JP2016533499A5 - - Google Patents
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- JP2016533499A5 JP2016533499A5 JP2016527092A JP2016527092A JP2016533499A5 JP 2016533499 A5 JP2016533499 A5 JP 2016533499A5 JP 2016527092 A JP2016527092 A JP 2016527092A JP 2016527092 A JP2016527092 A JP 2016527092A JP 2016533499 A5 JP2016533499 A5 JP 2016533499A5
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- biomarkers
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- 239000000090 biomarker Substances 0.000 claims 39
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 18
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 18
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 17
- 230000009529 traumatic brain injury Effects 0.000 claims 17
- 239000012472 biological sample Substances 0.000 claims 11
- 239000000126 substance Substances 0.000 claims 9
- 238000002965 ELISA Methods 0.000 claims 8
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 claims 8
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 8
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 8
- 108700021154 Metallothionein 3 Proteins 0.000 claims 7
- 102100028708 Metallothionein-3 Human genes 0.000 claims 7
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims 7
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000000758 substrate Substances 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- 206010018985 Haemorrhage intracranial Diseases 0.000 claims 4
- 208000008574 Intracranial Hemorrhages Diseases 0.000 claims 4
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 238000004949 mass spectrometry Methods 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 102100027708 Astrotactin-1 Human genes 0.000 claims 2
- 101710120624 Astrotactin-1 Proteins 0.000 claims 2
- 101000960337 Homo sapiens Intercellular adhesion molecule 5 Proteins 0.000 claims 2
- 101000821885 Homo sapiens Protein S100-B Proteins 0.000 claims 2
- 102100039919 Intercellular adhesion molecule 5 Human genes 0.000 claims 2
- 101800000673 Neuregulin-3 Proteins 0.000 claims 2
- 108010015301 Neurogranin Proteins 0.000 claims 2
- 102000001775 Neurogranin Human genes 0.000 claims 2
- 108010005298 Oligodendrocyte-Myelin Glycoprotein Proteins 0.000 claims 2
- 102100026746 Oligodendrocyte-myelin glycoprotein Human genes 0.000 claims 2
- 102100022659 Pro-neuregulin-3, membrane-bound isoform Human genes 0.000 claims 2
- 102100021487 Protein S100-B Human genes 0.000 claims 2
- 102100022647 Reticulon-1 Human genes 0.000 claims 2
- 101710122684 Reticulon-1 Proteins 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 238000002591 computed tomography Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 108010022794 2',3'-Cyclic-Nucleotide Phosphodiesterases Proteins 0.000 claims 1
- 102100040458 2',3'-cyclic-nucleotide 3'-phosphodiesterase Human genes 0.000 claims 1
- AQQSXKSWTNWXKR-UHFFFAOYSA-N 2-(2-phenylphenanthro[9,10-d]imidazol-3-yl)acetic acid Chemical compound C1(=CC=CC=C1)C1=NC2=C(N1CC(=O)O)C1=CC=CC=C1C=1C=CC=CC=12 AQQSXKSWTNWXKR-UHFFFAOYSA-N 0.000 claims 1
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 1
- 102100032599 Adhesion G protein-coupled receptor B3 Human genes 0.000 claims 1
- 101100406366 Caenorhabditis elegans pad-2 gene Proteins 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102100020743 Dipeptidase 1 Human genes 0.000 claims 1
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
- 102100029108 Elongation factor 1-alpha 2 Human genes 0.000 claims 1
- 101710120808 Elongation factor 1-alpha 2 Proteins 0.000 claims 1
- 102100030376 Ermin Human genes 0.000 claims 1
- 101710095951 Ermin Proteins 0.000 claims 1
- 102300051542 Ermin isoform 2 Human genes 0.000 claims 1
- 102100030669 Glutamate receptor 3 Human genes 0.000 claims 1
- 101710087630 Glutamate receptor 3 Proteins 0.000 claims 1
- 101000796801 Homo sapiens Adhesion G protein-coupled receptor B3 Proteins 0.000 claims 1
- 101001032848 Homo sapiens Metabotropic glutamate receptor 3 Proteins 0.000 claims 1
- 101001067833 Homo sapiens Peptidyl-prolyl cis-trans isomerase A Proteins 0.000 claims 1
- 101000995300 Homo sapiens Protein NDRG2 Proteins 0.000 claims 1
- 101000679406 Homo sapiens Tubulin polymerization-promoting protein family member 3 Proteins 0.000 claims 1
