JP2014528076A5 - - Google Patents
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- Publication number
- JP2014528076A5 JP2014528076A5 JP2014531321A JP2014531321A JP2014528076A5 JP 2014528076 A5 JP2014528076 A5 JP 2014528076A5 JP 2014531321 A JP2014531321 A JP 2014531321A JP 2014531321 A JP2014531321 A JP 2014531321A JP 2014528076 A5 JP2014528076 A5 JP 2014528076A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- aquaporin
- exosomes
- item
- aki
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 55
- 210000001808 exosome Anatomy 0.000 claims description 26
- 210000002700 urine Anatomy 0.000 claims description 24
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 23
- 208000033626 Renal failure acute Diseases 0.000 claims description 23
- 201000011040 acute kidney failure Diseases 0.000 claims description 23
- 239000003550 marker Substances 0.000 claims description 13
- 102000004363 Aquaporin 3 Human genes 0.000 claims description 12
- 108090000991 Aquaporin 3 Proteins 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 102000012192 Cystatin C Human genes 0.000 claims description 7
- 108010061642 Cystatin C Proteins 0.000 claims description 7
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims description 7
- 101710185991 Hepatitis A virus cellular receptor 1 homolog Proteins 0.000 claims description 7
- 108010051335 Lipocalin-2 Proteins 0.000 claims description 7
- 102000013519 Lipocalin-2 Human genes 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 230000002485 urinary effect Effects 0.000 claims description 7
- 102000003810 Interleukin-18 Human genes 0.000 claims description 6
- 108090000171 Interleukin-18 Proteins 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 239000007850 fluorescent dye Substances 0.000 claims description 4
- 230000003834 intracellular effect Effects 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 4
- 230000008105 immune reaction Effects 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 210000000512 proximal kidney tubule Anatomy 0.000 claims 4
- 210000005239 tubule Anatomy 0.000 claims 2
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 210000000210 loop of henle Anatomy 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 108020001580 protein domains Proteins 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 102000004888 Aquaporin 1 Human genes 0.000 description 8
- 108090001004 Aquaporin 1 Proteins 0.000 description 8
- 108010036221 Aquaporin 2 Proteins 0.000 description 8
- 102100034414 Aquaporin-2 Human genes 0.000 description 8
- 238000012544 monitoring process Methods 0.000 description 5
- -1 IL-1beta Proteins 0.000 description 4
- 102000056430 Member 1 Solute Carrier Family 12 Human genes 0.000 description 4
- 108091006621 SLC12A1 Proteins 0.000 description 4
- 108091006649 SLC9A3 Proteins 0.000 description 4
- 102000046061 Sodium-Hydrogen Exchanger 3 Human genes 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 206010061481 Renal injury Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000001471 micro-filtration Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000037806 kidney injury Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2011/054187 WO2013041913A1 (en) | 2011-09-22 | 2011-09-22 | Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528076A JP2014528076A (ja) | 2014-10-23 |
| JP2014528076A5 true JP2014528076A5 (enExample) | 2014-12-04 |
| JP5893742B2 JP5893742B2 (ja) | 2016-03-23 |
Family
ID=47913944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531321A Expired - Fee Related JP5893742B2 (ja) | 2011-09-22 | 2011-09-22 | 早期における急性腎損傷をモニタリング、診断、および／または予後診断するための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140329334A1 (enExample) |
| EP (1) | EP2758774A4 (enExample) |
| JP (1) | JP5893742B2 (enExample) |
| KR (1) | KR20140076571A (enExample) |
| CN (1) | CN103917869A (enExample) |
| AU (1) | AU2011377379A1 (enExample) |
| BR (1) | BR112014006741A2 (enExample) |
| CA (1) | CA2849577A1 (enExample) |
| HK (1) | HK1199754A1 (enExample) |
| IL (1) | IL231626A0 (enExample) |
| IN (1) | IN2014DN03194A (enExample) |
| MX (1) | MX2014003422A (enExample) |
| PH (1) | PH12014500650A1 (enExample) |
| RU (1) | RU2014115999A (enExample) |
| WO (1) | WO2013041913A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| FR3014198B1 (fr) * | 2013-12-03 | 2017-03-03 | Biomerieux Sa | Procede d'isolement d'exosomes |
| ES2825708T3 (es) * | 2014-07-17 | 2021-05-17 | Univ Pennsylvania | Métodos para usar exosomas para monitorizar el estado de órgano trasplantado |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| JP2017534874A (ja) * | 2014-11-11 | 2017-11-24 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法および組成物。 |
| WO2016077537A1 (en) * | 2014-11-12 | 2016-05-19 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| WO2016140388A1 (ko) * | 2015-03-05 | 2016-09-09 | 경북대학교 산학협력단 | 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법 |
