CA2960830C - Detection of misfolded proteins - Google Patents
Detection of misfolded proteins Download PDFInfo
- Publication number
- CA2960830C CA2960830C CA2960830A CA2960830A CA2960830C CA 2960830 C CA2960830 C CA 2960830C CA 2960830 A CA2960830 A CA 2960830A CA 2960830 A CA2960830 A CA 2960830A CA 2960830 C CA2960830 C CA 2960830C
- Authority
- CA
- Canada
- Prior art keywords
- protein
- misfolded
- soluble
- incubation mixture
- incubation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049306P | 2014-09-11 | 2014-09-11 | |
| US62/049,306 | 2014-09-11 | ||
| PCT/US2015/049844 WO2016040907A1 (en) | 2014-09-11 | 2015-09-11 | Detection of misfolded proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2960830A1 CA2960830A1 (en) | 2016-03-17 |
| CA2960830C true CA2960830C (en) | 2023-09-05 |
Family
ID=55454515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2960830A Active CA2960830C (en) | 2014-09-11 | 2015-09-11 | Detection of misfolded proteins |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20160077112A1 (enExample) |
| EP (2) | EP3191599B1 (enExample) |
| JP (2) | JP6980953B2 (enExample) |
| KR (1) | KR102448128B1 (enExample) |
| CN (1) | CN107208125A (enExample) |
| AU (1) | AU2015314783B2 (enExample) |
| BR (1) | BR112017004899A2 (enExample) |
| CA (1) | CA2960830C (enExample) |
| ES (1) | ES2953855T3 (enExample) |
| HR (1) | HRP20231232T1 (enExample) |
| IL (2) | IL251052B (enExample) |
| MX (1) | MX2017003269A (enExample) |
| PL (1) | PL3191599T3 (enExample) |
| SG (2) | SG10202008464UA (enExample) |
| WO (1) | WO2016040907A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040905A1 (en) | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded alpha synuclein protein |
| GB201611840D0 (en) * | 2016-07-07 | 2016-08-24 | Univ Court Of The Univ Of Edinburgh The | Alpha-synuclein detection assay |
| JP7136790B2 (ja) | 2017-02-17 | 2022-09-13 | ブリストル－マイヤーズ スクイブ カンパニー | アルファ－シヌクレインに対する抗体およびその使用 |
| IL270612B2 (en) | 2017-05-16 | 2025-02-01 | Amprion Inc | Discovery of misfolded tau protein |
| CA3074914A1 (en) | 2017-10-02 | 2019-04-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| MA51295A (fr) * | 2017-12-21 | 2021-05-05 | H Lundbeck As | Dosage, procédé et traitement d'alpha-synucléinopathies |
| CN108088816A (zh) * | 2018-01-23 | 2018-05-29 | 深圳市国赛生物技术有限公司 | 小型特定蛋白分析仪 |
| GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| US20190353669A1 (en) * | 2018-05-16 | 2019-11-21 | Amprion, Inc. | Detection of Brain Injury or Neurological Disease using Tau Protein |
| JP7125544B2 (ja) | 2018-09-21 | 2022-08-24 | ディープマインド テクノロジーズ リミテッド | 品質スコアの勾配を使用した反復的なタンパク質構造予測 |
| JP7376040B2 (ja) * | 2019-09-03 | 2023-11-08 | 国立大学法人京都工芸繊維大学 | 神経変性疾患におけるバイオマーカー分子の検出方法 |
| AU2020343310A1 (en) * | 2019-09-04 | 2022-03-24 | Amprion, Inc. | Alpha-synuclein detection using beads |
| KR102277871B1 (ko) * | 2019-12-17 | 2021-07-15 | 원광대학교산학협력단 | 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트 |
| WO2021198098A1 (en) | 2020-04-03 | 2021-10-07 | Universität Zürich | Improved method of detecting biomarkers in a biological sample |
| CA3178674A1 (en) * | 2020-05-18 | 2021-11-25 | Amprion, Inc. | Alpha-synuclein substrates and methods for making and using the same |
| CA3199642A1 (en) * | 2020-11-21 | 2022-05-27 | Shuwen Biotech Co. Ltd. | Apparatus and method for detecting misfolded protein in biological sample |
| WO2022221876A1 (en) * | 2021-04-15 | 2022-10-20 | The Brigham And Women's Hospital, Inc. | Digital protein misfolding assays |
| CN114199875B (zh) * | 2022-02-18 | 2022-05-20 | 之江实验室 | 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2322660T3 (es) | 2000-07-07 | 2009-06-24 | Merck Serono Sa | Diagnostico precoz de enfermedades conformacionales. |
| CA2433754A1 (en) | 2001-01-03 | 2002-07-11 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha synuclein aggregation assays |
| GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| EP1820806A1 (en) * | 2006-02-16 | 2007-08-22 | Crossbeta Biosciences B.V. | Affinity regions |
| BRPI0607350A2 (pt) * | 2005-02-15 | 2009-09-01 | Adlyfe Inc | método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit |
| JP2009537153A (ja) * | 2006-05-19 | 2009-10-29 | アルニラム ファーマシューティカルズ， インコーポレイテッド | ＡｈａのＲＮＡｉ調節およびその治療上の使用 |