- 102100038352 Metabotropic glutamate receptor 3 Human genes 0.000 claims 1
- 241000282339 Mustela Species 0.000 claims 1
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 claims 1
- 102100034436 Protein NDRG2 Human genes 0.000 claims 1
- 108050005730 Septin 7 Proteins 0.000 claims 1
- 102000017496 Septin 7 Human genes 0.000 claims 1
- 102100028969 Tubulin alpha-1B chain Human genes 0.000 claims 1
- 101710112367 Tubulin alpha-1B chain Proteins 0.000 claims 1
- 102100036821 Tubulin beta-4B chain Human genes 0.000 claims 1
- 101710161045 Tubulin beta-4B chain Proteins 0.000 claims 1
- 102100022563 Tubulin polymerization-promoting protein Human genes 0.000 claims 1
- 101710158555 Tubulin polymerization-promoting protein Proteins 0.000 claims 1
- 102100022567 Tubulin polymerization-promoting protein family member 3 Human genes 0.000 claims 1
- 108091006550 Zinc transporters Proteins 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000007477 logistic regression Methods 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 102000001235 protein arginine deiminase Human genes 0.000 claims 1
- 108060006632 protein arginine deiminase Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019195925A JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
| JP2021181686A JP2022023999A (ja) | 2013-07-17 | 2021-11-08 | 脳損傷の予測方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361847213P | 2013-07-17 | 2013-07-17 | |
| US61/847,213 | 2013-07-17 | ||
| PCT/US2014/046986 WO2015009907A1 (en) | 2013-07-17 | 2014-07-17 | A multi-protein biomarker assay for brain injury detection and outcome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019195925A Division JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533499A JP2016533499A (ja) | 2016-10-27 |
| JP2016533499A5 true JP2016533499A5 (enExample) | 2017-08-24 |
| JP6611710B2 JP6611710B2 (ja) | 2019-11-27 |
Family
ID=52346714
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527092A Active JP6611710B2 (ja) | 2013-07-17 | 2014-07-17 | 脳損傷の検出および転帰についてのマルチプロテインバイオマーカー測定法 |
| JP2019195925A Active JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
| JP2021181686A Pending JP2022023999A (ja) | 2013-07-17 | 2021-11-08 | 脳損傷の予測方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019195925A Active JP6980291B2 (ja) | 2013-07-17 | 2019-10-29 | 脳損傷の診断／予後判定／評価において有用な組成物及びキット |
| JP2021181686A Pending JP2022023999A (ja) | 2013-07-17 | 2021-11-08 | 脳損傷の予測方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10534003B2 (enExample) |
| EP (2) | EP3757226A3 (enExample) |
| JP (3) | JP6611710B2 (enExample) |
| IL (1) | IL243393A0 (enExample) |
| WO (1) | WO2015009907A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12172017B2 (en) * | 2011-05-09 | 2024-12-24 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| US9709573B2 (en) | 2012-03-13 | 2017-07-18 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| WO2015009907A1 (en) | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| WO2016125148A1 (en) | 2015-02-05 | 2016-08-11 | Immunarray Ltd. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| US10667737B2 (en) | 2015-03-23 | 2020-06-02 | International Business Machines Corporation | Monitoring a person for indications of a brain injury |
| FI20155280A7 (fi) | 2015-04-15 | 2016-10-16 | Medicortex Finland Oy | Aivovamman prognostisia ja diagnostisia glykaanipohjaisia biomarkkereita |
| US10244971B2 (en) * | 2015-05-12 | 2019-04-02 | International Business Machines Corporation | Mouthguard for analysis of biomarkers for traumatic brain injury |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| CN108882885A (zh) | 2016-01-20 | 2018-11-23 | 赛博恩特医疗器械公司 | 迷走神经刺激的控制 |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| EP4521116A3 (en) * | 2016-10-03 | 2025-05-28 | Abbott Laboratories | Improved methods of assessing uch-l1 status in patient samples |
| US12020820B1 (en) | 2017-03-03 | 2024-06-25 | Cerner Innovation, Inc. | Predicting sphingolipidoses (fabry's disease) and decision support |
| US11335461B1 (en) * | 2017-03-06 | 2022-05-17 | Cerner Innovation, Inc. | Predicting glycogen storage diseases (Pompe disease) and decision support |
| CA3261113A1 (en) | 2017-03-23 | 2025-10-27 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1 |
