KR102448128B1 - 미스폴딩된 단백질의 검출 - Google Patents

미스폴딩된 단백질의 검출 Download PDF

Info

Publication number
KR102448128B1
KR102448128B1 KR1020177009707A KR20177009707A KR102448128B1 KR 102448128 B1 KR102448128 B1 KR 102448128B1 KR 1020177009707 A KR1020177009707 A KR 1020177009707A KR 20177009707 A KR20177009707 A KR 20177009707A KR 102448128 B1 KR102448128 B1 KR 102448128B1
Authority
KR
South Korea
Prior art keywords
delete delete
protein
monomeric
incubation
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020177009707A
Other languages
English (en)
Korean (ko)
Other versions
KR20170103741A (ko
Inventor
클라우디오 소토 자라
모하마드 샤나와즈
러셀 엠. 리보비츠
베네딕트 케이. 볼라트
Original Assignee
보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템
암프리온, 인코퍼레이티드
클라우디오 소토 자라
모하마드 샤나와즈
러셀 엠. 리보비츠
베네딕트 케이. 볼라트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템, 암프리온, 인코퍼레이티드, 클라우디오 소토 자라, 모하마드 샤나와즈, 러셀 엠. 리보비츠, 베네딕트 케이. 볼라트 filed Critical 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템
Publication of KR20170103741A publication Critical patent/KR20170103741A/ko
Application granted granted Critical
Publication of KR102448128B1 publication Critical patent/KR102448128B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
KR1020177009707A 2014-09-11 2015-09-11 미스폴딩된 단백질의 검출 Active KR102448128B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049306P 2014-09-11 2014-09-11
US62/049,306 2014-09-11
PCT/US2015/049844 WO2016040907A1 (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

Publications (2)

Publication Number Publication Date
KR20170103741A KR20170103741A (ko) 2017-09-13
KR102448128B1 true KR102448128B1 (ko) 2022-09-27

Family

ID=55454515

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177009707A Active KR102448128B1 (ko) 2014-09-11 2015-09-11 미스폴딩된 단백질의 검출

Country Status (15)

Country Link
US (1) US20160077112A1 (enExample)
EP (2) EP3191599B1 (enExample)
JP (2) JP6980953B2 (enExample)
KR (1) KR102448128B1 (enExample)
CN (1) CN107208125A (enExample)
AU (1) AU2015314783B2 (enExample)
BR (1) BR112017004899A2 (enExample)
CA (1) CA2960830C (enExample)
ES (1) ES2953855T3 (enExample)
HR (1) HRP20231232T1 (enExample)
IL (2) IL251052B (enExample)
MX (1) MX2017003269A (enExample)
PL (1) PL3191599T3 (enExample)
SG (2) SG11201701953RA (enExample)
WO (1) WO2016040907A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
US11079396B2 (en) * 2019-09-04 2021-08-03 Amprion, Inc. Alpha-synuclein detection using beads
GB201611840D0 (en) * 2016-07-07 2016-08-24 Univ Court Of The Univ Of Edinburgh The Alpha-synuclein detection assay
KR102573778B1 (ko) 2017-02-17 2023-08-31 브리스톨-마이어스 스큅 컴퍼니 알파-시뉴클레인에 대한 항체 및 그의 용도
CN110869763B (zh) * 2017-05-16 2022-07-29 安培里翁公司 错误折叠tau蛋白质的检测
US11313867B2 (en) 2017-10-02 2022-04-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
CN111630382A (zh) * 2017-12-21 2020-09-04 H.隆德贝克有限公司 α-共核蛋白病的测定、方法和治疗
CN108088816A (zh) * 2018-01-23 2018-05-29 深圳市国赛生物技术有限公司 小型特定蛋白分析仪
GB201803553D0 (en) 2018-03-06 2018-04-18 Univ Newcastle Detection of pathological protein aggregation
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
CN112585686B (zh) 2018-09-21 2024-07-09 渊慧科技有限公司 通过组合距离图裁剪来确定蛋白距离图
JP7376040B2 (ja) * 2019-09-03 2023-11-08 国立大学法人京都工芸繊維大学 神経変性疾患におけるバイオマーカー分子の検出方法
KR102277871B1 (ko) * 2019-12-17 2021-07-15 원광대학교산학협력단 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample
MX2022014319A (es) * 2020-05-18 2023-02-27 Amprion Inc Sustratos de alfa-sinucleína y métodos para la fabricación y el uso de los mismos.
CA3199642A1 (en) * 2020-11-21 2022-05-27 Shuwen Biotech Co. Ltd. Apparatus and method for detecting misfolded protein in biological sample
WO2022221876A1 (en) * 2021-04-15 2022-10-20 The Brigham And Women's Hospital, Inc. Digital protein misfolding assays
CN114199875B (zh) * 2022-02-18 2022-05-20 之江实验室 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders
US20130137112A1 (en) * 2009-11-30 2013-05-30 Wayne Forrest Patton Dyes for analysis of protein aggregation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60138146D1 (de) 2000-07-07 2009-05-07 Serono Lab Frühdiagnose von konformationellen Erkrankungen
EP1366368A2 (en) 2001-01-03 2003-12-03 Ortho-Mcneil Pharmaceutical, Inc. Alpha synuclein aggregation assays
GB0203446D0 (en) * 2002-02-14 2002-04-03 Univ Lancaster Detection and/or monitoring of synuclein-related diseases
EP1820806A1 (en) * 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Affinity regions
EP1853915B1 (en) * 2005-02-15 2011-10-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
CN101489566B (zh) * 2006-05-19 2012-04-18 阿尔尼拉姆医药品有限公司 Aha基因的RNAi调控及其治疗性应用
JP2010043865A (ja) * 2006-12-12 2010-02-25 Olympus Corp 異常型プリオンの検出方法
CA2779565A1 (en) * 2009-11-24 2011-06-03 Probiodrug Ag Novel diagnostic method for the diagnosis of alzheimer's disease or mild cognitive impairment
US20130288389A1 (en) * 2011-01-18 2013-10-31 Prionics Ag Methods for amplification and detection of prions
US9534044B2 (en) 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof
WO2016040903A1 (en) * 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded amyloid beta protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080118938A1 (en) * 2006-09-06 2008-05-22 Lisbell Estrada Methods and Compositions for the Detection of Protein Folding Disorders
US20130137112A1 (en) * 2009-11-30 2013-05-30 Wayne Forrest Patton Dyes for analysis of protein aggregation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
H. M. EUGENIA et al., ‘Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA)’, Journal of Biological Chemistry, 2014, Vol. 289, pp 11897-1190*
Journal of Biological Chemistry, 2014, Vol. 289, pp 11897-11905. 1부.*

