KR102448128B1 - 미스폴딩된 단백질의 검출 - Google Patents

미스폴딩된 단백질의 검출 Download PDF

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KR102448128B1
KR102448128B1 KR1020177009707A KR20177009707A KR102448128B1 KR 102448128 B1 KR102448128 B1 KR 102448128B1 KR 1020177009707 A KR1020177009707 A KR 1020177009707A KR 20177009707 A KR20177009707 A KR 20177009707A KR 102448128 B1 KR102448128 B1 KR 102448128B1
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KR20170103741A (ko
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클라우디오 소토 자라
모하마드 샤나와즈
러셀 엠. 리보비츠
베네딕트 케이. 볼라트
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보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템
암프리온, 인코퍼레이티드
클라우디오 소토 자라
모하마드 샤나와즈
러셀 엠. 리보비츠
베네딕트 케이. 볼라트
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N2800/00—Detection or diagnosis of diseases
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KR1020177009707A 2014-09-11 2015-09-11 미스폴딩된 단백질의 검출 Active KR102448128B1 (ko)

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US201462049306P 2014-09-11 2014-09-11
US62/049,306 2014-09-11
PCT/US2015/049844 WO2016040907A1 (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

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KR20170103741A KR20170103741A (ko) 2017-09-13
KR102448128B1 true KR102448128B1 (ko) 2022-09-27

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US (1) US20160077112A1 (enExample)
EP (2) EP3191599B1 (enExample)
JP (2) JP6980953B2 (enExample)
KR (1) KR102448128B1 (enExample)
CN (1) CN107208125A (enExample)
AU (1) AU2015314783B2 (enExample)
BR (1) BR112017004899A2 (enExample)
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SG (2) SG10202008464UA (enExample)
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
GB201611840D0 (en) * 2016-07-07 2016-08-24 Univ Court Of The Univ Of Edinburgh The Alpha-synuclein detection assay
JP7136790B2 (ja) 2017-02-17 2022-09-13 ブリストル－マイヤーズ スクイブ カンパニー アルファ－シヌクレインに対する抗体およびその使用
IL270612B2 (en) 2017-05-16 2025-02-01 Amprion Inc Discovery of misfolded tau protein
CA3074914A1 (en) 2017-10-02 2019-04-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
MA51295A (fr) * 2017-12-21 2021-05-05 H Lundbeck As Dosage, procédé et traitement d'alpha-synucléinopathies
CN108088816A (zh) * 2018-01-23 2018-05-29 深圳市国赛生物技术有限公司 小型特定蛋白分析仪
GB201803553D0 (en) 2018-03-06 2018-04-18 Univ Newcastle Detection of pathological protein aggregation
US20190353669A1 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of Brain Injury or Neurological Disease using Tau Protein
JP7125544B2 (ja) 2018-09-21 2022-08-24 ディープマインド テクノロジーズ リミテッド 品質スコアの勾配を使用した反復的なタンパク質構造予測
JP7376040B2 (ja) * 2019-09-03 2023-11-08 国立大学法人京都工芸繊維大学 神経変性疾患におけるバイオマーカー分子の検出方法
AU2020343310A1 (en) * 2019-09-04 2022-03-24 Amprion, Inc. Alpha-synuclein detection using beads
KR102277871B1 (ko) * 2019-12-17 2021-07-15 원광대학교산학협력단 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample
CA3178674A1 (en) * 2020-05-18 2021-11-25 Amprion, Inc. Alpha-synuclein substrates and methods for making and using the same
CA3199642A1 (en) * 2020-11-21 2022-05-27 Shuwen Biotech Co. Ltd. Apparatus and method for detecting misfolded protein in biological sample
WO2022221876A1 (en) * 2021-04-15 2022-10-20 The Brigham And Women's Hospital, Inc. Digital protein misfolding assays
CN114199875B (zh) * 2022-02-18 2022-05-20 之江实验室 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders
US20130137112A1 (en) * 2009-11-30 2013-05-30 Wayne Forrest Patton Dyes for analysis of protein aggregation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2322660T3 (es) 2000-07-07 2009-06-24 Merck Serono Sa Diagnostico precoz de enfermedades conformacionales.
CA2433754A1 (en) 2001-01-03 2002-07-11 Ortho-Mcneil Pharmaceutical, Inc. Alpha synuclein aggregation assays
GB0203446D0 (en) * 2002-02-14 2002-04-03 Univ Lancaster Detection and/or monitoring of synuclein-related diseases
EP1820806A1 (en) * 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Affinity regions
BRPI0607350A2 (pt) * 2005-02-15 2009-09-01 Adlyfe Inc método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit
JP2009537153A (ja) * 2006-05-19 2009-10-29 アルニラム ファーマシューティカルズ， インコーポレイテッド ＡｈａのＲＮＡｉ調節およびその治療上の使用
JP2010043865A (ja) * 2006-12-12 2010-02-25 Olympus Corp 異常型プリオンの検出方法
JP2013511734A (ja) * 2009-11-24 2013-04-04 プロビオドルグ エージー アルツハイマー病又は軽度認知障害の診断のための新規診断方法
US9910049B2 (en) * 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
EP2666020A1 (en) * 2011-01-18 2013-11-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for amplification and detection of prions
US9534044B2 (en) 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders
US20130137112A1 (en) * 2009-11-30 2013-05-30 Wayne Forrest Patton Dyes for analysis of protein aggregation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
H. M. EUGENIA et al., ‘Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA)’, Journal of Biological Chemistry, 2014, Vol. 289, pp 11897-1190*
Journal of Biological Chemistry, 2014, Vol. 289, pp 11897-11905. 1부.*

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HRP20231232T1 (hr) 2024-01-19
CA2960830C (en) 2023-09-05
PL3191599T3 (pl) 2023-12-27
US20160077112A1 (en) 2016-03-17
EP4292654A3 (en) 2024-01-03
MX2017003269A (es) 2017-12-04
IL251052B (en) 2022-05-01
AU2015314783B2 (en) 2021-10-21
WO2016040907A1 (en) 2016-03-17
CN107208125A (zh) 2017-09-26
SG11201701953RA (en) 2017-04-27
JP6980953B2 (ja) 2021-12-15
EP3191599C0 (en) 2023-08-02
EP4292654A2 (en) 2023-12-20
JP2017530373A (ja) 2017-10-12
BR112017004899A2 (pt) 2017-12-12
KR20170103741A (ko) 2017-09-13
CA2960830A1 (en) 2016-03-17
EP3191599A4 (en) 2018-03-14
EP3191599A1 (en) 2017-07-19
ES2953855T3 (es) 2023-11-16
SG10202008464UA (en) 2020-10-29
JP7104943B2 (ja) 2022-07-22
JP2022000629A (ja) 2022-01-04
IL291809B2 (en) 2023-06-01
IL291809A (en) 2022-06-01
EP3191599B1 (en) 2023-08-02
IL251052A0 (en) 2017-04-30
AU2015314783A1 (en) 2017-04-27

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