| CN110546513A (zh) | 2017-04-15 | 2019-12-06 | 雅培实验室 | 使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法 |
| ES3053676T3 (en) | 2017-04-28 | 2026-01-23 | Abbott Lab | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
| US11709168B2 (en) | 2017-05-23 | 2023-07-25 | Brainbox Solutions, Inc. | Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma |
| AU2018272054B2 (en) | 2017-05-25 | 2024-10-31 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
| JP7269182B2 (ja) | 2017-05-30 | 2023-05-08 | アボット・ラボラトリーズ | 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法 |
| CA3068041C (en) | 2017-07-03 | 2024-06-25 | Abbott Laboratories | Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood |
| EP3654032B1 (en) * | 2017-07-14 | 2023-09-27 | Mcbi Inc. | Disease detection method |
| EP3668402B1 (en) | 2017-08-14 | 2024-07-31 | Setpoint Medical Corporation | Vagus nerve stimulation pre-screening test |
| AU2018324195B2 (en) | 2017-09-01 | 2024-12-12 | Venn Biosciences Corporation | Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring |
| US11923048B1 (en) | 2017-10-03 | 2024-03-05 | Cerner Innovation, Inc. | Determining mucopolysaccharidoses and decision support tool |
| US11022617B2 (en) | 2017-12-09 | 2021-06-01 | Abbott Laboratories | Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using glial fibrillary acidic protein (GFAP) and/or ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) |
| EP3721234A1 (en) | 2017-12-09 | 2020-10-14 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1 |
| AU2018395255B2 (en) * | 2017-12-29 | 2025-02-20 | Abbott Laboratories | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury |
| WO2020006445A1 (en) * | 2018-06-29 | 2020-01-02 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomarkers and treatment methods for traumatic brain injury associated impairments |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| CA3128367A1 (en) * | 2019-02-01 | 2020-08-06 | Venn Biosciences Corporation | Biomarkers for diagnosing ovarian cancer |
| US12343535B2 (en) | 2019-04-12 | 2025-07-01 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| US12613250B2 (en) | 2019-04-30 | 2026-04-28 | University Of Florida Research Foundation, Incorporated | Biomarker panel for sepsis encephalopathy |
| KR102464243B1 (ko) * | 2020-04-01 | 2022-11-08 | 프리시젼바이오 주식회사 | 외상성 뇌손상 바이오마커 검출용 시분해 형광분석 측방유동 분석장치 및 이를 이용한 외상성 뇌손상 바이오마커 측정방법 |
| US11938324B2 (en) | 2020-05-21 | 2024-03-26 | The Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
| EP3982123A1 (en) * | 2020-10-08 | 2022-04-13 | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca | Markers and their use in brain injury |
| KR102189144B1 (ko) * | 2020-10-15 | 2020-12-09 | 서울대학교병원 | 만성신장질환 악화 예측 마커 및 이를 이용한 악화 예측 방법 |
| WO2022245878A1 (en) | 2021-05-17 | 2022-11-24 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
| EP4466064A4 (en) | 2022-01-20 | 2026-01-14 | Setpoint Medical Corp | TREATMENT OF INFLAMMATORY DISORDERS |
| FI130340B (en) * | 2022-02-22 | 2023-06-29 | Medicortex Finland Oy | Procedure for the diagnosis of traumatic brain injury |
| CN114594273B (zh) * | 2022-05-09 | 2024-02-27 | 上海众启生物科技有限公司 | 一种脑梗塞生物标记物及其应用 |
| WO2023239621A1 (en) * | 2022-06-05 | 2023-12-14 | Branelie Health, Inc. | Healthcare system for and methods of managing brain injury or concussion |
| JP7489723B2 (ja) * | 2022-10-05 | 2024-05-24 | 和哉 松尾 | プログラム、情報処理装置、情報処理方法、および学習モデルの生成方法 |
| WO2025188805A1 (en) * | 2024-03-04 | 2025-09-12 | University Of Denver | Blood based rapid diagnostic system for brain hemorrhage detection and associated methods |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4981785A (en) | 1988-06-06 | 1991-01-01 | Ventrex Laboratories, Inc. | Apparatus and method for performing immunoassays |
| SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5376313A (en) | 1992-03-27 | 1994-12-27 | Abbott Laboratories | Injection molding a plastic assay cuvette having low birefringence |
| WO1994028418A1 (en) | 1993-05-28 | 1994-12-08 | Baylor College Of Medicine | Method and apparatus for desorption and ionization of analytes |
| US5866434A (en) | 1994-12-08 | 1999-02-02 | Meso Scale Technology | Graphitic nanotubes in luminescence assays |
