 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 206010050337 Cerumen impaction Diseases 0.000 claims 2
- 241000282994 Cervidae Species 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 239000007995 HEPES buffer Substances 0.000 claims 2
- 239000007987 MES buffer Substances 0.000 claims 2
- 239000007993 MOPS buffer Substances 0.000 claims 2
- JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 claims 2
- XFFSCOOTVXBLCK-QAVVBOBSSA-N OC(=O)c1cc(ccc1O)\N=N\c1ccc(cc1)-c1ccc(cc1)\N=N\c1ccc(O)c(c1)C(O)=O Chemical compound OC(=O)c1cc(ccc1O)\N=N\c1ccc(cc1)-c1ccc(cc1)\N=N\c1ccc(O)c(c1)C(O)=O XFFSCOOTVXBLCK-QAVVBOBSSA-N 0.000 claims 2
- 239000007990 PIPES buffer Substances 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 208000002151 Pleural effusion Diseases 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 239000007994 TES buffer Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004381 amniotic fluid Anatomy 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 238000004630 atomic force microscopy Methods 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 210000002939 cerumen Anatomy 0.000 claims 2
- KPMVHELZNRNSMN-UHFFFAOYSA-N chembl1985849 Chemical compound N1=CC=C2NCCN21 KPMVHELZNRNSMN-UHFFFAOYSA-N 0.000 claims 2
- 230000000052 comparative effect Effects 0.000 claims 2
- 238000001493 electron microscopy Methods 0.000 claims 2
- 210000000416 exudates and transudate Anatomy 0.000 claims 2
- 210000003608 fece Anatomy 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- 238000001114 immunoprecipitation Methods 0.000 claims 2
- 210000002751 lymph Anatomy 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 210000003097 mucus Anatomy 0.000 claims 2
- 229920000123 polythiophene Polymers 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 238000004611 spectroscopical analysis Methods 0.000 claims 2
- 210000001179 synovial fluid Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 238000001262 western blot Methods 0.000 claims 2
- KLFRZDOQQDHVSS-UHFFFAOYSA-N 2-[[5-[5-(4-hydroxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile Chemical compound C1=CC(O)=CC=C1C1=CC=C(C=2SC(C=C(C#N)C#N)=CC=2)S1 KLFRZDOQQDHVSS-UHFFFAOYSA-N 0.000 claims 1
- 102000003802 alpha-Synuclein Human genes 0.000 claims 1
- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000006337 proteolytic cleavage Effects 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021081274A JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049306P | 2014-09-11 | 2014-09-11 | |
| US62/049,306 | 2014-09-11 | ||
| PCT/US2015/049844 WO2016040907A1 (en) | 2014-09-11 | 2015-09-11 | Detection of misfolded proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021081274A Division JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530373A JP2017530373A (ja) | 2017-10-12 |
| JP2017530373A5 true JP2017530373A5 (enExample) | 2018-10-25 |
| JP6980953B2 JP6980953B2 (ja) | 2021-12-15 |
Family
ID=55454515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533721A Active JP6980953B2 (ja) | 2014-09-11 | 2015-09-11 | ミスフォールディングタンパク質の検出 |
| JP2021081274A Active JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021081274A Active JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20160077112A1 (enExample) |
| EP (2) | EP4292654A3 (enExample) |
| JP (2) | JP6980953B2 (enExample) |
| KR (1) | KR102448128B1 (enExample) |
| CN (1) | CN107208125A (enExample) |
| AU (1) | AU2015314783B2 (enExample) |
| BR (1) | BR112017004899A2 (enExample) |
| CA (1) | CA2960830C (enExample) |
| ES (1) | ES2953855T3 (enExample) |
| HR (1) | HRP20231232T1 (enExample) |
| IL (2) | IL251052B (enExample) |
| MX (1) | MX2017003269A (enExample) |
| PL (1) | PL3191599T3 (enExample) |
| SG (2) | SG11201701953RA (enExample) |
| WO (1) | WO2016040907A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10989718B2 (en) | 2014-09-11 | 2021-04-27 | Amprion, Inc. | Detection of misfolded alpha synuclein protein |
| GB201611840D0 (en) * | 2016-07-07 | 2016-08-24 | Univ Court Of The Univ Of Edinburgh The | Alpha-synuclein detection assay |
| US11142570B2 (en) | 2017-02-17 | 2021-10-12 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| TW201901153A (zh) * | 2017-05-16 | 2019-01-01 | 美商安培恩股份有限公司 | 折疊錯誤之ｔａｕ蛋白的檢測及檢測折疊錯誤之ｔａｕ蛋白的套組 |
