CA2849577A1 - Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage - Google Patents

Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage Download PDF

Info

Publication number
CA2849577A1
CA2849577A1 CA2849577A CA2849577A CA2849577A1 CA 2849577 A1 CA2849577 A1 CA 2849577A1 CA 2849577 A CA2849577 A CA 2849577A CA 2849577 A CA2849577 A CA 2849577A CA 2849577 A1 CA2849577 A1 CA 2849577A1
Authority
CA
Canada
Prior art keywords
exosomes
antibodies
ngal
immunopurification
urine sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2849577A
Other languages
English (en)
French (fr)
Inventor
Carlos Ernesto Irarrazabal Munoz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de los Andes Chile
Original Assignee
Universidad de los Andes Chile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47913944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2849577(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Universidad de los Andes Chile filed Critical Universidad de los Andes Chile
Publication of CA2849577A1 publication Critical patent/CA2849577A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CA2849577A 2011-09-22 2011-09-22 Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage Abandoned CA2849577A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2011/054187 WO2013041913A1 (en) 2011-09-22 2011-09-22 Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage

Publications (1)

Publication Number Publication Date
CA2849577A1 true CA2849577A1 (en) 2013-03-28

Family

ID=47913944

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2849577A Abandoned CA2849577A1 (en) 2011-09-22 2011-09-22 Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage

Country Status (15)

Country Link
US (1) US20140329334A1 (enExample)
EP (1) EP2758774A4 (enExample)
JP (1) JP5893742B2 (enExample)
KR (1) KR20140076571A (enExample)
CN (1) CN103917869A (enExample)
AU (1) AU2011377379A1 (enExample)
BR (1) BR112014006741A2 (enExample)
CA (1) CA2849577A1 (enExample)
HK (1) HK1199754A1 (enExample)
IL (1) IL231626A0 (enExample)
IN (1) IN2014DN03194A (enExample)
MX (1) MX2014003422A (enExample)
PH (1) PH12014500650A1 (enExample)
RU (1) RU2014115999A (enExample)
WO (1) WO2013041913A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014182330A1 (en) 2013-05-06 2014-11-13 Hitachi Chemical Company Ltd Devices and methods for capturing target molecules
FR3014198B1 (fr) * 2013-12-03 2017-03-03 Biomerieux Sa Procede d'isolement d'exosomes
ES2825708T3 (es) * 2014-07-17 2021-05-17 Univ Pennsylvania Métodos para usar exosomas para monitorizar el estado de órgano trasplantado
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
JP2017534874A (ja) * 2014-11-11 2017-11-24 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物。
WO2016077537A1 (en) * 2014-11-12 2016-05-19 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
WO2016140388A1 (ko) * 2015-03-05 2016-09-09 경북대학교 산학협력단 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법
US20160320390A1 (en) * 2015-05-01 2016-11-03 Morehouse School Of Medicine Compositions and methods for capturing exosomes
ES2950426T3 (es) * 2015-08-12 2023-10-09 Univ Columbia Procedimientos de tratamiento de la depleción de volumen y la lesión renal
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
JP6531987B2 (ja) * 2015-10-01 2019-06-19 国立大学法人名古屋大学 腎疾患診断のためのエクソソーム回収法
CN105441578B (zh) * 2016-01-19 2018-08-31 中南大学湘雅二医院 尿液外泌体microRNA分子标志物的应用及制备的试剂盒
JP7064665B2 (ja) 2016-03-07 2022-05-11 ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル 非侵襲的分子対照
CN106053811A (zh) * 2016-06-05 2016-10-26 浙江大学 一种尿液外泌体elisa的检测方法及其应用
RU2647327C2 (ru) * 2016-07-05 2018-03-15 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО КубГМУ Минздрава России) Способ ранней диагностики хронической болезни почек у пациентов с хронической обструктивной болезнью легких
JP2019168223A (ja) * 2016-08-12 2019-10-03 公立大学法人和歌山県立医科大学 エクソソームの膜に存在するタンパク質の検出方法
CN109425742A (zh) * 2017-08-23 2019-03-05 迪亚莱博（张家港）生物科技有限公司 一种化学发光法快速检测水通道蛋白1的试剂盒
JPWO2019045049A1 (ja) * 2017-09-01 2020-12-03 学校法人帝京大学 腎尿細管細胞特異的発現ベクター
RU2702023C1 (ru) * 2018-08-17 2019-10-04 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ диагностики острого повреждения почек после органосохраняющего хирургического лечения локализованного рака почки
ES2968898T3 (es) * 2019-06-06 2024-05-14 Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz Método in vitro para detectar enfermedad renal
EP3904883A1 (en) * 2020-04-07 2021-11-03 Sciomics GmbH Prediction and early diagnosis of acute kidney injury
RU2765678C1 (ru) * 2020-12-21 2022-02-01 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ прогнозирования риска развития острого повреждения почек у больных с острым коронарным синдромом
CN113189321B (zh) * 2021-04-12 2024-06-25 攸太科技(台州)有限公司 一种尿液检测方法
JP2025535454A (ja) * 2022-10-20 2025-10-24 コングク ユニバーシティ インダストリアル コーオペレーション コーポレーション 腎臓病の早期診断のためのバイオマーカー組成物およびそれを用いた腎臓病の早期診断に必要な情報を提供する方法
KR20250003155A (ko) * 2023-06-30 2025-01-07 연세대학교 산학협력단 급성신손상의 회복에 대한 정보 제공 방법 및 이를 이용한 키트
CN116883739A (zh) * 2023-07-10 2023-10-13 中国医学科学院生物医学工程研究所 一种基于图像识别的尿隐血分类方法和系统