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| KR100449615B1 (ko) | 1995-03-10 | 2004-12-08 | 메소 스케일 테크놀러지즈, 엘엘시 | 다-배열,다-특이적전기화학발광시험법 |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| EP0874993A1 (en) | 1995-12-22 | 1998-11-04 | Abbott Laboratories | Fluorescence polarization immunoassay diagnostic method |
| US5885529A (en) | 1996-06-28 | 1999-03-23 | Dpc Cirrus, Inc. | Automated immunoassay analyzer |
| NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| US6413783B1 (en) | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
| EP1068356B8 (en) | 1998-04-03 | 2007-01-03 | Adnexus Therapeutics, Inc. | Addressable protein arrays |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US6780606B1 (en) | 1999-02-26 | 2004-08-24 | Synx Pharma, Inc. | Method for diagnosing and distinguishing stroke and diagnostic devices for use therein |
| WO2000056934A1 (en) | 1999-03-24 | 2000-09-28 | Packard Bioscience Company | Continuous porous matrix arrays |
| WO2001031580A2 (en) | 1999-10-27 | 2001-05-03 | Biowulf Technologies, Llc | Methods and devices for identifying patterns in biological systems |
| AU2001280581A1 (en) | 2000-07-18 | 2002-01-30 | Correlogic Systems, Inc. | A process for discriminating between biological states based on hidden patterns from biological data |
| US20020164576A1 (en) | 2000-09-22 | 2002-11-07 | Pedersen Finn Skou | Methods for diagnosis and treatment of diseases associated with altered expression of Nrf2 |
| WO2002024867A2 (en) | 2000-09-22 | 2002-03-28 | University Of Aarhus | Novel compositions and methods for lymphoma and leukemia |
| WO2002042733A2 (en) | 2000-11-16 | 2002-05-30 | Ciphergen Biosystems, Inc. | Method for analyzing mass spectra |
| WO2003016910A1 (en) | 2001-08-20 | 2003-02-27 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US7113896B2 (en) | 2001-05-11 | 2006-09-26 | Zhen Zhang | System and methods for processing biological expression data |
| US6884591B2 (en) | 2001-06-25 | 2005-04-26 | The Cleveland Clinic Foundation | Peripheral marker of blood brain barrier permeability |
| US7144708B2 (en) | 2001-06-25 | 2006-12-05 | The Cleveland Clinic Foundation | Markers of blood barrier disruption and methods of using same |
| EP2420824B1 (en) | 2001-06-29 | 2018-11-28 | Meso Scale Technologies LLC | Multi-well plate having an array of wells and kit for use in the conduct of an ECL assay |
| US8815577B2 (en) | 2001-07-30 | 2014-08-26 | Meso Scale Technologies, Llc | Assay electrode having immobilized lipid/protein layers, methods of making the same and methods of using the same for luminescence test measurements |
| CA2932756C (en) | 2001-09-10 | 2020-07-07 | Meso Scale Technologies, Llc | Assay buffer, compositions containing the same, and methods of using the same |
| US7063946B2 (en) | 2001-09-10 | 2006-06-20 | Meso Scale Technologies, Llc. | Methods, reagents, kits and apparatus for protein function analysis |
| US20070098728A1 (en) | 2001-09-24 | 2007-05-03 | Pedersen Finn S | Novel compositions and methods in cancer |
| DK1456668T3 (da) | 2001-12-05 | 2007-09-10 | Sense Proteomic Ltd | Proteinarrays til alleliske varianter og anvendelser deraf |
| CA2473108A1 (en) | 2002-01-14 | 2003-07-24 | Henry Ford Health System | Materials from bone marrow stromal cells for use in forming blood vessels and producing angiogenic and trophic factors |
| US20020193950A1 (en) | 2002-02-25 | 2002-12-19 | Gavin Edward J. | Method for analyzing mass spectra |
| US7036946B1 (en) | 2002-09-13 | 2006-05-02 | Rockwell Collins, Inc. | LCD backlight with UV light-emitting diodes and planar reactive element |
| EP1587955A4 (en) * | 2002-12-24 | 2007-03-14 | Biosite Inc | DIFFERENTIAL DIAGNOSTIC MARKERS AND METHODS OF USE |
| CA3122193C (en) | 2002-12-26 | 2025-05-06 | Meso Scale Technologies, Llc. | ANALYSIS CARTRIDGES AND THEIR METHODS OF USE |
| EP1519194A1 (en) | 2003-09-24 | 2005-03-30 | Roche Diagnostics GmbH | Use of gfap for identification of intracerebral hemorrhage |
| US7981362B2 (en) | 2003-11-04 | 2011-07-19 | Meso Scale Technologies, Llc | Modular assay plates, reader systems and methods for test measurements |
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| AU2005238446B2 (en) | 2004-04-15 | 2009-07-30 | Banyan Biomarkers Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| ES2367311T3 (es) | 2004-04-15 | 2011-11-02 | University Of Florida Research Foundation, Inc. | Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales. |
