AU2015314783B2 - Detection of misfolded proteins - Google Patents

Detection of misfolded proteins Download PDF

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Publication number
AU2015314783B2
AU2015314783B2 AU2015314783A AU2015314783A AU2015314783B2 AU 2015314783 B2 AU2015314783 B2 AU 2015314783B2 AU 2015314783 A AU2015314783 A AU 2015314783A AU 2015314783 A AU2015314783 A AU 2015314783A AU 2015314783 B2 AU2015314783 B2 AU 2015314783B2
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Australia
Prior art keywords
protein
soluble
misfolded
incubation
incubation mixture
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AU2015314783A
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AU2015314783A1 (en
Inventor
Claudio Soto JARA
Russell M. Lebovitz
Mohammad Shahnawaz
Benedikt K. VOLLRATH
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The University of Texas System
Amprion Inc
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The University of Texas System
The University of Texas at Austin
Amprion Inc
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Assigned to BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, AMPRION, INC. reassignment BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM Request for Assignment Assignors: AMPRION, INC., BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Jara, Claudio, Lebovitz, Russell, SHAHNAWAZ, MOHAMMAD, VOLLRATH, BENEDIKT
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
AU2015314783A 2014-09-11 2015-09-11 Detection of misfolded proteins Active AU2015314783B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049306P 2014-09-11 2014-09-11
US62/049,306 2014-09-11
PCT/US2015/049844 WO2016040907A1 (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

Publications (2)

Publication Number Publication Date
AU2015314783A1 AU2015314783A1 (en) 2017-04-27
AU2015314783B2 true AU2015314783B2 (en) 2021-10-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015314783A Active AU2015314783B2 (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

Country Status (15)

Country Link
US (1) US20160077112A1 (enExample)
EP (2) EP3191599B1 (enExample)
JP (2) JP6980953B2 (enExample)
KR (1) KR102448128B1 (enExample)
CN (1) CN107208125A (enExample)
AU (1) AU2015314783B2 (enExample)
BR (1) BR112017004899A2 (enExample)
CA (1) CA2960830C (enExample)
ES (1) ES2953855T3 (enExample)
HR (1) HRP20231232T1 (enExample)
IL (2) IL251052B (enExample)
MX (1) MX2017003269A (enExample)
PL (1) PL3191599T3 (enExample)
SG (2) SG11201701953RA (enExample)
WO (1) WO2016040907A1 (enExample)

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US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
GB201611840D0 (en) * 2016-07-07 2016-08-24 Univ Court Of The Univ Of Edinburgh The Alpha-synuclein detection assay
JP7136790B2 (ja) 2017-02-17 2022-09-13 ブリストル－マイヤーズ スクイブ カンパニー アルファ－シヌクレインに対する抗体およびその使用
KR20200007945A (ko) 2017-05-16 2020-01-22 암프리온, 인코퍼레이티드 미스폴딩된 타우 단백질의 검출
EP3692373A1 (en) * 2017-10-02 2020-08-12 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
JP7498663B2 (ja) * 2017-12-21 2024-06-12 ハー・ルンドベック・アクチエゼルスカベット アルファ－シヌクレイン病のアッセイ、方法、及び治療
CN108088816A (zh) * 2018-01-23 2018-05-29 深圳市国赛生物技术有限公司 小型特定蛋白分析仪
GB201803553D0 (en) 2018-03-06 2018-04-18 Univ Newcastle Detection of pathological protein aggregation
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
CN112585684B (zh) 2018-09-21 2024-07-19 渊慧科技有限公司 使用质量得分的梯度的迭代蛋白结构预测
JP7376040B2 (ja) * 2019-09-03 2023-11-08 国立大学法人京都工芸繊維大学 神経変性疾患におけるバイオマーカー分子の検出方法
KR102793756B1 (ko) * 2019-09-04 2025-04-08 암프리온, 인코퍼레이티드 비드를 사용한 알파-시누클레인 검출
KR102277871B1 (ko) * 2019-12-17 2021-07-15 원광대학교산학협력단 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample
CA3178674A1 (en) * 2020-05-18 2021-11-25 Amprion, Inc. Alpha-synuclein substrates and methods for making and using the same
EP4249914A4 (en) * 2020-11-21 2024-10-23 Shuwen Biotech Co., Ltd. APPARATUS AND METHOD FOR DETECTION OF MISFOLDED PROTEIN IN A BIOLOGICAL SAMPLE
US20240192230A1 (en) * 2021-04-15 2024-06-13 The Brigham And Women’S Hospital, Inc. Digital Protein Misfolding Assays
CN114199875B (zh) * 2022-02-18 2022-05-20 之江实验室 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置

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US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders

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RS51523B (sr) 2000-07-07 2011-06-30 Laboratoires Serono Sa. Rana dijagnoza konformacionih bolesti
CA2433754A1 (en) 2001-01-03 2002-07-11 Ortho-Mcneil Pharmaceutical, Inc. Alpha synuclein aggregation assays
GB0203446D0 (en) * 2002-02-14 2002-04-03 Univ Lancaster Detection and/or monitoring of synuclein-related diseases
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JP2010043865A (ja) * 2006-12-12 2010-02-25 Olympus Corp 異常型プリオンの検出方法
JP2013511734A (ja) * 2009-11-24 2013-04-04 プロビオドルグ エージー アルツハイマー病又は軽度認知障害の診断のための新規診断方法
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Non-Patent Citations (2)

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Also Published As

Publication number Publication date
EP3191599A4 (en) 2018-03-14
JP6980953B2 (ja) 2021-12-15
KR20170103741A (ko) 2017-09-13
KR102448128B1 (ko) 2022-09-27
IL251052A0 (en) 2017-04-30
SG10202008464UA (en) 2020-10-29
EP3191599C0 (en) 2023-08-02
AU2015314783A1 (en) 2017-04-27
EP3191599B1 (en) 2023-08-02
WO2016040907A1 (en) 2016-03-17
CA2960830A1 (en) 2016-03-17
JP2022000629A (ja) 2022-01-04
IL291809B2 (en) 2023-06-01
CA2960830C (en) 2023-09-05
EP4292654A2 (en) 2023-12-20
PL3191599T3 (pl) 2023-12-27
IL291809A (en) 2022-06-01
JP7104943B2 (ja) 2022-07-22
HRP20231232T1 (hr) 2024-01-19
BR112017004899A2 (pt) 2017-12-12
EP3191599A1 (en) 2017-07-19
IL251052B (en) 2022-05-01
MX2017003269A (es) 2017-12-04
ES2953855T3 (es) 2023-11-16
JP2017530373A (ja) 2017-10-12
US20160077112A1 (en) 2016-03-17
EP4292654A3 (en) 2024-01-03
SG11201701953RA (en) 2017-04-27
CN107208125A (zh) 2017-09-26

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PC1 Assignment before grant (sect. 113)

Owner name: AMPRION, INC.

Free format text: FORMER APPLICANT(S): AMPRION, INC.; BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; SHAHNAWAZ, MOHAMMAD; JARA, CLAUDIO; VOLLRATH, BENEDIKT; LEBOVITZ, RUSSELL

Owner name: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Free format text: FORMER APPLICANT(S): AMPRION, INC.; BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; SHAHNAWAZ, MOHAMMAD; JARA, CLAUDIO; VOLLRATH, BENEDIKT; LEBOVITZ, RUSSELL

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