Also Published As

Publication number Publication date
EP4292654A2 (en) 2023-12-20
JP2017530373A (ja) 2017-10-12
AU2015314783A1 (en) 2017-04-27
WO2016040907A1 (en) 2016-03-17
CN107208125A (zh) 2017-09-26
JP7104943B2 (ja) 2022-07-22
MX2017003269A (es) 2017-12-04
EP3191599C0 (en) 2023-08-02
HRP20231232T1 (hr) 2024-01-19
IL251052A0 (en) 2017-04-30
IL291809A (en) 2022-06-01
US20160077112A1 (en) 2016-03-17
KR20170103741A (ko) 2017-09-13
IL291809B2 (en) 2023-06-01
EP3191599B1 (en) 2023-08-02
EP4292654A3 (en) 2024-01-03
JP6980953B2 (ja) 2021-12-15
CA2960830A1 (en) 2016-03-17
PL3191599T3 (pl) 2023-12-27
IL251052B (en) 2022-05-01
AU2015314783B2 (en) 2021-10-21
SG11201701953RA (en) 2017-04-27
EP3191599A4 (en) 2018-03-14
ES2953855T3 (es) 2023-11-16
JP2022000629A (ja) 2022-01-04
SG10202008464UA (en) 2020-10-29
EP3191599A1 (en) 2017-07-19
BR112017004899A2 (pt) 2017-12-12
CA2960830C (en) 2023-09-05

Similar Documents

Publication Publication Date Title
KR102448128B1 (ko) 미스폴딩된 단백질의 검출
US20240219406A1 (en) Detection of misfolded alpha synuclein protein
US9910049B2 (en) Detection of misfolded amyloid beta protein
US20220137073A1 (en) Detection of misfolded tau protein
Mair et al. FLEXITau: quantifying post-translational modifications of tau protein in vitro and in human disease
JP5009987B2 (ja) 体液中のアミロイド−βオリゴマーの検出方法
Haußmann et al. Analysis of amino-terminal variants of amyloid-β peptides by capillary isoelectric focusing immunoassay
US20210102961A1 (en) Detection of misfolded proteins
HK40105178A (en) Detection of misfolded proteins
US20190353669A1 (en) Detection of Brain Injury or Neurological Disease using Tau Protein

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4