JP2016533499A5 - - Google Patents
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- JP2016533499A5 JP2016533499A5 JP2016527092A JP2016527092A JP2016533499A5 JP 2016533499 A5 JP2016533499 A5 JP 2016533499A5 JP 2016527092 A JP2016527092 A JP 2016527092A JP 2016527092 A JP2016527092 A JP 2016527092A JP 2016533499 A5 JP2016533499 A5 JP 2016533499A5
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- JP
- Japan
- Prior art keywords
- biomarkers
- biomarker
- binding
- patient
- tbi
- Prior art date
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- 239000000090 biomarker Substances 0.000 claims 39
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 18
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 18
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 17
- 230000009529 traumatic brain injury Effects 0.000 claims 17
- 239000012472 biological sample Substances 0.000 claims 11
- 239000000126 substance Substances 0.000 claims 9
- 238000002965 ELISA Methods 0.000 claims 8
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 claims 8
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 8
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 8
- 108700021154 Metallothionein 3 Proteins 0.000 claims 7
- 102100028708 Metallothionein-3 Human genes 0.000 claims 7
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims 7
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000000758 substrate Substances 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- 206010018985 Haemorrhage intracranial Diseases 0.000 claims 4
- 208000008574 Intracranial Hemorrhages Diseases 0.000 claims 4
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 238000004949 mass spectrometry Methods 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 102100027708 Astrotactin-1 Human genes 0.000 claims 2
- 101710120624 Astrotactin-1 Proteins 0.000 claims 2
- 101000960337 Homo sapiens Intercellular adhesion molecule 5 Proteins 0.000 claims 2
- 101000821885 Homo sapiens Protein S100-B Proteins 0.000 claims 2
- 102100039919 Intercellular adhesion molecule 5 Human genes 0.000 claims 2
- 101800000673 Neuregulin-3 Proteins 0.000 claims 2
- 108010015301 Neurogranin Proteins 0.000 claims 2
- 102000001775 Neurogranin Human genes 0.000 claims 2
- 108010005298 Oligodendrocyte-Myelin Glycoprotein Proteins 0.000 claims 2
- 102100026746 Oligodendrocyte-myelin glycoprotein Human genes 0.000 claims 2
- 102100022659 Pro-neuregulin-3, membrane-bound isoform Human genes 0.000 claims 2
- 102100021487 Protein S100-B Human genes 0.000 claims 2
- 102100022647 Reticulon-1 Human genes 0.000 claims 2
- 101710122684 Reticulon-1 Proteins 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 238000002591 computed tomography Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 108010022794 2',3'-Cyclic-Nucleotide Phosphodiesterases Proteins 0.000 claims 1
- 102100040458 2',3'-cyclic-nucleotide 3'-phosphodiesterase Human genes 0.000 claims 1
- AQQSXKSWTNWXKR-UHFFFAOYSA-N 2-(2-phenylphenanthro[9,10-d]imidazol-3-yl)acetic acid Chemical compound C1(=CC=CC=C1)C1=NC2=C(N1CC(=O)O)C1=CC=CC=C1C=1C=CC=CC=12 AQQSXKSWTNWXKR-UHFFFAOYSA-N 0.000 claims 1
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 1
- 102100032599 Adhesion G protein-coupled receptor B3 Human genes 0.000 claims 1
- 101100406366 Caenorhabditis elegans pad-2 gene Proteins 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102100020743 Dipeptidase 1 Human genes 0.000 claims 1
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
- 102100029108 Elongation factor 1-alpha 2 Human genes 0.000 claims 1
- 101710120808 Elongation factor 1-alpha 2 Proteins 0.000 claims 1
- 102100030376 Ermin Human genes 0.000 claims 1
- 101710095951 Ermin Proteins 0.000 claims 1
- 102300051542 Ermin isoform 2 Human genes 0.000 claims 1
- 102100030669 Glutamate receptor 3 Human genes 0.000 claims 1
- 101710087630 Glutamate receptor 3 Proteins 0.000 claims 1
- 101000796801 Homo sapiens Adhesion G protein-coupled receptor B3 Proteins 0.000 claims 1
- 101001032848 Homo sapiens Metabotropic glutamate receptor 3 Proteins 0.000 claims 1
- 101001067833 Homo sapiens Peptidyl-prolyl cis-trans isomerase A Proteins 0.000 claims 1
- 101000995300 Homo sapiens Protein NDRG2 Proteins 0.000 claims 1
- 101000679406 Homo sapiens Tubulin polymerization-promoting protein family member 3 Proteins 0.000 claims 1
- 102100038352 Metabotropic glutamate receptor 3 Human genes 0.000 claims 1
- 241000282339 Mustela Species 0.000 claims 1
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 claims 1