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US20040241176A1 (en) * 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
WO2004013152A2 (en) * 2002-08-06 2004-02-12 Duke University Novel targets for lithium therapy
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
US8758991B2 (en) * 2006-04-26 2014-06-24 University Of Louisville Research Foundation, Inc. Isolation of membrane vesicles from biological fluids and methods of using same
DK2245199T3 (da) * 2008-02-01 2014-02-03 Gen Hospital Corp Anvendelse af mikrovesikler i diagnosticering, prognosticering og behandling af medicinske sygdomme og tilstande
US20110124519A1 (en) * 2008-03-18 2011-05-26 Frank Walter Falkenberg Method of assessing kidney function in a human subject
WO2010054025A1 (en) * 2008-11-05 2010-05-14 Abbott Laboratories Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, and methods of enrichment, analysis and use
JP2012508577A (ja) * 2008-11-12 2012-04-12 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 表現型を決定するためのエキソソームの使用方法およびそのシステム
RU2519722C2 (ru) * 2008-11-21 2014-06-20 Пхадиа Аб Способы, устройства и наборы для детекции или мониторинга острого повреждения почек
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
CA2800371C (en) * 2009-05-18 2018-01-02 Washington University Methods of renal cancer detection

Also Published As

Publication number Publication date
JP5893742B2 (ja) 2016-03-23
BR112014006741A2 (pt) 2017-03-28
EP2758774A4 (en) 2015-04-29
IL231626A0 (en) 2014-05-28
WO2013041913A1 (en) 2013-03-28
MX2014003422A (es) 2014-10-13
AU2011377379A1 (en) 2014-04-10
PH12014500650A1 (en) 2014-06-02
EP2758774A1 (en) 2014-07-30
IN2014DN03194A (enExample) 2015-05-22
KR20140076571A (ko) 2014-06-20
CN103917869A (zh) 2014-07-09
US20140329334A1 (en) 2014-11-06
JP2014528076A (ja) 2014-10-23
RU2014115999A (ru) 2015-10-27
HK1199754A1 (en) 2015-07-17

Similar Documents

Publication Publication Date Title
US20140329334A1 (en) Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage
Han et al. Biologic markers for the early detection of acute kidney injury
Tsigou et al. Role of new biomarkers: functional and structural damage
Malyszko et al. Neutrophil gelatinase-associated lipocalin is a new and sensitive marker of kidney function in chronic kidney disease patients and renal allograft recipients
EP2506016B1 (en) Diagnostic method for detecting acute kidney injury using heat shock protein 72 as a sensitive biomarker
US8592170B2 (en) High molecular weight Ngal as a biomarker for chronic kidney disease
CN107667294B (zh) 用于预测慢性肾病发生风险的方法
Baird et al. Urinary Clusterin is a biomarker of renal epithelial senescence and predicts human kidney disease progression
US10725026B2 (en) Method for predicting risk of exposure to interstitial fibrosis and tubular atrophy with clusterin
Sun et al. Associations between the concentrations of CD68, TGF-β1, renal injury index and prognosis in glomerular diseases
Christiansen et al. Increased urinary orosomucoid excretion is not related to impaired renal function in patients with type 2 diabetes
CN119604763A (zh) 用于区分进展性慢性肾脏疾病与稳定性慢性肾脏疾病的方法和组合物
JP6062439B2 (ja) 早期腎障害の評価マーカーとその測定方法
US20230059874A1 (en) New protein markers of renal damage
JPWO2011105474A1 (ja) 急性腎障害の検査方法
Khandpur et al. Association of Wilms tumor-1 protein in urinary exosomes with kidney injury: a population-based cross-sectional study
Kaur et al. A pilot study on the differential urine proteomic profile of subjects with community-acquired acute kidney injury who recover versus those who do not recover completely at 4 months after hospital discharge
ES2994235A1 (es) Metodos para predecir el riesgo de dano renal mediante la deteccion de podocitos binucleados en orina
Asya et al. Expression Profiles of CLDN2, CLDN14, and CaSR Genes in Idiopathic Calcium Oxalate Kidney Stones Patients of South Panjab, Pakistan
Kahindo et al. Diagnostic value of serum creatinine versus urinary neutrophil gelatinase-associated lipocalin (uNGAL) in acute kidney injury in resource-limited settings
EP3812769A1 (en) A method for in vitro diagnosis of renal glomerular disease or for monitoring the progression of renal glomerular disease
Liberek et al. Sp151renal amyloidosis–a common cause of nephrotic syndrome in older patients
KR20250062590A (ko) 신장 이식 후 만성거부반응 진단용 조성물
Ghys Investigation of cystatin C for the detection of feline chronic kidney disease
Al-Jewari et al. SERUM AND URINARY FGF-23 LEVELS IN IRAQI PATIENTS WITH CKD.

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20170922