| US11313867B2 (en) | 2017-10-02 | 2022-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| WO2019121952A1 (en) * | 2017-12-21 | 2019-06-27 | H. Lundbeck A/S | Assay, method and treatment of alpha-synucleinopathies |
| CN108088816A (zh) * | 2018-01-23 | 2018-05-29 | 深圳市国赛生物技术有限公司 | 小型特定蛋白分析仪 |
| GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| WO2019222554A2 (en) * | 2018-05-16 | 2019-11-21 | Amprion, Inc. | Detection of brain injury or neurological disease using tau protein |
| CA3110200C (en) | 2018-09-21 | 2023-08-08 | Deepmind Technologies Limited | Iterative protein structure prediction using gradients of quality scores |
| JP7376040B2 (ja) * | 2019-09-03 | 2023-11-08 | 国立大学法人京都工芸繊維大学 | 神経変性疾患におけるバイオマーカー分子の検出方法 |
| CN115003824A (zh) * | 2019-09-04 | 2022-09-02 | 安培里翁公司 | 使用珠子检测α-突触核蛋白 |
| KR102277871B1 (ko) * | 2019-12-17 | 2021-07-15 | 원광대학교산학협력단 | 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트 |
| WO2021198098A1 (en) | 2020-04-03 | 2021-10-07 | Universität Zürich | Improved method of detecting biomarkers in a biological sample |
| WO2021236678A1 (en) * | 2020-05-18 | 2021-11-25 | Amprion, Inc. | Alpha-synuclein substrates and methods for making and using the same |
| CN118731363A (zh) * | 2020-11-21 | 2024-10-01 | 浙江数问生物技术有限公司 | 用于检测生物样本中的错误折叠蛋白质的装置和方法 |
| US20240192230A1 (en) * | 2021-04-15 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Digital Protein Misfolding Assays |
| CN114199875B (zh) * | 2022-02-18 | 2022-05-20 | 之江实验室 | 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007391B1 (ru) | 2000-07-07 | 2006-10-27 | Апплайд Резеч Системз Арс Холдинг Н.В. | Способ диагностики или выявления конформационного заболевания или его маркера и набор для использования в способе |
| EP1366368A2 (en) | 2001-01-03 | 2003-12-03 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha synuclein aggregation assays |
| GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| EP1820806A1 (en) * | 2006-02-16 | 2007-08-22 | Crossbeta Biosciences B.V. | Affinity regions |
| EP1853915B1 (en) * | 2005-02-15 | 2011-10-12 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
| BRPI0712034A2 (pt) * | 2006-05-19 | 2012-01-10 | Alnylam Pharmaceuticals Inc | modulação de rnai de aha e usos terapêuticos do mesmo |
| WO2008030973A2 (en) * | 2006-09-06 | 2008-03-13 | The Board Of Regents Of The University Of Texas System | Methods and compositions for the detection of protein folding disorders |
| JP2010043865A (ja) * | 2006-12-12 | 2010-02-25 | Olympus Corp | 異常型プリオンの検出方法 |
| JP2013511734A (ja) * | 2009-11-24 | 2013-04-04 | プロビオドルグ エージー | アルツハイマー病又は軽度認知障害の診断のための新規診断方法 |
| US9133343B2 (en) * | 2009-11-30 | 2015-09-15 | Enzo Biochem, Inc. | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications |
| AU2012207454B2 (en) * | 2011-01-18 | 2016-11-17 | Prionics Ag | Methods for amplification and detection of prions |
| US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
| WO2016040903A1 (en) * | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded amyloid beta protein |
-
2015
- 2015-09-11 EP EP23189057.5A patent/EP4292654A3/en active Pending
- 2015-09-11 BR BR112017004899A patent/BR112017004899A2/pt not_active Application Discontinuation
- 2015-09-11 SG SG11201701953RA patent/SG11201701953RA/en unknown
- 2015-09-11 JP JP2017533721A patent/JP6980953B2/ja active Active
- 2015-09-11 PL PL15839278.7T patent/PL3191599T3/pl unknown
- 2015-09-11 AU AU2015314783A patent/AU2015314783B2/en active Active
- 2015-09-11 KR KR1020177009707A patent/KR102448128B1/ko active Active
- 2015-09-11 CN CN201580058606.3A patent/CN107208125A/zh active Pending
- 2015-09-11 US US14/852,478 patent/US20160077112A1/en not_active Abandoned
- 2015-09-11 CA CA2960830A patent/CA2960830C/en active Active
- 2015-09-11 MX MX2017003269A patent/MX2017003269A/es unknown
- 2015-09-11 HR HRP20231232TT patent/HRP20231232T1/hr unknown
- 2015-09-11 SG SG10202008464UA patent/SG10202008464UA/en unknown
- 2015-09-11 ES ES15839278T patent/ES2953855T3/es active Active
- 2015-09-11 WO PCT/US2015/049844 patent/WO2016040907A1/en not_active Ceased
- 2015-09-11 EP EP15839278.7A patent/EP3191599B1/en active Active
-
2017
- 2017-03-09 IL IL251052A patent/IL251052B/en unknown
-
2021
- 2021-05-12 JP JP2021081274A patent/JP7104943B2/ja active Active
-
2022
- 2022-03-30 IL IL291809A patent/IL291809B2/en unknown
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