| US20080118938A1 (en) * | 2006-09-06 | 2008-05-22 | Lisbell Estrada | Methods and Compositions for the Detection of Protein Folding Disorders |
| JP2010043865A (ja) * | 2006-12-12 | 2010-02-25 | Olympus Corp | 異常型プリオンの検出方法 |
| JP2013511734A (ja) * | 2009-11-24 | 2013-04-04 | プロビオドルグ エージー | アルツハイマー病又は軽度認知障害の診断のための新規診断方法 |
| US9133343B2 (en) * | 2009-11-30 | 2015-09-15 | Enzo Biochem, Inc. | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications |
| US9910049B2 (en) * | 2014-09-11 | 2018-03-06 | Amprion, Inc. | Detection of misfolded amyloid beta protein |
| EP2666020A1 (en) * | 2011-01-18 | 2013-11-27 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods for amplification and detection of prions |
| US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
-
2015
- 2015-09-11 US US14/852,478 patent/US20160077112A1/en not_active Abandoned
- 2015-09-11 JP JP2017533721A patent/JP6980953B2/ja active Active
- 2015-09-11 CA CA2960830A patent/CA2960830C/en active Active
- 2015-09-11 EP EP15839278.7A patent/EP3191599B1/en active Active
- 2015-09-11 ES ES15839278T patent/ES2953855T3/es active Active
- 2015-09-11 SG SG10202008464UA patent/SG10202008464UA/en unknown
- 2015-09-11 EP EP23189057.5A patent/EP4292654A3/en active Pending
- 2015-09-11 BR BR112017004899A patent/BR112017004899A2/pt not_active Application Discontinuation
- 2015-09-11 KR KR1020177009707A patent/KR102448128B1/ko active Active
- 2015-09-11 WO PCT/US2015/049844 patent/WO2016040907A1/en not_active Ceased
- 2015-09-11 CN CN201580058606.3A patent/CN107208125A/zh active Pending
- 2015-09-11 HR HRP20231232TT patent/HRP20231232T1/hr unknown
- 2015-09-11 SG SG11201701953RA patent/SG11201701953RA/en unknown
- 2015-09-11 MX MX2017003269A patent/MX2017003269A/es unknown
- 2015-09-11 AU AU2015314783A patent/AU2015314783B2/en active Active
- 2015-09-11 PL PL15839278.7T patent/PL3191599T3/pl unknown
-
2017
- 2017-03-09 IL IL251052A patent/IL251052B/en unknown
-
2021
- 2021-05-12 JP JP2021081274A patent/JP7104943B2/ja active Active
-
2022
- 2022-03-30 IL IL291809A patent/IL291809B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20231232T1 (hr) | 2024-01-19 |
| PL3191599T3 (pl) | 2023-12-27 |
| US20160077112A1 (en) | 2016-03-17 |
| EP4292654A3 (en) | 2024-01-03 |
| MX2017003269A (es) | 2017-12-04 |
| IL251052B (en) | 2022-05-01 |
| AU2015314783B2 (en) | 2021-10-21 |
| WO2016040907A1 (en) | 2016-03-17 |
| CN107208125A (zh) | 2017-09-26 |
| SG11201701953RA (en) | 2017-04-27 |
| JP6980953B2 (ja) | 2021-12-15 |
| EP3191599C0 (en) | 2023-08-02 |
| EP4292654A2 (en) | 2023-12-20 |
| JP2017530373A (ja) | 2017-10-12 |
| BR112017004899A2 (pt) | 2017-12-12 |
| KR20170103741A (ko) | 2017-09-13 |
| CA2960830A1 (en) | 2016-03-17 |
| EP3191599A4 (en) | 2018-03-14 |
| EP3191599A1 (en) | 2017-07-19 |
| ES2953855T3 (es) | 2023-11-16 |
| SG10202008464UA (en) | 2020-10-29 |
| JP7104943B2 (ja) | 2022-07-22 |
| JP2022000629A (ja) | 2022-01-04 |
| IL291809B2 (en) | 2023-06-01 |
| IL291809A (en) | 2022-06-01 |
| EP3191599B1 (en) | 2023-08-02 |
| IL251052A0 (en) | 2017-04-30 |
| KR102448128B1 (ko) | 2022-09-27 |
| AU2015314783A1 (en) | 2017-04-27 |
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| Publication | Publication Date | Title |
|---|---|---|
| CA2960830C (en) | Detection of misfolded proteins | |
| US20240219406A1 (en) | Detection of misfolded alpha synuclein protein | |
| US9910049B2 (en) | Detection of misfolded amyloid beta protein | |
| US20220137073A1 (en) | Detection of misfolded tau protein | |
| US20210102961A1 (en) | Detection of misfolded proteins | |
| HK40105178A (en) | Detection of misfolded proteins | |
| US12540949B2 (en) | Detection of misfolded alpha synuclein protein | |
| US20190137515A1 (en) | Methods for estimating misfolded protein concentration in fluids and tissue by quantitative pmca | |
| US20190353669A1 (en) | Detection of Brain Injury or Neurological Disease using Tau Protein |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180911 |
|
| EEER | Examination request |
Effective date: 20180911 |
|
| EEER | Examination request |
Effective date: 20180911 |
|
| EEER | Examination request |
Effective date: 20180911 |
|
| EEER | Examination request |
Effective date: 20180911 |
|
| EEER | Examination request |
Effective date: 20180911 |
|
| EEER | Examination request |
Effective date: 20180911 |
|
| EEER | Examination request |
Effective date: 20180911 |