- 102100034436 Protein NDRG2 Human genes 0.000 claims 1
- 108050005730 Septin 7 Proteins 0.000 claims 1
- 102000017496 Septin 7 Human genes 0.000 claims 1
- 102100028969 Tubulin alpha-1B chain Human genes 0.000 claims 1
- 101710112367 Tubulin alpha-1B chain Proteins 0.000 claims 1
- 102100036821 Tubulin beta-4B chain Human genes 0.000 claims 1
- 101710161045 Tubulin beta-4B chain Proteins 0.000 claims 1
- 102100022563 Tubulin polymerization-promoting protein Human genes 0.000 claims 1
- 101710158555 Tubulin polymerization-promoting protein Proteins 0.000 claims 1
- 102100022567 Tubulin polymerization-promoting protein family member 3 Human genes 0.000 claims 1
- 108091006550 Zinc transporters Proteins 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000007477 logistic regression Methods 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 102000001235 protein arginine deiminase Human genes 0.000 claims 1
- 108060006632 protein arginine deiminase Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019195925A JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
| JP2021181686A JP2022023999A (ja) | 2013-07-17 | 2021-11-08 | 脳損傷の予測方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361847213P | 2013-07-17 | 2013-07-17 | |
| US61/847,213 | 2013-07-17 | ||
| PCT/US2014/046986 WO2015009907A1 (en) | 2013-07-17 | 2014-07-17 | A multi-protein biomarker assay for brain injury detection and outcome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019195925A Division JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533499A JP2016533499A (ja) | 2016-10-27 |
| JP2016533499A5 true JP2016533499A5 (enExample) | 2017-08-24 |
| JP6611710B2 JP6611710B2 (ja) | 2019-11-27 |
Family
ID=52346714
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527092A Active JP6611710B2 (ja) | 2013-07-17 | 2014-07-17 | 脳損傷の検出および転帰についてのマルチプロテインバイオマーカー測定法 |
| JP2019195925A Active JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
| JP2021181686A Pending JP2022023999A (ja) | 2013-07-17 | 2021-11-08 | 脳損傷の予測方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019195925A Active JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
| JP2021181686A Pending JP2022023999A (ja) | 2013-07-17 | 2021-11-08 | 脳損傷の予測方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10534003B2 (enExample) |
| EP (2) | EP3022322A4 (enExample) |
| JP (3) | JP6611710B2 (enExample) |
| IL (1) | IL243393A0 (enExample) |
| WO (1) | WO2015009907A1 (enExample) |
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| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| US20180024145A1 (en) | 2015-02-05 | 2018-01-25 | Immunarray USA, Inc. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| US10667737B2 (en) | 2015-03-23 | 2020-06-02 | International Business Machines Corporation | Monitoring a person for indications of a brain injury |
| FI20155280A7 (fi) * | 2015-04-15 | 2016-10-16 | Medicortex Finland Oy | Aivovamman prognostisia ja diagnostisia glykaanipohjaisia biomarkkereita |
| US10244971B2 (en) * | 2015-05-12 | 2019-04-02 | International Business Machines Corporation | Mouthguard for analysis of biomarkers for traumatic brain injury |
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| KR20230012585A (ko) | 2020-05-21 | 2023-01-26 | 더 파인스타인 인스티튜츠 포 메디칼 리서치 | 미주 신경 자극을 위한 시스템들 및 방법들 |
| EP3982123A1 (en) * | 2020-10-08 | 2022-04-13 | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca | Markers and their use in brain injury |
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-
2014
- 2014-07-17 EP EP14826786.7A patent/EP3022322A4/en not_active Ceased
- 2014-07-17 WO PCT/US2014/046986 patent/WO2015009907A1/en not_active Ceased
- 2014-07-17 EP EP20191259.9A patent/EP3757226A3/en active Pending
- 2014-07-17 JP JP2016527092A patent/JP6611710B2/ja active Active
- 2014-07-17 US US14/905,312 patent/US10534003B2/en active Active
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2015
- 2015-12-28 IL IL243393A patent/IL243393A0/en unknown
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2019
- 2019-10-29 JP JP2019195925A patent/JP6980291B2/ja active Active
- 2019-12-13 US US16/713,425 patent/US11499982B2/en active Active
-
2021
- 2021-11-08 JP JP2021181686A patent/JP2022023999A/ja active Pending
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2022
- 2022-11-08 US US17/982,769 patent/US12339288B2/en active Active
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2025
- 2025-05-22 US US19/215,660 patent/US20260043814A1/en active Pending
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