| US20160320390A1 (en) * | 2015-05-01 | 2016-11-03 | Morehouse School Of Medicine | Compositions and methods for capturing exosomes |
| ES2950426T3 (es) * | 2015-08-12 | 2023-10-09 | Univ Columbia | Procedimientos de tratamiento de la depleción de volumen y la lesión renal |
| US11028443B2 (en) | 2015-08-31 | 2021-06-08 | Showa Denko Materials Co., Ltd. | Molecular methods for assessing urothelial disease |
| JP6531987B2 (ja) * | 2015-10-01 | 2019-06-19 | 国立大学法人名古屋大学 | 腎疾患診断のためのエクソソーム回収法 |
| CN105441578B (zh) * | 2016-01-19 | 2018-08-31 | 中南大学湘雅二医院 | 尿液外泌体microRNA分子标志物的应用及制备的试剂盒 |
| JP7064665B2 (ja) | 2016-03-07 | 2022-05-11 | ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル | 非侵襲的分子対照 |
| CN106053811A (zh) * | 2016-06-05 | 2016-10-26 | 浙江大学 | 一种尿液外泌体elisa的检测方法及其应用 |
| RU2647327C2 (ru) * | 2016-07-05 | 2018-03-15 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО КубГМУ Минздрава России) | Способ ранней диагностики хронической болезни почек у пациентов с хронической обструктивной болезнью легких |
| JP2019168223A (ja) * | 2016-08-12 | 2019-10-03 | 公立大学法人和歌山県立医科大学 | エクソソームの膜に存在するタンパク質の検出方法 |
| CN109425742A (zh) * | 2017-08-23 | 2019-03-05 | 迪亚莱博（张家港）生物科技有限公司 | 一种化学发光法快速检测水通道蛋白1的试剂盒 |
| JPWO2019045049A1 (ja) * | 2017-09-01 | 2020-12-03 | 学校法人帝京大学 | 腎尿細管細胞特異的発現ベクター |
| RU2702023C1 (ru) * | 2018-08-17 | 2019-10-04 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ диагностики острого повреждения почек после органосохраняющего хирургического лечения локализованного рака почки |
| ES2968898T3 (es) * | 2019-06-06 | 2024-05-14 | Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz | Método in vitro para detectar enfermedad renal |
| EP3904883A1 (en) * | 2020-04-07 | 2021-11-03 | Sciomics GmbH | Prediction and early diagnosis of acute kidney injury |
| RU2765678C1 (ru) * | 2020-12-21 | 2022-02-01 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ прогнозирования риска развития острого повреждения почек у больных с острым коронарным синдромом |
| CN113189321B (zh) * | 2021-04-12 | 2024-06-25 | 攸太科技(台州)有限公司 | 一种尿液检测方法 |
| JP2025535454A (ja) * | 2022-10-20 | 2025-10-24 | コングク ユニバーシティ インダストリアル コーオペレーション コーポレーション | 腎臓病の早期診断のためのバイオマーカー組成物およびそれを用いた腎臓病の早期診断に必要な情報を提供する方法 |
| KR20250003155A (ko) * | 2023-06-30 | 2025-01-07 | 연세대학교 산학협력단 | 급성신손상의 회복에 대한 정보 제공 방법 및 이를 이용한 키트 |
| CN116883739A (zh) * | 2023-07-10 | 2023-10-13 | 中国医学科学院生物医学工程研究所 | 一种基于图像识别的尿隐血分类方法和系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US20040241176A1 (en) * | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| WO2004013152A2 (en) * | 2002-08-06 | 2004-02-12 | Duke University | Novel targets for lithium therapy |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| US8758991B2 (en) * | 2006-04-26 | 2014-06-24 | University Of Louisville Research Foundation, Inc. | Isolation of membrane vesicles from biological fluids and methods of using same |
| DK2245199T3 (da) * | 2008-02-01 | 2014-02-03 | Gen Hospital Corp | Anvendelse af mikrovesikler i diagnosticering, prognosticering og behandling af medicinske sygdomme og tilstande |
| US20110124519A1 (en) * | 2008-03-18 | 2011-05-26 | Frank Walter Falkenberg | Method of assessing kidney function in a human subject |
| WO2010054025A1 (en) * | 2008-11-05 | 2010-05-14 | Abbott Laboratories | Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, and methods of enrichment, analysis and use |
| JP2012508577A (ja) * | 2008-11-12 | 2012-04-12 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | 表現型を決定するためのエキソソームの使用方法およびそのシステム |
| RU2519722C2 (ru) * | 2008-11-21 | 2014-06-20 | Пхадиа Аб | Способы, устройства и наборы для детекции или мониторинга острого повреждения почек |
| GB0822836D0 (en) * | 2008-12-15 | 2009-01-21 | Oxford Biomedica Ltd | Method |
| CA2800371C (en) * | 2009-05-18 | 2018-01-02 | Washington University | Methods of renal cancer detection |
-
2011
- 2011-09-22 BR BR112014006741A patent/BR112014006741A2/pt not_active IP Right Cessation
- 2011-09-22 HK HK15100094.8A patent/HK1199754A1/xx unknown
- 2011-09-22 JP JP2014531321A patent/JP5893742B2/ja not_active Expired - Fee Related
- 2011-09-22 KR KR1020147009382A patent/KR20140076571A/ko not_active Withdrawn
- 2011-09-22 MX MX2014003422A patent/MX2014003422A/es not_active Application Discontinuation
- 2011-09-22 PH PH1/2014/500650A patent/PH12014500650A1/en unknown
- 2011-09-22 US US14/346,679 patent/US20140329334A1/en not_active Abandoned
- 2011-09-22 AU AU2011377379A patent/AU2011377379A1/en not_active Abandoned
- 2011-09-22 CA CA2849577A patent/CA2849577A1/en not_active Abandoned
- 2011-09-22 CN CN201180074742.3A patent/CN103917869A/zh active Pending
- 2011-09-22 EP EP20110872834 patent/EP2758774A4/en not_active Withdrawn
- 2011-09-22 RU RU2014115999/15A patent/RU2014115999A/ru unknown
- 2011-09-22 WO PCT/IB2011/054187 patent/WO2013041913A1/en not_active Ceased
-
2014
- 2014-03-20 IL IL231626A patent/IL231626A0/en unknown
- 2014-04-22 IN IN3194DEN2014 patent/IN2014DN03194A/en unknown
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