| US20140303041A1 (en) | 2004-04-15 | 2014-10-09 | University Of Florida Research Foundation Inc. | In vitro diagnostic devices for nervous system injury and other neural disorders |
| US7776583B2 (en) | 2004-06-03 | 2010-08-17 | Meso Scale Technologies, Llc | Methods and apparatuses for conducting assays |
| EP1774023B1 (en) | 2004-06-25 | 2013-05-01 | Washington University School Of Medicine | Markers for brain damage |
| US20060257943A1 (en) | 2005-01-25 | 2006-11-16 | Cis Biotech, Inc. | Ischemic biomarkers and their use to predict adverse neurological events from surgery |
| US7884260B2 (en) | 2005-06-14 | 2011-02-08 | University Of Chicago | Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination |
| GB2428240A (en) | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
| WO2007123976A2 (en) | 2006-04-18 | 2007-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody profiling for determination of patient responsiveness |
| WO2007136617A2 (en) | 2006-05-18 | 2007-11-29 | Walter Reed Army Institute Of Research (Wrair) | Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury |
| US8088584B2 (en) | 2006-10-16 | 2012-01-03 | Bayer Schering Pharma Aktiengesellschaft | LTBP2 as a biomarker and diagnostic target |
| JP5240945B2 (ja) | 2006-11-28 | 2013-07-17 | ピクター リミテッド | アッセイ膜およびその使用法 |
| WO2008097618A1 (en) | 2007-02-06 | 2008-08-14 | University Of Florida Research Foundation, Inc. | Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury |
| EP2015196A1 (en) | 2007-06-28 | 2009-01-14 | Siemens Aktiengesellschaft | Programmer interface for manufacturing execution system |
| EP2245466A2 (en) | 2008-02-04 | 2010-11-03 | Banyan Biomarkers, Inc. | Process to diagnose or treat brain injury |
| US8497078B2 (en) | 2008-05-23 | 2013-07-30 | The Johns Hopkins University | Biomarkers for myocardial ischemia |
| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| US20100190656A1 (en) | 2008-08-08 | 2010-07-29 | Integrated Diagnostics, Inc. | Breast Cancer Specific Markers and Methods of Use |
| US20140342381A1 (en) | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| AU2009282117B2 (en) | 2008-08-11 | 2016-05-12 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| EP3355059A3 (en) * | 2009-06-19 | 2018-09-26 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| US20170315136A9 (en) | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| HUE040281T2 (hu) | 2009-09-14 | 2019-03-28 | Banyan Biomarkers Inc | Autoantitest markerek traumás agysérülés diagnózisára |
| GB201008541D0 (en) | 2010-05-21 | 2010-07-07 | Univ Geneve | Diagnostic methods |
| EP2628013B1 (en) * | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarkers of brain injury |
| CN105823887B (zh) | 2011-01-28 | 2018-06-12 | 西瑞斯实验室有限公司 | 用于检测肠和血脑屏障通透性的方法及其测试材料 |
| JP2014518624A (ja) * | 2011-05-12 | 2014-08-07 | ザ・ジョンズ・ホプキンス・ユニバーシティー | ニューログラニン診断キットのためのアッセイ試薬 |
| WO2012170998A1 (en) | 2011-06-10 | 2012-12-13 | Cornell University | Immobilized protein system for rapid and enhanced multiplexed diagnostics |
| US20150119273A1 (en) | 2012-05-16 | 2015-04-30 | Trustees Of Boston University | Chronic Traumatic Encephalopathy in Blast-Exposed Individuals |
| WO2014194329A1 (en) | 2013-05-31 | 2014-12-04 | Banyan Biomarkers, Inc. | NEURAL SPECIFIC S100β FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION |
| WO2015009907A1 (en) | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| WO2015066211A1 (en) | 2013-10-29 | 2015-05-07 | Banyan Biomarkers, Inc. | Uch-l1 isoforms, assays and devices for detection of a neurological condition |
-
2014
- 2014-07-17 WO PCT/US2014/046986 patent/WO2015009907A1/en not_active Ceased
- 2014-07-17 EP EP20191259.9A patent/EP3757226A3/en active Pending
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- 2014-07-17 US US14/905,312 patent/US10534003B2/en active Active
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2015
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2021
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2022
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2025
- 2025-05-22 US US19/215,660 patent/US20260043814A1/en active Pending
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